GREMLIN Database
BIOW - 6-carboxyhexanoate--CoA ligase
UniProt: P53559 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 259 (234)
Sequences: 143 (122)
Seq/√Len: 8.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
75_I179_S4.9880.99
11_R148_R4.3790.99
32_R150_D4.3300.98
11_R64_Q3.6940.96
85_V91_G3.5000.94
30_G49_K3.2110.91
95_A204_V3.1670.90
181_V229_F3.1210.89
91_G200_I2.6270.79
200_I216_A2.3960.72
50_G61_M2.3770.71
206_G210_G2.3010.69
187_V240_Y2.2740.68
146_V229_F2.2530.67
200_I215_T2.1210.62
91_G216_A2.1140.62
11_R15_S2.1000.61
33_L74_T2.0460.59
95_A193_W2.0060.58
133_G231_I1.9960.57
64_Q148_R1.9800.57
49_K122_V1.9760.56
133_G230_F1.9390.55
36_F57_K1.9240.54
231_I240_Y1.9100.54
170_R184_H1.9020.53
104_V134_K1.8890.53
79_P210_G1.8440.51
177_L196_D1.8390.51
173_E177_L1.8100.50
147_S173_E1.7940.49
128_F228_V1.7830.49
137_D140_K1.7380.47
11_R147_S1.7120.46
53_H56_G1.7100.46
104_V189_A1.7020.45
27_I72_I1.6910.45
104_V112_A1.6660.44
54_S198_D1.6500.43
138_Q142_K1.6290.42
149_M229_F1.6250.42
56_G229_F1.6050.41
90_E251_I1.5940.41
60_F95_A1.5620.40
144_V166_P1.5550.39
95_A230_F1.5130.38
109_I113_Y1.4910.37
43_V201_T1.4700.36
173_E229_F1.4700.36
49_K170_R1.4700.36
50_G181_V1.4520.35
58_P247_Q1.4420.35
95_A217_M1.4300.35
199_Y211_Y1.4220.34
149_M176_A1.4180.34
7_F58_P1.4150.34
122_V226_C1.4130.34
33_L148_R1.4050.34
66_E217_M1.4040.34
193_W230_F1.4020.34
34_I204_V1.3960.33
30_G170_R1.3840.33
46_L150_D1.3630.32
11_R33_L1.3480.32
95_A191_L1.3470.32
7_F17_N1.3460.32
56_G146_V1.3160.31
149_M181_V1.3090.30
112_A137_D1.3030.30
43_V47_L1.3000.30
142_K245_E1.2870.30
208_K236_D1.2870.30
82_T215_T1.2860.30
25_K251_I1.2840.29
112_A231_I1.2760.29
50_G147_S1.2580.29
68_V188_V1.2580.29
53_H229_F1.2570.29
34_I249_I1.2510.28
26_H29_G1.2370.28
26_H31_E1.2370.28
28_S31_E1.2370.28
242_H246_K1.2260.28
63_I220_Y1.2260.28
232_D237_V1.2130.27
10_V66_E1.2070.27
189_A251_I1.2050.27
82_T217_M1.1950.27
91_G138_Q1.1900.26
116_I177_L1.1650.26
113_Y144_V1.1490.25
24_G32_R1.1470.25
32_R46_L1.1380.25
63_I131_H1.1130.24
149_M173_E1.1110.24
65_F188_V1.1100.24
11_R193_W1.0890.23
126_V176_A1.0880.23
43_V116_I1.0850.23
70_E242_H1.0730.23
87_C122_V1.0540.22
65_F234_S1.0450.22
10_V65_F1.0430.22
146_V244_L1.0430.22
50_G229_F1.0410.22
38_E116_I1.0390.22
173_E176_A1.0370.22
10_V184_H1.0310.22
63_I84_E1.0310.22
147_S181_V1.0260.21
58_P109_I1.0220.21
51_L146_V1.0190.21
43_V103_G1.0150.21
77_P168_H1.0140.21
112_A126_V1.0120.21
119_W137_D1.0090.21
186_A228_V1.0050.21
50_G146_V1.0040.21
175_L189_A1.0000.21
127_L240_Y0.9940.21
75_I221_G0.9920.21
127_L241_I0.9880.20
65_F221_G0.9840.20
130_I171_I0.9770.20
40_K48_E0.9730.20
33_L52_S0.9640.20
86_S90_E0.9600.20
36_F128_F0.9590.20
15_S146_V0.9480.19
15_S183_R0.9450.19
204_V217_M0.9410.19
236_D239_T0.9400.19
59_D150_D0.9360.19
108_V137_D0.9350.19
127_L246_K0.9340.19
101_K179_S0.9280.19
55_R197_P0.9260.19
173_E181_V0.9210.19
57_K219_E0.9100.18
96_R110_E0.9010.18
57_K68_V0.8980.18
50_G189_A0.8960.18
129_D183_R0.8920.18
11_R127_L0.8890.18
171_I231_I0.8790.18
65_F226_C0.8790.18
46_L166_P0.8750.18
112_A230_F0.8720.18
55_R77_P0.8720.18
146_V191_L0.8640.17
63_I100_E0.8600.17
108_V138_Q0.8590.17
122_V180_K0.8550.17
77_P210_G0.8490.17
129_D198_D0.8490.17
30_G43_V0.8470.17
149_M177_L0.8470.17
80_V221_G0.8460.17
222_T229_F0.8450.17
192_C199_Y0.8450.17
39_M217_M0.8430.17
99_L180_K0.8370.17
180_K229_F0.8360.17
41_H68_V0.8200.16
180_K197_P0.8180.16
104_V230_F0.8160.16
168_H193_W0.8150.16
108_V130_I0.8100.16
173_E197_P0.8090.16
83_N98_L0.8070.16
51_L205_A0.8050.16
127_L249_I0.8040.16
24_G147_S0.8010.16
157_E179_S0.8000.16
176_A243_D0.7940.16
49_K182_S0.7930.16
205_A210_G0.7900.16
41_H187_V0.7860.16
197_P221_G0.7830.16
182_S185_P0.7810.15
201_T214_I0.7790.15
204_V250_L0.7780.15
60_F64_Q0.7680.15
39_M103_G0.7680.15
30_G122_V0.7660.15
174_A192_C0.7660.15
74_T214_I0.7630.15
223_E238_N0.7570.15
217_M222_T0.7570.15
232_D235_N0.7560.15
155_N188_V0.7550.15
99_L204_V0.7500.15
148_R246_K0.7500.15
10_V220_Y0.7480.15
63_I200_I0.7480.15
24_G230_F0.7480.15
55_R193_W0.7480.15
76_Q179_S0.7460.15
146_V178_A0.7430.15
190_E211_Y0.7430.15
119_W128_F0.7430.15
126_V232_D0.7370.15
49_K61_M0.7350.15
136_M144_V0.7280.14
10_V175_L0.7260.14
87_C94_L0.7200.14
59_D230_F0.7160.14
85_V216_A0.7120.14
123_R137_D0.7090.14
53_H173_E0.7050.14
65_F92_Q0.7040.14
91_G228_V0.6990.14
232_D240_Y0.6960.14
13_R28_S0.6940.14
13_R29_G0.6940.14
13_R26_H0.6940.14
13_R31_E0.6940.14
138_Q168_H0.6930.14
183_R212_Q0.6920.14
100_E106_R0.6900.14
50_G53_H0.6900.14
132_T224_E0.6880.14
170_R201_T0.6870.14
58_P189_A0.6820.13
15_S116_I0.6760.13
112_A133_G0.6720.13
146_V216_A0.6710.13
61_M95_A0.6700.13
182_S251_I0.6690.13
64_Q245_E0.6680.13
150_D180_K0.6680.13
58_P229_F0.6680.13
179_S183_R0.6640.13
39_M42_T0.6610.13
170_R176_A0.6610.13
175_L196_D0.6590.13
25_K223_E0.6580.13
206_G212_Q0.6550.13
36_F73_K0.6550.13
34_I122_V0.6540.13
142_K186_A0.6530.13
168_H230_F0.6510.13
122_V137_D0.6510.13
72_I147_S0.6480.13
58_P170_R0.6460.13
97_L101_K0.6430.13
12_M31_E0.6410.13
12_M29_G0.6410.13
12_M28_S0.6410.13
12_M26_H0.6410.13
94_L188_V0.6400.13
119_W216_A0.6370.13
7_F200_I0.6350.13
49_K139_T0.6320.13
149_M172_K0.6320.13
12_M56_G0.6310.13
84_E118_E0.6290.12
77_P151_W0.6280.12
170_R173_E0.6270.12
55_R103_G0.6260.12
75_I200_I0.6240.12
80_V228_V0.6240.12
112_A188_V0.6230.12
88_P113_Y0.6230.12
168_H171_I0.6200.12
146_V181_V0.6200.12
93_K188_V0.6190.12
53_H146_V0.6180.12
46_L65_F0.6170.12
197_P249_I0.6130.12
191_L244_L0.6100.12
64_Q212_Q0.6040.12
10_V16_M0.6040.12
41_H128_F0.6040.12
91_G103_G0.6020.12
8_Y164_H0.6000.12
192_C195_D0.5980.12
49_K137_D0.5960.12
63_I132_T0.5950.12
47_L82_T0.5930.12
9_S12_M0.5880.12
9_S13_R0.5870.12
68_V205_A0.5850.12
44_N131_H0.5830.12
217_M220_Y0.5830.12
74_T252_E0.5820.12
42_T71_S0.5810.12
103_G142_K0.5810.12
126_V240_Y0.5780.12
180_K249_I0.5780.12
117_P175_L0.5750.12
27_I222_T0.5740.12
36_F41_H0.5740.12
44_N114_E0.5730.12
91_G120_S0.5690.11
50_G56_G0.5690.11
11_R151_W0.5680.11
182_S206_G0.5650.11
131_H251_I0.5650.11
127_L231_I0.5620.11
237_V246_K0.5600.11
49_K240_Y0.5590.11
75_I146_V0.5580.11
170_R210_G0.5580.11
192_C211_Y0.5570.11
27_I56_G0.5520.11
99_L150_D0.5510.11
214_I247_Q0.5470.11
63_I86_S0.5460.11
63_I75_I0.5450.11
208_K221_G0.5440.11
104_V207_K0.5430.11
32_R133_G0.5430.11
59_D62_Q0.5420.11
106_R237_V0.5410.11
173_E196_D0.5410.11
33_L252_E0.5400.11
54_S173_E0.5370.11
108_V230_F0.5370.11
99_L181_V0.5370.11
73_K87_C0.5360.11
79_P237_V0.5360.11
180_K188_V0.5340.11
173_E185_P0.5330.11
102_E204_V0.5330.11
94_L132_T0.5320.11
10_V214_I0.5280.11
143_G244_L0.5280.11
56_G72_I0.5280.11
72_I229_F0.5260.11
40_K152_P0.5250.11
49_K250_L0.5200.11
35_P42_T0.5200.11
80_V230_F0.5170.11
87_C248_P0.5150.11
97_L207_K0.5140.11
33_L212_Q0.5140.11
94_L137_D0.5130.11
119_W251_I0.5110.11
76_Q252_E0.5090.11
15_S193_W0.5070.10
72_I105_S0.5070.10
55_R95_A0.5060.10
47_L150_D0.5060.10
99_L250_L0.5050.10
37_H97_L0.5050.10
47_L55_R0.5050.10
166_P232_D0.5040.10
34_I62_Q0.5030.10
82_T103_G0.5030.10
10_V73_K0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4nexA 2 0.5869 11 0.976 Contact Map
2lr4A 1 0.3282 10.5 0.976 Contact Map
3oiqB 1 0.1158 9.7 0.976 Contact Map
4wjqA 1 0.3089 7.4 0.978 Contact Map
4k90B 1 0.4479 7 0.978 Contact Map
2r2yA 1 0.3514 6.3 0.978 Contact Map
1p4kA 2 0.583 6.3 0.978 Contact Map
2gqcA 1 0.1429 5.4 0.979 Contact Map
2mnjA 1 0.0888 5.4 0.979 Contact Map
2px0A 4 0.5714 5.3 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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