GREMLIN Database
BIOK - L-Lysine--8-amino-7-oxononanoate transaminase
UniProt: P53555 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 448 (382)
Sequences: 20803 (12019)
Seq/√Len: 615.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_K74_G4.2401.00
238_R242_T3.9801.00
405_L438_Q3.9071.00
37_K45_E3.5541.00
197_L236_G3.5341.00
350_K430_S3.3791.00
95_T333_A3.1801.00
32_S39_K3.0621.00
262_K268_H2.8491.00
339_N342_E2.8321.00
350_K426_A2.7731.00
64_E337_S2.7381.00
67_D71_K2.6661.00
360_A437_K2.6641.00
343_Q347_K2.5461.00
425_T428_E2.5181.00
49_G432_M2.3421.00
95_T336_E2.3391.00
354_L433_V2.3351.00
236_G239_E2.3141.00
330_E333_A2.3021.00
64_E330_E2.2621.00
346_E426_A2.2331.00
239_E243_T2.2091.00
201_A243_T2.1991.00
31_E41_I2.1891.00
64_E334_L2.1801.00
401_K404_E2.1691.00
62_K334_L2.1551.00
37_K428_E2.1531.00
405_L442_E2.1231.00
177_P199_E2.0821.00
401_K442_E2.0471.00
39_K45_E2.0081.00
361_L437_K2.0041.00
138_K210_E1.9851.00
407_M435_I1.9721.00
354_L430_S1.9401.00
215_S249_I1.9151.00
95_T329_L1.9091.00
92_L328_A1.9061.00
401_K405_L1.8221.00
349_K353_F1.8211.00
66_D70_K1.7991.00
106_R296_E1.7971.00
296_E300_K1.7921.00
352_H356_Q1.7871.00
87_V91_Q1.7841.00
110_S290_A1.7691.00
431_E435_I1.7641.00
94_E98_D1.7591.00
40_D44_K1.7581.00
105_T296_E1.7501.00
214_L241_C1.7461.00
31_E75_K1.7421.00
69_I327_V1.7341.00
334_L338_E1.7291.00
200_L237_V1.7261.00
44_K406_G1.7201.00
216_I237_V1.7131.00
365_G379_V1.7091.00
34_T63_K1.6281.00
37_K431_E1.6231.00
69_I73_L1.6211.00
352_H369_Q1.6121.00
361_L441_H1.5941.00
117_M277_A1.5851.00
278_A291_V1.5791.00
354_L357_D1.5731.00
138_K174_Y1.5701.00
201_A205_E1.5681.00
142_M233_Y1.5461.00
143_K177_P1.5341.00
204_L246_V1.5271.00
262_K345_A1.5251.00
354_L434_A1.5211.00
283_T289_I1.5171.00
45_E431_E1.5151.00
93_A109_Y1.5141.00
287_L324_G1.5121.00
99_I336_E1.5061.00
347_K350_K1.5041.00
127_Y298_I1.4841.00
71_K75_K1.4811.00
36_I428_E1.4751.00
347_K429_L1.4671.00
232_G235_A1.4311.00
352_H374_C1.4281.00
100_S293_F1.4281.00
36_I423_A1.4251.00
198_R202_Q1.4241.00
201_A236_G1.4101.00
250_V266_C1.4031.00
179_P230_P1.3961.00
278_A293_F1.3861.00
330_E334_L1.3861.00
40_D46_Y1.3841.00
95_T98_D1.3801.00
401_K439_A1.3701.00
139_F213_A1.3661.00
140_I211_I1.3651.00
141_A175_K1.3651.00
91_Q329_L1.3641.00
343_Q346_E1.3611.00
356_Q359_H1.3551.00
405_L439_A1.3531.00
238_R248_M1.3531.00
107_V293_F1.3471.00
30_I38_V1.3451.00
329_L333_A1.3341.00
289_I325_C1.3341.00
120_A277_A1.3331.00
238_R241_C1.3321.00
63_K67_D1.3311.00
124_A249_I1.3301.00
119_I292_T1.3281.00
198_R201_A1.3281.00
350_K354_L1.3211.00
402_M409_T1.3121.00
121_L139_F1.3121.00
262_K267_E1.3071.00
354_L437_K1.3051.00
197_L240_L1.2991.00
282_I289_I1.2911.00
437_K441_H1.2881.00
91_Q333_A1.2861.00
62_K338_E1.2811.00
424_S429_L1.2731.00
156_V173_S1.2711.00
216_I234_L1.2641.00
263_M267_E1.2581.00
32_S75_K1.2581.00
342_E346_E1.2531.00
205_E244_Y1.2491.00
97_I107_V1.2471.00
250_V271_V1.2471.00
214_L237_V1.2431.00
98_D336_E1.2421.00
282_I291_V1.2391.00
347_K426_A1.2371.00
232_G269_E1.2351.00
289_I328_A1.2331.00
34_T61_R1.2301.00
117_M215_S1.2301.00
69_I323_L1.2281.00
269_E370_L1.2261.00
266_C276_M1.2221.00
275_L294_A1.2221.00
127_Y301_A1.2201.00
202_Q206_E1.2011.00
67_D70_K1.2001.00
358_L433_V1.1951.00
176_A203_L1.1911.00
68_A330_E1.1811.00
58_H334_L1.1741.00
136_K245_D1.1721.00
333_A337_S1.1671.00
201_A240_L1.1641.00
110_S292_T1.1621.00
106_R300_K1.1611.00
268_H370_L1.1571.00
235_A239_E1.1561.00
402_M435_I1.1541.00
428_E431_E1.1381.00
70_K73_L1.1341.00
66_D73_L1.1341.00
272_Q295_T1.1291.00
61_R66_D1.1261.00
247_L298_I1.1201.00
66_D74_G1.1191.00
34_T45_E1.1171.00
128_W212_A1.1151.00
156_V215_S1.1051.00
434_A438_Q1.1031.00
37_K47_Y1.0981.00
275_L292_T1.0871.00
407_M432_M1.0831.00
341_V344_V1.0821.00
402_M439_A1.0781.00
109_Y325_C1.0751.00
258_G341_V1.0711.00
201_A244_Y1.0701.00
235_A270_N1.0651.00
426_A430_S1.0611.00
114_A153_A1.0601.00
353_F357_D1.0491.00
402_M407_M1.0481.00
121_L156_V1.0461.00
264_F278_A1.0431.00
345_A349_K1.0411.00
92_L329_L1.0411.00
241_C246_V1.0381.00
431_E434_A1.0271.00
405_L435_I1.0261.00
284_G331_N1.0251.00
36_I47_Y1.0241.00
334_L337_S1.0111.00
155_S170_M1.0071.00
103_K272_Q1.0071.00
65_L327_V0.9961.00
31_E87_V0.9911.00
430_S434_A0.9901.00
123_M292_T0.9891.00
141_A215_S0.9781.00
261_G267_E0.9741.00
237_V248_M0.9731.00
201_A239_E0.9721.00
204_L211_I0.9701.00
335_F340_I0.9661.00
31_E43_G0.9621.00
116_A277_A0.9581.00
58_H331_N0.9531.00
34_T39_K0.9421.00
343_Q426_A0.9411.00
239_E242_T0.9361.00
326_A330_E0.9361.00
358_L437_K0.9341.00
365_G377_E0.9331.00
427_E430_S0.9321.00
142_M229_M0.9291.00
29_I41_I0.9281.00
57_V281_G0.9261.00
218_S250_V0.9201.00
199_E202_Q0.9201.00
375_G415_V0.9191.00
335_F341_V0.9161.00
240_L244_Y0.9111.00
220_V370_L0.9101.00
31_E39_K0.9091.00
257_F335_F0.9051.00
234_L269_E0.9011.00
138_K211_I0.8931.00
342_E345_A0.8921.00
104_L293_F0.8911.00
400_L404_E0.8911.00
56_N284_G0.8901.00
340_I344_V0.8881.00
47_Y428_E0.8881.00
114_A150_T0.8851.00
142_M178_I0.8841.00
64_E67_D0.8791.00
178_I229_M0.8791.00
377_E414_D0.8791.00
231_E235_A0.8791.00
29_I90_T0.8771.00
36_I425_T0.8751.00
99_I263_M0.8731.00
67_D74_G0.8691.00
213_A249_I0.8691.00
138_K205_E0.8681.00
58_H65_L0.8681.00
228_V370_L0.8671.00
71_K74_G0.8661.00
203_L206_E0.8621.00
49_G424_S0.8611.00
137_Q210_E0.8581.00
95_T99_I0.8581.00
99_I332_L0.8561.00
47_Y431_E0.8561.00
366_D377_E0.8551.00
268_H345_A0.8531.00
397_K401_K0.8411.00
359_H364_V0.8391.00
49_G407_M0.8361.00
208_H244_Y0.8361.00
120_A249_I0.8351.00
354_L429_L0.8331.00
124_A213_A0.8311.00
111_D115_E0.8271.00
287_L323_L0.8241.00
137_Q172_E0.8231.00
64_E333_A0.8231.00
232_G236_G0.8221.00
127_Y247_L0.8191.00
123_M294_A0.8191.00
245_D297_D0.8171.00
71_K326_A0.8171.00
242_T272_Q0.8121.00
41_I87_V0.8121.00
424_S432_M0.8121.00
257_F332_L0.8111.00
373_M419_L0.8101.00
229_M232_G0.8081.00
124_A247_L0.8061.00
36_I421_P0.8031.00
238_R271_V0.8021.00
176_A200_L0.7981.00
357_D360_A0.7981.00
372_F424_S0.7971.00
348_S352_H0.7961.00
177_P180_Y0.7921.00
30_I33_G0.7911.00
220_V373_M0.7901.00
126_Q313_F0.7901.00
128_W245_D0.7901.00
257_F282_I0.7851.00
64_E68_A0.7851.00
353_F356_Q0.7851.00
110_S116_A0.7821.00
255_T373_M0.7821.00
341_V345_A0.7781.00
214_L246_V0.7771.00
91_Q95_T0.7771.00
102_K276_M0.7751.00
101_P266_C0.7741.00
35_G423_A0.7731.00
97_I104_L0.7721.00
263_M341_V0.7711.00
96_L293_F0.7701.00
204_L240_L0.7691.00
228_V369_Q0.7641.00
378_L398_V0.7631.00
346_E350_K0.7631.00
357_D437_K0.7601.00
92_L325_C0.7591.00
88_P326_A0.7591.00
121_L215_S0.7581.00
107_V291_V0.7581.00
242_T248_M0.7571.00
438_Q442_E0.7561.00
200_L214_L0.7521.00
236_G240_L0.7491.00
418_F436_M0.7461.00
47_Y432_M0.7431.00
350_K353_F0.7431.00
257_F278_A0.7411.00
368_R377_E0.7401.00
316_H319_T0.7361.00
264_F276_M0.7361.00
68_A327_V0.7351.00
263_M336_E0.7351.00
266_C271_V0.7331.00
54_W419_L0.7321.00
124_A275_L0.7281.00
398_V436_M0.7281.00
360_A441_H0.7271.00
174_Y203_L0.7271.00
218_S234_L0.7261.00
51_S419_L0.7261.00
241_C248_M0.7251.00
95_T332_L0.7231.00
278_A282_I0.7171.00
211_I246_V0.7161.00
367_I374_C0.7151.00
260_T268_H0.7131.00
65_L284_G0.7131.00
207_H210_E0.7111.00
112_S115_E0.7071.00
89_A93_A0.7031.00
50_F410_R0.7011.00
297_D300_K0.7011.00
199_E203_L0.7001.00
38_V408_L0.7001.00
88_P329_L0.6971.00
310_K313_F0.6971.00
432_M435_I0.6951.00
377_E415_V0.6941.00
379_V382_K0.6911.00
86_N89_A0.6911.00
44_K404_E0.6911.00
176_A199_E0.6901.00
122_K314_H0.6871.00
257_F263_M0.6871.00
88_P92_L0.6861.00
367_I376_A0.6861.00
152_G170_M0.6861.00
73_L323_L0.6841.00
369_Q374_C0.6841.00
222_G373_M0.6841.00
344_V348_S0.6821.00
88_P325_C0.6811.00
398_V439_A0.6801.00
117_M153_A0.6771.00
248_M271_V0.6771.00
347_K372_F0.6761.00
75_K87_V0.6751.00
90_T94_E0.6741.00
399_S411_P0.6741.00
298_I301_A0.6731.00
396_Y400_L0.6711.00
348_S369_Q0.6711.00
110_S115_E0.6711.00
85_T90_T0.6701.00
235_A269_E0.6701.00
127_Y297_D0.6681.00
220_V260_T0.6651.00
33_G76_I0.6651.00
433_V437_K0.6631.00
427_E431_E0.6621.00
216_I248_M0.6611.00
61_R73_L0.6591.00
92_L289_I0.6581.00
72_Q75_K0.6581.00
418_F432_M0.6581.00
140_I200_L0.6561.00
346_E349_K0.6561.00
249_I275_L0.6561.00
101_P267_E0.6551.00
123_M302_F0.6541.00
136_K246_V0.6541.00
350_K429_L0.6511.00
47_Y407_M0.6501.00
104_L276_M0.6491.00
77_A287_L0.6491.00
204_L244_Y0.6481.00
234_L250_V0.6481.00
376_A436_M0.6471.00
253_V277_A0.6451.00
358_L361_L0.6441.00
347_K424_S0.6421.00
351_L433_V0.6411.00
125_F168_P0.6411.00
359_H366_D0.6391.00
361_L440_I0.6381.00
439_A442_E0.6381.00
146_Y149_D0.6371.00
138_K172_E0.6371.00
402_M436_M0.6361.00
295_T298_I0.6361.00
119_I314_H0.6341.00
58_H340_I0.6341.00
343_Q429_L0.6341.00
294_A299_Y0.6321.00
88_P91_Q0.6271.00
343_Q425_T0.6261.00
258_G335_F0.6261.00
120_A275_L0.6251.00
257_F264_F0.6251.00
100_S278_A0.6241.00
378_L440_I0.6241.00
100_S276_M0.6231.00
416_I436_M0.6231.00
231_E370_L0.6201.00
398_V402_M0.6191.00
73_L327_V0.6191.00
221_Q224_S0.6171.00
407_M431_E0.6151.00
33_G38_V0.6151.00
279_G290_A0.6101.00
65_L331_N0.6091.00
99_I264_F0.6081.00
176_A179_P0.6081.00
101_P104_L0.6071.00
142_M237_V0.6061.00
327_V330_E0.6051.00
140_I176_A0.6041.00
65_L330_E0.6041.00
50_F408_L0.6021.00
347_K425_T0.6001.00
123_M275_L0.5981.00
279_G318_Y0.5981.00
51_S421_P0.5971.00
36_I424_S0.5971.00
68_A71_K0.5961.00
72_Q88_P0.5941.00
397_K400_L0.5931.00
436_M440_I0.5911.00
200_L240_L0.5911.00
57_V422_L0.5911.00
29_I85_T0.5901.00
143_K175_K0.5891.00
351_L374_C0.5891.00
128_W136_K0.5891.00
142_M176_A0.5881.00
231_E269_E0.5871.00
242_T297_D0.5861.00
218_S266_C0.5861.00
92_L109_Y0.5851.00
344_V422_L0.5851.00
202_Q205_E0.5851.00
136_K210_E0.5831.00
221_Q227_I0.5821.00
141_A173_S0.5811.00
45_E435_I0.5811.00
72_Q76_I0.5811.00
140_I203_L0.5771.00
214_L242_T0.5741.00
113_G253_V0.5721.00
32_S45_E0.5711.00
31_E34_T0.5691.00
349_K352_H0.5681.00
435_I439_A0.5681.00
197_L200_L0.5651.00
398_V416_I0.5651.00
266_C273_P0.5621.00
99_I262_K0.5621.00
400_L403_R0.5611.00
103_K295_T0.5611.00
228_V269_E0.5601.00
33_G56_N0.5601.00
125_F151_I0.5601.00
359_H367_I0.5591.00
97_I293_F0.5571.00
435_I438_Q0.5571.00
240_L243_T0.5571.00
263_M332_L0.5571.00
69_I77_A0.5561.00
351_L429_L0.5561.00
363_H379_V0.5541.00
200_L236_G0.5541.00
222_G254_A0.5531.00
344_V372_F0.5531.00
197_L201_A0.5531.00
364_V440_I0.5521.00
176_A180_Y0.5521.00
330_E337_S0.5501.00
407_M439_A0.5501.00
424_S428_E0.5501.00
376_A418_F0.5490.99
399_S403_R0.5490.99
198_R236_G0.5490.99
142_M216_I0.5480.99
380_R383_E0.5480.99
28_L31_E0.5470.99
100_S264_F0.5460.99
218_S255_T0.5460.99
329_L336_E0.5460.99
57_V335_F0.5460.99
68_A333_A0.5450.99
275_L298_I0.5440.99
398_V440_I0.5430.99
84_M408_L0.5410.99
174_Y177_P0.5410.99
351_L354_L0.5410.99
350_K433_V0.5400.99
128_W132_G0.5380.99
364_V376_A0.5380.99
254_A373_M0.5360.99
423_A428_E0.5350.99
368_R375_G0.5340.99
66_D284_G0.5340.99
47_Y424_S0.5330.99
263_M335_F0.5320.99
224_S227_I0.5320.99
75_K88_P0.5320.99
336_E339_N0.5320.99
34_T37_K0.5300.99
223_A417_A0.5300.99
237_V246_V0.5280.99
73_L77_A0.5270.99
340_I343_Q0.5260.99
432_M436_M0.5260.99
58_H62_K0.5240.99
321_N324_G0.5230.99
403_R408_L0.5220.99
429_L432_M0.5210.99
121_L152_G0.5210.99
406_G435_I0.5190.99
97_I105_T0.5180.99
30_I84_M0.5180.99
29_I87_V0.5170.99
30_I76_I0.5140.99
65_L69_I0.5140.99
200_L233_Y0.5140.99
102_K266_C0.5120.99
65_L334_L0.5120.99
378_L394_I0.5120.99
332_L336_E0.5110.99
121_L173_S0.5110.99
349_K356_Q0.5090.99
368_R415_V0.5080.99
431_E438_Q0.5080.99
40_D406_G0.5080.99
94_E97_I0.5070.99
421_P424_S0.5070.99
158_S175_K0.5050.99
254_A417_A0.5030.99
276_M293_F0.5030.99
410_R413_G0.5030.99
363_H440_I0.5020.99
235_A238_R0.5010.99
247_L275_L0.5000.99
197_L237_V0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4e3qA 3 0.9933 100 0.371 Contact Map
4a0gA 2 0.9576 100 0.379 Contact Map
3hmuA 2 0.9844 100 0.38 Contact Map
3i5tA 2 0.9799 100 0.389 Contact Map
4uoxA 3 0.9174 100 0.393 Contact Map
4atqA 7 0.933 100 0.395 Contact Map
3oksA 2 0.933 100 0.396 Contact Map
4ffcA 4 0.9353 100 0.406 Contact Map
1z7dA 2 0.8348 100 0.409 Contact Map
2epjA 2 0.9219 100 0.413 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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