GREMLIN Database
YTCP - Probable ABC transporter permease protein YtcP
UniProt: P53561 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 286 (247)
Sequences: 66965 (44410)
Seq/√Len: 2825.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
176_G180_K4.2901.00
70_L74_F3.2001.00
153_K157_Q3.1031.00
32_S56_Y3.0041.00
168_K177_I2.9611.00
96_R164_E2.8031.00
164_E182_V2.6471.00
68_S223_L2.6121.00
67_K70_L2.5911.00
167_A177_I2.5661.00
173_N176_G2.5151.00
54_D57_R2.4351.00
80_T194_S2.4131.00
82_V143_A2.3981.00
155_F189_A2.3711.00
66_Y70_L2.3671.00
57_R61_S2.3351.00
152_L190_I2.3291.00
54_D58_Y2.3201.00
175_L179_F2.3021.00
174_D177_I2.2621.00
78_I139_I2.2321.00
88_S178_F2.1491.00
176_G179_F2.0611.00
99_L102_R2.0581.00
172_C176_G2.0551.00
249_E252_I2.0481.00
95_S157_Q2.0471.00
148_N193_I2.0391.00
156_F186_S2.0161.00
163_L185_L1.9521.00
167_A172_C1.8481.00
84_M194_S1.8451.00
30_A34_A1.8361.00
88_S186_S1.8281.00
76_T198_A1.7881.00
74_F135_Y1.7741.00
106_M153_K1.7711.00
87_S148_N1.7671.00
67_K71_V1.7321.00
168_K174_D1.7241.00
26_I30_A1.7071.00
94_L149_L1.7021.00
164_E177_I1.6821.00
88_S152_L1.6751.00
90_M149_L1.6591.00
74_F78_I1.6421.00
218_W226_Q1.6381.00
79_G201_Y1.5991.00
58_Y252_I1.5301.00
164_E168_K1.5261.00
29_I258_V1.5111.00
23_L27_H1.5101.00
98_D102_R1.4751.00
91_A152_L1.4621.00
161_S164_E1.4291.00
58_Y61_S1.4291.00
101_G104_P1.4231.00
11_Y15_L1.4201.00
192_T196_F1.4131.00
183_L190_I1.4091.00
95_S153_K1.4081.00
148_N197_Y1.3871.00
205_Y209_I1.3771.00
52_S55_A1.3701.00
207_T211_Y1.3621.00
53_L57_R1.3611.00
27_H31_A1.3511.00
156_F182_V1.3451.00
124_L127_K1.3311.00
83_S197_Y1.3261.00
152_L193_I1.3261.00
123_F127_K1.3111.00
161_S165_E1.2881.00
139_I143_A1.2831.00
167_A181_I1.2811.00
85_F89_L1.2761.00
96_R161_S1.2581.00
141_P211_Y1.2471.00
135_Y217_K1.2091.00
88_S190_I1.2031.00
225_R229_I1.1961.00
92_Y156_F1.1891.00
56_Y258_V1.1841.00
159_I185_L1.1841.00
264_V268_Y1.1741.00
78_I81_A1.1741.00
162_S165_E1.1731.00
64_I67_K1.1721.00
81_A85_F1.1691.00
173_N177_I1.1431.00
223_L227_I1.1411.00
218_W221_Q1.1391.00
269_P273_K1.1291.00
135_Y139_I1.1241.00
28_V258_V1.1181.00
84_M190_I1.1081.00
15_L19_L1.1041.00
136_W139_I1.1031.00
75_V219_P1.1031.00
187_L191_A1.1001.00
104_P107_F1.0921.00
38_E50_T1.0921.00
92_Y178_F1.0841.00
226_Q230_V1.0831.00
134_S220_I1.0761.00
151_I193_I1.0741.00
35_T38_E1.0691.00
152_L189_A1.0691.00
185_L188_P1.0591.00
204_T208_A1.0541.00
220_I224_L1.0501.00
71_V74_F1.0501.00
55_A251_T1.0491.00
164_E174_D1.0471.00
60_F66_Y1.0441.00
212_L217_K1.0381.00
104_P108_L1.0361.00
79_G83_S1.0201.00
78_I82_V1.0071.00
221_Q229_I0.9991.00
95_S156_F0.9971.00
89_L93_G0.9831.00
92_Y174_D0.9811.00
58_Y62_T0.9791.00
73_V77_V0.9751.00
32_S36_V0.9741.00
270_F274_H0.9691.00
204_T207_T0.9691.00
216_A220_I0.9681.00
223_L226_Q0.9641.00
136_W140_L0.9641.00
126_V137_A0.9551.00
221_Q225_R0.9551.00
172_C177_I0.9521.00
102_R157_Q0.9501.00
138_L208_A0.9481.00
226_Q229_I0.9451.00
221_Q224_L0.9431.00
177_I180_K0.9421.00
79_G142_T0.9391.00
27_H30_A0.9351.00
219_P222_V0.9331.00
8_M12_G0.9321.00
10_I14_L0.9311.00
130_G133_D0.9281.00
131_L136_W0.9231.00
8_M11_Y0.9081.00
7_D11_Y0.9041.00
142_T201_Y0.9001.00
148_N152_L0.9001.00
186_S189_A0.8991.00
155_F186_S0.8981.00
100_I103_Q0.8921.00
141_P207_T0.8901.00
91_A95_S0.8881.00
77_V81_A0.8811.00
65_I256_V0.8781.00
82_V139_I0.8781.00
31_A254_M0.8741.00
152_L186_S0.8721.00
252_I256_V0.8601.00
83_S87_S0.8591.00
187_L190_I0.8581.00
81_A194_S0.8531.00
110_V150_I0.8521.00
69_L73_V0.8481.00
71_V135_Y0.8471.00
18_A22_V0.8441.00
94_L106_M0.8441.00
36_V40_V0.8371.00
87_S149_L0.8371.00
33_F51_F0.8361.00
31_A34_A0.8331.00
178_F183_L0.8301.00
82_V85_F0.8191.00
103_Q106_M0.8181.00
218_W223_L0.8181.00
59_I259_V0.8161.00
34_A38_E0.8161.00
179_F183_L0.8151.00
79_G139_I0.8121.00
74_F77_V0.8101.00
214_D217_K0.8081.00
137_A141_P0.8041.00
91_A149_L0.8011.00
33_F52_S0.8001.00
197_Y201_Y0.8001.00
205_Y225_R0.7931.00
28_V254_M0.7881.00
93_G99_L0.7811.00
187_L274_H0.7781.00
266_L270_F0.7761.00
220_I223_L0.7751.00
74_F136_W0.7731.00
177_I182_V0.7701.00
271_I274_H0.7701.00
122_T125_V0.7681.00
37_E40_V0.7681.00
128_S131_L0.7671.00
91_A156_F0.7641.00
163_L181_I0.7641.00
124_L128_S0.7591.00
215_S218_W0.7591.00
70_L73_V0.7581.00
174_D178_F0.7581.00
23_L26_I0.7571.00
152_L156_F0.7561.00
224_L227_I0.7521.00
58_Y249_E0.7481.00
123_F126_V0.7451.00
138_L142_T0.7451.00
84_M152_L0.7401.00
223_L228_V0.7401.00
75_V142_T0.7391.00
230_V247_P0.7381.00
75_V135_Y0.7371.00
110_V113_M0.7331.00
94_L105_L0.7331.00
47_I50_T0.7291.00
78_I143_A0.7251.00
250_Q253_K0.7241.00
178_F182_V0.7231.00
222_V225_R0.7211.00
260_A264_V0.7201.00
139_I142_T0.7201.00
254_M258_V0.7151.00
133_D214_D0.7081.00
161_S168_K0.7071.00
68_S71_V0.7071.00
12_G15_L0.7031.00
83_S145_N0.7011.00
83_S148_N0.6971.00
80_T198_A0.6911.00
17_F21_C0.6911.00
250_Q254_M0.6901.00
159_I186_S0.6881.00
251_T254_M0.6881.00
76_T80_T0.6871.00
220_I227_I0.6841.00
94_L153_K0.6831.00
35_T49_T0.6831.00
190_I193_I0.6801.00
28_V257_I0.6801.00
117_G206_M0.6791.00
34_A48_P0.6781.00
270_F273_K0.6711.00
208_A219_P0.6701.00
87_S152_L0.6691.00
31_A35_T0.6681.00
59_I256_V0.6681.00
93_G97_R0.6661.00
216_A219_P0.6661.00
252_I255_A0.6651.00
268_Y272_Q0.6611.00
225_R228_V0.6601.00
59_I252_I0.6601.00
69_L220_I0.6591.00
66_Y69_L0.6581.00
145_N197_Y0.6571.00
35_T50_T0.6551.00
72_S221_Q0.6511.00
9_L13_F0.6481.00
106_M150_I0.6471.00
127_K132_L0.6461.00
80_T84_M0.6441.00
129_L132_L0.6411.00
248_P252_I0.6411.00
122_T211_Y0.6381.00
190_I194_S0.6361.00
166_S170_D0.6351.00
172_C180_K0.6341.00
113_M146_A0.6341.00
51_F54_D0.6321.00
182_V185_L0.6321.00
212_L218_W0.6311.00
142_T145_N0.6301.00
135_Y138_L0.6301.00
62_T66_Y0.6271.00
57_R60_F0.6261.00
189_A193_I0.6251.00
55_A58_Y0.6241.00
134_S137_A0.6211.00
137_A211_Y0.6211.00
9_L12_G0.6211.00
56_Y255_A0.6171.00
217_K221_Q0.6161.00
34_A50_T0.6161.00
166_S169_I0.6161.00
76_T201_Y0.6121.00
220_I225_R0.6111.00
216_A228_V0.6111.00
145_N200_T0.6101.00
13_F17_F0.6081.00
115_F119_M0.6061.00
14_L18_A0.6061.00
83_S201_Y0.6021.00
38_E49_T0.5981.00
126_V132_L0.5961.00
90_M109_V0.5951.00
136_W143_A0.5941.00
118_G210_L0.5921.00
31_A36_V0.5901.00
113_M147_F0.5871.00
101_G105_L0.5871.00
138_L143_A0.5861.00
50_T53_L0.5831.00
107_F111_F0.5821.00
18_A21_C0.5791.00
206_M210_L0.5771.00
97_R100_I0.5761.00
99_L105_L0.5751.00
254_M257_I0.5751.00
199_V203_N0.5741.00
53_L56_Y0.5731.00
151_I189_A0.5731.00
64_I218_W0.5711.00
60_F63_D0.5691.00
141_P144_I0.5671.00
257_I260_A0.5631.00
135_Y141_P0.5621.00
142_T208_A0.5611.00
108_L112_T0.5601.00
109_V146_A0.5601.00
220_I229_I0.5591.00
75_V139_I0.5591.00
134_S143_A0.5561.00
98_D103_Q0.5551.00
72_S202_W0.5541.00
173_N179_F0.5461.00
29_I33_F0.5441.00
80_T201_Y0.5431.00
159_I164_E0.5431.00
32_S255_A0.5411.00
220_I226_Q0.5401.00
138_L212_L0.5401.00
91_A153_K0.5391.00
123_F132_L0.5371.00
98_D161_S0.5351.00
11_Y14_L0.5341.00
200_T203_N0.5341.00
75_V79_G0.5331.00
134_S138_L0.5311.00
48_P51_F0.5301.00
34_A49_T0.5271.00
265_L269_P0.5271.00
105_L109_V0.5271.00
80_T85_F0.5271.00
7_D10_I0.5241.00
197_Y200_T0.5231.00
19_L23_L0.5231.00
112_T146_A0.5221.00
127_K130_G0.5191.00
63_D66_Y0.5191.00
75_V138_L0.5181.00
76_T202_W0.5171.00
220_I228_V0.5121.00
62_T252_I0.5111.00
263_P266_L0.5111.00
103_Q107_F0.5101.00
52_S56_Y0.5101.00
230_V249_E0.5101.00
63_D67_K0.5091.00
32_S35_T0.5091.00
84_M89_L0.5081.00
206_M209_I0.5081.00
79_G143_A0.5051.00
90_M93_G0.5041.00
36_V48_P0.5031.00
128_S132_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tquN 1 0.965 100 0.257 Contact Map
3rlfG 1 0.9231 100 0.311 Contact Map
2onkC 2 0.8322 100 0.356 Contact Map
4tquM 1 0.8671 100 0.376 Contact Map
3d31C 2 0.8147 100 0.384 Contact Map
3rlfF 1 0.8811 100 0.414 Contact Map
4ymuD 2 0.7308 99.9 0.517 Contact Map
3tuiA 2 0.7133 99.9 0.552 Contact Map
2a65A 2 0.7972 8.5 0.952 Contact Map
4xp4A 1 0.8077 5.5 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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