GREMLIN Database
BSAA - Glutathione peroxidase homolog BsaA
UniProt: P52035 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 160 (155)
Sequences: 4239 (2757)
Seq/√Len: 221.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_Q49_D3.1421.00
50_T151_E3.0541.00
132_D136_E2.8521.00
74_E93_S2.8301.00
151_E155_V2.5151.00
10_T14_K2.4761.00
43_Q148_K2.3551.00
95_V103_H2.3351.00
96_D101_N2.2571.00
141_Y153_D2.1981.00
24_K57_E2.1251.00
59_L92_F2.0791.00
19_Q22_A2.0531.00
16_M21_F2.0481.00
102_A107_V1.9441.00
138_V157_L1.9071.00
98_N110_T1.8841.00
9_R15_D1.8841.00
7_K15_D1.8831.00
61_F92_F1.8691.00
3_I26_L1.8091.00
65_Q96_D1.8021.00
12_T78_Q1.7471.00
25_V133_R1.7371.00
11_I91_M1.7091.00
48_Y52_Q1.6331.00
45_Q88_T1.6251.00
102_A110_T1.6231.00
16_M20_P1.6111.00
9_R93_S1.5901.00
6_M108_Y1.5841.00
11_I74_E1.5831.00
139_G153_D1.5591.00
7_K17_T1.5541.00
37_F143_P1.5381.00
64_N71_P1.5341.00
73_E76_D1.5341.00
42_K82_E1.5241.00
54_E155_V1.5091.00
27_M130_I1.4991.00
46_E50_T1.4941.00
10_T16_M1.4871.00
41_L70_E1.4741.00
132_D157_L1.4411.00
46_E148_K1.4401.00
48_Y57_E1.4281.00
25_V157_L1.4231.00
113_A137_I1.4061.00
64_N68_N1.4041.00
27_M150_L1.3821.00
127_T140_R1.3781.00
17_T20_P1.3451.00
42_K46_E1.3381.00
132_D138_V1.3321.00
4_Y22_A1.2881.00
43_Q146_N1.2701.00
16_M92_F1.2681.00
60_G91_M1.2671.00
3_I6_M1.2561.00
8_V103_H1.2501.00
49_D88_T1.2471.00
61_F95_V1.2431.00
6_M105_L1.2051.00
79_E83_T1.1921.00
122_I129_F1.1671.00
72_G76_D1.1651.00
52_Q57_E1.1411.00
78_Q82_E1.1331.00
60_G87_V1.1011.00
8_V61_F1.0721.00
11_I78_Q1.0711.00
130_I153_D1.0541.00
3_I18_L1.0481.00
71_P94_K1.0461.00
123_K127_T1.0451.00
153_D156_K1.0361.00
51_Y151_E1.0361.00
31_T41_L1.0331.00
8_V92_F1.0331.00
60_G70_E1.0271.00
38_T80_F1.0161.00
152_D155_V1.0001.00
26_L57_E0.9981.00
33_S70_E0.9971.00
38_T41_L0.9881.00
122_I127_T0.9861.00
115_G142_S0.9771.00
112_H137_I0.9761.00
57_E90_P0.9601.00
3_I28_I0.9581.00
18_L105_L0.9571.00
98_N102_A0.9431.00
63_C96_D0.9411.00
27_M56_L0.9411.00
21_F92_F0.9401.00
114_K120_K0.9381.00
37_F144_N0.9371.00
102_A121_A0.9301.00
43_Q46_E0.9271.00
95_V106_F0.9250.99
145_T149_E0.9100.99
34_K67_M0.9080.99
51_Y155_V0.8960.99
111_E120_K0.8940.99
77_I94_K0.8810.99
29_V44_L0.8800.99
127_T142_S0.8770.99
33_S91_M0.8730.99
70_E91_M0.8590.99
129_F140_R0.8590.99
8_V105_L0.8400.99
127_T143_P0.8250.99
3_I105_L0.8090.99
36_G69_Q0.8020.99
28_I131_V0.8010.99
47_L154_I0.7880.98
40_Q81_C0.7820.98
33_S80_F0.7780.98
34_K84_N0.7700.98
51_Y54_E0.7660.98
65_Q98_N0.7650.98
11_I93_S0.7620.98
142_S145_T0.7600.98
139_G150_L0.7570.98
115_G118_G0.7500.98
108_Y111_E0.7480.98
34_K71_P0.7470.98
48_Y58_I0.7430.98
153_D157_L0.7420.98
33_S60_G0.7350.97
25_V56_L0.7230.97
98_N121_A0.7140.97
80_F85_Y0.7130.97
48_Y90_P0.7100.97
141_Y150_L0.7030.97
41_L77_I0.7020.97
55_G158_L0.7020.97
74_E77_I0.6990.97
49_D86_G0.6950.96
23_G134_N0.6920.96
110_T122_I0.6910.96
70_E77_I0.6890.96
48_Y56_L0.6890.96
39_S85_Y0.6890.96
64_N72_G0.6830.96
51_Y55_G0.6810.96
6_M103_H0.6800.96
21_F26_L0.6800.96
49_D52_Q0.6760.96
112_H136_E0.6630.95
55_G133_R0.6580.95
72_G77_I0.6570.95
45_Q87_V0.6520.95
65_Q101_N0.6480.95
116_M142_S0.6410.94
76_D79_E0.6410.94
77_I80_F0.6390.94
24_K56_L0.6390.94
37_F123_K0.6370.94
37_F127_T0.6370.94
116_M120_K0.6340.94
108_Y112_H0.6330.94
28_I105_L0.6310.94
147_P150_L0.6290.94
118_G121_A0.6250.94
28_I59_L0.6200.93
78_Q83_T0.6170.93
61_F103_H0.6150.93
3_I108_Y0.6150.93
23_G135_G0.6150.93
130_I141_Y0.6120.93
60_G89_F0.6070.93
150_L153_D0.6050.93
11_I77_I0.6040.93
41_L72_G0.6020.92
148_K151_E0.6000.92
8_V18_L0.5980.92
4_Y133_R0.5960.92
50_T155_V0.5950.92
82_E86_G0.5920.92
64_N94_K0.5900.92
43_Q150_L0.5850.91
21_F90_P0.5850.91
31_T127_T0.5830.91
11_I60_G0.5820.91
59_L90_P0.5820.91
93_S103_H0.5800.91
52_Q88_T0.5790.91
20_P90_P0.5730.90
82_E85_Y0.5730.90
150_L154_I0.5720.90
4_Y108_Y0.5700.90
32_A35_C0.5680.90
123_K144_N0.5670.90
45_Q89_F0.5670.90
122_I140_R0.5660.90
45_Q81_C0.5660.90
132_D137_I0.5630.90
114_K117_L0.5620.90
41_L80_F0.5600.89
52_Q55_G0.5570.89
61_F105_L0.5550.89
81_C87_V0.5540.89
31_T70_E0.5520.89
40_Q43_Q0.5500.89
133_R157_L0.5480.88
71_P77_I0.5480.88
31_T106_F0.5440.88
21_F59_L0.5440.88
69_Q124_W0.5440.88
39_S42_K0.5430.88
29_V106_F0.5420.88
39_S146_N0.5400.88
65_Q97_V0.5390.88
31_T60_G0.5370.87
41_L126_F0.5340.87
75_A79_E0.5290.87
37_F67_M0.5290.87
46_E49_D0.5280.87
40_Q45_Q0.5240.86
154_I158_L0.5230.86
48_Y55_G0.5170.85
37_F98_N0.5160.85
107_V111_E0.5120.85
103_H107_V0.5110.85
81_C84_N0.5100.85
70_E87_V0.5090.85
146_N149_E0.5080.84
8_V11_I0.5060.84
48_Y88_T0.5040.84
123_K143_P0.5000.84
78_Q91_M0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2p5qA 3 0.9938 100 0.586 Contact Map
2i3yA 3 1 99.9 0.602 Contact Map
2r37A 3 1 99.9 0.604 Contact Map
2f8aA 3 0.9938 99.9 0.608 Contact Map
3dwvA 1 0.9875 99.9 0.615 Contact Map
2vupA 1 1 99.9 0.618 Contact Map
2p31A 1 0.9625 99.9 0.624 Contact Map
3cmiA 1 0.8875 99.9 0.631 Contact Map
3kijA 1 0.9688 99.9 0.632 Contact Map
2v1mA 1 0.9938 99.9 0.636 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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