GREMLIN Database
PANC - Pantothenate synthetase
UniProt: P52998 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 286 (276)
Sequences: 3555 (2531)
Seq/√Len: 152.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_A51_V3.5491.00
180_D196_R3.2111.00
79_A90_L2.9091.00
133_T166_M2.8381.00
154_V172_P2.7361.00
75_I92_T2.6211.00
237_T266_A2.4881.00
43_K47_E2.4701.00
41_A82_A2.4431.00
42_D85_A2.4091.00
39_T173_V2.3881.00
48_N145_Y2.3781.00
108_H126_D2.2861.00
178_E184_K2.2571.00
43_K46_Q2.2551.00
47_E145_Y2.2231.00
200_P203_Y2.1891.00
25_G48_N2.1841.00
245_S248_E2.1241.00
140_K167_D2.1061.00
17_Y50_A2.0971.00
45_R88_D2.0911.00
106_T126_D2.0911.00
4_I89_I2.0871.00
41_A53_M2.0651.00
26_F54_S2.0101.00
48_N143_R1.9841.00
148_L174_D1.9831.00
136_F168_I1.9611.00
143_R169_E1.9581.00
203_Y207_Q1.9381.00
13_A89_I1.8881.00
53_M87_V1.8841.00
35_E42_D1.8801.00
210_A214_Q1.8681.00
74_D77_R1.8631.00
145_Y173_V1.8521.00
195_E268_S1.8441.00
32_F74_D1.8211.00
77_R81_L1.8121.00
5_T75_I1.8091.00
243_L261_L1.8051.00
38_L81_L1.8031.00
22_K50_A1.8001.00
236_G267_F1.7891.00
148_L277_I1.7391.00
137_N166_M1.7271.00
6_D9_Q1.7221.00
56_F95_A1.7211.00
195_E269_K1.7131.00
190_Y270_A1.6561.00
151_A260_I1.6501.00
10_L14_I1.6491.00
192_T195_E1.6031.00
52_I139_V1.5861.00
132_L157_V1.5521.00
209_S223_V1.5371.00
53_M82_A1.5371.00
7_I138_L1.5241.00
133_T160_L1.5051.00
120_S239_D1.4691.00
209_S261_L1.4681.00
23_S49_D1.4591.00
252_V259_M1.4541.00
112_R156_V1.4481.00
7_I97_D1.4461.00
43_K173_V1.4421.00
10_L138_L1.4351.00
3_Q79_A1.4341.00
14_I18_H1.4211.00
208_T230_I1.4171.00
6_D97_D1.4041.00
212_L226_A1.4011.00
2_R13_A1.3991.00
80_A84_N1.3971.00
47_E143_R1.3971.00
198_E235_S1.3961.00
41_A87_V1.3871.00
26_F139_V1.3871.00
4_I10_L1.3781.00
227_A241_V1.3681.00
144_A170_L1.3641.00
228_K232_E1.3441.00
65_N69_E1.3431.00
109_V129_A1.3371.00
25_G145_Y1.3321.00
4_I13_A1.3241.00
13_A17_Y1.3131.00
129_A156_V1.3081.00
107_I133_T1.3081.00
161_I170_L1.3061.00
213_V278_I1.2931.00
38_L85_A1.2931.00
224_I228_K1.2931.00
242_E251_P1.2911.00
117_C262_A1.2801.00
158_D172_P1.2801.00
64_P190_Y1.2621.00
202_L263_V1.2521.00
63_G123_G1.2501.00
11_K140_K1.2461.00
66_E190_Y1.2371.00
136_F144_A1.2251.00
217_E222_A1.2201.00
148_L154_V1.2141.00
148_L172_P1.2091.00
91_F138_L1.2061.00
260_I277_I1.1911.00
180_D200_P1.1861.00
80_A83_E1.1851.00
209_S241_V1.1811.00
133_T164_F1.1701.00
198_E234_T1.1681.00
207_Q210_A1.1681.00
63_G66_E1.1501.00
225_K229_D1.1481.00
134_K165_F1.1331.00
99_Y131_V1.1291.00
105_V163_D1.1291.00
63_G190_Y1.1261.00
113_T156_V1.1231.00
155_A158_D1.1231.00
148_L260_I1.1221.00
143_R171_V1.1211.00
47_E171_V1.1160.99
35_E184_K1.1070.99
101_G162_S1.0920.99
17_Y22_K1.0880.99
28_P54_S1.0790.99
32_F189_V1.0690.99
75_I79_A1.0680.99
205_A209_S1.0620.99
24_I52_I1.0590.99
239_D266_A1.0590.99
117_C242_E1.0490.99
219_D222_A1.0480.99
22_K49_D1.0470.99
42_D46_Q1.0270.99
82_A87_V1.0270.99
7_I11_K1.0220.99
244_Y262_A1.0110.99
94_D97_D1.0050.99
157_V170_L1.0040.99
201_K204_R1.0010.99
25_G44_A1.0000.99
79_A92_T0.9980.99
43_K145_Y0.9970.99
45_R51_V0.9920.99
178_E196_R0.9880.99
18_H142_T0.9880.99
32_F77_R0.9870.99
154_V170_L0.9850.99
200_P267_F0.9840.99
190_Y269_K0.9810.99
204_R230_I0.9750.99
38_L41_A0.9740.99
129_A160_L0.9710.99
264_A273_I0.9670.99
98_M138_L0.9640.98
5_T92_T0.9570.98
236_G265_V0.9570.98
38_L82_A0.9550.98
50_A88_D0.9520.98
39_T176_V0.9510.98
7_I165_F0.9490.98
98_M134_K0.9480.98
109_V126_D0.9440.98
238_I265_V0.9300.98
245_S257_G0.9290.98
54_S139_V0.9180.98
201_K234_T0.9180.98
15_K142_T0.9140.98
138_L165_F0.9110.98
14_I24_I0.9100.98
221_E225_K0.9050.98
15_K140_K0.9030.98
136_F146_F0.8970.98
76_E80_A0.8870.97
33_L41_A0.8830.97
70_A190_Y0.8800.97
195_E270_A0.8780.97
109_V113_T0.8740.97
60_A103_K0.8740.97
148_L151_A0.8720.97
116_L244_Y0.8720.97
7_I91_F0.8690.97
241_V263_V0.8670.97
116_L262_A0.8600.97
229_D233_T0.8600.97
224_I243_L0.8550.97
209_S227_A0.8520.97
230_I234_T0.8510.97
197_K200_P0.8460.97
210_A276_I0.8460.97
224_I241_V0.8450.97
198_E267_F0.8420.96
201_K205_A0.8400.96
212_L216_G0.8370.96
70_A269_K0.8370.96
246_Y260_I0.8360.96
25_G47_E0.8360.96
224_I242_E0.8340.96
4_I138_L0.8210.96
3_Q75_I0.8170.96
2_R9_Q0.8140.96
60_A130_I0.8100.96
161_I168_I0.8080.96
79_A83_E0.8070.95
208_T211_E0.8060.95
232_E238_I0.8040.95
14_I52_I0.8000.95
55_I90_L0.7970.95
194_E197_K0.7890.95
10_L139_V0.7870.95
226_A229_D0.7870.95
77_R80_A0.7850.95
77_R189_V0.7850.95
17_Y89_I0.7780.95
151_A244_Y0.7760.94
212_L217_E0.7740.94
16_Q20_E0.7730.94
228_K238_I0.7730.94
115_V244_Y0.7720.94
33_L55_I0.7720.94
57_V73_R0.7720.94
15_K167_D0.7660.94
159_G162_S0.7610.94
50_A89_I0.7610.94
112_R115_V0.7600.94
43_K171_V0.7600.94
247_P258_K0.7570.94
115_V250_E0.7570.94
39_T42_D0.7540.94
39_T43_K0.7520.93
211_E215_A0.7470.93
65_N190_Y0.7440.93
111_R250_E0.7420.93
25_G143_R0.7380.93
14_I89_I0.7380.93
123_G126_D0.7370.93
91_F97_D0.7350.93
5_T94_D0.7330.93
112_R159_G0.7310.92
114_D123_G0.7300.92
107_I130_I0.7290.92
133_T137_N0.7280.92
198_E201_K0.7270.92
224_I227_A0.7270.92
132_L160_L0.7250.92
14_I142_T0.7230.92
208_T212_L0.7180.92
203_Y276_I0.7170.92
23_S48_N0.7100.91
23_S143_R0.7090.91
151_A249_L0.7090.91
145_Y171_V0.7030.91
231_I238_I0.7000.91
261_L278_I0.6970.91
63_G124_H0.6940.90
41_A51_V0.6930.90
110_E113_T0.6930.90
8_S97_D0.6920.90
201_K230_I0.6920.90
176_V184_K0.6890.90
26_F135_L0.6840.90
241_V261_L0.6820.90
105_V164_F0.6810.90
213_V259_M0.6810.90
38_L84_N0.6790.89
205_A230_I0.6780.89
206_L276_I0.6780.89
178_E200_P0.6770.89
14_I50_A0.6750.89
82_A86_G0.6750.89
38_L55_I0.6740.89
116_L242_E0.6730.89
244_Y249_L0.6710.89
205_A208_T0.6700.89
151_A277_I0.6680.89
159_G163_D0.6660.89
82_A90_L0.6640.88
4_I9_Q0.6630.88
119_R123_G0.6630.88
243_L259_M0.6610.88
113_T129_A0.6600.88
246_Y277_I0.6560.88
3_Q90_L0.6550.88
137_N140_K0.6530.88
117_C240_Y0.6530.88
14_I17_Y0.6510.87
205_A231_I0.6510.87
59_P95_A0.6500.87
64_P270_A0.6480.87
220_P243_L0.6460.87
11_K14_I0.6440.87
192_T270_A0.6430.87
194_E198_E0.6360.86
118_G123_G0.6330.86
213_V223_V0.6330.86
35_E38_L0.6330.86
52_I89_I0.6320.86
161_I166_M0.6320.86
136_F170_L0.6290.86
227_A263_V0.6290.86
227_A261_L0.6280.85
128_V136_F0.6250.85
151_A155_A0.6230.85
38_L42_D0.6220.85
108_H114_D0.6220.85
151_A246_Y0.6190.85
126_D130_I0.6170.84
64_P68_F0.6160.84
66_E69_E0.6160.84
155_A249_L0.6160.84
5_T9_Q0.6150.84
262_A277_I0.6130.84
23_S142_T0.6130.84
28_P136_F0.6110.84
112_R249_L0.6110.84
60_A124_H0.6100.84
104_N111_R0.6090.84
53_M90_L0.6070.84
44_A145_Y0.6070.84
201_K236_G0.6060.83
160_L166_M0.6050.83
4_I14_I0.6050.83
104_N159_G0.6050.83
105_V159_G0.6040.83
115_V251_P0.6040.83
172_P175_T0.6030.83
18_H140_K0.6000.83
63_G117_C0.5980.83
205_A227_A0.5950.82
81_L85_A0.5940.82
74_D189_V0.5920.82
192_T268_S0.5910.82
129_A133_T0.5840.81
246_Y259_M0.5820.81
264_A271_R0.5820.81
238_I241_V0.5820.81
198_E236_G0.5810.81
13_A16_Q0.5800.81
18_H21_G0.5790.81
220_P224_I0.5790.81
245_S256_A0.5790.81
271_R275_N0.5770.80
103_K106_T0.5770.80
208_T226_A0.5770.80
26_F90_L0.5710.80
13_A50_A0.5700.80
162_S247_P0.5700.80
115_V262_A0.5700.80
255_I259_M0.5700.80
70_A270_A0.5690.79
107_I129_A0.5690.79
178_E203_Y0.5640.79
146_F170_L0.5630.79
45_R85_A0.5630.79
117_C120_S0.5630.79
200_P204_R0.5600.78
180_D189_V0.5590.78
132_L146_F0.5560.78
132_L135_L0.5550.78
212_L215_A0.5550.78
23_S169_E0.5540.78
242_E262_A0.5540.78
207_Q211_E0.5520.77
151_A262_A0.5520.77
115_V118_G0.5500.77
25_G49_D0.5490.77
245_S259_M0.5490.77
112_R118_G0.5470.77
207_Q276_I0.5470.77
211_E214_Q0.5460.77
225_K228_K0.5450.76
266_A269_K0.5440.76
16_Q19_S0.5430.76
112_R155_A0.5430.76
10_L52_I0.5420.76
134_K137_N0.5420.76
116_L249_L0.5410.76
100_P103_K0.5400.76
219_D254_E0.5400.76
131_V134_K0.5400.76
94_D98_M0.5380.76
230_I233_T0.5370.75
42_D45_R0.5360.75
244_Y260_I0.5360.75
116_L241_V0.5300.74
82_A85_A0.5290.74
28_P135_L0.5290.74
91_F134_K0.5270.74
128_V156_V0.5270.74
141_P168_I0.5270.74
144_A161_I0.5250.74
2_R16_Q0.5250.74
3_Q92_T0.5220.73
124_H128_V0.5180.73
240_Y271_R0.5170.73
132_L136_F0.5160.73
229_D232_E0.5160.73
161_I167_D0.5150.72
180_D197_K0.5140.72
8_S12_E0.5120.72
135_L139_V0.5120.72
235_S265_V0.5100.72
9_Q12_E0.5090.72
222_A225_K0.5070.71
132_L144_A0.5060.71
231_I267_F0.5050.71
107_I126_D0.5040.71
11_K167_D0.5020.70
178_E182_L0.5010.70
24_I50_A0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1v8fA 4 0.958 100 0.025 Contact Map
3mxtA 2 0.9825 100 0.068 Contact Map
3innA 4 0.9825 100 0.068 Contact Map
3q12A 2 0.986 100 0.109 Contact Map
2ejcA 2 0.9755 100 0.196 Contact Map
3ag6A 2 0.9825 100 0.199 Contact Map
3uk2A 2 0.958 100 0.205 Contact Map
3covA 2 0.965 100 0.243 Contact Map
3n8hA 2 0.9091 100 0.248 Contact Map
2x0kA 5 0.8531 99.5 0.862 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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