GREMLIN Database
RNC - Ribonuclease 3
UniProt: P51833 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 249 (221)
Sequences: 4812 (3423)
Seq/√Len: 230.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
75_R154_E4.0601.00
110_S113_D3.2191.00
24_Q34_E2.9221.00
29_V148_Q2.8681.00
122_E127_R2.8351.00
75_R79_A2.6911.00
58_N136_V2.6501.00
197_S211_I2.5701.00
211_I218_P2.3561.00
195_K213_S2.3251.00
107_H130_P2.2501.00
72_T157_L2.2401.00
196_I210_A2.2111.00
207_E223_N2.2071.00
213_S218_P2.2011.00
210_A230_A2.1621.00
68_V71_L2.1051.00
211_I221_V2.1021.00
70_E74_S2.0901.00
152_P155_S2.0591.00
144_L156_F2.0461.00
31_F37_L1.9961.00
67_A70_E1.9911.00
76_F80_K1.9791.00
195_K211_I1.9631.00
198_N209_E1.9531.00
209_E223_N1.9391.00
107_H128_K1.8891.00
177_K231_E1.8641.00
233_H236_Q1.8501.00
115_V136_V1.8491.00
209_E221_V1.8291.00
105_L137_F1.8141.00
38_Y116_L1.7951.00
175_D178_S1.7811.00
99_E134_A1.7661.00
44_S59_E1.7491.00
176_F236_Q1.7401.00
106_A133_L1.7091.00
199_E206_R1.7021.00
39_Q56_E1.6981.00
151_E154_E1.6781.00
236_Q240_A1.6381.00
148_Q152_P1.6381.00
201_G204_H1.6211.00
111_F140_F1.5691.00
220_G237_E1.5631.00
46_Y116_L1.5481.00
137_F141_I1.5301.00
108_E164_K1.5181.00
220_G238_A1.4931.00
141_I156_F1.4811.00
200_K209_E1.4601.00
156_F160_Y1.4471.00
104_S164_K1.4461.00
74_S93_R1.4441.00
222_G234_A1.4331.00
84_M88_D1.4121.00
76_F158_K1.4121.00
183_Y239_L1.4041.00
41_F111_F1.4031.00
26_R110_S1.4001.00
80_K166_N1.3881.00
149_G152_P1.3871.00
229_E233_H1.3761.00
200_K207_E1.3761.00
31_F147_D1.3541.00
155_S159_V1.3231.00
24_Q31_F1.3201.00
225_R229_E1.3021.00
180_L212_V1.3021.00
233_H237_E1.3001.00
47_V57_D1.2901.00
220_G241_K1.2821.00
42_T116_L1.2681.00
62_E138_E1.2671.00
72_T150_L1.2651.00
205_N225_R1.2651.00
224_G233_H1.2621.00
34_E38_Y1.2551.00
203_A206_R1.2531.00
21_K25_E1.2471.00
214_L219_L1.2461.00
71_L150_L1.2411.00
98_C101_S1.2401.00
23_F27_I1.2391.00
106_A137_F1.2281.00
237_E241_K1.2221.00
21_K30_H1.2201.00
218_P221_V1.2201.00
62_E66_D1.2161.00
154_E158_K1.2071.00
22_E26_R1.2061.00
24_Q30_H1.2051.00
41_F136_V1.2001.00
26_R114_L1.1951.00
66_D138_E1.1931.00
212_V220_G1.1821.00
41_F140_F1.1791.00
107_H133_L1.1501.00
176_F232_Q1.1281.00
121_E129_R1.1211.00
219_L238_A1.1021.00
69_L141_I1.1021.00
107_H112_G1.0961.00
99_E131_A1.0921.00
75_R145_Y1.0911.00
24_Q29_V1.0871.00
112_G133_L1.0821.00
28_S159_V1.0791.00
68_V142_G1.0771.00
158_K162_F1.0731.00
67_A93_R1.0621.00
190_G215_K1.0541.00
103_V134_A1.0451.00
44_S58_N1.0311.00
184_V192_L1.0171.00
60_R78_F1.0161.00
181_Q194_Y1.0101.00
141_I157_L1.0101.00
237_E240_A1.0001.00
103_V107_H0.9971.00
108_E163_P0.9961.00
193_E213_S0.9921.00
140_F144_L0.9851.00
31_F148_Q0.9761.00
29_V32_Q0.9721.00
193_E216_G0.9711.00
100_P130_P0.9701.00
23_F114_L0.9601.00
58_N139_A0.9491.00
84_M92_L0.9351.00
153_V157_L0.9341.00
131_A135_D0.9091.00
32_Q147_D0.9081.00
72_T154_E0.8970.99
109_L160_Y0.8960.99
239_L243_Q0.8960.99
162_F166_N0.8950.99
105_L161_V0.8900.99
101_S164_K0.8880.99
96_I165_I0.8860.99
30_H34_E0.8820.99
73_I161_V0.8740.99
184_V214_L0.8710.99
35_K38_Y0.8650.99
196_I199_E0.8500.99
226_S229_E0.8460.99
29_V147_D0.8430.99
179_Q239_L0.8420.99
178_S182_E0.8420.99
25_E30_H0.8390.99
23_F140_F0.8290.99
85_S88_D0.8160.99
182_E185_Q0.8100.99
183_Y187_D0.8010.99
179_Q183_Y0.7980.99
31_F143_A0.7970.99
33_N39_Q0.7960.99
72_T153_V0.7940.99
71_L75_R0.7930.99
96_I101_S0.7890.99
22_E25_E0.7870.99
121_E126_G0.7790.98
24_Q37_L0.7740.98
60_R89_L0.7740.98
213_S219_L0.7720.98
126_G129_R0.7690.98
66_D97_V0.7660.98
79_A158_K0.7610.98
62_E135_D0.7540.98
103_V130_P0.7530.98
192_L212_V0.7510.98
23_F26_R0.7490.98
37_L140_F0.7470.98
136_V139_A0.7460.98
152_P156_F0.7410.98
181_Q185_Q0.7410.98
36_L147_D0.7340.98
90_T93_R0.7330.98
144_L153_V0.7330.98
61_L142_G0.7320.98
143_A147_D0.7280.98
77_L89_L0.7270.98
67_A71_L0.7240.98
37_L147_D0.7190.97
41_F109_L0.7170.97
99_E135_D0.7170.97
68_V145_Y0.7150.97
70_E93_R0.7140.97
29_V144_L0.7130.97
80_K162_F0.7130.97
144_L160_Y0.7100.97
129_R132_L0.7080.97
49_E118_G0.7040.97
175_D232_Q0.7030.97
174_M179_Q0.6980.97
177_K194_Y0.6970.97
112_G128_K0.6950.97
21_K34_E0.6930.97
183_Y242_L0.6900.97
69_L102_L0.6860.97
27_I160_Y0.6770.96
103_V133_L0.6740.96
96_I161_V0.6740.96
29_V37_L0.6730.96
44_S57_D0.6730.96
219_L241_K0.6720.96
63_F89_L0.6710.96
224_G229_E0.6690.96
72_T158_K0.6620.96
20_F24_Q0.6590.96
97_V138_E0.6590.96
20_F41_F0.6570.96
87_G90_T0.6560.96
196_I231_E0.6540.96
150_L154_E0.6530.96
153_V156_F0.6460.95
37_L148_Q0.6460.95
115_V132_L0.6460.95
49_E120_G0.6450.95
179_Q243_Q0.6440.95
20_F23_F0.6440.95
23_F111_F0.6430.95
109_L137_F0.6410.95
222_G233_H0.6390.95
96_I168_G0.6390.95
90_T97_V0.6340.95
101_S161_V0.6330.95
46_Y49_E0.6280.94
137_F160_Y0.6250.94
62_E97_V0.6250.94
202_P206_R0.6250.94
94_A134_A0.6230.94
184_V191_S0.6230.94
201_G206_R0.6220.94
183_Y243_Q0.6190.94
73_I97_V0.6190.94
29_V156_F0.6180.94
22_E113_D0.6170.94
177_K235_A0.6160.94
39_Q57_D0.6150.94
32_Q148_Q0.6150.94
177_K181_Q0.6150.94
188_G192_L0.6150.94
33_N36_L0.6150.94
100_P229_E0.6150.94
155_S158_K0.6120.94
59_E62_E0.6120.94
40_A143_A0.6100.94
99_E130_P0.6070.93
59_E135_D0.6060.93
213_S216_G0.6030.93
64_L78_F0.6000.93
36_L146_L0.5990.93
104_S107_H0.5990.93
37_L41_F0.5990.93
84_M89_L0.5960.93
93_R102_L0.5950.93
63_F66_D0.5910.92
90_T138_E0.5900.92
90_T94_A0.5900.92
22_E114_L0.5880.92
27_I140_F0.5860.92
63_F138_E0.5840.92
49_E119_K0.5810.92
227_K231_E0.5790.92
105_L157_L0.5720.91
23_F106_A0.5720.91
200_K223_N0.5690.91
67_A92_L0.5670.91
21_K24_Q0.5660.91
66_D135_D0.5650.91
159_V162_F0.5620.91
37_L114_L0.5610.90
66_D93_R0.5600.90
94_A97_V0.5600.90
106_A136_V0.5600.90
93_R98_C0.5590.90
67_A90_T0.5580.90
66_D90_T0.5550.90
70_E73_I0.5550.90
77_L92_L0.5540.90
145_Y150_L0.5540.90
90_T118_G0.5530.90
121_E124_T0.5520.90
117_L120_G0.5520.90
126_G132_L0.5510.90
197_S209_E0.5510.90
151_E155_S0.5490.89
208_F231_E0.5490.89
66_D87_G0.5460.89
180_L239_L0.5460.89
87_G115_V0.5450.89
87_G138_E0.5450.89
111_F137_F0.5400.89
181_Q231_E0.5400.89
167_D170_F0.5390.89
124_T129_R0.5380.89
181_Q235_A0.5380.89
63_F97_V0.5370.88
196_I227_K0.5370.88
212_V238_A0.5350.88
78_F89_L0.5310.88
102_L134_A0.5300.88
125_G128_K0.5290.88
29_V152_P0.5290.88
24_Q27_I0.5280.88
88_D91_K0.5270.88
117_L125_G0.5250.87
67_A74_S0.5240.87
168_G171_S0.5230.87
102_L141_I0.5220.87
148_Q153_V0.5210.87
176_F239_L0.5210.87
81_Y145_Y0.5200.87
36_L61_L0.5180.87
221_V237_E0.5170.87
91_K178_S0.5160.86
217_E241_K0.5150.86
141_I153_V0.5130.86
238_A241_K0.5120.86
125_G129_R0.5110.86
60_R64_L0.5100.86
20_F34_E0.5100.86
169_A172_H0.5100.86
222_G237_E0.5100.86
36_L143_A0.5100.86
20_F114_L0.5090.86
218_P241_K0.5020.85
102_L137_F0.5000.85
164_K168_G0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1o0wA 2 0.9438 100 0.166 Contact Map
3n3wA 2 0.5904 100 0.18 Contact Map
3j7yc 1 0.9598 100 0.188 Contact Map
4ce4h 1 0.8956 100 0.188 Contact Map
2a11A 2 0.6064 100 0.197 Contact Map
1vw45 1 0.996 100 0.201 Contact Map
2nugA 2 0.8594 100 0.202 Contact Map
3c4bA 2 0.9076 100 0.23 Contact Map
3rv0A 2 0.9679 100 0.232 Contact Map
4oogC 2 0.9036 100 0.257 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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