GREMLIN Database
FTSY - Signal recognition particle receptor FtsY
UniProt: P51835 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 329 (291)
Sequences: 6923 (3494)
Seq/√Len: 204.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
171_G178_V5.7981.00
197_A201_R3.8581.00
71_E289_N3.2911.00
125_L137_I3.0621.00
152_V203_A3.0041.00
154_A194_A2.9541.00
259_K263_K2.9271.00
144_M205_V2.9211.00
222_K225_E2.8631.00
96_S317_Y2.6911.00
150_S203_A2.6591.00
168_E180_K2.6521.00
98_K101_E2.5591.00
225_E264_A2.5581.00
75_E98_K2.5081.00
49_E77_K2.3501.00
153_L171_G2.3391.00
168_E172_E2.3381.00
196_H200_A2.2941.00
165_E168_E2.2921.00
191_I208_C2.2911.00
142_H146_Q2.2471.00
143_K147_E2.1681.00
181_Q193_D2.1661.00
241_E296_K2.1541.00
243_L271_A2.1351.00
137_I207_I2.0731.00
301_G306_D2.0671.00
260_E263_K2.0431.00
174_T304_V2.0291.00
259_K290_E2.0211.00
262_S293_I1.9831.00
311_D314_S1.9281.00
145_K175_G1.9121.00
154_A206_L1.8631.00
136_T271_A1.8321.00
143_K297_L1.7751.00
215_Q253_N1.7751.00
177_P203_A1.7531.00
228_K266_N1.7451.00
156_G191_I1.7421.00
258_A291_L1.7261.00
79_E98_K1.7111.00
87_D90_E1.6951.00
218_V222_K1.6851.00
243_L269_G1.6731.00
125_L207_I1.6681.00
222_K226_K1.6581.00
138_G170_W1.6301.00
169_V172_E1.6241.00
141_A153_L1.6141.00
241_E268_T1.6001.00
267_V293_I1.5621.00
186_D226_K1.5441.00
153_L167_L1.5391.00
145_K176_V1.5261.00
30_R33_F1.5211.00
125_L140_L1.5201.00
143_K309_E1.5191.00
79_E97_E1.5181.00
100_V313_E1.5161.00
141_A176_V1.5071.00
272_L284_V1.4981.00
196_H199_K1.4911.00
308_Q314_S1.4861.00
152_V177_P1.4811.00
168_E178_V1.4771.00
197_A200_A1.4561.00
179_I197_A1.4511.00
71_E75_E1.4431.00
262_S267_V1.4181.00
64_V285_L1.4011.00
138_G174_T1.3981.00
142_H305_D1.3941.00
189_A193_D1.3921.00
75_E101_E1.3911.00
188_A230_V1.3751.00
149_K204_D1.3621.00
248_A272_L1.3601.00
137_I153_L1.3561.00
243_L296_K1.3541.00
123_I205_V1.3461.00
122_V195_V1.3341.00
208_C231_I1.3221.00
256_A259_K1.3131.00
100_V316_V1.3091.00
149_K205_V1.3021.00
60_I69_V1.3001.00
116_Q119_R1.2961.00
186_D189_A1.2831.00
70_M74_D1.2701.00
142_H304_V1.2521.00
170_W304_V1.2511.00
197_A203_A1.2421.00
179_I193_D1.2391.00
275_L298_V1.2361.00
152_V197_A1.2261.00
116_Q121_N1.2231.00
142_H145_K1.2181.00
153_L207_I1.2141.00
177_P197_A1.2101.00
256_A260_E1.2031.00
194_A206_L1.2021.00
122_V208_C1.1991.00
191_I231_I1.1981.00
35_N39_D1.1941.00
198_A206_L1.1941.00
126_V242_V1.1901.00
195_V206_L1.1851.00
182_T185_S1.1811.00
300_L308_Q1.1731.00
99_L316_V1.1671.00
69_V73_I1.1631.00
99_L285_L1.1621.00
225_E229_R1.1601.00
195_V231_I1.1551.00
250_T254_A1.1501.00
96_S100_V1.1501.00
188_A226_K1.1301.00
228_K242_V1.1281.00
188_A227_V1.1251.00
181_Q189_A1.1221.00
165_E183_A1.1221.00
181_Q185_S1.1211.00
151_V203_A1.1161.00
93_S97_E1.1141.00
121_N240_H1.1141.00
32_S36_K1.1131.00
158_T190_V1.1051.00
136_T299_G1.1041.00
269_G296_K1.1011.00
152_V206_L1.1001.00
164_I180_K1.0991.00
152_V198_A1.0831.00
136_T307_L1.0721.00
74_D78_K1.0671.00
124_L208_C1.0601.00
193_D196_H1.0551.00
246_L272_L1.0531.00
112_E115_I1.0491.00
72_L76_L1.0441.00
192_Y196_H1.0421.00
138_G304_V1.0401.00
297_L309_E1.0321.00
107_D112_E1.0271.00
125_L271_A1.0231.00
270_I287_I1.0221.00
312_P316_V1.0191.00
101_E105_S1.0121.00
117_D121_N1.0101.00
145_K174_T1.0081.00
215_Q256_A1.0031.00
67_T290_E1.0021.00
123_I207_I1.0001.00
153_L178_V0.9981.00
71_E74_D0.9951.00
232_E239_P0.9921.00
74_D77_K0.9811.00
164_I181_Q0.9771.00
172_E175_G0.9731.00
142_H174_T0.9731.00
131_V137_I0.9711.00
228_K232_E0.9701.00
156_G208_C0.9681.00
226_K230_V0.9620.99
111_S114_N0.9610.99
107_D309_E0.9570.99
29_T34_Q0.9530.99
54_E57_E0.9470.99
122_V206_L0.9460.99
118_G121_N0.9360.99
121_N241_E0.9350.99
159_F190_V0.9340.99
68_T289_N0.9190.99
111_S115_I0.9160.99
23_K27_E0.9070.99
155_A164_I0.9030.99
40_L47_V0.9020.99
131_V250_T0.8960.99
206_L231_I0.8850.99
79_E83_R0.8810.99
185_S189_A0.8770.99
171_G174_T0.8760.99
79_E101_E0.8760.99
24_D27_E0.8700.99
154_A208_C0.8690.99
251_G254_A0.8640.99
25_G28_K0.8600.99
284_V295_V0.8550.99
154_A191_I0.8540.99
219_N222_K0.8530.99
262_S266_N0.8530.99
56_E69_V0.8510.99
192_Y230_V0.8490.99
299_G307_L0.8480.99
31_N35_N0.8480.99
76_L98_K0.8410.99
170_W174_T0.8390.99
232_E240_H0.8370.99
29_T33_F0.8350.99
27_E31_N0.8280.98
213_R223_E0.8220.98
115_I121_N0.8170.98
275_L315_Y0.8170.98
144_M207_I0.8160.98
168_E171_G0.8160.98
28_K32_S0.8140.98
78_K82_R0.8140.98
184_G189_A0.8030.98
124_L227_V0.8010.98
124_L242_V0.8010.98
153_L174_T0.8000.98
94_V98_K0.7940.98
191_I227_V0.7920.98
300_L307_L0.7890.98
25_G29_T0.7870.98
242_V265_T0.7830.98
125_L136_T0.7820.98
75_E78_K0.7780.98
143_K146_Q0.7740.98
65_G286_A0.7690.98
115_I205_V0.7670.98
289_N292_H0.7630.97
195_V199_K0.7620.97
58_V61_S0.7590.97
105_S312_P0.7540.97
23_K30_R0.7540.97
104_N312_P0.7540.97
222_K229_R0.7540.97
162_G215_Q0.7510.97
49_E53_E0.7510.97
288_R292_H0.7500.97
164_I182_T0.7500.97
215_Q257_Q0.7490.97
63_D253_N0.7480.97
70_M73_I0.7470.97
23_K33_F0.7460.97
57_E61_S0.7460.97
59_L64_V0.7440.97
150_S202_N0.7420.97
246_L287_I0.7360.97
99_L320_F0.7310.97
124_L228_K0.7310.97
52_F77_K0.7300.97
151_V177_P0.7290.97
146_Q305_D0.7280.97
125_L243_L0.7250.97
207_I307_L0.7250.97
51_F88_P0.7240.96
156_G227_V0.7230.96
48_D81_K0.7180.96
47_V52_F0.7130.96
248_A275_L0.7120.96
92_Q96_S0.7120.96
107_D311_D0.7110.96
177_P201_R0.7090.96
225_E265_T0.7090.96
170_W173_R0.7070.96
158_T187_P0.7060.96
100_V312_P0.7050.96
71_E102_I0.7040.96
164_I183_A0.7030.96
255_M290_E0.6950.96
260_E264_A0.6940.96
126_V265_T0.6930.95
255_M286_A0.6920.95
115_I149_K0.6920.95
113_L121_N0.6920.95
119_R199_K0.6910.95
25_G30_R0.6900.95
253_N257_Q0.6900.95
44_Y47_V0.6890.95
122_V240_H0.6850.95
241_E269_G0.6840.95
171_G177_P0.6840.95
273_T277_G0.6840.95
83_R90_E0.6830.95
155_A181_Q0.6810.95
73_I77_K0.6800.95
100_V104_N0.6770.95
82_R85_I0.6770.95
47_V91_V0.6770.95
199_K202_N0.6770.95
242_V268_T0.6760.95
83_R94_V0.6740.95
48_D51_F0.6730.95
255_M291_L0.6720.95
47_V50_D0.6720.95
244_L270_I0.6680.95
27_E30_R0.6640.94
128_V131_V0.6630.94
189_A192_Y0.6630.94
52_F80_V0.6610.94
33_F36_K0.6570.94
262_S265_T0.6520.94
52_F91_V0.6470.94
123_I297_L0.6470.94
193_D197_A0.6460.93
52_F73_I0.6460.93
120_L206_L0.6450.93
253_N256_A0.6450.93
159_F187_P0.6430.93
162_G211_A0.6420.93
97_E101_E0.6390.93
155_A180_K0.6380.93
271_A297_L0.6370.93
104_N313_E0.6360.93
191_I230_V0.6360.93
151_V204_D0.6360.93
64_V72_L0.6350.93
22_F29_T0.6320.93
242_V266_N0.6320.93
59_L69_V0.6300.93
154_A179_I0.6300.93
152_V201_R0.6290.93
195_V230_V0.6270.92
56_E73_I0.6260.92
171_G176_V0.6260.92
100_V317_Y0.6260.92
187_P227_V0.6240.92
79_E94_V0.6230.92
283_I286_A0.6230.92
226_K229_R0.6220.92
142_H307_L0.6200.92
168_E182_T0.6140.92
188_A229_R0.6140.92
30_R34_Q0.6130.92
120_L198_A0.6120.92
131_V248_A0.6100.91
135_T299_G0.6090.91
35_N40_L0.6080.91
153_L176_V0.6080.91
310_F315_Y0.6080.91
34_Q37_V0.6070.91
181_Q190_V0.6060.91
144_M147_E0.6060.91
80_V94_V0.6060.91
97_E100_V0.6050.91
165_E182_T0.6030.91
225_E263_K0.6000.91
191_I195_V0.6000.91
173_R306_D0.5990.91
36_K41_V0.5990.91
128_V216_N0.5980.91
90_E93_S0.5970.91
173_R303_K0.5960.90
100_V103_Y0.5960.90
150_S204_D0.5950.90
156_G190_V0.5950.90
126_V176_V0.5940.90
22_F27_E0.5930.90
277_G302_E0.5900.90
174_T177_P0.5890.90
98_K102_I0.5880.90
112_E147_E0.5870.90
255_M283_I0.5850.90
215_Q260_E0.5840.90
113_L123_I0.5810.89
254_A283_I0.5810.89
32_S35_N0.5790.89
141_A174_T0.5780.89
29_T32_S0.5770.89
34_Q38_N0.5760.89
48_D52_F0.5750.89
22_F26_L0.5740.89
140_L144_M0.5720.89
287_I291_L0.5700.88
104_N107_D0.5700.88
227_V231_I0.5690.88
79_E84_N0.5690.88
313_E317_Y0.5680.88
229_R232_E0.5670.88
113_L144_M0.5660.88
220_L224_L0.5640.88
270_I293_I0.5640.88
37_V51_F0.5600.88
246_L254_A0.5600.88
181_Q197_A0.5600.88
203_A206_L0.5580.87
150_S177_P0.5580.87
120_L204_D0.5570.87
171_G180_K0.5570.87
67_T289_N0.5560.87
185_S193_D0.5560.87
169_V173_R0.5540.87
259_K287_I0.5540.87
218_V264_A0.5540.87
114_N240_H0.5530.87
105_S292_H0.5510.87
157_D166_Q0.5480.86
53_E70_M0.5480.86
228_K265_T0.5450.86
129_N302_E0.5450.86
40_L58_V0.5440.86
216_N222_K0.5420.86
266_N293_I0.5420.86
242_V267_V0.5400.86
256_A290_E0.5370.85
38_N41_V0.5350.85
275_L300_L0.5350.85
254_A278_T0.5340.85
221_M253_N0.5340.85
140_L271_A0.5330.85
140_L207_I0.5320.85
131_V302_E0.5320.85
47_V88_P0.5320.85
189_A200_A0.5290.84
45_R48_D0.5280.84
67_T70_M0.5270.84
52_F76_L0.5270.84
193_D201_R0.5270.84
249_T278_T0.5270.84
42_S82_R0.5260.84
129_N214_L0.5230.84
188_A191_I0.5230.84
96_S320_F0.5220.84
228_K262_S0.5220.84
251_G280_K0.5200.83
273_T278_T0.5200.83
164_I168_E0.5190.83
72_L98_K0.5150.83
158_T188_A0.5140.83
94_V97_E0.5140.83
214_L277_G0.5130.83
173_R304_V0.5130.83
75_E289_N0.5120.83
63_D281_G0.5100.82
69_V72_L0.5090.82
217_K220_L0.5070.82
89_K92_Q0.5060.82
129_N159_F0.5060.82
46_K49_E0.5040.82
111_S288_R0.5030.81
35_N38_N0.5030.81
298_V310_F0.5010.81
119_R202_N0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2og2A 1 0.9119 100 0.43 Contact Map
1vmaA 1 0.8875 100 0.431 Contact Map
2yhsA 1 0.9362 100 0.445 Contact Map
2px0A 4 0.7781 100 0.452 Contact Map
4c7oA 1 0.8875 100 0.453 Contact Map
2v3cC 1 0.8997 100 0.464 Contact Map
1ls1A 1 0.8663 100 0.474 Contact Map
3b9qA 1 0.8997 100 0.474 Contact Map
2j37W 1 0.8845 100 0.477 Contact Map
2xxaA 1 0.8997 100 0.483 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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