GREMLIN Database
YTBQ - Uncharacterized protein YtbQ
UniProt: P53560 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 253 (232)
Sequences: 53314 (35905)
Seq/√Len: 2357.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_G29_V3.2281.00
3_K26_E2.8241.00
20_G199_S2.7491.00
86_D90_R2.6391.00
241_N244_E2.3951.00
62_A205_I2.2891.00
80_E83_K2.2761.00
106_K164_S2.2041.00
110_A201_F2.1791.00
231_V237_S2.1711.00
30_L44_A2.0951.00
65_N109_F2.0921.00
132_T135_D2.0791.00
20_G24_D2.0641.00
44_A51_E2.0201.00
20_G202_K2.0091.00
199_S239_Q1.9981.00
64_L205_I1.9951.00
170_I201_F1.9731.00
48_N51_E1.9691.00
7_A65_N1.9531.00
28_T60_T1.9191.00
5_L60_T1.9101.00
154_G165_V1.8961.00
6_I18_A1.8691.00
3_K28_T1.8611.00
174_V245_L1.8501.00
24_D206_E1.8241.00
199_S203_A1.8201.00
28_T40_S1.8131.00
228_E232_N1.7691.00
168_L204_A1.7661.00
26_E40_S1.7631.00
28_T42_I1.7121.00
111_S115_V1.7101.00
49_Y97_R1.6951.00
47_A86_D1.6941.00
93_Y153_I1.6431.00
92_S150_S1.6201.00
17_L198_L1.6151.00
17_L64_L1.6131.00
202_K206_E1.6111.00
90_R93_Y1.5981.00
93_Y97_R1.5941.00
24_D202_K1.5771.00
137_P148_L1.5541.00
33_D41_S1.5511.00
66_L110_A1.5391.00
85_T149_T1.5341.00
100_A161_N1.5331.00
148_L152_Q1.5241.00
61_D105_Q1.4961.00
17_L66_L1.4651.00
20_G23_S1.4621.00
63_I99_A1.4481.00
49_Y94_Y1.4451.00
4_V25_Y1.4421.00
88_F146_L1.4341.00
13_I173_V1.4121.00
230_A234_L1.4041.00
82_E86_D1.3911.00
20_G198_L1.3791.00
203_A207_T1.3781.00
18_A29_V1.3561.00
133_T229_S1.3541.00
19_E177_E1.3521.00
96_C157_F1.3221.00
106_K166_I1.3211.00
95_L107_L1.3191.00
46_A91_A1.3181.00
9_G18_A1.3151.00
131_I135_D1.3101.00
244_E247_N1.3081.00
64_L201_F1.3051.00
143_Y147_K1.3031.00
25_Y206_E1.3001.00
152_Q155_H1.2991.00
193_S245_L1.2941.00
99_A107_L1.2771.00
192_L197_L1.2651.00
10_N31_D1.2621.00
170_I197_L1.2611.00
171_G225_W1.2511.00
110_A170_I1.2471.00
28_T58_K1.2341.00
227_I231_V1.2291.00
65_N92_S1.2271.00
97_R100_A1.2211.00
158_Y165_V1.2181.00
227_I238_P1.2121.00
5_L30_L1.2091.00
22_I39_A1.2081.00
109_F150_S1.2051.00
145_V149_T1.2041.00
109_F154_G1.2011.00
20_G195_P1.1931.00
29_V39_A1.1791.00
96_C107_L1.1771.00
155_H167_N1.1731.00
168_L201_F1.1521.00
57_P60_T1.1371.00
16_L195_P1.1371.00
109_F167_N1.1351.00
21_L202_K1.1281.00
194_H198_L1.1281.00
57_P63_I1.1101.00
97_R101_E1.1101.00
69_V87_V1.1071.00
99_A104_I1.1061.00
46_A67_L1.1051.00
19_E23_S1.1011.00
4_V62_A1.0901.00
108_V168_L1.0701.00
66_L201_F1.0691.00
106_K208_N1.0611.00
98_A102_L1.0551.00
229_S233_E1.0541.00
100_A163_L1.0541.00
16_L194_H1.0531.00
35_F39_A1.0511.00
107_L154_G1.0421.00
122_D130_E1.0391.00
52_L98_A1.0331.00
96_C154_G1.0221.00
40_S58_K1.0121.00
4_V21_L1.0101.00
22_I38_K1.0041.00
87_V91_A1.0031.00
173_V197_L0.9971.00
15_R177_E0.9961.00
54_K101_E0.9941.00
90_R94_Y0.9891.00
3_K61_D0.9841.00
156_L160_E0.9831.00
153_I156_L0.9811.00
30_L52_L0.9811.00
155_H165_V0.9801.00
3_K60_T0.9751.00
94_Y97_R0.9671.00
151_E169_R0.9631.00
132_T226_S0.9601.00
3_K25_Y0.9561.00
57_P102_L0.9531.00
193_S196_D0.9521.00
174_V193_S0.9451.00
111_S151_E0.9421.00
57_P98_A0.9371.00
12_V194_H0.9351.00
85_T89_Y0.9251.00
34_H43_Q0.9251.00
89_Y149_T0.9201.00
33_D43_Q0.9111.00
22_I27_V0.9111.00
18_A27_V0.9081.00
98_A101_E0.8991.00
51_E56_I0.8981.00
155_H159_L0.8981.00
4_V64_L0.8951.00
47_A87_V0.8941.00
7_A67_L0.8931.00
17_L21_L0.8901.00
50_E54_K0.8861.00
166_I204_A0.8841.00
85_T90_R0.8811.00
113_N171_G0.8801.00
30_L51_E0.8791.00
121_K132_T0.8761.00
32_K45_D0.8741.00
84_M146_L0.8731.00
243_A247_N0.8721.00
42_I56_I0.8701.00
166_I208_N0.8701.00
12_V175_T0.8661.00
30_L56_I0.8651.00
49_Y101_E0.8591.00
134_S229_S0.8531.00
203_A206_E0.8481.00
7_A95_L0.8471.00
16_L19_E0.8371.00
200_I230_A0.8351.00
31_D41_S0.8321.00
92_S154_G0.8311.00
28_T59_D0.8291.00
96_C153_I0.8211.00
121_K135_D0.8171.00
115_V137_P0.8161.00
199_S202_K0.8151.00
94_Y98_A0.8121.00
69_V83_K0.8111.00
188_K222_G0.8081.00
149_T152_Q0.8071.00
62_A106_K0.8061.00
63_I95_L0.8051.00
97_R157_F0.7971.00
16_L20_G0.7971.00
77_D84_M0.7971.00
81_F145_V0.7931.00
173_V192_L0.7911.00
199_S236_F0.7901.00
69_V84_M0.7881.00
78_I142_L0.7761.00
105_Q164_S0.7721.00
25_Y61_D0.7691.00
57_P99_A0.7661.00
204_A234_L0.7641.00
52_L94_Y0.7611.00
168_L200_I0.7601.00
157_F161_N0.7591.00
91_A94_Y0.7541.00
145_V156_L0.7501.00
214_Y217_V0.7501.00
4_V205_I0.7491.00
115_V151_E0.7411.00
145_V152_Q0.7401.00
48_N52_L0.7381.00
42_I58_K0.7381.00
83_K86_D0.7371.00
85_T146_L0.7321.00
92_S96_C0.7321.00
176_D193_S0.7311.00
16_L198_L0.7291.00
152_Q156_L0.7281.00
228_E231_V0.7261.00
150_S154_G0.7241.00
56_I60_T0.7231.00
171_G190_T0.7211.00
198_L202_K0.7201.00
114_H144_G0.7181.00
36_D39_A0.7161.00
120_E135_D0.7151.00
51_E54_K0.7141.00
100_A157_F0.7121.00
65_N95_L0.7051.00
5_L44_A0.6991.00
83_K87_V0.6981.00
10_N33_D0.6941.00
149_T153_I0.6901.00
45_D48_N0.6841.00
3_K58_K0.6831.00
133_T230_A0.6811.00
170_I173_V0.6731.00
211_Y214_Y0.6721.00
35_F38_K0.6721.00
81_F142_L0.6671.00
229_S232_N0.6671.00
63_I107_L0.6651.00
26_E38_K0.6651.00
172_T189_K0.6611.00
5_L63_I0.6611.00
141_N144_G0.6601.00
3_K59_D0.6591.00
21_L205_I0.6551.00
164_S209_I0.6551.00
16_L177_E0.6551.00
5_L57_P0.6531.00
100_A162_K0.6531.00
204_A230_A0.6501.00
164_S210_R0.6481.00
203_A235_G0.6441.00
68_A88_F0.6431.00
209_I233_E0.6431.00
58_K102_L0.6431.00
6_I21_L0.6421.00
137_P152_Q0.6411.00
227_I236_F0.6371.00
139_S144_G0.6371.00
85_T145_V0.6311.00
15_R19_E0.6311.00
24_D199_S0.6251.00
216_A219_D0.6241.00
119_Y131_I0.6241.00
154_G167_N0.6181.00
200_I236_F0.6181.00
62_A105_Q0.6161.00
13_I197_L0.6151.00
108_V201_F0.6141.00
196_D199_S0.6141.00
182_H211_Y0.6111.00
155_H158_Y0.6091.00
69_V88_F0.6081.00
220_N223_R0.6071.00
108_V204_A0.6051.00
203_A234_L0.6051.00
230_A233_E0.6041.00
17_L201_F0.6031.00
156_L159_L0.6031.00
214_Y218_S0.5951.00
16_L176_D0.5891.00
213_T216_A0.5891.00
207_T210_R0.5891.00
115_V169_R0.5871.00
25_Y62_A0.5871.00
142_L145_V0.5851.00
146_L150_S0.5821.00
215_Y218_S0.5801.00
5_L56_I0.5781.00
139_S148_L0.5761.00
153_I157_F0.5731.00
31_D34_H0.5711.00
117_D138_L0.5701.00
63_I104_I0.5681.00
54_K98_A0.5681.00
106_K209_I0.5661.00
49_Y98_A0.5651.00
113_N225_W0.5651.00
196_D239_Q0.5651.00
66_L170_I0.5651.00
239_Q244_E0.5611.00
212_G215_Y0.5591.00
176_D195_P0.5591.00
29_V41_S0.5581.00
108_V205_I0.5571.00
19_E195_P0.5571.00
203_A236_F0.5561.00
157_F163_L0.5551.00
112_S115_V0.5541.00
18_A22_I0.5481.00
122_D222_G0.5471.00
6_I29_V0.5461.00
164_S208_N0.5431.00
88_F143_Y0.5401.00
12_V16_L0.5371.00
214_Y219_D0.5351.00
172_T191_L0.5321.00
28_T56_I0.5301.00
215_Y219_D0.5301.00
17_L202_K0.5271.00
202_K205_I0.5261.00
25_Y202_K0.5261.00
24_D203_A0.5241.00
215_Y221_P0.5231.00
18_A39_A0.5221.00
116_T169_R0.5221.00
158_Y163_L0.5221.00
130_E135_D0.5161.00
62_A108_V0.5161.00
207_T233_E0.5131.00
99_A102_L0.5121.00
142_L146_L0.5081.00
42_I51_E0.5061.00
143_Y146_L0.5051.00
92_S109_F0.5041.00
21_L25_Y0.5041.00
6_I9_G0.5021.00
59_D102_L0.5021.00
178_M181_L0.5021.00
44_A56_I0.5011.00
89_Y146_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sb8A 2 0.9605 100 0.24 Contact Map
4wkgA 5 0.9605 100 0.244 Contact Map
3rufA 2 0.9605 100 0.244 Contact Map
2yy7A 2 0.9605 100 0.246 Contact Map
3wmwA 2 0.8458 100 0.252 Contact Map
1orrA 3 0.9842 100 0.255 Contact Map
3slgA 4 0.9447 100 0.256 Contact Map
1gy8A 2 0.9723 100 0.258 Contact Map
2c20A 2 0.9565 100 0.258 Contact Map
2z1mA 4 0.9565 100 0.261 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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