GREMLIN Database
MSRA - Peptide methionine sulfoxide reductase MsrA
UniProt: P54154 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 177 (156)
Sequences: 5942 (3645)
Seq/√Len: 291.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
109_K113_E3.3211.00
9_T104_H3.2121.00
8_A70_Y3.1661.00
7_I60_Q3.0251.00
78_W115_S2.7491.00
103_Y109_K2.2721.00
36_T58_A2.2521.00
116_K133_I2.0931.00
32_V139_F2.0481.00
40_T47_E1.9621.00
10_F73_L1.8871.00
86_A130_V1.8611.00
103_Y135_K1.8601.00
78_W116_K1.8111.00
5_K29_E1.8041.00
25_Q76_L1.7891.00
36_T136_A1.7831.00
12_G18_M1.7801.00
26_P67_V1.7791.00
51_E96_S1.7771.00
56_R98_R1.7591.00
32_V141_E1.7591.00
9_T60_Q1.7551.00
6_E105_N1.7391.00
11_A58_A1.7111.00
71_E111_L1.7001.00
33_S147_Q1.6721.00
44_T47_E1.6461.00
69_P72_K1.6381.00
18_M80_Q1.6151.00
32_V60_Q1.6031.00
6_E108_Q1.5871.00
117_Q121_E1.5731.00
5_K65_P1.5721.00
23_D148_H1.5711.00
37_G100_A1.5381.00
101_I112_A1.5321.00
25_Q68_F1.5211.00
71_E114_A1.5081.00
106_D109_K1.4791.00
56_R134_L1.4751.00
110_E114_A1.4751.00
23_D151_K1.4511.00
88_G93_R1.4371.00
85_D88_G1.4221.00
56_R100_A1.4201.00
38_G55_H1.3941.00
81_I99_A1.3691.00
32_V62_T1.3661.00
7_I62_T1.3621.00
9_T58_A1.3351.00
15_F35_Y1.2831.00
74_L111_L1.2611.00
30_K62_T1.2581.00
144_G152_K1.2421.00
6_E63_F1.2401.00
64_H67_V1.2271.00
11_A100_A1.2261.00
75_E115_S1.2141.00
9_T36_T1.2111.00
54_G95_S1.1861.00
6_E65_P1.1831.00
23_D31_V1.1681.00
104_H108_Q1.1351.00
36_T137_E1.1191.00
114_A118_R1.1191.00
12_G80_Q1.1151.00
100_A134_L1.1141.00
71_E118_R1.1001.00
125_F128_P1.0691.00
148_H151_K1.0661.00
19_V23_D1.0651.00
99_A131_T1.0631.00
107_K110_E1.0491.00
102_F132_D1.0421.00
5_K62_T1.0421.00
49_C96_S1.0381.00
9_T136_A1.0261.00
72_K75_E1.0261.00
81_I131_T1.0241.00
43_P140_Y0.9971.00
100_A132_D0.9971.00
103_Y133_I0.9911.00
104_H136_A0.9901.00
120_A129_I0.9691.00
113_E117_Q0.9681.00
10_F74_L0.9551.00
28_I68_F0.9541.00
20_K161_R0.9541.00
21_P80_Q0.9531.00
119_L129_I0.9451.00
41_E138_P0.9361.00
20_K23_D0.9341.00
98_R132_D0.9281.00
63_F108_Q0.9261.00
7_I104_H0.9251.00
48_V53_T0.9161.00
46_E145_Y0.9131.00
95_S98_R0.9121.00
10_F70_Y0.9031.00
70_Y112_A0.9021.00
35_Y143_E0.9011.00
22_F61_I0.8891.00
41_E140_Y0.8881.00
159_R162_T0.8801.00
106_D110_E0.8771.00
10_F22_F0.8671.00
56_R102_F0.8611.00
40_T43_P0.8601.00
109_K135_K0.8581.00
115_S119_L0.8551.00
149_F156_H0.8481.00
91_A160_Y0.8271.00
74_L101_I0.8271.00
113_E116_K0.8261.00
116_K129_I0.8251.00
110_E113_E0.8231.00
20_K150_Y0.8221.00
25_Q28_I0.8201.00
40_T53_T0.8131.00
6_E107_K0.8030.99
68_F72_K0.7980.99
17_C150_Y0.7970.99
134_L137_E0.7940.99
36_T138_P0.7890.99
75_E118_R0.7840.99
19_V31_V0.7820.99
116_K120_A0.7810.99
112_A133_I0.7810.99
114_A117_Q0.7680.99
47_E52_T0.7680.99
39_H54_G0.7680.99
107_K111_L0.7670.99
42_N140_Y0.7660.99
87_G95_S0.7630.99
21_P76_L0.7560.99
74_L115_S0.7510.99
28_I61_I0.7490.99
156_H159_R0.7480.99
24_E151_K0.7470.99
155_A159_R0.7450.99
85_D130_V0.7380.99
71_E115_S0.7370.99
76_L79_Q0.7240.99
29_E32_V0.7240.99
10_F61_I0.7200.99
18_M21_P0.7180.99
119_L124_I0.7130.99
85_D93_R0.7120.99
120_A128_P0.7100.99
87_G93_R0.7090.99
71_E75_E0.7070.99
15_F143_E0.6980.99
158_Q162_T0.6940.99
76_L80_Q0.6930.99
113_E133_I0.6920.99
33_S148_H0.6800.98
34_G139_F0.6770.98
47_E53_T0.6760.98
20_K24_E0.6750.98
118_R121_E0.6750.98
141_E144_G0.6740.98
40_T55_H0.6710.98
115_S118_R0.6690.98
77_F99_A0.6680.98
20_K151_K0.6650.98
48_V96_S0.6620.98
74_L78_W0.6600.98
60_Q104_H0.6590.98
21_P161_R0.6550.98
156_H160_Y0.6410.98
37_G55_H0.6410.98
29_E62_T0.6370.97
50_S53_T0.6360.97
148_H152_K0.6330.97
120_A124_I0.6300.97
20_K158_Q0.6300.97
70_Y108_Q0.6280.97
33_S59_V0.6250.97
37_G102_F0.6240.97
84_T125_F0.6230.97
111_L115_S0.6210.97
11_A56_R0.6190.97
150_Y154_P0.6140.97
111_L114_A0.6100.97
36_T100_A0.6030.96
51_E95_S0.6030.96
84_T130_V0.5990.96
145_Y153_N0.5960.96
91_A159_R0.5900.96
29_E67_V0.5900.96
91_A161_R0.5860.96
77_F81_I0.5860.96
20_K25_Q0.5830.96
35_Y49_C0.5820.96
17_C21_P0.5810.96
103_Y112_A0.5800.96
17_C33_S0.5780.96
105_N108_Q0.5760.95
18_M59_V0.5750.95
53_T95_S0.5750.95
36_T102_F0.5740.95
157_Y160_Y0.5710.95
28_I31_V0.5700.95
103_Y136_A0.5700.95
117_Q120_A0.5680.95
106_D135_K0.5680.95
43_P47_E0.5670.95
50_S95_S0.5660.95
31_V59_V0.5600.95
40_T44_T0.5590.95
56_R99_A0.5530.94
89_Q94_G0.5510.94
82_D88_G0.5500.94
49_C91_A0.5440.94
153_N156_H0.5440.94
86_A95_S0.5410.94
149_F153_N0.5390.94
56_R95_S0.5370.93
158_Q161_R0.5360.93
82_D127_D0.5360.93
26_P68_F0.5340.93
18_M77_F0.5320.93
44_T49_C0.5290.93
85_D125_F0.5160.92
102_F134_L0.5150.92
49_C160_Y0.5150.92
56_R87_G0.5140.92
26_P29_E0.5120.92
30_K141_E0.5110.92
18_M33_S0.5080.91
46_E49_C0.5030.91
10_F101_I0.5010.91
154_P159_R0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bqhA 1 0.9153 100 0.049 Contact Map
3e0mA 4 0.9605 100 0.057 Contact Map
1ff3A 5 0.9605 100 0.059 Contact Map
1fvgA 1 0.8927 100 0.06 Contact Map
4d7lA 3 0.9661 100 0.075 Contact Map
3pimA 2 0.887 100 0.077 Contact Map
2j89A 1 0.9718 100 0.079 Contact Map
1nwaA 1 0.9153 100 0.086 Contact Map
4gwbA 2 0.9209 100 0.103 Contact Map
4lwlA 1 0.9209 100 0.171 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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