GREMLIN Database
AAT1 - Aspartate aminotransferase
UniProt: P53001 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 393 (347)
Sequences: 43540 (29835)
Seq/√Len: 1601.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_V57_N3.2871.00
116_E137_K2.9431.00
75_S283_N2.8761.00
96_C102_A2.8691.00
302_T379_E2.7551.00
351_E387_R2.6991.00
297_E301_N2.6611.00
111_L136_G2.6611.00
81_K87_E2.5581.00
314_S327_N2.5531.00
182_E186_S2.5311.00
298_H375_L2.4251.00
115_D165_K2.4071.00
71_E279_I2.3761.00
157_K194_E2.3721.00
380_E384_R2.3071.00
251_G256_I2.2931.00
46_Q50_D2.1451.00
116_E139_V2.1421.00
181_T184_E2.1031.00
304_Y308_I2.0911.00
304_Y317_K2.0781.00
104_Y108_Q2.0611.00
121_T140_Y1.9991.00
306_K309_E1.9681.00
306_K382_I1.9391.00
75_S78_E1.9141.00
74_N90_P1.8911.00
246_I278_A1.8691.00
155_Q159_A1.7991.00
78_E283_N1.7911.00
186_S190_E1.7801.00
150_K184_E1.7711.00
302_T306_K1.7681.00
306_K386_K1.7581.00
200_V232_I1.7531.00
70_A74_N1.7501.00
50_D54_R1.7451.00
82_R286_S1.7351.00
77_A90_P1.7091.00
92_Q253_E1.7061.00
131_V136_G1.7041.00
339_D342_E1.7041.00
346_A388_F1.6911.00
157_K187_A1.6841.00
152_S155_Q1.6791.00
128_P132_K1.6701.00
49_I53_V1.6681.00
91_S253_E1.6671.00
380_E383_E1.6671.00
155_Q158_N1.6511.00
374_S377_L1.6461.00
192_C199_I1.6441.00
351_E384_R1.6351.00
54_R280_A1.6301.00
75_S279_I1.6291.00
302_T375_L1.6261.00
74_N78_E1.6241.00
345_K349_E1.6101.00
308_I315_C1.5891.00
196_D228_Q1.5811.00
182_E216_V1.5791.00
106_L230_V1.5781.00
301_N305_A1.5661.00
128_P140_Y1.5651.00
271_T274_A1.5541.00
305_A309_E1.5521.00
153_P187_A1.5501.00
204_I234_G1.5491.00
117_V131_V1.5361.00
116_E163_K1.5311.00
121_T142_E1.5311.00
306_K383_E1.5181.00
342_E346_A1.5161.00
187_A190_E1.4961.00
76_I248_Y1.4921.00
249_A259_M1.4901.00
118_I164_T1.4801.00
69_L276_Y1.4671.00
35_L381_A1.4601.00
154_E187_A1.4551.00
50_D53_V1.4481.00
106_L200_V1.4471.00
107_F131_V1.4411.00
306_K379_E1.4371.00
304_Y315_C1.4351.00
67_G260_T1.4311.00
116_E161_T1.4291.00
88_Y250_A1.4081.00
184_E187_A1.3981.00
303_I324_L1.3961.00
99_A232_I1.3951.00
290_E294_E1.3941.00
49_I57_N1.3921.00
119_I138_P1.3881.00
51_A54_R1.3861.00
295_A298_H1.3831.00
308_I317_K1.3781.00
341_D359_S1.3721.00
355_I367_V1.3681.00
113_E135_G1.3631.00
166_A200_V1.3621.00
116_E164_T1.3611.00
80_F250_A1.3541.00
51_A280_A1.3461.00
78_E82_R1.3431.00
70_A90_P1.3421.00
235_V278_A1.3391.00
279_I283_N1.3351.00
144_L184_E1.3351.00
304_Y324_L1.3251.00
309_E386_K1.3161.00
52_A56_M1.3161.00
342_E345_K1.3141.00
52_A277_G1.3081.00
303_I382_I1.3071.00
295_A375_L1.3011.00
258_A261_N1.2931.00
340_V359_S1.2911.00
108_Q134_A1.2891.00
325_F358_G1.2881.00
142_E155_Q1.2831.00
192_C197_I1.2821.00
160_I191_V1.2821.00
327_N366_N1.2711.00
157_K195_H1.2601.00
30_H352_K1.2591.00
89_K92_Q1.2561.00
71_E283_N1.2531.00
153_P191_V1.2491.00
233_N248_Y1.2471.00
157_K191_V1.2371.00
327_N365_E1.2311.00
157_K161_T1.2271.00
190_E194_E1.2261.00
227_E252_S1.2181.00
182_E220_Q1.2151.00
183_E186_S1.2141.00
191_V195_H1.2111.00
186_S221_L1.1961.00
191_V197_I1.1901.00
257_K261_N1.1881.00
144_L155_Q1.1841.00
118_I141_V1.1801.00
183_E187_A1.1761.00
94_I256_I1.1721.00
310_I386_K1.1711.00
97_T101_H1.1711.00
295_A299_R1.1711.00
67_G73_K1.1711.00
379_E383_E1.1701.00
326_P369_L1.1691.00
71_E276_Y1.1651.00
190_E193_L1.1631.00
102_A249_A1.1591.00
112_D115_D1.1531.00
107_F168_V1.1481.00
383_E387_R1.1471.00
375_L379_E1.1461.00
54_R58_E1.1381.00
377_L380_E1.1381.00
300_L371_Y1.1381.00
294_E297_E1.1291.00
280_A283_N1.1281.00
211_G319_E1.1281.00
290_E293_R1.1261.00
193_L226_K1.1231.00
182_E221_L1.1121.00
107_F111_L1.1111.00
280_A284_G1.1051.00
300_L304_Y1.1051.00
73_K77_A1.0981.00
109_V262_L1.0891.00
230_V251_G1.0891.00
198_L230_V1.0851.00
217_S220_Q1.0841.00
302_T305_A1.0781.00
299_R302_T1.0741.00
144_L152_S1.0691.00
54_R57_N1.0661.00
76_I95_V1.0661.00
276_Y279_I1.0651.00
101_H263_A1.0651.00
167_I197_I1.0551.00
89_K253_E1.0551.00
158_N162_E1.0501.00
291_E295_A1.0441.00
306_K310_I1.0331.00
71_E74_N1.0311.00
294_E298_H1.0311.00
263_A267_T1.0311.00
47_H50_D1.0291.00
47_H284_G1.0241.00
344_V355_I1.0231.00
161_T164_T1.0211.00
314_S329_K1.0211.00
160_I197_I1.0141.00
46_Q49_I1.0131.00
80_F248_Y1.0111.00
111_L117_V1.0051.00
72_L95_V1.0041.00
341_D345_K0.9931.00
31_D352_K0.9911.00
301_N317_K0.9901.00
210_Y297_E0.9871.00
305_A308_I0.9841.00
161_T195_H0.9841.00
198_L228_Q0.9781.00
117_V166_A0.9751.00
189_G229_T0.9741.00
329_K365_E0.9701.00
287_E291_E0.9691.00
131_V138_P0.9661.00
76_I93_I0.9621.00
230_V249_A0.9611.00
42_F295_A0.9581.00
92_Q256_I0.9541.00
77_A93_I0.9511.00
31_D380_E0.9511.00
77_A89_K0.9491.00
153_P157_K0.9471.00
141_V159_A0.9451.00
313_F328_A0.9441.00
347_L355_I0.9411.00
288_P291_E0.9271.00
111_L166_A0.9261.00
340_V365_E0.9241.00
193_L227_E0.9221.00
256_I260_T0.9221.00
216_V220_Q0.9171.00
193_L228_Q0.9141.00
209_T215_H0.9121.00
132_K138_P0.9111.00
346_A351_E0.9071.00
93_I250_A0.9061.00
102_A232_I0.9041.00
198_L255_I0.9011.00
154_E158_N0.8991.00
50_D57_N0.8951.00
230_V255_I0.8931.00
110_I166_A0.8921.00
49_I56_M0.8921.00
105_T263_A0.8891.00
384_R387_R0.8861.00
291_E294_E0.8831.00
253_E257_K0.8801.00
69_L279_I0.8801.00
110_I198_L0.8751.00
123_Y170_N0.8731.00
347_L385_I0.8711.00
99_A234_G0.8701.00
129_E132_K0.8681.00
120_P151_I0.8671.00
303_I306_K0.8641.00
153_P188_L0.8641.00
351_E388_F0.8641.00
232_I249_A0.8631.00
118_I159_A0.8601.00
328_A367_V0.8571.00
300_L318_P0.8561.00
346_A349_E0.8541.00
287_E290_E0.8531.00
97_T271_T0.8501.00
299_R374_S0.8491.00
246_I270_P0.8481.00
343_F347_L0.8471.00
298_H302_T0.8431.00
199_I218_I0.8421.00
251_G259_M0.8421.00
94_I259_M0.8401.00
47_H280_A0.8311.00
218_I221_L0.8301.00
154_E157_K0.8291.00
69_L275_Q0.8261.00
127_Y168_V0.8251.00
341_D357_P0.8211.00
70_A73_K0.8201.00
164_T197_I0.8181.00
78_E81_K0.8151.00
288_P292_M0.8151.00
60_H276_Y0.8101.00
79_K207_K0.8071.00
143_G173_S0.8041.00
246_I274_A0.8021.00
153_P184_E0.7991.00
182_E214_K0.7951.00
120_P141_V0.7951.00
43_N49_I0.7931.00
29_G352_K0.7931.00
51_A55_S0.7881.00
301_N304_Y0.7861.00
109_V259_M0.7861.00
92_Q226_K0.7841.00
355_I369_L0.7811.00
343_F367_V0.7811.00
218_I229_T0.7811.00
223_D226_K0.7761.00
100_K126_S0.7701.00
99_A204_I0.7701.00
104_Y134_A0.7681.00
286_S290_E0.7681.00
139_V159_A0.7661.00
101_H267_T0.7641.00
369_L381_A0.7631.00
340_V357_P0.7621.00
189_G199_I0.7611.00
325_F366_N0.7601.00
79_K84_Q0.7591.00
219_A231_I0.7581.00
150_K181_T0.7581.00
52_A273_I0.7571.00
313_F326_P0.7561.00
118_I156_L0.7531.00
298_H301_N0.7511.00
121_T362_G0.7481.00
47_H288_P0.7471.00
373_T377_L0.7461.00
86_I219_A0.7421.00
94_I249_A0.7391.00
55_S58_E0.7381.00
108_Q262_L0.7371.00
173_S176_T0.7321.00
305_A379_E0.7291.00
310_I382_I0.7271.00
207_K238_S0.7261.00
238_S289_L0.7221.00
79_K286_S0.7211.00
344_V357_P0.7191.00
77_A88_Y0.7181.00
73_K90_P0.7171.00
303_I371_Y0.7161.00
353_V384_R0.7151.00
79_K239_H0.7091.00
101_H105_T0.7091.00
144_L150_K0.7061.00
272_S276_Y0.7051.00
105_T259_M0.7051.00
209_T212_G0.7031.00
340_V344_V0.7021.00
106_L259_M0.7001.00
211_G297_E0.6951.00
289_L293_R0.6951.00
201_S218_I0.6951.00
139_V164_T0.6941.00
160_I195_H0.6931.00
353_V385_I0.6921.00
118_I167_I0.6891.00
160_I164_T0.6841.00
299_R375_L0.6841.00
297_E300_L0.6831.00
276_Y280_A0.6831.00
193_L223_D0.6821.00
40_P296_F0.6811.00
141_V155_Q0.6801.00
119_I131_V0.6801.00
219_A222_S0.6801.00
300_L317_K0.6791.00
116_E165_K0.6781.00
383_E386_K0.6751.00
376_D379_E0.6701.00
44_T47_H0.6691.00
292_M296_F0.6651.00
216_V221_L0.6621.00
251_G255_I0.6611.00
307_L326_P0.6601.00
31_D377_L0.6581.00
117_V136_G0.6571.00
151_I184_E0.6561.00
75_S282_Y0.6481.00
169_I185_L0.6461.00
326_P366_N0.6461.00
65_P70_A0.6451.00
302_T382_I0.6441.00
180_Y184_E0.6441.00
150_K178_V0.6421.00
139_V161_T0.6421.00
203_E231_I0.6401.00
293_R297_E0.6381.00
120_P173_S0.6381.00
216_V219_A0.6381.00
227_E254_D0.6381.00
55_S277_G0.6371.00
111_L115_D0.6341.00
343_F388_F0.6331.00
84_Q206_E0.6331.00
53_V56_M0.6311.00
206_E233_N0.6301.00
254_D257_K0.6271.00
260_T263_A0.6261.00
257_K260_T0.6251.00
68_G73_K0.6241.00
156_L191_V0.6231.00
96_C249_A0.6231.00
142_E159_A0.6201.00
74_N77_A0.6151.00
104_Y266_S0.6151.00
330_E336_G0.6151.00
44_T48_I0.6141.00
187_A191_V0.6141.00
156_L167_I0.6141.00
35_L378_L0.6121.00
127_Y131_V0.6101.00
146_E150_K0.6081.00
158_N161_T0.6081.00
98_G245_R0.6071.00
303_I378_L0.6051.00
119_I140_Y0.6041.00
104_Y130_Q0.6021.00
180_Y185_L0.6001.00
235_V248_Y0.5981.00
353_V381_A0.5961.00
94_I260_T0.5951.00
161_T194_E0.5921.00
72_L278_A0.5911.00
292_M295_A0.5891.00
347_L388_F0.5871.00
64_T69_L0.5871.00
374_S379_E0.5861.00
171_S203_E0.5861.00
55_S276_Y0.5861.00
52_A55_S0.5851.00
348_L354_A0.5851.00
172_P320_G0.5851.00
235_V282_Y0.5851.00
125_V360_G0.5841.00
178_V319_E0.5831.00
46_Q57_N0.5811.00
277_G280_A0.5791.00
192_C196_D0.5791.00
58_E280_A0.5781.00
336_G339_D0.5781.00
71_E75_S0.5771.00
344_V347_L0.5751.00
179_M209_T0.5751.00
100_K124_W0.5751.00
44_T49_I0.5751.00
275_Q279_I0.5741.00
73_K260_T0.5741.00
45_P48_I0.5731.00
80_F231_I0.5721.00
95_V246_I0.5691.00
208_L296_F0.5691.00
109_V258_A0.5681.00
34_G37_A0.5681.00
185_L218_I0.5671.00
210_Y300_L0.5671.00
315_C324_L0.5661.00
32_V354_A0.5661.00
33_I380_E0.5651.00
203_E206_E0.5631.00
211_G300_L0.5631.00
79_K285_P0.5621.00
167_I192_C0.5611.00
222_S227_E0.5591.00
380_E387_R0.5571.00
107_F134_A0.5541.00
103_L130_Q0.5541.00
94_I251_G0.5511.00
358_G361_F0.5501.00
263_A270_P0.5481.00
142_E152_S0.5471.00
102_A247_G0.5461.00
218_I222_S0.5461.00
168_V200_V0.5451.00
34_G39_E0.5451.00
145_E327_N0.5441.00
108_Q266_S0.5441.00
48_I281_A0.5431.00
302_T378_L0.5431.00
205_Y323_Y0.5411.00
358_G366_N0.5411.00
171_S179_M0.5411.00
107_F166_A0.5401.00
359_S364_P0.5391.00
316_V327_N0.5381.00
29_G32_V0.5381.00
47_H287_E0.5361.00
203_E217_S0.5361.00
119_I128_P0.5351.00
159_A162_E0.5351.00
114_E137_K0.5341.00
105_T262_L0.5321.00
97_T270_P0.5311.00
72_L279_I0.5281.00
309_E379_E0.5271.00
88_Y92_Q0.5271.00
252_S255_I0.5261.00
151_I156_L0.5261.00
64_T272_S0.5241.00
215_H218_I0.5231.00
344_V367_V0.5221.00
140_Y363_S0.5201.00
72_L76_I0.5201.00
344_V348_L0.5191.00
55_S280_A0.5161.00
115_D163_K0.5161.00
217_S221_L0.5151.00
192_C228_Q0.5131.00
149_F366_N0.5121.00
157_K160_I0.5111.00
112_D165_K0.5101.00
107_F130_Q0.5101.00
81_K86_I0.5101.00
51_A277_G0.5081.00
284_G287_E0.5071.00
220_Q223_D0.5071.00
106_L232_I0.5061.00
189_G218_I0.5061.00
310_I313_F0.5051.00
107_F136_G0.5051.00
75_S79_K0.5051.00
141_V151_I0.5051.00
217_S231_I0.5041.00
69_L272_S0.5041.00
48_I241_M0.5041.00
79_K206_E0.5031.00
384_R388_F0.5021.00
146_E184_E0.5011.00
166_A198_L0.5001.00
193_L222_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1j32A 2 0.9873 100 0.27 Contact Map
3dydA 2 0.944 100 0.278 Contact Map
2x5dA 3 0.9542 100 0.281 Contact Map
1b5pA 2 0.9618 100 0.284 Contact Map
1gd9A 2 0.9695 100 0.285 Contact Map
3h14A 2 0.9313 100 0.291 Contact Map
1o4sA 2 0.9593 100 0.293 Contact Map
1xi9A 4 0.9746 100 0.293 Contact Map
1yizA 2 0.9746 100 0.293 Contact Map
2o0rA 2 0.9593 100 0.294 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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