GREMLIN Database
MSRB - Peptide methionine sulfoxide reductase MsrB
UniProt: P54155 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 143 (124)
Sequences: 4682 (2614)
Seq/√Len: 234.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_N16_Q2.9891.00
31_N118_S2.9281.00
18_E22_N2.8701.00
78_K91_R2.5801.00
18_E24_G2.4871.00
20_T97_S2.3801.00
46_V97_S2.3401.00
81_T86_I2.3361.00
23_N91_R2.2061.00
16_Q45_I2.1401.00
79_L86_I2.1011.00
90_V116_I2.0651.00
49_K94_T2.0421.00
4_N7_E1.9421.00
68_T109_P1.8741.00
56_D68_T1.8551.00
47_S95_A1.8141.00
43_V124_V1.8011.00
20_T46_V1.7641.00
36_H123_F1.7401.00
52_F114_Y1.7241.00
37_K60_S1.7171.00
49_K93_R1.7031.00
39_E126_K1.6081.00
20_T45_I1.5921.00
56_D69_K1.5741.00
50_P71_I1.5291.00
104_N112_L1.5111.00
23_N78_K1.4751.00
19_V119_A1.4551.00
76_E91_R1.4491.00
77_E112_L1.4391.00
27_P30_Q1.4281.00
49_K74_E1.4221.00
82_S85_M1.4161.00
92_S95_A1.3971.00
34_W37_K1.3881.00
105_D111_G1.3591.00
21_Q46_V1.3491.00
33_Y36_H1.3431.00
43_V48_G1.3131.00
15_M18_E1.3101.00
76_E96_D1.3081.00
83_H86_I1.3021.00
48_G122_R1.3011.00
32_E118_S1.2761.00
5_K22_N1.2581.00
37_K59_D1.2511.00
54_S57_K1.2131.00
76_E93_R1.2001.00
38_E125_P1.1941.00
91_R96_D1.1871.00
32_E122_R1.1581.00
44_D92_S1.1501.00
68_T110_N1.1501.00
41_L71_I1.1311.00
8_K21_Q1.1291.00
7_E10_K1.0951.00
7_E11_S1.0871.00
15_M119_A1.0821.00
5_K21_Q1.0681.00
44_D95_A1.0531.00
8_K11_S1.0301.00
53_T126_K1.0211.00
44_D47_S0.9951.00
36_H42_Y0.9891.00
47_S92_S0.9821.00
80_D87_R0.9811.00
41_L50_P0.9771.00
6_E10_K0.9691.00
29_F35_D0.9631.00
33_Y123_F0.9501.00
5_K9_I0.9451.00
37_K62_C0.9361.00
17_Y21_Q0.9331.00
38_E123_F0.9331.00
39_E55_K0.9031.00
8_K46_V0.9001.00
20_T120_A0.8920.99
77_E88_T0.8880.99
9_I17_Y0.8690.99
14_R18_E0.8680.99
38_E127_H0.8640.99
29_F34_W0.8550.99
90_V99_L0.8540.99
43_V122_R0.8490.99
15_M19_V0.8370.99
99_L116_I0.8320.99
81_T84_G0.8280.99
17_Y22_N0.8260.99
58_F68_T0.8190.99
74_E94_T0.8160.99
68_T108_G0.8160.99
58_F62_C0.8110.99
46_V95_A0.8040.99
15_M27_P0.8040.99
4_N8_K0.8040.99
74_E93_R0.8000.99
45_I97_S0.7930.99
26_E119_A0.7770.99
42_Y54_S0.7740.99
57_K60_S0.7710.98
43_V50_P0.7690.98
34_W59_D0.7590.98
104_N111_G0.7520.98
53_T71_I0.7510.98
23_N96_D0.7460.98
33_Y118_S0.7450.98
35_D59_D0.7210.98
5_K17_Y0.7080.97
75_V99_L0.6950.97
31_N34_W0.6940.97
34_W66_S0.6820.97
80_D101_H0.6800.97
45_I120_A0.6780.97
8_K17_Y0.6760.97
70_P77_E0.6750.96
39_E54_S0.6750.96
116_I121_L0.6700.96
90_V114_Y0.6660.96
23_N82_S0.6630.96
28_P83_H0.6580.96
15_M24_G0.6540.96
70_P114_Y0.6380.95
5_K8_K0.6380.95
107_P111_G0.6370.95
102_V112_L0.6340.95
36_H57_K0.6330.95
52_F102_V0.6320.95
6_E9_I0.6280.95
21_Q97_S0.6240.95
44_D97_S0.6230.95
23_N83_H0.6210.94
89_E115_C0.6170.94
36_H118_S0.6170.94
105_D108_G0.6120.94
41_L53_T0.6100.94
62_C66_S0.6090.94
80_D85_M0.6080.94
87_R101_H0.6070.94
45_I122_R0.6070.94
69_K72_E0.6010.93
73_E77_E0.5970.93
69_K77_E0.5920.93
36_H67_F0.5890.93
17_Y46_V0.5860.93
52_F77_E0.5840.92
16_Q119_A0.5840.92
48_G124_V0.5800.92
70_P73_E0.5750.92
53_T56_D0.5720.92
81_T85_M0.5690.91
69_K109_P0.5690.91
89_E98_H0.5630.91
77_E104_N0.5620.91
54_S123_F0.5600.91
47_S97_S0.5550.90
70_P90_V0.5530.90
77_E114_Y0.5510.90
103_F113_R0.5500.90
30_Q34_W0.5490.90
25_T98_H0.5480.90
98_H101_H0.5470.90
36_H54_S0.5450.90
73_E93_R0.5450.90
28_P31_N0.5410.89
90_V102_V0.5410.89
30_Q118_S0.5350.89
11_S46_V0.5330.89
42_Y52_F0.5320.88
62_C84_G0.5260.88
46_V96_D0.5220.88
92_S97_S0.5220.88
11_S17_Y0.5210.87
34_W42_Y0.5160.87
53_T69_K0.5160.87
31_N36_H0.5150.87
116_I120_A0.5110.86
107_P110_N0.5100.86
49_K95_A0.5050.86
30_Q119_A0.5040.86
21_Q45_I0.5040.86
103_F115_C0.5010.85
8_K47_S0.5010.85
56_D116_I0.5000.85
59_D66_S0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3e0oA 3 0.986 100 0.014 Contact Map
3e0mA 4 1 100 0.034 Contact Map
3hcgA 3 0.993 100 0.038 Contact Map
3cxkA 2 0.8881 100 0.064 Contact Map
2k8dA 1 0.9091 100 0.067 Contact Map
2l1uA 1 0.9441 100 0.09 Contact Map
3hcjA 1 1 100 0.097 Contact Map
2kv1A 1 0.8322 100 0.301 Contact Map
3maoA 1 0.7203 100 0.302 Contact Map
5amhA 1 0.6154 72.3 0.932 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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