FTSY - BACSU - GREMLIN Contacts

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FTSY - Signal recognition particle receptor FtsY

UniProt:	P51835	Sequences: MSFFKKLKEKITKQTDSVSEKFKDGLEKTRNSFQNKVNDLVSRYRKVDEDFFEELEEVLISADVGFTTVMELIDELKKEVKRRNIQDPKEVQSVISEKLVEIYNSGDEQISELNIQDGRLNVILLVGVNGVGKTTTIGKLAHKMKQEGKSVVLAAGDTFRAGAIEQLEVWGERTGVPVIKQTAGSDPAAVIYDAVHAAKARNADVLICDTAGRLQNKVNLMKELEKVKRVIEREVPEAPHEVLLALDATTGQNAMAQAKEFSKATNVTGIALTKLDGTAKGGIVLAIRNELHIPVKLVGLGEKVDDLQEFDPESYVYGLFSDLVEKADD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	329 (291)
Sequences:	6923 (3494)
Seq/√Len:	204.8

ECOLI - FTSY SRP54
BACSU - FTSY FLHF SRP54
HALSA - Q9HMN3 SRP54
SULSO - Q980G1 SRP54

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
171_G	178_V	5.798	1.00
197_A	201_R	3.858	1.00
71_E	289_N	3.291	1.00
125_L	137_I	3.062	1.00
152_V	203_A	3.004	1.00
154_A	194_A	2.954	1.00
259_K	263_K	2.927	1.00
144_M	205_V	2.921	1.00
222_K	225_E	2.863	1.00
96_S	317_Y	2.691	1.00
150_S	203_A	2.659	1.00
168_E	180_K	2.652	1.00
98_K	101_E	2.559	1.00
225_E	264_A	2.558	1.00
75_E	98_K	2.508	1.00
49_E	77_K	2.350	1.00
153_L	171_G	2.339	1.00
168_E	172_E	2.338	1.00
196_H	200_A	2.294	1.00
165_E	168_E	2.292	1.00
191_I	208_C	2.291	1.00
142_H	146_Q	2.247	1.00
143_K	147_E	2.168	1.00
181_Q	193_D	2.166	1.00
241_E	296_K	2.154	1.00
243_L	271_A	2.135	1.00
137_I	207_I	2.073	1.00
301_G	306_D	2.067	1.00
260_E	263_K	2.043	1.00
174_T	304_V	2.029	1.00
259_K	290_E	2.021	1.00
262_S	293_I	1.983	1.00
311_D	314_S	1.928	1.00
145_K	175_G	1.912	1.00
154_A	206_L	1.863	1.00
136_T	271_A	1.832	1.00
143_K	297_L	1.775	1.00
215_Q	253_N	1.775	1.00
177_P	203_A	1.753	1.00
228_K	266_N	1.745	1.00
156_G	191_I	1.742	1.00
258_A	291_L	1.726	1.00
79_E	98_K	1.711	1.00
87_D	90_E	1.695	1.00
218_V	222_K	1.685	1.00
243_L	269_G	1.673	1.00
125_L	207_I	1.668	1.00
222_K	226_K	1.658	1.00
138_G	170_W	1.630	1.00
169_V	172_E	1.624	1.00
141_A	153_L	1.614	1.00
241_E	268_T	1.600	1.00
267_V	293_I	1.562	1.00
186_D	226_K	1.544	1.00
153_L	167_L	1.539	1.00
145_K	176_V	1.526	1.00
30_R	33_F	1.521	1.00
125_L	140_L	1.520	1.00
143_K	309_E	1.519	1.00
79_E	97_E	1.518	1.00
100_V	313_E	1.516	1.00
141_A	176_V	1.507	1.00
272_L	284_V	1.498	1.00
196_H	199_K	1.491	1.00
308_Q	314_S	1.486	1.00
152_V	177_P	1.481	1.00
168_E	178_V	1.477	1.00
197_A	200_A	1.456	1.00
179_I	197_A	1.451	1.00
71_E	75_E	1.443	1.00
262_S	267_V	1.418	1.00
64_V	285_L	1.401	1.00
138_G	174_T	1.398	1.00
142_H	305_D	1.394	1.00
189_A	193_D	1.392	1.00
75_E	101_E	1.391	1.00
188_A	230_V	1.375	1.00
149_K	204_D	1.362	1.00
248_A	272_L	1.360	1.00
137_I	153_L	1.356	1.00
243_L	296_K	1.354	1.00
123_I	205_V	1.346	1.00
122_V	195_V	1.334	1.00
208_C	231_I	1.322	1.00
256_A	259_K	1.313	1.00
100_V	316_V	1.309	1.00
149_K	205_V	1.302	1.00
60_I	69_V	1.300	1.00
116_Q	119_R	1.296	1.00
186_D	189_A	1.283	1.00
70_M	74_D	1.270	1.00
142_H	304_V	1.252	1.00
170_W	304_V	1.251	1.00
197_A	203_A	1.242	1.00
179_I	193_D	1.239	1.00
275_L	298_V	1.236	1.00
152_V	197_A	1.226	1.00
116_Q	121_N	1.223	1.00
142_H	145_K	1.218	1.00
153_L	207_I	1.214	1.00
177_P	197_A	1.210	1.00
256_A	260_E	1.203	1.00
194_A	206_L	1.202	1.00
122_V	208_C	1.199	1.00
191_I	231_I	1.198	1.00
35_N	39_D	1.194	1.00
198_A	206_L	1.194	1.00
126_V	242_V	1.190	1.00
195_V	206_L	1.185	1.00
182_T	185_S	1.181	1.00
300_L	308_Q	1.173	1.00
99_L	316_V	1.167	1.00
69_V	73_I	1.163	1.00
99_L	285_L	1.162	1.00
225_E	229_R	1.160	1.00
195_V	231_I	1.155	1.00
250_T	254_A	1.150	1.00
96_S	100_V	1.150	1.00
188_A	226_K	1.130	1.00
228_K	242_V	1.128	1.00
188_A	227_V	1.125	1.00
181_Q	189_A	1.122	1.00
165_E	183_A	1.122	1.00
181_Q	185_S	1.121	1.00
151_V	203_A	1.116	1.00
93_S	97_E	1.114	1.00
121_N	240_H	1.114	1.00
32_S	36_K	1.113	1.00
158_T	190_V	1.105	1.00
136_T	299_G	1.104	1.00
269_G	296_K	1.101	1.00
152_V	206_L	1.100	1.00
164_I	180_K	1.099	1.00
152_V	198_A	1.083	1.00
136_T	307_L	1.072	1.00
74_D	78_K	1.067	1.00
124_L	208_C	1.060	1.00
193_D	196_H	1.055	1.00
246_L	272_L	1.053	1.00
112_E	115_I	1.049	1.00
72_L	76_L	1.044	1.00
192_Y	196_H	1.042	1.00
138_G	304_V	1.040	1.00
297_L	309_E	1.032	1.00
107_D	112_E	1.027	1.00
125_L	271_A	1.023	1.00
270_I	287_I	1.022	1.00
312_P	316_V	1.019	1.00
101_E	105_S	1.012	1.00
117_D	121_N	1.010	1.00
145_K	174_T	1.008	1.00
215_Q	256_A	1.003	1.00
67_T	290_E	1.002	1.00
123_I	207_I	1.000	1.00
153_L	178_V	0.998	1.00
71_E	74_D	0.995	1.00
232_E	239_P	0.992	1.00
74_D	77_K	0.981	1.00
164_I	181_Q	0.977	1.00
172_E	175_G	0.973	1.00
142_H	174_T	0.973	1.00
131_V	137_I	0.971	1.00
228_K	232_E	0.970	1.00
156_G	208_C	0.968	1.00
226_K	230_V	0.962	0.99
111_S	114_N	0.961	0.99
107_D	309_E	0.957	0.99
29_T	34_Q	0.953	0.99
54_E	57_E	0.947	0.99
122_V	206_L	0.946	0.99
118_G	121_N	0.936	0.99
121_N	241_E	0.935	0.99
159_F	190_V	0.934	0.99
68_T	289_N	0.919	0.99
111_S	115_I	0.916	0.99
23_K	27_E	0.907	0.99
155_A	164_I	0.903	0.99
40_L	47_V	0.902	0.99
131_V	250_T	0.896	0.99
206_L	231_I	0.885	0.99
79_E	83_R	0.881	0.99
185_S	189_A	0.877	0.99
171_G	174_T	0.876	0.99
79_E	101_E	0.876	0.99
24_D	27_E	0.870	0.99
154_A	208_C	0.869	0.99
251_G	254_A	0.864	0.99
25_G	28_K	0.860	0.99
284_V	295_V	0.855	0.99
154_A	191_I	0.854	0.99
219_N	222_K	0.853	0.99
262_S	266_N	0.853	0.99
56_E	69_V	0.851	0.99
192_Y	230_V	0.849	0.99
299_G	307_L	0.848	0.99
31_N	35_N	0.848	0.99
76_L	98_K	0.841	0.99
170_W	174_T	0.839	0.99
232_E	240_H	0.837	0.99
29_T	33_F	0.835	0.99
27_E	31_N	0.828	0.98
213_R	223_E	0.822	0.98
115_I	121_N	0.817	0.98
275_L	315_Y	0.817	0.98
144_M	207_I	0.816	0.98
168_E	171_G	0.816	0.98
28_K	32_S	0.814	0.98
78_K	82_R	0.814	0.98
184_G	189_A	0.803	0.98
124_L	227_V	0.801	0.98
124_L	242_V	0.801	0.98
153_L	174_T	0.800	0.98
94_V	98_K	0.794	0.98
191_I	227_V	0.792	0.98
300_L	307_L	0.789	0.98
25_G	29_T	0.787	0.98
242_V	265_T	0.783	0.98
125_L	136_T	0.782	0.98
75_E	78_K	0.778	0.98
143_K	146_Q	0.774	0.98
65_G	286_A	0.769	0.98
115_I	205_V	0.767	0.98
289_N	292_H	0.763	0.97
195_V	199_K	0.762	0.97
58_V	61_S	0.759	0.97
105_S	312_P	0.754	0.97
23_K	30_R	0.754	0.97
104_N	312_P	0.754	0.97
222_K	229_R	0.754	0.97
162_G	215_Q	0.751	0.97
49_E	53_E	0.751	0.97
288_R	292_H	0.750	0.97
164_I	182_T	0.750	0.97
215_Q	257_Q	0.749	0.97
63_D	253_N	0.748	0.97
70_M	73_I	0.747	0.97
23_K	33_F	0.746	0.97
57_E	61_S	0.746	0.97
59_L	64_V	0.744	0.97
150_S	202_N	0.742	0.97
246_L	287_I	0.736	0.97
99_L	320_F	0.731	0.97
124_L	228_K	0.731	0.97
52_F	77_K	0.730	0.97
151_V	177_P	0.729	0.97
146_Q	305_D	0.728	0.97
125_L	243_L	0.725	0.97
207_I	307_L	0.725	0.97
51_F	88_P	0.724	0.96
156_G	227_V	0.723	0.96
48_D	81_K	0.718	0.96
47_V	52_F	0.713	0.96
248_A	275_L	0.712	0.96
92_Q	96_S	0.712	0.96
107_D	311_D	0.711	0.96
177_P	201_R	0.709	0.96
225_E	265_T	0.709	0.96
170_W	173_R	0.707	0.96
158_T	187_P	0.706	0.96
100_V	312_P	0.705	0.96
71_E	102_I	0.704	0.96
164_I	183_A	0.703	0.96
255_M	290_E	0.695	0.96
260_E	264_A	0.694	0.96
126_V	265_T	0.693	0.95
255_M	286_A	0.692	0.95
115_I	149_K	0.692	0.95
113_L	121_N	0.692	0.95
119_R	199_K	0.691	0.95
25_G	30_R	0.690	0.95
253_N	257_Q	0.690	0.95
44_Y	47_V	0.689	0.95
122_V	240_H	0.685	0.95
241_E	269_G	0.684	0.95
171_G	177_P	0.684	0.95
273_T	277_G	0.684	0.95
83_R	90_E	0.683	0.95
155_A	181_Q	0.681	0.95
73_I	77_K	0.680	0.95
100_V	104_N	0.677	0.95
82_R	85_I	0.677	0.95
47_V	91_V	0.677	0.95
199_K	202_N	0.677	0.95
242_V	268_T	0.676	0.95
83_R	94_V	0.674	0.95
48_D	51_F	0.673	0.95
255_M	291_L	0.672	0.95
47_V	50_D	0.672	0.95
244_L	270_I	0.668	0.95
27_E	30_R	0.664	0.94
128_V	131_V	0.663	0.94
189_A	192_Y	0.663	0.94
52_F	80_V	0.661	0.94
33_F	36_K	0.657	0.94
262_S	265_T	0.652	0.94
52_F	91_V	0.647	0.94
123_I	297_L	0.647	0.94
193_D	197_A	0.646	0.93
52_F	73_I	0.646	0.93
120_L	206_L	0.645	0.93
253_N	256_A	0.645	0.93
159_F	187_P	0.643	0.93
162_G	211_A	0.642	0.93
97_E	101_E	0.639	0.93
155_A	180_K	0.638	0.93
271_A	297_L	0.637	0.93
104_N	313_E	0.636	0.93
191_I	230_V	0.636	0.93
151_V	204_D	0.636	0.93
64_V	72_L	0.635	0.93
22_F	29_T	0.632	0.93
242_V	266_N	0.632	0.93
59_L	69_V	0.630	0.93
154_A	179_I	0.630	0.93
152_V	201_R	0.629	0.93
195_V	230_V	0.627	0.92
56_E	73_I	0.626	0.92
171_G	176_V	0.626	0.92
100_V	317_Y	0.626	0.92
187_P	227_V	0.624	0.92
79_E	94_V	0.623	0.92
283_I	286_A	0.623	0.92
226_K	229_R	0.622	0.92
142_H	307_L	0.620	0.92
168_E	182_T	0.614	0.92
188_A	229_R	0.614	0.92
30_R	34_Q	0.613	0.92
120_L	198_A	0.612	0.92
131_V	248_A	0.610	0.91
135_T	299_G	0.609	0.91
35_N	40_L	0.608	0.91
153_L	176_V	0.608	0.91
310_F	315_Y	0.608	0.91
34_Q	37_V	0.607	0.91
181_Q	190_V	0.606	0.91
144_M	147_E	0.606	0.91
80_V	94_V	0.606	0.91
97_E	100_V	0.605	0.91
165_E	182_T	0.603	0.91
225_E	263_K	0.600	0.91
191_I	195_V	0.600	0.91
173_R	306_D	0.599	0.91
36_K	41_V	0.599	0.91
128_V	216_N	0.598	0.91
90_E	93_S	0.597	0.91
173_R	303_K	0.596	0.90
100_V	103_Y	0.596	0.90
150_S	204_D	0.595	0.90
156_G	190_V	0.595	0.90
126_V	176_V	0.594	0.90
22_F	27_E	0.593	0.90
277_G	302_E	0.590	0.90
174_T	177_P	0.589	0.90
98_K	102_I	0.588	0.90
112_E	147_E	0.587	0.90
255_M	283_I	0.585	0.90
215_Q	260_E	0.584	0.90
113_L	123_I	0.581	0.89
254_A	283_I	0.581	0.89
32_S	35_N	0.579	0.89
141_A	174_T	0.578	0.89
29_T	32_S	0.577	0.89
34_Q	38_N	0.576	0.89
48_D	52_F	0.575	0.89
22_F	26_L	0.574	0.89
140_L	144_M	0.572	0.89
287_I	291_L	0.570	0.88
104_N	107_D	0.570	0.88
227_V	231_I	0.569	0.88
79_E	84_N	0.569	0.88
313_E	317_Y	0.568	0.88
229_R	232_E	0.567	0.88
113_L	144_M	0.566	0.88
220_L	224_L	0.564	0.88
270_I	293_I	0.564	0.88
37_V	51_F	0.560	0.88
246_L	254_A	0.560	0.88
181_Q	197_A	0.560	0.88
203_A	206_L	0.558	0.87
150_S	177_P	0.558	0.87
120_L	204_D	0.557	0.87
171_G	180_K	0.557	0.87
67_T	289_N	0.556	0.87
185_S	193_D	0.556	0.87
169_V	173_R	0.554	0.87
259_K	287_I	0.554	0.87
218_V	264_A	0.554	0.87
114_N	240_H	0.553	0.87
105_S	292_H	0.551	0.87
157_D	166_Q	0.548	0.86
53_E	70_M	0.548	0.86
228_K	265_T	0.545	0.86
129_N	302_E	0.545	0.86
40_L	58_V	0.544	0.86
216_N	222_K	0.542	0.86
266_N	293_I	0.542	0.86
242_V	267_V	0.540	0.86
256_A	290_E	0.537	0.85
38_N	41_V	0.535	0.85
275_L	300_L	0.535	0.85
254_A	278_T	0.534	0.85
221_M	253_N	0.534	0.85
140_L	271_A	0.533	0.85
140_L	207_I	0.532	0.85
131_V	302_E	0.532	0.85
47_V	88_P	0.532	0.85
189_A	200_A	0.529	0.84
45_R	48_D	0.528	0.84
67_T	70_M	0.527	0.84
52_F	76_L	0.527	0.84
193_D	201_R	0.527	0.84
249_T	278_T	0.527	0.84
42_S	82_R	0.526	0.84
129_N	214_L	0.523	0.84
188_A	191_I	0.523	0.84
96_S	320_F	0.522	0.84
228_K	262_S	0.522	0.84
251_G	280_K	0.520	0.83
273_T	278_T	0.520	0.83
164_I	168_E	0.519	0.83
72_L	98_K	0.515	0.83
158_T	188_A	0.514	0.83
94_V	97_E	0.514	0.83
214_L	277_G	0.513	0.83
173_R	304_V	0.513	0.83
75_E	289_N	0.512	0.83
63_D	281_G	0.510	0.82
69_V	72_L	0.509	0.82
217_K	220_L	0.507	0.82
89_K	92_Q	0.506	0.82
129_N	159_F	0.506	0.82
46_K	49_E	0.504	0.82
111_S	288_R	0.503	0.81
35_N	38_N	0.503	0.81
298_V	310_F	0.501	0.81
119_R	202_N	0.500	0.81

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2og2A	1	0.9119	100	0.43	Contact Map
1vmaA	1	0.8875	100	0.431	Contact Map
2yhsA	1	0.9362	100	0.445	Contact Map
2px0A	4	0.7781	100	0.452	Contact Map
4c7oA	1	0.8875	100	0.453	Contact Map
2v3cC	1	0.8997	100	0.464	Contact Map
1ls1A	1	0.8663	100	0.474	Contact Map
3b9qA	1	0.8997	100	0.474	Contact Map
2j37W	1	0.8845	100	0.477	Contact Map
2xxaA	1	0.8997	100	0.483	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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