PANC - BACSU - GREMLIN Contacts

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PANC - Pantothenate synthetase

UniProt:	P52998	Sequences: MRQITDISQLKEAIKQYHSEGKSIGFVPTMGFLHEGHLTLADKARQENDAVIMSIFVNPAQFGPNEDFEAYPRDIERDAALAENAGVDILFTPDAHDMYPGEKNVTIHVERRTDVLCGRSREGHFDGVAIVLTKLFNLVKPTRAYFGLKDAQQVAVVDGLISDFFMDIELVPVDTVREEDGLAKSSRNVYLTAEERKEAPKLYRALQTSAELVQAGERDPEAVIKAAKDIIETTSGTIDYVELYSYPELEPVNEIAGKMILAVAVAFSKARLIDNIIIDIREMERI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	286 (276)
Sequences:	3555 (2531)
Seq/√Len:	152.3

ECOLI - PANC
BACSU - PANC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
44_A	51_V	3.549	1.00
180_D	196_R	3.211	1.00
79_A	90_L	2.909	1.00
133_T	166_M	2.838	1.00
154_V	172_P	2.736	1.00
75_I	92_T	2.621	1.00
237_T	266_A	2.488	1.00
43_K	47_E	2.470	1.00
41_A	82_A	2.443	1.00
42_D	85_A	2.409	1.00
39_T	173_V	2.388	1.00
48_N	145_Y	2.378	1.00
108_H	126_D	2.286	1.00
178_E	184_K	2.257	1.00
43_K	46_Q	2.255	1.00
47_E	145_Y	2.223	1.00
200_P	203_Y	2.189	1.00
25_G	48_N	2.184	1.00
245_S	248_E	2.124	1.00
140_K	167_D	2.106	1.00
17_Y	50_A	2.097	1.00
45_R	88_D	2.091	1.00
106_T	126_D	2.091	1.00
4_I	89_I	2.087	1.00
41_A	53_M	2.065	1.00
26_F	54_S	2.010	1.00
48_N	143_R	1.984	1.00
148_L	174_D	1.983	1.00
136_F	168_I	1.961	1.00
143_R	169_E	1.958	1.00
203_Y	207_Q	1.938	1.00
13_A	89_I	1.888	1.00
53_M	87_V	1.884	1.00
35_E	42_D	1.880	1.00
210_A	214_Q	1.868	1.00
74_D	77_R	1.863	1.00
145_Y	173_V	1.852	1.00
195_E	268_S	1.844	1.00
32_F	74_D	1.821	1.00
77_R	81_L	1.812	1.00
5_T	75_I	1.809	1.00
243_L	261_L	1.805	1.00
38_L	81_L	1.803	1.00
22_K	50_A	1.800	1.00
236_G	267_F	1.789	1.00
148_L	277_I	1.739	1.00
137_N	166_M	1.727	1.00
6_D	9_Q	1.722	1.00
56_F	95_A	1.721	1.00
195_E	269_K	1.713	1.00
190_Y	270_A	1.656	1.00
151_A	260_I	1.650	1.00
10_L	14_I	1.649	1.00
192_T	195_E	1.603	1.00
52_I	139_V	1.586	1.00
132_L	157_V	1.552	1.00
209_S	223_V	1.537	1.00
53_M	82_A	1.537	1.00
7_I	138_L	1.524	1.00
133_T	160_L	1.505	1.00
120_S	239_D	1.469	1.00
209_S	261_L	1.468	1.00
23_S	49_D	1.459	1.00
252_V	259_M	1.454	1.00
112_R	156_V	1.448	1.00
7_I	97_D	1.446	1.00
43_K	173_V	1.442	1.00
10_L	138_L	1.435	1.00
3_Q	79_A	1.434	1.00
14_I	18_H	1.421	1.00
208_T	230_I	1.417	1.00
6_D	97_D	1.404	1.00
212_L	226_A	1.401	1.00
2_R	13_A	1.399	1.00
80_A	84_N	1.397	1.00
47_E	143_R	1.397	1.00
198_E	235_S	1.396	1.00
41_A	87_V	1.387	1.00
26_F	139_V	1.387	1.00
4_I	10_L	1.378	1.00
227_A	241_V	1.368	1.00
144_A	170_L	1.364	1.00
228_K	232_E	1.344	1.00
65_N	69_E	1.343	1.00
109_V	129_A	1.337	1.00
25_G	145_Y	1.332	1.00
4_I	13_A	1.324	1.00
13_A	17_Y	1.313	1.00
129_A	156_V	1.308	1.00
107_I	133_T	1.308	1.00
161_I	170_L	1.306	1.00
213_V	278_I	1.293	1.00
38_L	85_A	1.293	1.00
224_I	228_K	1.293	1.00
242_E	251_P	1.291	1.00
117_C	262_A	1.280	1.00
158_D	172_P	1.280	1.00
64_P	190_Y	1.262	1.00
202_L	263_V	1.252	1.00
63_G	123_G	1.250	1.00
11_K	140_K	1.246	1.00
66_E	190_Y	1.237	1.00
136_F	144_A	1.225	1.00
217_E	222_A	1.220	1.00
148_L	154_V	1.214	1.00
148_L	172_P	1.209	1.00
91_F	138_L	1.206	1.00
260_I	277_I	1.191	1.00
180_D	200_P	1.186	1.00
80_A	83_E	1.185	1.00
209_S	241_V	1.181	1.00
133_T	164_F	1.170	1.00
198_E	234_T	1.168	1.00
207_Q	210_A	1.168	1.00
63_G	66_E	1.150	1.00
225_K	229_D	1.148	1.00
134_K	165_F	1.133	1.00
99_Y	131_V	1.129	1.00
105_V	163_D	1.129	1.00
63_G	190_Y	1.126	1.00
113_T	156_V	1.123	1.00
155_A	158_D	1.123	1.00
148_L	260_I	1.122	1.00
143_R	171_V	1.121	1.00
47_E	171_V	1.116	0.99
35_E	184_K	1.107	0.99
101_G	162_S	1.092	0.99
17_Y	22_K	1.088	0.99
28_P	54_S	1.079	0.99
32_F	189_V	1.069	0.99
75_I	79_A	1.068	0.99
205_A	209_S	1.062	0.99
24_I	52_I	1.059	0.99
239_D	266_A	1.059	0.99
117_C	242_E	1.049	0.99
219_D	222_A	1.048	0.99
22_K	49_D	1.047	0.99
42_D	46_Q	1.027	0.99
82_A	87_V	1.027	0.99
7_I	11_K	1.022	0.99
244_Y	262_A	1.011	0.99
94_D	97_D	1.005	0.99
157_V	170_L	1.004	0.99
201_K	204_R	1.001	0.99
25_G	44_A	1.000	0.99
79_A	92_T	0.998	0.99
43_K	145_Y	0.997	0.99
45_R	51_V	0.992	0.99
178_E	196_R	0.988	0.99
18_H	142_T	0.988	0.99
32_F	77_R	0.987	0.99
154_V	170_L	0.985	0.99
200_P	267_F	0.984	0.99
190_Y	269_K	0.981	0.99
204_R	230_I	0.975	0.99
38_L	41_A	0.974	0.99
129_A	160_L	0.971	0.99
264_A	273_I	0.967	0.99
98_M	138_L	0.964	0.98
5_T	92_T	0.957	0.98
236_G	265_V	0.957	0.98
38_L	82_A	0.955	0.98
50_A	88_D	0.952	0.98
39_T	176_V	0.951	0.98
7_I	165_F	0.949	0.98
98_M	134_K	0.948	0.98
109_V	126_D	0.944	0.98
238_I	265_V	0.930	0.98
245_S	257_G	0.929	0.98
54_S	139_V	0.918	0.98
201_K	234_T	0.918	0.98
15_K	142_T	0.914	0.98
138_L	165_F	0.911	0.98
14_I	24_I	0.910	0.98
221_E	225_K	0.905	0.98
15_K	140_K	0.903	0.98
136_F	146_F	0.897	0.98
76_E	80_A	0.887	0.97
33_L	41_A	0.883	0.97
70_A	190_Y	0.880	0.97
195_E	270_A	0.878	0.97
109_V	113_T	0.874	0.97
60_A	103_K	0.874	0.97
148_L	151_A	0.872	0.97
116_L	244_Y	0.872	0.97
7_I	91_F	0.869	0.97
241_V	263_V	0.867	0.97
116_L	262_A	0.860	0.97
229_D	233_T	0.860	0.97
224_I	243_L	0.855	0.97
209_S	227_A	0.852	0.97
230_I	234_T	0.851	0.97
197_K	200_P	0.846	0.97
210_A	276_I	0.846	0.97
224_I	241_V	0.845	0.97
198_E	267_F	0.842	0.96
201_K	205_A	0.840	0.96
212_L	216_G	0.837	0.96
70_A	269_K	0.837	0.96
246_Y	260_I	0.836	0.96
25_G	47_E	0.836	0.96
224_I	242_E	0.834	0.96
4_I	138_L	0.821	0.96
3_Q	75_I	0.817	0.96
2_R	9_Q	0.814	0.96
60_A	130_I	0.810	0.96
161_I	168_I	0.808	0.96
79_A	83_E	0.807	0.95
208_T	211_E	0.806	0.95
232_E	238_I	0.804	0.95
14_I	52_I	0.800	0.95
55_I	90_L	0.797	0.95
194_E	197_K	0.789	0.95
10_L	139_V	0.787	0.95
226_A	229_D	0.787	0.95
77_R	80_A	0.785	0.95
77_R	189_V	0.785	0.95
17_Y	89_I	0.778	0.95
151_A	244_Y	0.776	0.94
212_L	217_E	0.774	0.94
16_Q	20_E	0.773	0.94
228_K	238_I	0.773	0.94
115_V	244_Y	0.772	0.94
33_L	55_I	0.772	0.94
57_V	73_R	0.772	0.94
15_K	167_D	0.766	0.94
159_G	162_S	0.761	0.94
50_A	89_I	0.761	0.94
112_R	115_V	0.760	0.94
43_K	171_V	0.760	0.94
247_P	258_K	0.757	0.94
115_V	250_E	0.757	0.94
39_T	42_D	0.754	0.94
39_T	43_K	0.752	0.93
211_E	215_A	0.747	0.93
65_N	190_Y	0.744	0.93
111_R	250_E	0.742	0.93
25_G	143_R	0.738	0.93
14_I	89_I	0.738	0.93
123_G	126_D	0.737	0.93
91_F	97_D	0.735	0.93
5_T	94_D	0.733	0.93
112_R	159_G	0.731	0.92
114_D	123_G	0.730	0.92
107_I	130_I	0.729	0.92
133_T	137_N	0.728	0.92
198_E	201_K	0.727	0.92
224_I	227_A	0.727	0.92
132_L	160_L	0.725	0.92
14_I	142_T	0.723	0.92
208_T	212_L	0.718	0.92
203_Y	276_I	0.717	0.92
23_S	48_N	0.710	0.91
23_S	143_R	0.709	0.91
151_A	249_L	0.709	0.91
145_Y	171_V	0.703	0.91
231_I	238_I	0.700	0.91
261_L	278_I	0.697	0.91
63_G	124_H	0.694	0.90
41_A	51_V	0.693	0.90
110_E	113_T	0.693	0.90
8_S	97_D	0.692	0.90
201_K	230_I	0.692	0.90
176_V	184_K	0.689	0.90
26_F	135_L	0.684	0.90
241_V	261_L	0.682	0.90
105_V	164_F	0.681	0.90
213_V	259_M	0.681	0.90
38_L	84_N	0.679	0.89
205_A	230_I	0.678	0.89
206_L	276_I	0.678	0.89
178_E	200_P	0.677	0.89
14_I	50_A	0.675	0.89
82_A	86_G	0.675	0.89
38_L	55_I	0.674	0.89
116_L	242_E	0.673	0.89
244_Y	249_L	0.671	0.89
205_A	208_T	0.670	0.89
151_A	277_I	0.668	0.89
159_G	163_D	0.666	0.89
82_A	90_L	0.664	0.88
4_I	9_Q	0.663	0.88
119_R	123_G	0.663	0.88
243_L	259_M	0.661	0.88
113_T	129_A	0.660	0.88
246_Y	277_I	0.656	0.88
3_Q	90_L	0.655	0.88
137_N	140_K	0.653	0.88
117_C	240_Y	0.653	0.88
14_I	17_Y	0.651	0.87
205_A	231_I	0.651	0.87
59_P	95_A	0.650	0.87
64_P	270_A	0.648	0.87
220_P	243_L	0.646	0.87
11_K	14_I	0.644	0.87
192_T	270_A	0.643	0.87
194_E	198_E	0.636	0.86
118_G	123_G	0.633	0.86
213_V	223_V	0.633	0.86
35_E	38_L	0.633	0.86
52_I	89_I	0.632	0.86
161_I	166_M	0.632	0.86
136_F	170_L	0.629	0.86
227_A	263_V	0.629	0.86
227_A	261_L	0.628	0.85
128_V	136_F	0.625	0.85
151_A	155_A	0.623	0.85
38_L	42_D	0.622	0.85
108_H	114_D	0.622	0.85
151_A	246_Y	0.619	0.85
126_D	130_I	0.617	0.84
64_P	68_F	0.616	0.84
66_E	69_E	0.616	0.84
155_A	249_L	0.616	0.84
5_T	9_Q	0.615	0.84
262_A	277_I	0.613	0.84
23_S	142_T	0.613	0.84
28_P	136_F	0.611	0.84
112_R	249_L	0.611	0.84
60_A	124_H	0.610	0.84
104_N	111_R	0.609	0.84
53_M	90_L	0.607	0.84
44_A	145_Y	0.607	0.84
201_K	236_G	0.606	0.83
160_L	166_M	0.605	0.83
4_I	14_I	0.605	0.83
104_N	159_G	0.605	0.83
105_V	159_G	0.604	0.83
115_V	251_P	0.604	0.83
172_P	175_T	0.603	0.83
18_H	140_K	0.600	0.83
63_G	117_C	0.598	0.83
205_A	227_A	0.595	0.82
81_L	85_A	0.594	0.82
74_D	189_V	0.592	0.82
192_T	268_S	0.591	0.82
129_A	133_T	0.584	0.81
246_Y	259_M	0.582	0.81
264_A	271_R	0.582	0.81
238_I	241_V	0.582	0.81
198_E	236_G	0.581	0.81
13_A	16_Q	0.580	0.81
18_H	21_G	0.579	0.81
220_P	224_I	0.579	0.81
245_S	256_A	0.579	0.81
271_R	275_N	0.577	0.80
103_K	106_T	0.577	0.80
208_T	226_A	0.577	0.80
26_F	90_L	0.571	0.80
13_A	50_A	0.570	0.80
162_S	247_P	0.570	0.80
115_V	262_A	0.570	0.80
255_I	259_M	0.570	0.80
70_A	270_A	0.569	0.79
107_I	129_A	0.569	0.79
178_E	203_Y	0.564	0.79
146_F	170_L	0.563	0.79
45_R	85_A	0.563	0.79
117_C	120_S	0.563	0.79
200_P	204_R	0.560	0.78
180_D	189_V	0.559	0.78
132_L	146_F	0.556	0.78
132_L	135_L	0.555	0.78
212_L	215_A	0.555	0.78
23_S	169_E	0.554	0.78
242_E	262_A	0.554	0.78
207_Q	211_E	0.552	0.77
151_A	262_A	0.552	0.77
115_V	118_G	0.550	0.77
25_G	49_D	0.549	0.77
245_S	259_M	0.549	0.77
112_R	118_G	0.547	0.77
207_Q	276_I	0.547	0.77
211_E	214_Q	0.546	0.77
225_K	228_K	0.545	0.76
266_A	269_K	0.544	0.76
16_Q	19_S	0.543	0.76
112_R	155_A	0.543	0.76
10_L	52_I	0.542	0.76
134_K	137_N	0.542	0.76
116_L	249_L	0.541	0.76
100_P	103_K	0.540	0.76
219_D	254_E	0.540	0.76
131_V	134_K	0.540	0.76
94_D	98_M	0.538	0.76
230_I	233_T	0.537	0.75
42_D	45_R	0.536	0.75
244_Y	260_I	0.536	0.75
116_L	241_V	0.530	0.74
82_A	85_A	0.529	0.74
28_P	135_L	0.529	0.74
91_F	134_K	0.527	0.74
128_V	156_V	0.527	0.74
141_P	168_I	0.527	0.74
144_A	161_I	0.525	0.74
2_R	16_Q	0.525	0.74
3_Q	92_T	0.522	0.73
124_H	128_V	0.518	0.73
240_Y	271_R	0.517	0.73
132_L	136_F	0.516	0.73
229_D	232_E	0.516	0.73
161_I	167_D	0.515	0.72
180_D	197_K	0.514	0.72
8_S	12_E	0.512	0.72
135_L	139_V	0.512	0.72
235_S	265_V	0.510	0.72
9_Q	12_E	0.509	0.72
222_A	225_K	0.507	0.71
132_L	144_A	0.506	0.71
231_I	267_F	0.505	0.71
107_I	126_D	0.504	0.71
11_K	167_D	0.502	0.70
178_E	182_L	0.501	0.70
24_I	50_A	0.500	0.70

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1v8fA	4	0.958	100	0.025	Contact Map
3mxtA	2	0.9825	100	0.068	Contact Map
3innA	4	0.9825	100	0.068	Contact Map
3q12A	2	0.986	100	0.109	Contact Map
2ejcA	2	0.9755	100	0.196	Contact Map
3ag6A	2	0.9825	100	0.199	Contact Map
3uk2A	2	0.958	100	0.205	Contact Map
3covA	2	0.965	100	0.243	Contact Map
3n8hA	2	0.9091	100	0.248	Contact Map
2x0kA	5	0.8531	99.5	0.862	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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