GREMLIN Database
SMC - Chromosome partition protein Smc
UniProt: P51834 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 1186 (1166)
Sequences: 2992 (2450)
Seq/√Len: 71.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
629_D632_G5.2961.00
1050_S1137_K4.4031.00
81_T99_S4.2271.00
222_L973_V4.0421.00
527_L550_V3.4921.00
998_N1002_K3.4261.00
221_E972_R3.3361.00
1034_N1038_V3.2531.00
614_R618_Q3.1991.00
4_K97_E3.1681.00
341_K345_V3.1381.00
553_D556_S3.1021.00
81_T101_T3.0751.00
760_S764_E3.0751.00
848_K851_K3.0551.00
627_T646_I2.9711.00
628_E632_G2.8921.00
874_A877_H2.8851.00
891_L895_Q2.8621.00
688_E692_K2.8511.00
837_K841_T2.8501.00
529_S608_T2.8261.00
468_Q471_K2.8161.00
715_A718_R2.7931.00
552_D556_S2.7851.00
867_G870_K2.7351.00
1056_R1077_Q2.7291.00
611_P614_R2.7031.00
972_R975_L2.6461.00
944_Y948_E2.5921.00
965_D968_E2.5761.00
770_K774_E2.5551.00
812_L816_K2.5501.00
806_E809_S2.5281.00
242_S246_E2.5051.00
832_N835_R2.4691.00
44_I1115_V2.4681.00
450_S454_A2.4551.00
772_K776_E2.4281.00
898_K902_G2.4141.00
685_R688_E2.3991.00
358_A362_E2.3761.00
855_S859_S2.3611.00
442_A445_E2.3601.00
264_A268_K2.3491.00
681_D685_R2.3481.00
562_Q566_Q2.3251.00
1009_E1013_E2.3231.00
100_V128_F2.2991.00
538_I603_A2.2971.00
229_L966_P2.2911.00
355_Q359_Q2.2831.00
434_K735_L2.2781.00
554_E578_S2.2721.00
225_V969_A2.2671.00
379_E382_K2.2621.00
357_R361_K2.2591.00
900_Q904_D2.2551.00
302_G306_V2.2491.00
775_E779_A2.2491.00
335_L339_L2.2421.00
835_R839_E2.2321.00
741_A744_N2.2241.00
476_L479_A2.2241.00
490_K679_L2.2141.00
849_E853_D2.2081.00
771_R775_E2.2071.00
807_S811_E2.2001.00
577_L616_V2.1881.00
453_G457_D2.1841.00
742_E746_N2.1761.00
344_A348_T2.1751.00
503_F507_V2.1551.00
1066_D1069_H2.1551.00
457_D461_K2.1341.00
805_K812_L2.1331.00
994_F998_N2.1161.00
79_E103_R2.1001.00
722_E725_R2.0941.00
758_A762_S2.0871.00
887_E891_L2.0831.00
727_K730_D2.0801.00
446_Q450_S2.0761.00
348_T352_E2.0631.00
607_V621_L2.0621.00
5_R19_S2.0591.00
243_T247_K2.0591.00
245_K249_Q2.0421.00
333_T336_K2.0411.00
844_E848_K2.0401.00
783_K786_Q2.0391.00
761_E765_E2.0381.00
203_E206_K2.0341.00
475_A478_Q2.0191.00
813_T816_K2.0151.00
723_G726_L2.0071.00
805_K809_S2.0061.00
779_A783_K1.9981.00
697_E704_K1.9951.00
602_V605_E1.9931.00
708_Q711_E1.9871.00
769_R772_K1.9511.00
271_D275_K1.9461.00
630_L654_V1.9441.00
702_T706_S1.9391.00
509_E513_A1.9381.00
414_Q417_A1.9321.00
720_T723_G1.9291.00
428_H431_S1.9281.00
730_D734_Q1.9261.00
842_E846_A1.9251.00
855_S858_T1.9251.00
483_V686_L1.9211.00
507_V511_L1.9211.00
885_T888_L1.9061.00
464_Q468_Q1.9031.00
528_I617_I1.8921.00
877_H881_D1.8901.00
250_M254_E1.8861.00
948_E952_S1.8821.00
884_K887_E1.8771.00
330_Q334_V1.8761.00
800_T804_T1.8741.00
4_K85_D1.8711.00
340_S343_E1.8551.00
880_N884_K1.8541.00
723_G727_K1.8541.00
841_T844_E1.8431.00
470_E473_E1.8341.00
945_L948_E1.8321.00
475_A479_A1.8271.00
507_V510_V1.8271.00
748_H755_E1.8261.00
347_E350_Q1.8191.00
350_Q354_K1.8121.00
765_E769_R1.8041.00
848_K852_E1.7941.00
881_D884_K1.7881.00
552_D612_A1.7871.00
827_K831_D1.7841.00
778_S782_E1.7841.00
820_A824_Q1.7771.00
879_L883_T1.7761.00
473_E477_Y1.7741.00
810_N814_E1.7721.00
225_V972_R1.7671.00
257_A261_A1.7581.00
514_K517_L1.7561.00
838_K841_T1.7531.00
945_L952_S1.7461.00
361_K364_Q1.7421.00
771_R774_E1.7411.00
294_S301_E1.7401.00
889_I893_R1.7381.00
609_F614_R1.7361.00
444_I448_I1.7361.00
803_S807_S1.7361.00
813_T817_I1.7281.00
278_A282_S1.7221.00
454_A457_D1.7201.00
860_E864_S1.7171.00
410_A414_Q1.7121.00
493_L497_Q1.7101.00
535_E677_R1.7091.00
687_A690_E1.7081.00
703_L707_I1.7071.00
377_K380_Q1.7061.00
465_K703_L1.7061.00
764_E768_V1.7041.00
726_L730_D1.7001.00
489_K678_E1.6931.00
292_V296_E1.6871.00
692_K695_L1.6851.00
438_E442_A1.6801.00
377_K381_L1.6791.00
1028_E1032_R1.6751.00
443_R447_E1.6751.00
716_D720_T1.6731.00
412_T419_N1.6711.00
320_Q324_A1.6711.00
791_I798_K1.6711.00
489_K493_L1.6701.00
83_T99_S1.6701.00
786_Q790_D1.6661.00
147_E150_L1.6631.00
682_V686_L1.6611.00
949_Y952_S1.6571.00
872_E876_K1.6571.00
206_K994_F1.6561.00
449_H452_V1.6561.00
606_L626_I1.6561.00
684_K688_E1.6561.00
521_R552_D1.6531.00
706_S709_D1.6521.00
114_I124_I1.6420.99
869_E873_E1.6420.99
298_E302_G1.6390.99
328_F331_K1.6390.99
354_K357_R1.6370.99
888_L892_R1.6360.99
746_N750_E1.6360.99
339_L343_E1.6330.99
1041_R1058_E1.6320.99
734_Q737_E1.6320.99
907_E910_L1.6310.99
22_F1145_I1.6260.99
435_A438_E1.6260.99
305_E308_K1.6250.99
467_R470_E1.6220.99
342_Q345_V1.6210.99
893_R896_R1.6170.99
356_L359_Q1.6150.99
503_F506_G1.6130.99
826_C830_E1.6090.99
329_Q333_T1.6040.99
601_G605_E1.5930.99
893_R897_I1.5900.99
671_S675_R1.5860.99
343_E347_E1.5840.99
776_E779_A1.5790.99
256_L260_S1.5720.99
924_L928_E1.5710.99
789_E793_R1.5680.99
332_E336_K1.5670.99
1076_A1097_T1.5660.99
817_I821_K1.5640.99
349_L352_E1.5550.99
455_Y459_Q1.5550.99
533_K649_L1.5530.99
360_V364_Q1.5530.99
916_L919_Q1.5460.99
774_E781_S1.5460.99
1008_K1012_T1.5440.99
713_K716_D1.5370.99
828_G832_N1.5370.99
447_E450_S1.5360.99
1034_N1067_L1.5360.99
878_K881_D1.5340.99
309_E312_K1.5310.99
987_N990_S1.5290.99
275_K278_A1.5250.99
337_E341_K1.5250.99
875_A879_L1.5220.99
853_D856_F1.5200.99
495_T499_D1.5190.99
774_E778_S1.5190.99
254_E257_A1.5180.99
490_K494_E1.5140.99
192_E1008_K1.5140.99
724_L727_K1.5130.99
432_A436_A1.5110.99
815_L818_A1.5090.99
859_S863_S1.5090.99
910_L914_K1.5040.99
362_E366_A1.5030.99
91_L98_V1.5020.99
863_S867_G1.4990.99
714_L718_R1.4940.99
851_K855_S1.4890.99
363_K366_A1.4880.99
373_N376_E1.4880.99
899_L906_Y1.4870.99
886_I890_A1.4790.99
753_D757_S1.4770.99
522_G527_L1.4750.99
931_L935_E1.4750.99
386_F389_L1.4740.99
247_K250_M1.4740.99
827_K830_E1.4730.99
909_E912_E1.4720.99
743_K746_N1.4710.99
743_K747_T1.4710.99
836_L840_L1.4680.99
762_S765_E1.4670.99
696_L699_E1.4650.99
777_L784_M1.4610.99
864_S871_L1.4600.99
325_I329_Q1.4550.99
486_A490_K1.4540.99
691_E695_L1.4500.99
1001_Y1005_S1.4490.99
819_A822_K1.4470.99
833_L840_L1.4470.99
645_R653_V1.4450.99
1002_K1006_E1.4450.99
428_H432_A1.4430.99
506_G510_V1.4430.99
324_A328_F1.4410.99
745_I752_Y1.4380.99
858_T862_S1.4360.99
431_S746_N1.4360.99
1036_T1040_I1.4260.99
1047_V1051_L1.4260.99
352_E356_L1.4230.99
101_T113_L1.4200.99
214_D218_K1.4180.98
834_A838_K1.4170.98
1067_L1070_S1.4130.98
793_R797_Q1.4130.98
482_Y685_R1.4110.98
729_Q732_K1.4100.98
225_V973_V1.4070.98
767_K771_R1.4000.98
218_K979_A1.3950.98
253_E256_L1.3940.98
829_E832_N1.3930.98
435_A439_T1.3910.98
298_E301_E1.3900.98
899_L902_G1.3900.98
217_E221_E1.3890.98
28_A1157_A1.3890.98
429_D433_R1.3870.98
883_T886_I1.3870.98
5_R83_T1.3870.98
703_L706_S1.3870.98
736_Y740_V1.3870.98
434_K438_E1.3840.98
439_T443_R1.3830.98
870_K874_A1.3780.98
206_K210_S1.3780.98
695_L699_E1.3770.98
678_E682_V1.3760.98
892_R895_Q1.3740.98
910_L917_Y1.3740.98
893_R903_L1.3710.98
1086_L1094_R1.3700.98
492_M496_M1.3700.98
1058_E1075_I1.3690.98
459_Q463_E1.3690.98
949_Y953_F1.3680.98
884_K888_L1.3670.98
382_K386_F1.3620.98
541_A624_V1.3600.98
373_N377_K1.3600.98
431_S435_A1.3590.98
147_E1094_R1.3590.98
820_A823_E1.3540.98
197_E1000_R1.3540.98
718_R722_E1.3520.98
239_G242_S1.3510.98
742_E749_L1.3510.98
865_T869_E1.3490.98
7_D17_R1.3460.98
494_E498_G1.3440.98
603_A626_I1.3430.98
625_L644_Y1.3420.98
520_I549_V1.3410.98
381_L384_D1.3390.98
1016_N1020_Q1.3360.98
830_E834_A1.3360.98
1110_P1114_C1.3340.98
785_K788_E1.3280.98
787_L791_I1.3280.98
436_A440_E1.3270.98
337_E340_S1.3260.98
864_S867_G1.3250.98
675_R679_L1.3240.98
747_T750_E1.3230.98
100_V124_I1.3210.98
302_G309_E1.3210.98
882_K886_I1.3200.98
975_L979_A1.3200.98
476_L693_T1.3170.98
802_S805_K1.3150.98
318_Q322_E1.3130.98
869_E872_E1.3110.97
801_Q805_K1.3100.97
502_G507_V1.3100.97
437_C441_F1.3090.97
503_F511_L1.3090.97
902_G905_T1.3080.97
835_R838_K1.3070.97
317_N320_Q1.3070.97
728_Q732_K1.3070.97
326_V329_Q1.3060.97
1081_K1093_E1.3010.97
609_F617_I1.3000.97
817_I828_G1.2980.97
790_D793_R1.2970.97
809_S812_L1.2950.97
764_E767_K1.2940.97
340_S344_A1.2910.97
322_E326_V1.2880.97
603_A606_L1.2870.97
185_Q1015_K1.2800.97
856_F860_E1.2790.97
551_T557_A1.2790.97
394_S398_E1.2770.97
670_N675_R1.2770.97
839_E842_E1.2740.97
424_L428_H1.2700.97
573_T576_P1.2690.97
747_T751_L1.2680.97
733_G737_E1.2670.97
952_S956_A1.2670.97
489_K497_Q1.2670.97
506_G511_L1.2660.97
310_R313_N1.2660.97
553_D578_S1.2660.97
521_R612_A1.2650.97
458_M710_M1.2640.97
915_R922_T1.2640.97
455_Y714_L1.2630.97
477_Y480_Y1.2620.97
923_L926_D1.2600.97
482_Y485_Q1.2590.97
53_A58_G1.2560.97
780_V783_K1.2550.97
897_I904_D1.2510.97
946_R949_Y1.2470.97
319_E323_E1.2450.97
287_Q291_L1.2430.97
401_L405_Q1.2420.96
319_E322_E1.2400.96
873_E877_H1.2400.96
819_A823_E1.2380.96
818_A822_K1.2370.96
506_G509_E1.2350.96
931_L934_M1.2350.96
268_K271_D1.2340.96
750_E753_D1.2300.96
1031_K1035_D1.2280.96
739_Q743_K1.2270.96
503_F508_K1.2260.96
812_L815_L1.2260.96
510_V514_K1.2230.96
680_E684_K1.2230.96
418_D422_K1.2230.96
893_R900_Q1.2210.96
290_L294_S1.2210.96
407_S410_A1.2210.96
968_E972_R1.2210.96
85_D88_D1.2190.96
788_E791_I1.2180.96
808_L812_L1.2170.96
336_K340_S1.2160.96
339_L346_F1.2160.96
816_K823_E1.2160.96
469_Y700_V1.2150.96
766_R770_K1.2090.96
804_T811_E1.2070.96
471_K475_A1.2040.96
911_K914_K1.2010.96
294_S298_E1.2010.96
312_K316_Q1.2000.96
10_G16_E1.2000.96
270_E274_D1.1970.96
829_E833_L1.1950.96
326_V330_Q1.1950.96
828_G835_R1.1940.96
860_E863_S1.1940.96
380_Q384_D1.1940.96
734_Q738_L1.1940.96
867_G871_L1.1930.96
462_Y707_I1.1920.96
790_D794_L1.1900.96
825_A829_E1.1900.96
103_R113_L1.1890.96
261_A264_A1.1870.95
496_M500_F1.1860.95
821_K828_G1.1830.95
672_L679_L1.1830.95
334_V338_E1.1820.95
561_I574_F1.1810.95
451_Q717_L1.1810.95
246_E249_Q1.1810.95
846_A849_E1.1800.95
933_R937_E1.1790.95
841_T845_L1.1790.95
345_V349_L1.1790.95
908_R911_K1.1790.95
471_K474_S1.1750.95
805_K816_K1.1750.95
285_E289_V1.1750.95
333_T337_E1.1740.95
945_L953_F1.1740.95
386_F390_N1.1730.95
489_K496_M1.1730.95
198_L202_V1.1720.95
944_Y947_E1.1710.95
402_L426_E1.1700.95
414_Q418_D1.1690.95
138_F142_S1.1660.95
940_N943_Q1.1660.95
934_M937_E1.1640.95
465_K468_Q1.1620.95
444_I447_E1.1620.95
1015_K1019_F1.1610.95
557_A662_G1.1610.95
904_D907_E1.1610.95
676_S680_E1.1600.95
886_I893_R1.1600.95
896_R900_Q1.1590.95
1098_A1105_I1.1560.95
491_D495_T1.1540.95
1051_L1100_A1.1530.95
478_Q482_Y1.1520.95
892_R899_L1.1510.95
880_N883_T1.1450.94
44_I48_L1.1440.94
845_L849_E1.1420.94
895_Q898_K1.1420.94
926_D930_K1.1400.94
79_E101_T1.1370.94
335_L342_Q1.1350.94
731_V734_Q1.1350.94
306_V309_E1.1330.94
686_L690_E1.1330.94
1023_E1027_E1.1320.94
509_E514_K1.1290.94
226_E977_K1.1290.94
846_A850_A1.1290.94
691_E694_A1.1260.94
715_A719_E1.1260.94
89_H96_H1.1250.94
142_S145_K1.1240.94
421_E424_L1.1230.94
944_Y952_S1.1220.94
422_K426_E1.1220.94
874_A878_K1.1210.94
421_E425_Q1.1180.94
919_Q923_L1.1180.94
178_E182_F1.1180.94
709_D713_K1.1170.94
721_G725_R1.1170.94
455_Y721_G1.1170.94
903_L910_L1.1160.94
381_L385_Y1.1140.94
741_A745_I1.1130.94
808_L826_C1.1110.94
423_H427_R1.1100.94
811_E814_E1.1070.93
305_E309_E1.1070.93
359_Q362_E1.1060.93
833_L837_K1.1060.93
678_E681_D1.1040.93
791_I795_T1.1040.93
846_A853_D1.1020.93
360_V812_L1.1010.93
209_A213_K1.0980.93
862_S865_T1.0980.93
781_S788_E1.0970.93
239_G243_T1.0960.93
246_E250_M1.0930.93
154_A1071_G1.0930.93
948_E951_L1.0900.93
483_V486_A1.0890.93
1043_H1046_Q1.0880.93
210_S214_D1.0880.93
461_K706_S1.0880.93
628_E649_L1.0870.93
762_S769_R1.0800.93
627_T633_A1.0790.93
778_S781_S1.0790.93
383_S387_E1.0780.92
410_A417_A1.0770.92
461_K464_Q1.0760.92
769_R776_E1.0740.92
531_E608_T1.0730.92
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393_A422_K0.5150.44
28_A42_D0.5150.44
799_Q823_E0.5150.44
439_T442_A0.5150.44
927_E930_K0.5140.44
904_D922_T0.5140.44
540_I647_V0.5140.44
811_E815_L0.5130.43
427_R745_I0.5130.43
158_R177_A0.5130.43
148_E151_S0.5130.43
918_K934_M0.5130.43
1125_E1165_M0.5120.43
215_Y219_K0.5120.43
658_G661_T0.5120.43
61_M1148_T0.5120.43
891_L894_D0.5120.43
436_A439_T0.5120.43
505_Q514_K0.5120.43
169_K180_K0.5120.43
558_R631_K0.5110.43
1083_L1130_R0.5100.43
396_R400_Q0.5100.43
346_F350_Q0.5100.43
769_R778_S0.5100.43
1052_F1161_Y0.5090.43
61_M1078_P0.5090.43
672_L675_R0.5090.43
1142_T1154_M0.5090.43
13_S1099_I0.5090.43
720_T749_L0.5090.43
425_Q429_D0.5090.43
1039_Q1042_S0.5080.43
676_S683_T0.5060.43
133_L1036_T0.5060.43
488_S491_D0.5050.42
27_T1128_V0.5050.42
266_E270_E0.5050.42
179_N183_E0.5050.42
495_T498_G0.5040.42
1033_F1061_L0.5040.42
137_A142_S0.5040.42
12_K42_D0.5040.42
773_L780_V0.5040.42
10_G1148_T0.5040.42
330_Q333_T0.5030.42
144_G166_G0.5030.42
81_T121_L0.5030.42
48_L1043_H0.5030.42
814_E834_A0.5030.42
683_T687_A0.5030.42
834_A856_F0.5030.42
721_G724_L0.5030.42
1040_I1119_V0.5020.42
902_G915_R0.5020.42
141_I1119_V0.5020.42
823_E827_K0.5020.42
774_E783_K0.5020.42
607_V939_D0.5020.42
260_S263_S0.5020.42
10_G45_R0.5000.42
1107_K1141_D0.5000.42
142_S1029_M0.5000.42
804_T808_L0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ux3A 1 0.3642 100 0.698 Contact Map
3zgxA 2 0.296 100 0.712 Contact Map
1w1wA 2 0.2723 100 0.748 Contact Map
4ad8A 1 0.3533 100 0.776 Contact Map
4i99A 2 0.274 100 0.794 Contact Map
4rsiB 1 0.3221 100 0.81 Contact Map
3auyA 2 0.3002 100 0.815 Contact Map
4rsiA 1 0.2352 100 0.82 Contact Map
3ktaB 1 0.1341 100 0.831 Contact Map
4abyA 1 0.2858 100 0.848 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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