BIOB - BACSU - GREMLIN Contacts

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BIOB - Biotin synthase

UniProt:	P53557	Sequences: MNQWMELADRVLAGAEVTDEEALSILHCPDEDILLLMHGAFHIRKHFYGKKVKLNMIMNAKSGLCPENCGYCSQSAISKAPIESYRMVNKETLLEGAKRAHDLNIGTYCIVASGRGPSNREVDQVVDAVQEIKETYGLKICACLGLLKPEQAKRLKDAGVDRYNHNLNTSQRNHSNITTSHTYDDRVNTVEIAKESGLSPCSGAIIGMKETKQDVIDIAKSLKALDADSIPVNFLHAIDGTPLEGVNELNPLYCLKVLALFRFINPSKEIRISGGREVNLRTLQPLGLYAANSIFVGDYLTTAGQEETEDHKMLSDLGFEVESVEEMKASLSAKS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	335 (305)
Sequences:	5942 (3549)
Seq/√Len:	203.2

ECOLI - BIOB THIH
BACSU - BIOB
HALSA - COFH COFG

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
149_P	195_E	4.349	1.00
171_Q	184_D	4.313	1.00
172_R	214_D	3.119	1.00
41_F	45_K	3.046	1.00
123_D	154_R	3.046	1.00
19_D	217_D	3.018	1.00
170_S	214_D	2.945	1.00
68_N	77_I	2.924	1.00
43_I	263_F	2.752	1.00
126_V	154_R	2.675	1.00
89_N	92_T	2.670	1.00
271_R	292_N	2.645	1.00
230_I	265_N	2.606	1.00
149_P	153_K	2.563	1.00
191_E	228_D	2.542	1.00
122_V	126_V	2.530	1.00
149_P	192_I	2.518	1.00
23_L	213_Q	2.331	1.00
220_K	264_I	2.313	1.00
188_N	192_I	2.228	1.00
19_D	220_K	2.201	1.00
184_D	188_N	2.178	1.00
153_K	157_D	2.068	1.00
51_K	320_E	2.050	1.00
95_E	98_K	1.974	1.00
202_S	222_L	1.951	1.00
212_K	253_Y	1.944	1.00
215_V	253_Y	1.899	1.00
98_K	102_D	1.889	1.00
25_I	260_L	1.861	1.00
167_L	218_I	1.854	1.00
156_K	196_S	1.812	1.00
90_K	131_E	1.785	1.00
18_T	21_E	1.783	1.00
172_R	217_D	1.779	1.00
22_A	264_I	1.779	1.00
90_K	127_D	1.762	1.00
98_K	132_I	1.758	1.00
39_G	263_F	1.749	1.00
90_K	124_Q	1.734	1.00
240_G	243_L	1.723	1.00
94_L	131_E	1.703	1.00
23_L	27_H	1.703	1.00
150_E	153_K	1.689	1.00
32_D	35_L	1.672	1.00
92_T	95_E	1.667	1.00
219_A	261_F	1.666	1.00
94_L	98_K	1.664	1.00
162_R	199_S	1.656	1.00
45_K	50_K	1.618	1.00
300_L	304_G	1.612	1.00
240_G	244_E	1.587	1.00
93_L	128_A	1.582	1.00
23_L	216_I	1.575	1.00
50_K	320_E	1.565	1.00
41_F	44_R	1.557	1.00
130_Q	161_D	1.537	1.00
148_K	151_Q	1.533	1.00
156_K	198_L	1.530	1.00
152_A	196_S	1.529	1.00
19_D	216_I	1.524	1.00
173_N	176_N	1.523	1.00
270_I	291_A	1.511	1.00
99_R	102_D	1.503	1.00
191_E	195_E	1.503	1.00
185_D	188_N	1.502	1.00
37_M	290_A	1.498	1.00
100_A	105_I	1.490	1.00
215_V	257_V	1.476	1.00
237_A	248_E	1.475	1.00
19_D	213_Q	1.463	1.00
285_P	316_D	1.460	1.00
42_H	46_H	1.454	1.00
307_E	311_H	1.443	1.00
182_T	185_D	1.443	1.00
308_T	312_K	1.439	1.00
306_E	309_E	1.435	1.00
19_D	23_L	1.426	1.00
41_F	289_Y	1.411	1.00
312_K	316_D	1.397	1.00
17_V	263_F	1.390	1.00
147_L	155_L	1.379	1.00
54_L	311_H	1.370	1.00
27_H	212_K	1.368	1.00
255_L	287_G	1.362	1.00
154_R	157_D	1.357	1.00
240_G	245_G	1.347	1.00
119_N	151_Q	1.346	1.00
119_N	154_R	1.342	1.00
281_R	316_D	1.341	1.00
311_H	315_S	1.323	1.00
12_L	42_H	1.323	1.00
126_V	130_Q	1.321	1.00
272_I	287_G	1.321	1.00
300_L	303_A	1.318	1.00
149_P	196_S	1.316	1.00
192_I	195_E	1.315	1.00
191_E	225_L	1.299	1.00
220_K	224_A	1.297	1.00
95_E	99_R	1.295	1.00
133_K	161_D	1.286	1.00
27_H	213_Q	1.285	1.00
183_Y	187_V	1.282	1.00
141_C	145_G	1.282	1.00
127_D	130_Q	1.280	1.00
90_K	128_A	1.269	1.00
59_N	62_S	1.263	1.00
128_A	131_E	1.260	1.00
171_Q	175_S	1.257	1.00
38_H	42_H	1.255	1.00
272_I	291_A	1.254	1.00
241_T	244_E	1.236	1.00
172_R	176_N	1.226	1.00
241_T	245_G	1.224	1.00
170_S	217_D	1.222	1.00
26_L	260_L	1.218	1.00
22_A	216_I	1.218	1.00
22_A	220_K	1.217	1.00
204_A	218_I	1.198	1.00
289_Y	317_L	1.192	1.00
211_T	214_D	1.181	1.00
312_K	315_S	1.175	1.00
214_D	217_D	1.173	1.00
171_Q	183_Y	1.171	1.00
251_P	283_L	1.169	1.00
153_K	156_K	1.167	1.00
206_I	257_V	1.165	1.00
131_E	134_E	1.160	1.00
33_I	256_K	1.148	1.00
187_V	221_S	1.147	1.00
44_R	48_Y	1.146	1.00
24_S	28_C	1.140	1.00
153_K	196_S	1.133	1.00
206_I	254_C	1.132	1.00
126_V	158_A	1.131	1.00
188_N	191_E	1.120	1.00
29_P	256_K	1.120	1.00
86_R	115_R	1.117	1.00
171_Q	221_S	1.108	1.00
94_L	128_A	1.107	1.00
91_E	95_E	1.099	1.00
64_L	86_R	1.094	1.00
118_S	121_E	1.093	1.00
142_A	145_G	1.091	1.00
219_A	264_I	1.084	1.00
17_V	22_A	1.075	1.00
280_L	286_L	1.072	1.00
16_E	223_K	1.057	1.00
165_H	186_R	1.053	1.00
43_I	46_H	1.052	1.00
309_E	312_K	1.045	1.00
154_R	158_A	1.043	1.00
121_E	124_Q	1.042	1.00
190_V	200_P	1.036	1.00
167_L	183_Y	1.035	1.00
124_Q	127_D	1.034	1.00
39_G	43_I	1.021	1.00
26_L	257_V	1.019	1.00
139_K	143_C	1.017	1.00
216_I	220_K	1.011	1.00
172_R	211_T	1.003	1.00
288_L	314_L	1.001	1.00
90_K	94_L	0.997	1.00
88_V	93_L	0.996	1.00
183_Y	221_S	0.995	1.00
22_A	260_L	0.991	1.00
140_I	145_G	0.990	1.00
217_D	220_K	0.988	1.00
258_L	287_G	0.985	1.00
26_L	212_K	0.982	1.00
165_H	189_T	0.978	1.00
128_A	132_I	0.968	1.00
97_A	132_I	0.963	0.99
221_S	224_A	0.959	0.99
63_G	74_Q	0.959	0.99
36_L	256_K	0.953	0.99
96_G	99_R	0.952	0.99
16_E	266_P	0.948	0.99
315_S	321_V	0.939	0.99
39_G	42_H	0.939	0.99
50_K	319_F	0.935	0.99
315_S	320_E	0.933	0.99
60_A	93_L	0.932	0.99
120_R	123_D	0.928	0.99
122_V	155_L	0.922	0.99
60_A	112_A	0.918	0.99
68_N	75_S	0.914	0.99
41_F	319_F	0.913	0.99
62_S	112_A	0.910	0.99
250_N	253_Y	0.907	0.99
44_R	319_F	0.906	0.99
212_K	257_V	0.904	0.99
29_P	32_D	0.902	0.99
140_I	143_C	0.882	0.99
99_R	103_L	0.880	0.99
255_L	290_A	0.876	0.99
170_S	209_K	0.872	0.99
28_C	36_L	0.867	0.99
63_G	82_I	0.864	0.99
222_L	230_I	0.862	0.99
101_H	137_G	0.859	0.99
139_K	142_A	0.856	0.99
33_I	37_M	0.853	0.99
194_K	200_P	0.853	0.99
242_P	245_G	0.853	0.99
54_L	314_L	0.852	0.99
144_L	163_Y	0.844	0.99
285_P	313_M	0.842	0.99
282_T	285_P	0.841	0.99
187_V	191_E	0.835	0.99
129_V	160_V	0.831	0.98
130_Q	158_A	0.830	0.98
192_I	196_S	0.826	0.98
73_S	238_I	0.825	0.98
101_H	136_Y	0.824	0.98
94_L	134_E	0.822	0.98
191_E	224_A	0.820	0.98
173_N	209_K	0.814	0.98
241_T	246_V	0.813	0.98
15_A	21_E	0.809	0.98
152_A	198_L	0.808	0.98
40_A	289_Y	0.805	0.98
58_M	108_Y	0.804	0.98
163_Y	193_A	0.801	0.98
314_L	321_V	0.801	0.98
94_L	97_A	0.800	0.98
236_H	302_T	0.800	0.98
174_H	186_R	0.798	0.98
98_K	133_K	0.798	0.98
51_K	322_E	0.798	0.98
35_L	38_H	0.797	0.98
60_A	110_I	0.796	0.98
12_L	39_G	0.793	0.98
239_D	244_E	0.791	0.98
170_S	173_N	0.790	0.98
94_L	133_K	0.787	0.98
314_L	319_F	0.787	0.98
123_D	127_D	0.786	0.98
68_N	180_S	0.786	0.98
222_L	265_N	0.781	0.98
141_C	144_L	0.780	0.98
141_C	147_L	0.780	0.98
96_G	108_Y	0.775	0.98
119_N	123_D	0.767	0.97
85_Y	92_T	0.766	0.97
194_K	226_D	0.766	0.97
251_P	280_L	0.765	0.97
64_L	84_S	0.762	0.97
47_F	269_E	0.761	0.97
37_M	259_A	0.761	0.97
208_M	246_V	0.760	0.97
56_M	105_I	0.759	0.97
237_A	245_G	0.758	0.97
232_V	261_F	0.757	0.97
94_L	132_I	0.754	0.97
75_S	242_P	0.753	0.97
42_H	45_K	0.751	0.97
109_C	273_S	0.746	0.97
220_K	223_K	0.740	0.97
243_L	246_V	0.740	0.97
216_I	264_I	0.738	0.97
98_K	101_H	0.738	0.97
123_D	126_V	0.736	0.97
67_E	114_G	0.736	0.97
219_A	222_L	0.734	0.97
173_N	208_M	0.733	0.97
81_P	240_G	0.732	0.97
110_I	128_A	0.728	0.97
37_M	255_L	0.727	0.96
125_V	144_L	0.726	0.96
67_E	180_S	0.726	0.96
28_C	38_H	0.726	0.96
172_R	175_S	0.724	0.96
308_T	311_H	0.723	0.96
52_V	319_F	0.715	0.96
44_R	52_V	0.715	0.96
258_L	291_A	0.710	0.96
127_D	131_E	0.709	0.96
98_K	136_Y	0.708	0.96
160_V	198_L	0.707	0.96
177_I	243_L	0.704	0.96
97_A	136_Y	0.702	0.96
184_D	221_S	0.700	0.96
62_S	85_Y	0.699	0.96
47_F	266_P	0.698	0.96
56_M	100_A	0.697	0.96
26_L	216_I	0.694	0.95
151_Q	154_R	0.694	0.95
23_L	212_K	0.694	0.95
167_L	221_S	0.693	0.95
255_L	286_L	0.690	0.95
88_V	96_G	0.687	0.95
216_I	260_L	0.682	0.95
152_A	189_T	0.682	0.95
120_R	124_Q	0.681	0.95
16_E	227_A	0.679	0.95
54_L	321_V	0.679	0.95
279_N	283_L	0.679	0.95
256_K	260_L	0.679	0.95
176_N	209_K	0.677	0.95
219_A	265_N	0.676	0.95
101_H	106_G	0.671	0.95
28_C	256_K	0.669	0.94
199_S	269_E	0.669	0.94
234_F	254_C	0.668	0.94
91_E	94_L	0.667	0.94
148_K	189_T	0.667	0.94
169_T	173_N	0.667	0.94
143_C	147_L	0.667	0.94
269_E	292_N	0.666	0.94
273_S	295_F	0.666	0.94
252_L	283_L	0.665	0.94
237_A	244_E	0.662	0.94
78_S	242_P	0.661	0.94
17_V	264_I	0.661	0.94
47_F	267_S	0.660	0.94
169_T	214_D	0.659	0.94
139_K	145_G	0.658	0.94
146_L	186_R	0.657	0.94
78_S	116_G	0.656	0.94
212_K	215_V	0.654	0.94
37_M	41_F	0.650	0.94
76_A	83_E	0.649	0.93
190_V	202_S	0.645	0.93
52_V	288_L	0.637	0.93
222_L	228_D	0.635	0.93
148_K	185_D	0.634	0.93
242_P	246_V	0.633	0.93
24_S	27_H	0.632	0.93
53_K	322_E	0.632	0.93
20_E	24_S	0.632	0.93
129_V	140_I	0.631	0.93
295_F	300_L	0.630	0.92
54_L	307_E	0.627	0.92
240_G	246_V	0.626	0.92
20_E	213_Q	0.625	0.92
12_L	46_H	0.624	0.92
119_N	122_V	0.622	0.92
314_L	317_L	0.622	0.92
193_A	198_L	0.621	0.92
124_Q	128_A	0.620	0.92
148_K	192_I	0.618	0.92
287_G	291_A	0.615	0.92
34_L	37_M	0.615	0.92
190_V	194_K	0.615	0.92
206_I	215_V	0.614	0.92
34_L	286_L	0.613	0.91
249_L	254_C	0.612	0.91
174_H	178_T	0.612	0.91
130_Q	134_E	0.610	0.91
55_N	233_N	0.610	0.91
35_L	39_G	0.609	0.91
21_E	24_S	0.608	0.91
296_V	303_A	0.606	0.91
143_C	146_L	0.605	0.91
130_Q	157_D	0.604	0.91
274_G	291_A	0.603	0.91
252_L	256_K	0.602	0.91
265_N	268_K	0.602	0.91
71_Y	186_R	0.600	0.91
283_L	286_L	0.598	0.90
70_G	78_S	0.598	0.90
201_C	233_N	0.594	0.90
281_R	309_E	0.594	0.90
22_A	219_A	0.593	0.90
68_N	76_A	0.593	0.90
206_I	249_L	0.591	0.90
109_C	164_N	0.591	0.90
70_G	176_N	0.589	0.90
122_V	142_A	0.588	0.90
122_V	154_R	0.587	0.90
130_Q	133_K	0.587	0.90
295_F	303_A	0.586	0.90
253_Y	257_V	0.586	0.90
34_L	38_H	0.586	0.90
115_R	146_L	0.585	0.89
144_L	147_L	0.583	0.89
144_L	155_L	0.582	0.89
251_P	286_L	0.582	0.89
281_R	313_M	0.581	0.89
55_N	166_N	0.579	0.89
48_Y	292_N	0.579	0.89
122_V	151_Q	0.576	0.89
250_N	254_C	0.574	0.89
293_S	298_D	0.573	0.88
59_N	275_G	0.571	0.88
59_N	273_S	0.570	0.88
141_C	162_R	0.569	0.88
305_Q	309_E	0.569	0.88
205_I	208_M	0.567	0.88
152_A	163_Y	0.566	0.88
231_P	234_F	0.565	0.88
74_Q	109_C	0.565	0.88
227_A	266_P	0.563	0.88
222_L	268_K	0.559	0.87
213_Q	217_D	0.559	0.87
33_I	252_L	0.559	0.87
262_R	292_N	0.558	0.87
59_N	205_I	0.557	0.87
50_K	314_L	0.557	0.87
187_V	225_L	0.556	0.87
202_S	227_A	0.556	0.87
140_I	144_L	0.556	0.87
38_H	41_F	0.555	0.87
193_A	196_S	0.555	0.87
147_L	151_Q	0.553	0.87
141_C	146_L	0.553	0.87
313_M	316_D	0.553	0.87
261_F	265_N	0.553	0.87
274_G	284_Q	0.551	0.86
140_I	160_V	0.551	0.86
103_L	308_T	0.550	0.86
52_V	314_L	0.549	0.86
142_A	146_L	0.548	0.86
167_L	225_L	0.547	0.86
258_L	270_I	0.546	0.86
225_L	229_S	0.545	0.86
251_P	282_T	0.545	0.86
48_Y	51_K	0.544	0.86
295_F	299_Y	0.544	0.86
63_G	73_S	0.543	0.86
60_A	144_L	0.543	0.86
73_S	299_Y	0.542	0.86
152_A	193_A	0.542	0.86
142_A	160_V	0.540	0.85
95_E	102_D	0.535	0.85
285_P	317_L	0.533	0.85
277_E	305_Q	0.533	0.85
238_I	241_T	0.530	0.84
194_K	228_D	0.529	0.84
107_T	141_C	0.527	0.84
276_R	287_G	0.527	0.84
62_S	113_S	0.527	0.84
94_L	136_Y	0.525	0.84
112_A	125_V	0.525	0.84
58_M	297_G	0.525	0.84
19_D	22_A	0.524	0.84
173_N	177_I	0.523	0.84
28_C	32_D	0.523	0.84
226_D	268_K	0.521	0.83
172_R	213_Q	0.521	0.83
201_C	273_S	0.519	0.83
296_V	299_Y	0.518	0.83
96_G	100_A	0.517	0.83
257_V	260_L	0.516	0.83
59_N	111_V	0.515	0.83
53_K	201_C	0.514	0.82
212_K	260_L	0.512	0.82
14_G	21_E	0.511	0.82
205_I	275_G	0.511	0.82
293_S	296_V	0.510	0.82
201_C	275_G	0.509	0.82
129_V	133_K	0.508	0.82
36_L	259_A	0.506	0.82
199_S	228_D	0.506	0.82
282_T	286_L	0.502	0.81
210_E	215_V	0.500	0.81
133_K	136_Y	0.500	0.81

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1r30A	2	0.9194	100	0.407	Contact Map
3t7vA	1	0.9552	100	0.421	Contact Map
4r33A	2	0.9672	100	0.441	Contact Map
3iixA	1	0.9701	100	0.449	Contact Map
4wcxA	1	0.9791	100	0.483	Contact Map
4rtbA	2	0.9582	100	0.506	Contact Map
4u0oB	1	0.7642	100	0.665	Contact Map
4jc0A	1	0.9075	99.8	0.77	Contact Map
2qgqA	1	0.7284	99.8	0.771	Contact Map
1oltA	1	0.9254	99.8	0.775	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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