GREMLIN Database
PAND - Aspartate 1-decarboxylase
UniProt: P52999 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 127 (117)
Sequences: 1733 (849)
Seq/√Len: 78.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_M59_I3.4371.00
45_Q56_E3.2781.00
53_A78_L3.0181.00
30_E61_P2.7931.00
34_D64_R2.6301.00
47_V88_I2.5081.00
109_N113_K2.4801.00
30_E64_R2.4371.00
31_D65_G2.3851.00
28_I69_I2.1481.00
26_I46_I2.1001.00
27_T62_G2.0661.00
10_L108_L2.0581.00
43_K56_E2.0451.00
35_A114_I2.0141.00
7_S42_E1.9841.00
48_N79_V1.8641.00
33_I59_I1.8061.00
49_N84_K1.8021.00
31_D64_R1.7361.00
36_V106_A1.7361.00
26_I44_V1.7221.00
77_R80_Q1.7201.00
4_T92_M1.6741.00
2_Y92_M1.6691.00
3_R95_D1.5981.00
67_G113_K1.5841.00
55_L79_V1.5680.99
93_M98_A1.5520.99
50_N77_R1.4870.99
17_E70_C1.4770.99
37_G104_K1.4210.99
4_T43_K1.4140.99
10_L13_A1.3670.99
3_R37_G1.3350.98
7_S91_K1.3250.98
40_P61_P1.2980.98
38_M89_S1.2900.98
69_I87_I1.2810.98
28_I87_I1.2770.98
32_L108_L1.2500.97
13_A108_L1.2330.97
93_M101_H1.2270.97
50_N84_K1.2190.97
47_V90_Y1.2120.97
30_E34_D1.2000.97
33_I38_M1.1910.97
6_M88_I1.1550.96
84_K110_D1.1290.95
13_A85_V1.1200.95
39_L99_A1.1020.95
14_T84_K1.0620.94
45_Q90_Y1.0590.93
31_D34_D1.0330.93
28_I59_I1.0120.92
93_M97_E0.9930.91
39_L98_A0.9910.91
12_R84_K0.9700.90
69_I85_V0.9690.90
6_M41_N0.9680.90
23_V47_V0.9640.90
15_V79_V0.9640.90
27_T70_C0.9520.89
49_N74_A0.9460.89
94_S97_E0.9430.89
5_M39_L0.9420.89
16_T68_V0.9360.88
33_I36_V0.9290.88
23_V107_V0.9210.88
35_A106_A0.9050.87
8_G37_G0.8950.86
5_M93_M0.8830.85
26_I79_V0.8780.85
8_G38_M0.8770.85
3_R98_A0.8750.85
98_A101_H0.8750.85
71_L77_R0.8710.85
48_N53_A0.8690.84
29_D66_S0.8590.84
3_R7_S0.8540.83
28_I33_I0.8540.83
7_S89_S0.8440.83
4_T42_E0.8410.82
33_I61_P0.8290.81
32_L67_G0.8260.81
47_V74_A0.7970.79
74_A90_Y0.7840.78
71_L79_V0.7840.78
26_I85_V0.7620.76
2_Y94_S0.7590.75
21_N84_K0.7560.75
40_P49_N0.7480.74
39_L95_D0.7420.74
15_V85_V0.7370.73
41_N103_P0.7360.73
8_G104_K0.7350.73
50_N83_D0.7320.73
18_A80_Q0.7210.72
8_G89_S0.7190.71
55_L78_L0.7110.71
36_V107_V0.7060.70
78_L81_E0.7020.70
77_R83_D0.6930.69
37_G95_D0.6890.68
31_D35_A0.6860.68
95_D99_A0.6750.67
20_L77_R0.6470.63
31_D67_G0.6450.63
62_G68_V0.6430.63
17_E68_V0.6390.62
7_S37_G0.6370.62
74_A86_I0.6320.62
5_M98_A0.6270.61
12_R21_N0.6270.61
21_N77_R0.6260.61
55_L71_L0.6210.60
96_Q100_S0.6200.60
108_L114_I0.6190.60
13_A69_I0.6140.59
5_M95_D0.6110.59
46_I56_E0.6110.59
36_V117_M0.6100.59
51_N83_D0.6070.58
36_V104_K0.6050.58
55_L75_A0.6040.58
62_G72_N0.6030.58
12_R23_V0.6030.58
41_N88_I0.5990.57
109_N115_E0.5970.57
48_N83_D0.5950.57
91_K101_H0.5950.57
23_V115_E0.5940.57
43_K90_Y0.5900.56
106_A117_M0.5760.55
63_K66_S0.5750.54
46_I79_V0.5700.54
27_T72_N0.5680.54
3_R39_L0.5630.53
18_A70_C0.5610.53
29_D65_G0.5610.53
20_L35_A0.5610.53
21_N50_N0.5600.52
5_M101_H0.5600.52
19_N70_C0.5550.52
7_S101_H0.5540.52
44_V87_I0.5530.52
42_E45_Q0.5490.51
8_G106_A0.5480.51
34_D37_G0.5470.51
3_R91_K0.5470.51
54_R75_A0.5470.51
48_N51_N0.5460.51
41_N101_H0.5450.51
62_G66_S0.5430.50
100_S111_Q0.5430.50
17_E71_L0.5420.50
26_I70_C0.5380.50
51_N90_Y0.5380.50
36_V108_L0.5360.49
3_R42_E0.5330.49
45_Q88_I0.5330.49
42_E89_S0.5290.49
23_V40_P0.5270.48
108_L112_N0.5260.48
10_L28_I0.5260.48
18_A46_I0.5230.48
67_G108_L0.5230.48
107_V116_Q0.5220.48
14_T110_D0.5200.47
14_T67_G0.5190.47
95_D98_A0.5130.46
53_A77_R0.5070.46
74_A88_I0.5030.45
32_L109_N0.5020.45
81_E116_Q0.5000.45
32_L106_A0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pqhA 3 0.9134 100 0.028 Contact Map
2c45A 3 0.8898 100 0.044 Contact Map
3ougA 5 0.8425 100 0.077 Contact Map
3plxB 3 0.7874 100 0.263 Contact Map
1vc3B 3 0.748 100 0.278 Contact Map
1uheA 5 0.7638 100 0.305 Contact Map
3plxA 3 0.189 99 0.79 Contact Map
1vc3A 1 0.189 99 0.79 Contact Map
1uheB 2 0.189 99 0.79 Contact Map
1cz4A 1 0.9134 85.9 0.917 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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