GREMLIN Database
BIOF2 - 8-amino-7-oxononanoate synthase 2
UniProt: P53556 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 389 (359)
Sequences: 6396 (3930)
Seq/√Len: 207.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_Q67_Q4.2111.00
92_K282_N4.1241.00
300_M373_D4.0461.00
159_E197_R4.0101.00
151_R157_D3.8161.00
340_K381_S3.6401.00
187_P190_Q3.2211.00
157_D161_K3.1491.00
175_T179_F3.0851.00
173_I195_A2.8871.00
279_E282_N2.8511.00
92_K278_H2.8291.00
300_M369_M2.7811.00
159_E198_Y2.7101.00
304_S376_L2.6281.00
293_L297_Y2.5431.00
92_K285_E2.4201.00
248_G253_I2.3241.00
105_F260_A2.3201.00
159_E163_N2.3101.00
60_D64_T2.2931.00
248_G252_F2.2721.00
189_D224_F2.2491.00
233_G245_F2.2341.00
157_D160_N2.2221.00
155_M194_L2.1781.00
206_D209_A2.1631.00
216_S222_E2.1601.00
95_S285_E2.0851.00
304_S373_D2.0621.00
100_E250_A2.0401.00
175_T204_V2.0181.00
57_R279_E2.0141.00
308_M380_H1.9861.00
287_S290_K1.9291.00
127_L161_K1.9061.00
59_I66_L1.8811.00
324_I333_F1.8781.00
190_Q193_S1.8601.00
368_S371_D1.8521.00
128_S132_N1.8281.00
296_S369_M1.8231.00
120_P126_I1.8191.00
304_S307_N1.8061.00
55_D283_I1.7461.00
342_I374_H1.7381.00
215_D222_E1.7251.00
33_E40_N1.7191.00
116_L174_V1.7171.00
102_A247_A1.6991.00
44_W367_H1.6951.00
60_D67_Q1.6931.00
336_K339_G1.6911.00
41_Q338_Q1.6861.00
57_R286_A1.6501.00
300_M304_S1.6471.00
130_Q151_R1.6431.00
44_W375_L1.6191.00
64_T68_Q1.6131.00
308_M376_L1.6121.00
328_H332_L1.6101.00
138_D261_R1.6091.00
96_F218_Q1.6051.00
301_I363_I1.5881.00
85_W278_H1.5871.00
136_M174_V1.5861.00
140_C147_T1.5781.00
195_A202_V1.5701.00
235_L277_A1.5581.00
126_I140_C1.5561.00
241_A277_A1.5281.00
163_N198_Y1.5271.00
114_G262_T1.5191.00
94_A102_A1.5181.00
127_L171_R1.5071.00
206_D220_T1.4941.00
65_A275_A1.4721.00
242_E270_P1.4661.00
333_F382_I1.4491.00
288_R292_Q1.4381.00
173_I200_A1.4151.00
344_A359_I1.4071.00
336_K340_K1.4061.00
303_T307_N1.4031.00
88_K278_H1.3971.00
59_I63_Q1.3961.00
150_Y175_T1.3951.00
77_R82_N1.3851.00
93_I281_F1.3831.00
210_T239_V1.3791.00
374_H378_T1.3641.00
115_V246_A1.3621.00
172_F203_V1.3581.00
310_Y383_G1.3481.00
300_M372_I1.3411.00
33_E371_D1.3261.00
148_V161_K1.3171.00
250_A254_D1.3131.00
297_Y369_M1.3101.00
192_I196_K1.3091.00
125_V148_V1.3081.00
63_Q66_L1.3071.00
134_A261_R1.2971.00
283_I287_S1.2881.00
335_E339_G1.2811.00
101_A250_A1.2701.00
326_D329_K1.2671.00
301_I305_L1.2661.00
155_M187_P1.2631.00
73_S268_A1.2591.00
194_L198_Y1.2571.00
64_T67_Q1.2551.00
292_Q296_S1.2431.00
158_L173_I1.2401.00
57_R283_I1.2361.00
173_I194_L1.2331.00
35_N40_N1.2321.00
84_V88_K1.2281.00
97_K247_A1.2261.00
87_E91_K1.2041.00
177_G220_T1.1981.00
120_P172_F1.1951.00
115_V203_V1.1901.00
177_G209_A1.1821.00
155_M190_Q1.1791.00
82_N87_E1.1761.00
97_K210_T1.1681.00
162_L194_L1.1661.00
327_A357_S1.1561.00
114_G260_A1.1551.00
336_K382_I1.1531.00
93_I235_L1.1531.00
152_H184_T1.1531.00
159_E194_L1.1531.00
349_P354_P1.1521.00
297_Y300_M1.1501.00
299_S303_T1.1481.00
125_V165_T1.1471.00
301_I361_I1.1401.00
151_R154_D1.1401.00
278_H282_N1.1351.00
182_D358_R1.1271.00
132_N136_M1.1241.00
297_Y372_I1.1231.00
153_I187_P1.1231.00
123_E169_Q1.1221.00
196_K229_D1.1211.00
361_I375_L1.1081.00
165_T171_R1.1051.00
191_I202_V1.1011.00
192_I202_V1.0991.00
162_L200_A1.0981.00
221_S226_V1.0911.00
56_R60_D1.0781.00
91_K95_S1.0651.00
150_Y179_F1.0561.00
101_A253_I1.0481.00
61_A65_A1.0431.00
93_I245_F1.0421.00
342_I375_L1.0411.00
218_Q222_E1.0361.00
125_V169_Q1.0351.00
333_F383_G1.0341.00
112_N135_S1.0331.00
340_K378_T1.0291.00
85_W275_A1.0281.00
120_P124_D1.0251.00
99_T247_A1.0251.00
94_A247_A1.0211.00
27_D84_V1.0181.00
295_F298_I1.0171.00
297_Y365_S1.0141.00
160_N164_E1.0101.00
107_S110_L1.0051.00
101_A257_L0.9981.00
156_N160_N0.9981.00
99_T248_G0.9971.00
275_A279_E0.9961.00
175_T191_I0.9951.00
154_D157_D0.9911.00
369_M373_D0.9871.00
161_K164_E0.9861.00
331_V346_A0.9721.00
110_L266_Q0.9701.00
342_I378_T0.9671.00
337_L378_T0.9661.00
185_I224_F0.9631.00
193_S197_R0.9611.00
249_S252_F0.9581.00
128_S140_C0.9581.00
216_S285_E0.9560.99
304_S308_M0.9540.99
330_T357_S0.9530.99
62_A276_A0.9500.99
349_P357_S0.9480.99
58_L276_A0.9470.99
125_V168_Y0.9470.99
69_F84_V0.9450.99
331_V348_R0.9420.99
181_M347_I0.9380.99
87_E101_A0.9370.99
89_L274_C0.9360.99
172_F201_F0.9350.99
279_E283_I0.9340.99
272_A276_A0.9320.99
57_R60_D0.9310.99
175_T188_L0.9310.99
322_V361_I0.9300.99
85_W274_C0.9290.99
86_H274_C0.9260.99
77_R90_E0.9260.99
75_G79_T0.9260.99
270_P273_S0.9240.99
42_T371_D0.9230.99
96_F281_F0.9230.99
239_V284_I0.9220.99
289_E293_L0.9210.99
60_D63_Q0.9210.99
26_M34_R0.9200.99
51_G366_D0.9150.99
55_D58_L0.9140.99
128_S149_V0.9140.99
364_T367_H0.9110.99
185_I213_L0.9080.99
89_L277_A0.9050.99
158_L191_I0.8990.99
293_L296_S0.8990.99
116_L120_P0.8970.99
332_L335_E0.8970.99
210_T245_F0.8950.99
131_L182_D0.8940.99
302_R315_D0.8940.99
203_V232_I0.8930.99
45_S345_P0.8920.99
363_I372_I0.8910.99
134_A138_D0.8900.99
195_A200_A0.8900.99
325_G357_S0.8830.99
82_N86_H0.8770.99
131_L358_R0.8770.99
255_F259_H0.8770.99
61_A275_A0.8770.99
324_I329_K0.8700.99
298_I320_I0.8690.99
293_L369_M0.8680.99
44_W372_I0.8630.99
216_S288_R0.8630.99
186_A191_I0.8590.99
330_T346_A0.8580.99
66_L272_A0.8570.99
32_P371_D0.8530.99
371_D374_H0.8520.99
99_T231_V0.8520.99
214_G219_G0.8500.99
177_G206_D0.8490.99
130_Q149_V0.8480.99
127_L191_I0.8480.99
106_S242_E0.8440.99
127_L158_L0.8440.99
88_K92_K0.8390.99
213_L317_T0.8390.99
116_L172_F0.8370.99
113_V262_T0.8320.99
189_D223_Y0.8310.99
220_T224_F0.8280.99
124_D169_Q0.8280.99
116_L203_V0.8210.98
236_S244_G0.8210.98
230_I252_F0.8200.98
121_E124_D0.8180.98
295_F299_S0.8180.98
178_V185_I0.8160.98
62_A66_L0.8130.98
124_D172_F0.8110.98
242_E269_I0.8110.98
65_A85_W0.8090.98
304_S377_Q0.8080.98
222_E288_R0.8050.98
293_L368_S0.8050.98
150_Y158_L0.8040.98
332_L336_K0.8030.98
123_E146_D0.8000.98
55_D290_K0.7990.98
185_I223_Y0.7960.98
42_T342_I0.7940.98
377_Q381_S0.7940.98
153_I176_D0.7920.98
156_N190_Q0.7910.98
185_I317_T0.7910.98
188_L204_V0.7900.98
155_M191_I0.7880.98
301_I320_I0.7850.98
128_S147_T0.7840.98
132_N176_D0.7800.98
127_L148_V0.7800.98
109_Y113_V0.7760.98
233_G247_A0.7760.98
45_S80_T0.7750.98
61_A279_E0.7740.98
375_L379_F0.7730.98
89_L278_H0.7710.98
122_K144_K0.7710.98
374_H377_Q0.7700.98
62_A71_T0.7700.98
361_I379_F0.7690.98
137_I141_R0.7680.98
340_K382_I0.7600.97
159_E190_Q0.7560.97
66_L71_T0.7540.97
128_S137_I0.7530.97
322_V379_F0.7520.97
85_W88_K0.7510.97
160_N163_N0.7500.97
369_M372_I0.7490.97
338_Q343_Y0.7490.97
246_A256_L0.7470.97
86_H104_L0.7460.97
111_A232_I0.7450.97
103_L253_I0.7450.97
282_N286_A0.7440.97
54_S59_I0.7430.97
77_R263_F0.7420.97
291_R295_F0.7370.97
153_I184_T0.7370.97
377_Q380_H0.7310.97
111_A115_V0.7310.97
193_S196_K0.7310.97
83_S86_H0.7310.97
65_A69_F0.7300.97
103_L257_L0.7300.97
113_V117_S0.7280.97
127_L165_T0.7260.97
27_D35_N0.7250.97
294_L298_I0.7240.97
269_I274_C0.7240.97
313_K323_V0.7220.97
155_M158_L0.7200.96
156_N159_E0.7190.96
296_S300_M0.7180.96
209_A220_T0.7160.96
302_R320_I0.7150.96
52_L290_K0.7140.96
214_G217_G0.7130.96
210_T233_G0.7120.96
49_Y208_H0.7050.96
53_A240_G0.7040.96
290_K293_L0.7030.96
171_R200_A0.7020.96
289_E292_Q0.6980.96
56_R59_I0.6960.96
308_M377_Q0.6940.96
115_V232_I0.6840.95
69_F85_W0.6830.95
329_K332_L0.6800.95
221_S231_V0.6800.95
88_K282_N0.6790.95
42_T374_H0.6770.95
150_Y153_I0.6760.95
57_R287_S0.6750.95
280_A284_I0.6720.95
166_Q171_R0.6720.95
125_V171_R0.6690.95
105_F114_G0.6680.95
105_F246_A0.6670.95
53_A74_S0.6660.95
376_L380_H0.6660.95
333_F359_I0.6650.95
79_T345_P0.6650.95
215_D288_R0.6640.95
310_Y379_F0.6640.95
234_T244_G0.6610.94
178_V317_T0.6610.94
153_I179_F0.6610.94
162_L198_Y0.6610.94
211_G238_A0.6600.94
62_A275_A0.6590.94
120_P203_V0.6590.94
178_V209_A0.6580.94
297_Y363_I0.6580.94
165_T168_Y0.6560.94
102_A245_F0.6510.94
333_F337_L0.6510.94
302_R314_G0.6500.94
129_D152_H0.6490.94
39_E341_G0.6470.94
100_E249_S0.6460.94
306_K312_V0.6460.94
284_I291_R0.6430.94
305_L361_I0.6430.94
203_V230_I0.6430.94
311_V325_G0.6390.93
92_K281_F0.6380.93
242_E273_S0.6380.93
195_A229_D0.6380.93
347_I351_T0.6370.93
79_T347_I0.6320.93
58_L280_A0.6300.93
305_L379_F0.6280.93
97_K281_F0.6260.93
96_F284_I0.6260.93
303_T306_K0.6260.93
130_Q147_T0.6260.93
218_Q285_E0.6250.93
276_A280_A0.6240.93
31_V34_R0.6220.92
103_L263_F0.6210.92
326_D330_T0.6190.92
106_S110_L0.6180.92
98_L227_C0.6170.92
99_T249_S0.6160.92
148_V164_E0.6140.92
215_D223_Y0.6130.92
137_I149_V0.6120.92
304_S380_H0.6090.92
373_D376_L0.6080.92
215_D292_Q0.6080.92
91_K101_A0.6070.91
370_G374_H0.6060.91
73_S271_P0.6060.91
96_F285_E0.6060.91
213_L223_Y0.6050.91
113_V139_G0.6050.91
253_I257_L0.6040.91
223_Y316_H0.6020.91
288_R291_R0.6010.91
77_R266_Q0.6000.91
88_K91_K0.5990.91
107_S242_E0.5980.91
302_R316_H0.5950.91
204_V221_S0.5940.91
128_S136_M0.5940.91
51_G364_T0.5940.91
61_A64_T0.5940.91
97_K102_A0.5930.91
267_T351_T0.5920.90
334_A346_A0.5920.90
189_D193_S0.5900.90
150_Y173_I0.5880.90
208_H237_K0.5860.90
323_V358_R0.5860.90
124_D143_S0.5850.90
324_I330_T0.5850.90
31_V54_S0.5850.90
48_N53_A0.5830.90
97_K245_F0.5810.90
130_Q356_E0.5800.90
217_G291_R0.5790.89
293_L365_S0.5790.89
116_L136_M0.5790.89
302_R306_K0.5790.89
162_L171_R0.5770.89
290_K297_Y0.5760.89
124_D170_R0.5760.89
213_L220_T0.5740.89
300_M376_L0.5740.89
86_H268_A0.5730.89
25_S84_V0.5730.89
178_V213_L0.5720.89
168_Y171_R0.5720.89
33_E374_H0.5720.89
192_I195_A0.5720.89
236_S267_T0.5710.89
70_G272_A0.5710.89
138_D141_R0.5700.89
132_N179_F0.5690.89
170_R201_F0.5690.89
221_S227_C0.5680.89
126_I143_S0.5680.89
29_A54_S0.5650.88
92_K95_S0.5640.88
34_R43_V0.5640.88
301_I375_L0.5630.88
376_L379_F0.5610.88
334_A338_Q0.5580.88
133_H237_K0.5570.88
42_T375_L0.5560.87
212_V294_L0.5560.87
153_I175_T0.5560.87
151_R160_N0.5540.87
62_A65_A0.5530.87
241_A273_S0.5520.87
68_Q88_K0.5520.87
132_N140_C0.5510.87
106_S269_I0.5510.87
155_M159_E0.5500.87
177_G213_L0.5460.87
120_P145_A0.5450.86
62_A272_A0.5450.86
305_L376_L0.5440.86
65_A68_Q0.5420.86
230_I248_G0.5420.86
241_A276_A0.5420.86
171_R199_H0.5410.86
331_V335_E0.5390.86
283_I290_K0.5380.86
232_I244_G0.5380.86
184_T358_R0.5370.86
185_I220_T0.5340.85
114_G118_S0.5330.85
52_L283_I0.5330.85
337_L344_A0.5330.85
348_R351_T0.5320.85
106_S244_G0.5310.85
41_Q343_Y0.5310.85
64_T279_E0.5300.85
71_T272_A0.5300.85
213_L295_F0.5290.85
162_L173_I0.5290.85
301_I304_S0.5270.85
96_F210_T0.5260.84
192_I226_V0.5250.84
206_D231_V0.5240.84
76_S108_G0.5230.84
373_D377_Q0.5210.84
133_H180_S0.5190.84
298_I318_P0.5180.84
329_K333_F0.5170.83
150_Y176_D0.5160.83
99_T221_S0.5150.83
52_L58_L0.5130.83
239_V280_A0.5120.83
146_D169_Q0.5120.83
296_S299_S0.5120.83
201_F252_F0.5110.83
207_A234_T0.5110.83
370_G373_D0.5100.83
97_K231_V0.5090.83
133_H208_H0.5080.82
265_F351_T0.5060.82
206_D221_S0.5050.82
333_F336_K0.5050.82
175_T202_V0.5050.82
136_M203_V0.5040.82
33_E42_T0.5040.82
35_N38_G0.5040.82
290_K365_S0.5040.82
283_I286_A0.5040.82
39_E339_G0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2w8tA 2 1 100 0.455 Contact Map
3wy7A 2 0.946 100 0.468 Contact Map
2bwnA 2 0.9897 100 0.504 Contact Map
1bs0A 2 0.9769 100 0.508 Contact Map
3kkiA 2 0.9692 100 0.511 Contact Map
1fc4A 2 1 100 0.511 Contact Map
3tqxA 2 1 100 0.528 Contact Map
3a2bA 2 0.9923 100 0.54 Contact Map
4iw7A 2 0.8483 100 0.568 Contact Map
1vefA 2 0.91 100 0.648 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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