BIOI - BACSU - GREMLIN Contacts

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BIOI - Biotin biosynthesis cytochrome P450

UniProt:	P53554	Sequences: MTIASSTASSEFLKNPYSFYDTLRAVHPIYKGSFLKYPGWYVTGYEETAAILKDARFKVRTPLPESSTKYQDLSHVQNQMMLFQNQPDHRRLRTLASGAFTPRTTESYQPYIIETVHHLLDQVQGKKKMEVISDFAFPLASFVIANIIGVPEEDREQLKEWAASLIQTIDFTRSRKALTEGNIMAVQAMAYFKELIQKRKRHPQQDMISMLLKGREKDKLTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPDLIGTAVEECLRYESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITRSPNPHLSFGHGHHVCLGSSLARLEAQIAINTLLQRMPSLNLADFEWRYRPLFGFRALEELPVTFE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	395 (357)
Sequences:	44279 (32758)
Seq/√Len:	1733.7

BACSU - BIOI CPXY PKSS CYPX YJIB CYPC CYPE CYPD
HALSA - Q9HS37

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
322_N	325_V	3.992	1.00
322_N	327_D	3.264	1.00
301_R	304_E	3.213	1.00
200_K	222_E	2.991	1.00
243_L	355_A	2.978	1.00
260_K	329_T	2.964	1.00
292_D	302_Q	2.910	1.00
247_S	359_I	2.855	1.00
117_H	361_T	2.832	1.00
44_G	47_E	2.806	1.00
259_L	263_E	2.761	1.00
247_S	275_C	2.760	1.00
199_R	206_D	2.691	1.00
269_G	356_Q	2.659	1.00
294_D	299_T	2.649	1.00
292_D	299_T	2.477	1.00
171_F	174_S	2.433	1.00
294_D	297_G	2.433	1.00
289_A	300_I	2.427	1.00
258_L	262_R	2.401	1.00
257_Q	267_L	2.354	1.00
250_C	279_E	2.352	1.00
124_Q	366_M	2.274	1.00
197_Q	222_E	2.253	1.00
315_R	324_D	2.242	1.00
124_Q	365_R	2.201	1.00
261_L	271_A	2.189	1.00
40_W	304_E	2.110	1.00
42_V	51_I	2.092	1.00
262_R	367_P	2.063	1.00
193_K	226_A	2.035	1.00
254_H	257_Q	2.027	1.00
31_K	38_P	2.003	1.00
250_C	278_Y	1.956	1.00
139_L	358_A	1.930	1.00
198_K	202_H	1.908	1.00
47_E	296_C	1.888	1.00
193_K	222_E	1.877	1.00
113_I	361_T	1.875	1.00
29_I	42_V	1.874	1.00
136_A	244_I	1.840	1.00
260_K	267_L	1.834	1.00
258_L	367_P	1.834	1.00
21_D	24_R	1.802	1.00
111_Y	146_N	1.797	1.00
48_T	313_A	1.782	1.00
259_L	367_P	1.782	1.00
193_K	197_Q	1.764	1.00
275_C	326_F	1.749	1.00
197_Q	201_R	1.749	1.00
276_L	337_S	1.745	1.00
244_I	358_A	1.718	1.00
59_V	293_I	1.710	1.00
259_L	262_R	1.706	1.00
247_S	251_L	1.699	1.00
221_T	224_E	1.686	1.00
183_I	187_Q	1.683	1.00
273_E	352_R	1.676	1.00
344_V	348_S	1.675	1.00
92_L	228_T	1.674	1.00
194_E	198_K	1.655	1.00
28_P	44_G	1.654	1.00
272_V	355_A	1.640	1.00
33_S	38_P	1.576	1.00
160_E	164_S	1.568	1.00
292_D	301_R	1.565	1.00
114_E	146_N	1.549	1.00
136_A	248_V	1.539	1.00
362_L	369_L	1.531	1.00
206_D	209_S	1.529	1.00
249_L	253_Q	1.525	1.00
247_S	271_A	1.506	1.00
56_R	291_E	1.503	1.00
49_A	53_K	1.500	1.00
19_F	22_T	1.491	1.00
121_D	365_R	1.488	1.00
261_L	363_L	1.487	1.00
243_L	281_P	1.473	1.00
270_T	329_T	1.454	1.00
311_G	315_R	1.449	1.00
58_K	291_E	1.445	1.00
257_Q	260_K	1.444	1.00
314_N	337_S	1.444	1.00
111_Y	114_E	1.439	1.00
317_P	324_D	1.430	1.00
250_C	254_H	1.419	1.00
258_L	363_L	1.414	1.00
115_T	146_N	1.406	1.00
115_T	118_H	1.404	1.00
267_L	329_T	1.400	1.00
190_A	194_E	1.398	1.00
186_V	190_A	1.395	1.00
48_T	308_L	1.394	1.00
157_Q	161_W	1.393	1.00
252_L	258_L	1.372	1.00
87_P	90_R	1.371	1.00
109_Q	356_Q	1.369	1.00
113_I	117_H	1.366	1.00
248_V	362_L	1.356	1.00
361_T	364_Q	1.339	1.00
46_E	296_C	1.335	1.00
261_L	268_I	1.335	1.00
257_Q	271_A	1.334	1.00
209_S	213_K	1.327	1.00
317_P	323_P	1.324	1.00
86_Q	90_R	1.318	1.00
128_K	372_A	1.316	1.00
42_V	47_E	1.306	1.00
278_Y	315_R	1.296	1.00
268_I	363_L	1.295	1.00
30_Y	41_Y	1.290	1.00
197_Q	200_K	1.285	1.00
120_L	366_M	1.282	1.00
161_W	187_Q	1.274	1.00
19_F	23_L	1.273	1.00
22_T	25_A	1.270	1.00
291_E	302_Q	1.267	1.00
271_A	326_F	1.265	1.00
57_F	291_E	1.264	1.00
126_K	134_D	1.257	1.00
116_V	139_L	1.254	1.00
198_K	201_R	1.253	1.00
157_Q	187_Q	1.252	1.00
203_P	213_K	1.249	1.00
21_D	324_D	1.235	1.00
273_E	335_H	1.233	1.00
164_S	180_E	1.227	1.00
54_D	57_F	1.219	1.00
268_I	360_N	1.208	1.00
157_Q	160_E	1.204	1.00
119_L	139_L	1.195	1.00
104_T	107_S	1.194	1.00
28_P	318_S	1.189	1.00
43_T	309_L	1.177	1.00
117_H	121_D	1.171	1.00
293_I	299_T	1.168	1.00
91_R	224_E	1.166	1.00
262_R	363_L	1.163	1.00
179_T	183_I	1.161	1.00
271_A	275_C	1.153	1.00
265_P	364_Q	1.139	1.00
260_K	263_E	1.138	1.00
112_I	143_V	1.137	1.00
40_W	300_I	1.134	1.00
115_T	142_F	1.134	1.00
251_L	257_Q	1.126	1.00
314_N	335_H	1.120	1.00
120_L	361_T	1.114	1.00
106_E	109_Q	1.112	1.00
199_R	209_S	1.112	1.00
42_V	48_T	1.112	1.00
144_I	236_G	1.109	1.00
105_T	353_L	1.109	1.00
50_A	54_D	1.102	1.00
109_Q	113_I	1.098	1.00
257_Q	328_I	1.098	1.00
116_V	357_I	1.096	1.00
58_K	293_I	1.093	1.00
269_G	273_E	1.093	1.00
87_P	91_R	1.087	1.00
22_T	26_V	1.077	1.00
156_E	160_E	1.069	1.00
288_V	303_G	1.069	1.00
114_E	118_H	1.063	1.00
321_T	327_D	1.057	1.00
122_Q	126_K	1.055	1.00
46_E	318_S	1.055	1.00
112_I	353_L	1.053	1.00
215_R	222_E	1.052	1.00
121_D	124_Q	1.051	1.00
116_V	120_L	1.046	1.00
189_M	226_A	1.043	1.00
317_P	321_T	1.041	1.00
88_D	91_R	1.039	1.00
289_A	301_R	1.037	1.00
27_H	30_Y	1.034	1.00
319_I	334_P	1.030	1.00
112_I	350_L	1.023	1.00
195_L	198_K	1.017	1.00
45_Y	319_I	1.014	1.00
79_Q	88_D	1.012	1.00
351_A	355_A	1.011	1.00
367_P	370_N	1.008	1.00
24_R	317_P	1.005	1.00
55_A	59_V	1.004	1.00
84_Q	88_D	1.004	1.00
261_L	267_L	1.001	1.00
257_Q	329_T	0.999	1.00
109_Q	357_I	0.998	1.00
252_L	371_L	0.998	1.00
44_G	318_S	0.995	1.00
251_L	261_L	0.987	1.00
29_I	47_E	0.981	1.00
47_E	50_A	0.979	1.00
46_E	50_A	0.977	1.00
118_H	142_F	0.976	1.00
141_S	237_H	0.974	1.00
175_R	178_L	0.970	1.00
289_A	304_E	0.970	1.00
223_E	227_S	0.965	1.00
271_A	328_I	0.961	1.00
39_G	307_Y	0.960	1.00
176_K	180_E	0.958	1.00
113_I	360_N	0.957	1.00
255_P	259_L	0.956	1.00
289_A	292_D	0.953	1.00
100_F	346_L	0.948	1.00
90_R	94_T	0.946	1.00
215_R	219_K	0.946	1.00
130_E	134_D	0.945	1.00
246_N	279_E	0.942	1.00
113_I	357_I	0.941	1.00
348_S	352_R	0.936	1.00
96_A	346_L	0.931	1.00
244_I	355_A	0.928	1.00
118_H	122_Q	0.925	1.00
267_L	328_I	0.921	1.00
145_A	152_E	0.920	1.00
374_F	377_R	0.919	1.00
205_Q	209_S	0.917	1.00
252_L	369_L	0.915	1.00
251_L	258_L	0.915	1.00
164_S	184_M	0.907	1.00
101_T	104_T	0.905	1.00
117_H	365_R	0.904	1.00
250_C	275_C	0.904	1.00
331_S	334_P	0.903	1.00
118_H	121_D	0.896	1.00
131_V	248_V	0.896	1.00
116_V	361_T	0.896	1.00
146_N	151_P	0.895	1.00
150_V	198_K	0.895	1.00
250_C	253_Q	0.893	1.00
123_V	135_F	0.892	1.00
254_H	325_V	0.889	1.00
50_A	293_I	0.888	1.00
187_Q	190_A	0.887	1.00
115_T	151_P	0.886	1.00
189_M	193_K	0.885	1.00
135_F	358_A	0.884	1.00
256_E	260_K	0.882	1.00
139_L	143_V	0.879	1.00
102_P	106_E	0.875	1.00
288_V	305_Q	0.873	1.00
256_E	259_L	0.865	1.00
182_N	186_V	0.863	1.00
55_A	293_I	0.859	1.00
122_Q	125_G	0.857	1.00
265_P	360_N	0.857	1.00
266_D	270_T	0.853	1.00
220_L	224_E	0.850	1.00
360_N	364_Q	0.846	1.00
23_L	30_Y	0.844	1.00
222_E	226_A	0.843	1.00
130_E	133_S	0.841	1.00
285_T	310_L	0.833	1.00
60_R	63_L	0.833	1.00
160_E	163_A	0.833	1.00
200_K	203_P	0.830	1.00
180_E	184_M	0.829	1.00
267_L	270_T	0.829	1.00
289_A	303_G	0.828	1.00
189_M	223_E	0.825	1.00
194_E	197_Q	0.825	1.00
58_K	61_T	0.824	1.00
195_L	199_R	0.817	1.00
192_F	229_C	0.815	1.00
268_I	356_Q	0.813	1.00
248_V	363_L	0.812	1.00
247_S	326_F	0.810	1.00
80_M	231_L	0.809	1.00
163_A	167_Q	0.809	1.00
199_R	203_P	0.806	1.00
251_L	363_L	0.806	1.00
46_E	49_A	0.803	1.00
143_V	354_E	0.799	1.00
243_L	275_C	0.799	1.00
50_A	296_C	0.797	1.00
55_A	58_K	0.796	1.00
140_A	240_T	0.793	1.00
238_E	242_N	0.792	1.00
158_L	161_W	0.792	1.00
136_A	245_S	0.791	1.00
29_I	298_V	0.790	1.00
352_R	356_Q	0.788	1.00
210_M	213_K	0.788	1.00
299_T	302_Q	0.786	1.00
88_D	224_E	0.784	1.00
255_P	258_L	0.783	1.00
110_P	114_E	0.781	1.00
122_Q	138_P	0.780	1.00
246_N	378_Y	0.779	1.00
178_L	182_N	0.779	1.00
248_V	359_I	0.778	1.00
185_A	189_M	0.777	1.00
31_K	40_W	0.776	1.00
34_F	39_G	0.776	1.00
51_I	295_I	0.775	1.00
196_I	200_K	0.772	1.00
274_E	277_R	0.772	1.00
247_S	272_V	0.770	1.00
51_I	308_L	0.766	1.00
121_D	125_G	0.764	1.00
208_I	229_C	0.761	1.00
161_W	164_S	0.757	1.00
180_E	183_I	0.754	1.00
44_G	296_C	0.753	1.00
164_S	167_Q	0.753	1.00
264_N	267_L	0.752	1.00
111_Y	115_T	0.750	1.00
350_L	354_E	0.750	1.00
269_G	352_R	0.749	1.00
193_K	223_E	0.741	1.00
249_L	371_L	0.741	1.00
268_I	359_I	0.739	1.00
187_Q	191_Y	0.738	1.00
18_S	21_D	0.736	1.00
160_E	187_Q	0.734	1.00
200_K	215_R	0.733	1.00
280_S	314_N	0.731	1.00
149_G	206_D	0.728	1.00
204_Q	209_S	0.726	1.00
324_D	327_D	0.726	1.00
86_Q	342_H	0.724	1.00
48_T	336_L	0.724	1.00
236_G	239_T	0.723	1.00
176_K	179_T	0.723	1.00
189_M	230_I	0.721	1.00
310_L	336_L	0.719	1.00
159_K	163_A	0.716	1.00
316_D	319_I	0.714	1.00
175_R	179_T	0.713	1.00
186_V	189_M	0.712	1.00
154_D	191_Y	0.712	1.00
32_G	39_G	0.711	1.00
267_L	271_A	0.711	1.00
164_S	187_Q	0.709	1.00
88_D	92_L	0.708	1.00
157_Q	194_E	0.705	1.00
89_H	93_R	0.702	1.00
190_A	193_K	0.702	1.00
103_R	107_S	0.701	1.00
114_E	151_P	0.700	1.00
41_Y	309_L	0.696	1.00
38_P	304_E	0.694	1.00
156_E	159_K	0.690	1.00
184_M	187_Q	0.689	1.00
322_N	330_R	0.689	1.00
270_T	328_I	0.687	1.00
120_L	365_R	0.686	1.00
164_S	168_T	0.686	1.00
278_Y	324_D	0.683	1.00
300_I	306_V	0.680	1.00
166_I	169_I	0.680	1.00
199_R	202_H	0.679	1.00
240_T	354_E	0.678	1.00
189_M	227_S	0.677	1.00
52_L	308_L	0.677	1.00
84_Q	92_L	0.677	1.00
28_P	316_D	0.677	1.00
21_D	312_A	0.676	1.00
295_I	300_I	0.675	1.00
357_I	361_T	0.674	1.00
107_S	205_Q	0.674	1.00
257_Q	327_D	0.672	1.00
162_A	166_I	0.670	1.00
103_R	106_E	0.670	1.00
122_Q	135_F	0.669	1.00
235_A	239_T	0.667	1.00
96_A	232_L	0.666	1.00
276_L	335_H	0.662	1.00
80_M	84_Q	0.659	1.00
109_Q	353_L	0.659	1.00
33_S	36_K	0.659	1.00
296_C	299_T	0.659	1.00
356_Q	360_N	0.658	1.00
205_Q	213_K	0.657	1.00
361_T	365_R	0.657	1.00
260_K	264_N	0.657	1.00
253_Q	371_L	0.657	1.00
39_G	305_Q	0.657	1.00
32_G	41_Y	0.649	1.00
140_A	354_E	0.648	1.00
292_D	304_E	0.647	1.00
58_K	290_S	0.646	1.00
105_T	350_L	0.645	1.00
31_K	304_E	0.644	1.00
102_P	349_S	0.643	1.00
50_A	55_A	0.642	1.00
309_L	312_A	0.638	1.00
53_K	340_H	0.637	1.00
25_A	318_S	0.637	1.00
140_A	241_V	0.637	1.00
37_Y	305_Q	0.636	1.00
280_S	283_Q	0.636	1.00
61_T	290_S	0.635	1.00
243_L	276_L	0.635	1.00
253_Q	375_E	0.632	1.00
131_V	136_A	0.630	1.00
59_V	62_P	0.630	1.00
268_I	271_A	0.628	1.00
138_P	142_F	0.628	1.00
272_V	356_Q	0.627	1.00
50_A	295_I	0.627	1.00
286_A	307_Y	0.627	1.00
239_T	282_T	0.626	1.00
251_L	254_H	0.624	1.00
81_M	231_L	0.623	1.00
251_L	271_A	0.621	1.00
116_V	358_A	0.621	1.00
74_S	79_Q	0.621	1.00
327_D	330_R	0.619	1.00
45_Y	316_D	0.618	1.00
118_H	151_P	0.617	1.00
155_R	159_K	0.615	1.00
28_P	31_K	0.613	1.00
289_A	302_Q	0.613	1.00
27_H	298_V	0.612	1.00
248_V	369_L	0.612	1.00
110_P	113_I	0.612	1.00
339_G	344_V	0.612	1.00
60_R	290_S	0.610	1.00
45_Y	49_A	0.610	1.00
144_I	147_I	0.609	1.00
104_T	108_Y	0.609	1.00
89_H	343_H	0.609	1.00
51_I	57_F	0.607	1.00
61_T	84_Q	0.607	1.00
96_A	228_T	0.607	1.00
28_P	296_C	0.606	1.00
40_W	298_V	0.605	1.00
321_T	325_V	0.605	1.00
141_S	233_A	0.603	1.00
320_F	333_N	0.602	1.00
290_S	302_Q	0.602	1.00
93_R	97_S	0.601	1.00
178_L	181_G	0.598	1.00
177_A	181_G	0.598	1.00
56_R	59_V	0.597	1.00
270_T	327_D	0.596	1.00
340_H	344_V	0.595	1.00
250_C	326_F	0.594	1.00
154_D	157_Q	0.593	1.00
320_F	323_P	0.592	1.00
48_T	52_L	0.591	1.00
255_P	367_P	0.591	1.00
196_I	212_L	0.591	1.00
99_A	210_M	0.590	1.00
21_D	25_A	0.589	1.00
158_L	162_A	0.587	1.00
242_N	246_N	0.587	1.00
142_F	155_R	0.584	1.00
159_K	162_A	0.583	1.00
119_L	123_V	0.580	1.00
112_I	357_I	0.580	1.00
95_L	214_G	0.580	1.00
40_W	301_R	0.579	1.00
289_A	293_I	0.578	1.00
134_D	138_P	0.576	1.00
100_F	232_L	0.573	1.00
123_V	129_M	0.573	1.00
183_I	186_V	0.570	1.00
240_T	355_A	0.569	1.00
131_V	135_F	0.568	1.00
161_W	165_L	0.568	1.00
23_L	32_G	0.567	1.00
373_D	376_W	0.567	1.00
147_I	232_L	0.566	1.00
228_T	231_L	0.565	1.00
50_A	294_D	0.564	1.00
119_L	358_A	0.564	1.00
199_R	204_Q	0.562	1.00
256_E	325_V	0.561	1.00
167_Q	170_D	0.561	1.00
162_A	237_H	0.561	1.00
104_T	210_M	0.560	1.00
49_A	333_N	0.560	1.00
182_N	185_A	0.559	1.00
247_S	355_A	0.559	1.00
68_T	71_Q	0.556	1.00
205_Q	210_M	0.555	1.00
272_V	352_R	0.555	1.00
161_W	166_I	0.553	1.00
140_A	144_I	0.553	1.00
181_G	185_A	0.550	1.00
179_T	182_N	0.548	1.00
30_Y	43_T	0.548	1.00
166_I	170_D	0.547	1.00
250_C	257_Q	0.546	1.00
41_Y	307_Y	0.538	1.00
114_E	117_H	0.537	1.00
119_L	362_L	0.534	1.00
351_A	354_E	0.533	1.00
165_L	168_T	0.531	1.00
243_L	272_V	0.529	1.00
155_R	160_E	0.529	1.00
116_V	119_L	0.529	1.00
207_M	211_L	0.529	1.00
112_I	354_E	0.528	1.00
28_P	43_T	0.525	1.00
136_A	355_A	0.525	1.00
120_L	123_V	0.524	1.00
91_R	218_D	0.523	1.00
52_L	310_L	0.522	1.00
46_E	319_I	0.521	1.00
136_A	140_A	0.521	1.00
333_N	340_H	0.521	1.00
255_P	370_N	0.520	1.00
146_N	155_R	0.516	1.00
53_K	56_R	0.515	1.00
81_M	96_A	0.514	1.00
71_Q	74_S	0.514	1.00
375_E	378_Y	0.513	1.00
47_E	295_I	0.512	1.00
211_L	225_A	0.512	1.00
43_T	316_D	0.511	1.00
196_I	208_I	0.510	1.00
44_G	48_T	0.509	1.00
122_Q	142_F	0.509	1.00
181_G	184_M	0.509	1.00
276_L	281_P	0.508	1.00
224_E	228_T	0.508	1.00
206_D	210_M	0.507	1.00
44_G	313_A	0.507	1.00
120_L	124_Q	0.504	1.00
268_I	272_V	0.503	1.00
192_F	195_L	0.503	1.00
81_M	228_T	0.503	1.00
137_F	241_V	0.503	1.00
363_L	369_L	0.502	1.00
135_F	138_P	0.501	1.00
298_V	301_R	0.501	1.00
82_L	231_L	0.501	1.00
283_Q	311_G	0.501	1.00
79_Q	223_E	0.500	1.00
289_A	306_V	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3ejbB	1	0.9722	100	0.174	Contact Map
2uuqA	2	0.9722	100	0.185	Contact Map
2z3tA	1	0.9544	100	0.189	Contact Map
4tpnA	1	0.9468	100	0.19	Contact Map
3nc3A	1	0.9392	100	0.194	Contact Map
3bujA	1	0.9772	100	0.195	Contact Map
4egoA	3	0.9772	100	0.198	Contact Map
2xkrA	1	0.9646	100	0.198	Contact Map
1z8oA	1	0.9747	100	0.199	Contact Map
3r9bA	3	0.9696	100	0.204	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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