GREMLIN Database
BIOD - ATP-dependent dethiobiotin synthetase BioD
UniProt: P53558 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 231 (209)
Sequences: 4671 (2867)
Seq/√Len: 198.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
67_D101_R3.1691.00
26_L108_C3.1181.00
150_N154_L2.7741.00
140_I155_T2.7531.00
74_K86_E2.5841.00
135_Q165_P2.5751.00
157_K162_M2.4011.00
155_T158_Y2.2811.00
84_K123_E2.2181.00
75_A85_L2.2161.00
18_I201_T2.1931.00
132_K162_M2.1591.00
10_D13_V2.1551.00
130_V134_L2.1261.00
32_H107_E2.0241.00
183_K187_E1.9971.00
32_H106_H1.9961.00
18_I170_I1.9881.00
23_A33_V1.9871.00
209_K212_V1.9281.00
151_H154_L1.9171.00
156_V166_I1.9041.00
188_M192_L1.8991.00
122_G125_Y1.8861.00
138_M159_A1.8271.00
100_G103_R1.8171.00
19_S110_I1.7631.00
67_D105_K1.7561.00
43_I72_A1.7541.00
3_G136_L1.7381.00
142_A148_T1.6381.00
91_T94_E1.6221.00
157_K161_S1.5991.00
96_L133_A1.5881.00
187_E191_R1.5611.00
111_V136_L1.5551.00
119_V188_M1.5331.00
7_T138_M1.5331.00
75_A86_E1.5051.00
92_M133_A1.5041.00
142_A149_I1.4941.00
28_D61_T1.4841.00
45_R74_K1.4571.00
73_F88_K1.4471.00
144_P171_I1.4441.00
6_V22_L1.4421.00
4_F167_A1.4391.00
25_L29_N1.4271.00
69_T72_A1.4191.00
36_Y98_H1.4011.00
94_E97_S1.3941.00
132_K165_P1.3811.00
6_V141_V1.3751.00
188_M191_R1.3721.00
27_K61_T1.3651.00
10_D151_H1.3641.00
179_D183_K1.3411.00
128_S162_M1.3281.00
49_D54_L1.3271.00
137_P167_A1.3101.00
149_I171_I1.3091.00
6_V19_S1.3041.00
139_I198_L1.3011.00
96_L100_G1.2971.00
4_F139_I1.2941.00
143_R148_T1.2901.00
190_E197_I1.2841.00
96_L134_L1.2721.00
138_M164_L1.2541.00
36_Y99_W1.2491.00
92_M125_Y1.2381.00
142_A169_I1.2361.00
148_T152_T1.2341.00
99_W103_R1.2331.00
156_V195_V1.2321.00
169_I197_I1.2321.00
31_R108_C1.2301.00
117_I159_A1.2241.00
34_G106_H1.2211.00
154_L192_L1.2191.00
23_A110_I1.2101.00
184_T187_E1.1991.00
10_D143_R1.1981.00
7_T128_S1.1931.00
21_G25_L1.1801.00
122_G162_M1.1761.00
46_H54_L1.1541.00
27_K33_V1.1511.00
149_I189_I1.1451.00
156_V169_I1.1271.00
22_L26_L1.1241.00
76_P79_P1.1231.00
10_D145_R1.1181.00
97_S101_R1.1061.00
77_L80_Y1.1061.00
111_V130_V1.0831.00
3_G99_W1.0821.00
35_V59_S1.0711.00
83_G90_V1.0651.00
18_I141_V1.0621.00
152_T169_I1.0601.00
38_P111_V1.0571.00
150_N153_F1.0541.00
7_T113_G1.0511.00
8_G13_V1.0471.00
142_A152_T1.0381.00
53_S56_K1.0241.00
179_D182_E1.0241.00
114_A127_V1.0161.00
5_F131_I1.0131.00
125_Y133_A1.0041.00
86_E98_H1.0031.00
208_T211_T1.0031.00
140_I166_I1.0021.00
156_V193_C0.9991.00
132_K161_S0.9891.00
39_F95_V0.9750.99
156_V160_E0.9740.99
34_G109_F0.9740.99
3_G103_R0.9710.99
103_R109_F0.9570.99
54_L58_M0.9570.99
197_I200_V0.9560.99
71_F94_E0.9500.99
12_E50_S0.9490.99
76_P80_Y0.9470.99
93_E133_A0.9450.99
102_I109_F0.9440.99
118_S158_Y0.9420.99
93_E97_S0.9350.99
150_N155_T0.9350.99
143_R151_H0.9240.99
94_E98_H0.9240.99
77_L185_N0.9220.99
78_A81_V0.9210.99
100_G133_A0.9190.99
118_S128_S0.9170.99
20_S23_A0.9160.99
77_L81_V0.9120.99
4_F110_I0.9100.99
85_L180_E0.9100.99
101_R105_K0.9060.99
20_S54_L0.9040.99
98_H101_R0.9020.99
17_V204_L0.9000.99
187_E190_E0.8950.99
41_S77_L0.8920.99
131_I164_L0.8910.99
142_A153_F0.8910.99
41_S73_F0.8890.99
144_P148_T0.8880.99
27_K60_Q0.8830.99
10_D152_T0.8810.99
140_I156_V0.8760.99
141_V172_N0.8730.99
70_P98_H0.8720.99
26_L33_V0.8720.99
54_L57_D0.8710.99
13_V143_R0.8700.99
189_I193_C0.8690.99
36_Y102_I0.8620.99
169_I193_C0.8550.99
34_G102_I0.8460.99
36_Y70_P0.8400.98
33_V108_C0.8270.98
169_I195_V0.8250.98
7_T117_I0.8200.98
101_R104_E0.8190.98
186_P200_V0.8140.98
16_T54_L0.8080.98
23_A35_V0.8080.98
175_S178_P0.8060.98
5_F113_G0.8040.98
166_I195_V0.7950.98
117_I155_T0.7950.98
182_E186_P0.7900.98
73_F83_G0.7850.98
26_L31_R0.7830.98
157_K163_G0.7810.98
95_V125_Y0.7780.97
164_L195_V0.7750.97
159_A164_L0.7680.97
31_R107_E0.7640.97
25_L28_D0.7640.97
208_T212_V0.7630.97
182_E200_V0.7620.97
42_G76_P0.7610.97
27_K32_H0.7600.97
171_I186_P0.7580.97
204_L207_V0.7550.97
73_F89_T0.7550.97
186_P197_I0.7550.97
19_S55_L0.7490.97
118_S157_K0.7430.97
117_I128_S0.7400.97
92_M130_V0.7360.96
67_D98_H0.7340.96
18_I172_N0.7330.96
35_V55_L0.7320.96
71_F91_T0.7280.96
119_V185_N0.7250.96
39_F121_L0.7230.96
168_G198_L0.7180.96
128_S131_I0.7160.96
9_T148_T0.7150.96
149_I185_N0.7140.96
118_S162_M0.7080.96
126_L192_L0.7060.96
160_E194_G0.7050.96
33_V107_E0.7040.95
171_I200_V0.7030.95
190_E196_P0.7020.95
140_I169_I0.6970.95
23_A60_Q0.6960.95
149_I153_F0.6870.95
11_T146_L0.6870.95
52_T66_E0.6860.95
137_P165_P0.6860.95
38_P130_V0.6850.95
20_S55_L0.6840.95
92_M129_H0.6800.95
127_V131_I0.6770.94
32_H105_K0.6740.94
6_V170_I0.6740.94
129_H162_M0.6720.94
22_L139_I0.6720.94
171_I197_I0.6680.94
128_S158_Y0.6660.94
40_L49_D0.6640.94
159_A166_I0.6640.94
6_V139_I0.6570.93
92_M96_L0.6540.93
118_S153_F0.6520.93
43_I50_S0.6520.93
119_V182_E0.6510.93
17_V207_V0.6490.93
102_I106_H0.6480.93
48_P53_S0.6460.93
26_L110_I0.6460.93
42_G79_P0.6400.93
99_W134_L0.6380.92
52_T69_T0.6370.92
99_W111_V0.6370.92
3_G111_V0.6370.92
113_G127_V0.6360.92
112_E115_G0.6360.92
12_E17_V0.6330.92
117_I131_I0.6290.92
86_E94_E0.6240.92
99_W136_L0.6220.92
158_Y162_M0.6210.91
207_V212_V0.6200.91
76_P146_L0.6180.91
3_G134_L0.6180.91
155_T160_E0.6170.91
168_G196_P0.6140.91
95_V130_V0.6090.91
64_S67_D0.6070.91
173_G182_E0.6060.90
43_I48_P0.6050.90
38_P114_A0.6040.90
173_G203_K0.6030.90
21_G24_A0.6030.90
49_D57_D0.6020.90
153_F169_I0.6010.90
40_L69_T0.6010.90
45_R48_P0.6000.90
81_V184_T0.5970.90
157_K160_E0.5940.90
168_G199_G0.5930.89
40_L72_A0.5860.89
5_F127_V0.5860.89
118_S126_L0.5830.89
19_S35_V0.5810.89
154_L157_K0.5780.88
132_K164_L0.5720.88
140_I159_A0.5700.88
99_W130_V0.5700.88
154_L158_Y0.5700.88
85_L184_T0.5690.87
19_S22_L0.5690.87
56_K68_I0.5680.87
96_L130_V0.5660.87
173_G200_V0.5650.87
145_R148_T0.5650.87
78_A146_L0.5640.87
126_L153_F0.5630.87
119_V127_V0.5590.87
186_P190_E0.5590.87
158_Y161_S0.5540.86
206_N211_T0.5460.85
7_T140_I0.5460.85
25_L201_T0.5440.85
86_E101_R0.5440.85
96_L99_W0.5440.85
92_M95_V0.5430.85
183_K186_P0.5370.84
117_I140_I0.5340.84
10_D189_I0.5310.84
117_I164_L0.5280.83
178_P183_K0.5270.83
100_G104_E0.5250.83
207_V210_E0.5190.82
38_P71_F0.5170.82
65_H105_K0.5130.82
128_S157_K0.5100.81
129_H133_A0.5060.81
44_S50_S0.5060.81
171_I189_I0.5040.80
128_S138_M0.5030.80
43_I69_T0.5030.80
145_R185_N0.5000.80
123_E191_R0.5000.80
169_I189_I0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4a0gA 2 0.974 100 0.314 Contact Map
3fgnA 2 0.9654 100 0.521 Contact Map
2obnA 2 0.7835 100 0.535 Contact Map
1s1mA 4 0.9697 100 0.549 Contact Map
3of5A 2 0.9307 100 0.593 Contact Map
1byiA 2 0.9567 100 0.594 Contact Map
3zq6A 2 0.9134 100 0.605 Contact Map
3qxcA 2 0.9134 99.9 0.612 Contact Map
3ug7A 4 0.9264 99.9 0.619 Contact Map
4zdjA 4 0.9784 99.9 0.629 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0082 seconds.