ILVD - BACSU - GREMLIN Contacts

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ILVD - Dihydroxy-acid dehydratase

UniProt:	P51785	Sequences: MAELRSNMITQGIDRAPHRSLLRAAGVKEEDFGKPFIAVCNSYIDIVPGHVHLQEFGKIVKEAIREAGGVPFEFNTIGVDDGIAMGHIGMRYSLPSREIIADSVETVVSAHWFDGMVCIPNCDKITPGMLMAAMRINIPTIFVSGGPMAAGRTSDGRKISLSSVFEGVGAYQAGKINENELQELEQFGCPTCGSCSGMFTANSMNCLSEALGLALPGNGTILATSPERKEFVRKSAAQLMETIRKDIKPRDIVTVKAIDNAFALDMALGGSTNTVLHTLALANEAGVEYSLERINEVAERVPHLAKLAPASDVFIEDLHEAGGVSAALNELSKKEGALHLDALTVTGKTLGETIAGHEVKDYDVIHPLDQPFTEKGGLAVLFGNLAPDGAIIKTGGVQNGITRHEGPAVVFDSQDEALDGIINRKVKEGDVVIIRYEGPKGGPGMPEMLAPTSQIVGMGLGPKVALITDGRFSGASRGLSIGHVSPEAAEGGPLAFVENGDHIIVDIEKRILDVQVPEEEWEKRKANWKGFEPKVKTGYLARYSKLVTSANTGGIMKI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	558 (545)
Sequences:	4718 (1888)
Seq/√Len:	80.9

ECOLI - YAGF EDD YJHG ILVD
BACSU - ILVD
SULSO - ILVD

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
405_E	504_I	4.487	1.00
496_F	525_K	4.391	1.00
253_V	258_I	3.916	1.00
256_K	339_H	3.744	1.00
387_P	493_P	3.626	1.00
405_E	515_Q	3.576	1.00
496_F	521_W	3.465	1.00
504_I	515_Q	3.461	1.00
259_D	339_H	3.327	1.00
405_E	502_H	3.266	1.00
428_E	463_K	3.255	1.00
506_D	509_K	3.171	1.00
498_E	527_N	3.145	1.00
248_K	251_D	3.136	1.00
115_G	243_I	3.055	1.00
497_V	514_V	2.893	1.00
332_S	340_L	2.824	1.00
340_L	351_G	2.792	1.00
177_N	180_E	2.790	1.00
388_D	551_N	2.755	1.00
502_H	515_Q	2.750	1.00
137_N	250_R	2.741	1.00
137_N	251_D	2.681	1.00
366_H	370_Q	2.665	1.00
409_V	430_D	2.644	1.00
37_I	115_G	2.629	1.00
170_A	175_K	2.582	1.00
504_I	513_D	2.551	1.00
253_V	257_A	2.515	1.00
134_M	253_V	2.468	1.00
407_P	502_H	2.416	1.00
346_T	353_T	2.405	1.00
409_V	499_N	2.400	1.00
292_E	382_F	2.392	1.00
440_K	490_E	2.381	1.00
143_V	235_S	2.364	1.00
238_Q	241_E	2.329	1.00
498_E	520_E	2.319	1.00
213_L	253_V	2.318	1.00
130_L	213_L	2.318	1.00
517_P	520_E	2.295	1.00
520_E	523_K	2.282	1.00
384_N	513_D	2.280	1.00
141_I	239_L	2.252	1.00
264_L	328_L	2.210	1.00
220_T	315_I	2.205	1.00
263_A	300_R	2.199	1.00
23_R	186_Q	2.192	1.00
256_K	341_D	2.189	1.00
467_I	484_V	2.188	1.00
295_N	299_E	2.182	1.00
413_S	416_E	2.181	1.00
130_L	281_L	2.153	1.00
403_R	506_D	2.149	1.00
262_F	294_I	2.144	1.00
412_D	435_R	2.133	1.00
162_S	475_A	2.126	1.00
263_A	301_V	2.113	1.00
516_V	521_W	2.104	1.00
390_A	512_L	2.104	1.00
266_M	297_V	2.095	1.00
41_N	73_E	2.090	1.00
342_A	350_L	2.079	1.00
348_K	352_E	2.061	1.00
23_R	29_E	2.039	1.00
518_E	522_E	2.012	1.00
149_A	224_T	1.990	1.00
528_W	531_F	1.982	1.00
255_V	259_D	1.964	1.00
402_T	508_E	1.952	1.00
523_K	526_A	1.931	1.00
37_I	243_I	1.919	1.00
290_S	293_R	1.914	1.00
234_K	237_A	1.906	1.00
385_L	497_V	1.884	1.00
295_N	510_R	1.879	1.00
171_Y	176_I	1.867	1.00
514_V	521_W	1.850	1.00
69_G	240_M	1.842	1.00
118_C	140_T	1.830	1.00
141_I	238_Q	1.805	1.00
208_S	214_A	1.804	1.00
497_V	503_I	1.803	1.00
241_E	244_R	1.801	1.00
227_E	319_H	1.794	1.00
171_Y	178_E	1.789	1.00
349_T	352_E	1.782	1.00
523_K	527_N	1.779	1.00
259_D	296_E	1.757	1.00
328_L	350_L	1.742	1.00
412_D	416_E	1.733	1.00
379_A	510_R	1.726	1.00
497_V	516_V	1.711	1.00
134_M	285_A	1.699	1.00
521_W	525_K	1.693	1.00
66_E	237_A	1.679	1.00
133_A	140_T	1.676	1.00
522_E	526_A	1.672	1.00
532_E	536_K	1.658	1.00
328_L	354_I	1.651	1.00
541_A	545_K	1.651	1.00
241_E	245_K	1.634	1.00
115_G	239_L	1.632	1.00
403_R	508_E	1.627	1.00
214_A	218_N	1.620	1.00
404_H	407_P	1.610	1.00
108_V	116_M	1.608	1.00
263_A	297_V	1.598	1.00
176_I	180_E	1.595	1.00
64_I	69_G	1.594	1.00
238_Q	245_K	1.589	1.00
262_F	289_Y	1.589	1.00
419_D	423_N	1.572	1.00
150_A	316_E	1.568	1.00
141_I	345_V	1.564	1.00
203_S	270_G	1.562	1.00
55_E	229_K	1.545	0.99
210_A	264_L	1.544	0.99
412_D	436_Y	1.538	0.99
65_R	71_P	1.528	0.99
493_P	521_W	1.526	0.99
403_R	504_I	1.518	0.99
39_V	64_I	1.473	0.99
407_P	430_D	1.472	0.99
410_V	497_V	1.467	0.99
47_V	78_G	1.465	0.99
293_R	296_E	1.463	0.99
411_F	420_G	1.461	0.99
420_G	426_V	1.460	0.99
296_E	300_R	1.458	0.99
299_E	375_K	1.456	0.99
59_I	233_R	1.455	0.99
218_N	231_F	1.453	0.99
260_N	342_A	1.449	0.99
131_M	284_E	1.447	0.99
255_V	293_R	1.446	0.99
485_S	551_N	1.438	0.99
411_F	425_K	1.432	0.99
424_R	458_M	1.426	0.99
58_K	62_E	1.418	0.99
29_E	182_Q	1.412	0.99
408_A	503_I	1.409	0.99
31_D	34_K	1.394	0.99
57_G	119_I	1.393	0.99
60_V	117_V	1.387	0.99
516_V	520_E	1.383	0.99
153_T	180_E	1.379	0.99
354_I	357_H	1.374	0.99
283_N	552_T	1.369	0.99
522_E	525_K	1.364	0.99
40_C	107_V	1.359	0.99
313_V	363_D	1.350	0.99
513_D	518_E	1.344	0.99
256_K	259_D	1.342	0.99
62_E	65_R	1.338	0.99
27_V	72_F	1.338	0.99
242_T	247_I	1.332	0.98
330_E	334_K	1.323	0.98
348_K	353_T	1.312	0.98
275_V	279_L	1.309	0.98
318_L	327_A	1.304	0.98
203_S	274_T	1.303	0.98
306_K	312_D	1.301	0.98
416_E	419_D	1.297	0.98
79_V	110_A	1.280	0.98
64_I	236_A	1.280	0.98
45_D	61_K	1.279	0.98
53_L	121_N	1.279	0.98
408_A	497_V	1.262	0.98
213_L	249_P	1.262	0.98
37_I	64_I	1.262	0.98
278_T	289_Y	1.253	0.98
330_E	362_Y	1.245	0.98
63_A	236_A	1.240	0.98
252_I	257_A	1.238	0.98
59_I	229_K	1.238	0.98
36_F	72_F	1.236	0.98
130_L	208_S	1.229	0.97
160_S	314_F	1.228	0.97
255_V	296_E	1.225	0.97
292_E	296_E	1.215	0.97
210_A	328_L	1.214	0.97
38_A	108_V	1.212	0.97
183_E	187_F	1.212	0.97
253_V	285_A	1.211	0.97
432_V	455_I	1.210	0.97
258_I	281_L	1.208	0.97
46_I	113_F	1.208	0.97
496_F	516_V	1.208	0.97
117_V	239_L	1.206	0.97
495_A	528_W	1.205	0.97
54_Q	58_K	1.200	0.97
137_N	248_K	1.200	0.97
362_Y	370_Q	1.193	0.97
359_V	362_Y	1.193	0.97
403_R	509_K	1.187	0.97
332_S	338_L	1.184	0.97
433_I	503_I	1.181	0.97
38_A	116_M	1.178	0.97
384_N	518_E	1.174	0.97
117_V	236_A	1.173	0.97
533_P	536_K	1.171	0.97
496_F	528_W	1.166	0.96
159_I	184_L	1.165	0.96
485_S	549_S	1.163	0.96
335_E	368_L	1.160	0.96
132_A	136_I	1.159	0.96
410_V	499_N	1.157	0.96
388_D	485_S	1.156	0.96
338_L	350_L	1.149	0.96
521_W	524_R	1.148	0.96
433_I	497_V	1.144	0.96
16_A	164_V	1.143	0.96
303_H	373_T	1.141	0.96
288_E	552_T	1.139	0.96
77_I	103_S	1.137	0.96
415_D	446_P	1.136	0.96
398_Q	462_P	1.134	0.96
40_C	116_M	1.134	0.96
27_V	70_V	1.133	0.96
349_T	353_T	1.131	0.96
548_T	552_T	1.129	0.96
415_D	419_D	1.128	0.96
456_V	461_G	1.127	0.96
392_I	505_V	1.124	0.96
134_M	213_L	1.118	0.96
66_E	233_R	1.117	0.95
409_V	427_K	1.116	0.95
59_I	62_E	1.108	0.95
144_S	218_N	1.106	0.95
118_C	142_F	1.105	0.95
409_V	420_G	1.105	0.95
43_Y	54_Q	1.102	0.95
246_D	249_P	1.101	0.95
154_S	180_E	1.096	0.95
19_R	185_E	1.090	0.95
494_L	497_V	1.086	0.95
104_V	132_A	1.080	0.95
430_D	499_N	1.078	0.95
380_V	391_I	1.077	0.94
367_P	370_Q	1.076	0.94
332_S	351_G	1.071	0.94
465_A	505_V	1.064	0.94
63_A	66_E	1.064	0.94
255_V	288_E	1.061	0.94
220_T	319_H	1.061	0.94
221_I	225_S	1.058	0.94
549_S	552_T	1.057	0.94
29_E	186_Q	1.054	0.94
132_A	249_P	1.050	0.94
259_D	293_R	1.043	0.93
91_R	446_P	1.043	0.93
182_Q	186_Q	1.042	0.93
120_P	126_T	1.041	0.93
388_D	552_T	1.040	0.93
493_P	514_V	1.036	0.93
329_N	357_H	1.035	0.93
154_S	183_E	1.035	0.93
409_V	426_V	1.020	0.93
55_E	58_K	1.016	0.93
412_D	498_E	1.016	0.93
352_E	355_A	1.013	0.92
22_L	25_A	1.011	0.92
407_P	427_K	1.011	0.92
24_A	48_P	1.009	0.92
251_D	343_L	1.009	0.92
32_F	70_V	1.006	0.92
452_T	472_F	1.000	0.92
379_A	508_E	0.999	0.92
384_N	514_V	0.998	0.92
216_P	353_T	0.997	0.92
427_K	430_D	0.995	0.92
329_N	356_G	0.990	0.92
350_L	353_T	0.989	0.92
118_C	133_A	0.988	0.92
516_V	525_K	0.987	0.91
428_E	462_P	0.986	0.91
149_A	225_S	0.985	0.91
437_E	446_P	0.982	0.91
42_S	129_M	0.978	0.91
238_Q	242_T	0.977	0.91
428_E	458_M	0.977	0.91
211_L	258_I	0.975	0.91
17_P	168_V	0.975	0.91
62_E	233_R	0.974	0.91
456_V	480_S	0.970	0.91
332_S	354_I	0.968	0.91
388_D	549_S	0.968	0.91
525_K	528_W	0.963	0.90
87_H	111_H	0.956	0.90
385_L	493_P	0.955	0.90
539_Y	556_M	0.953	0.90
426_V	432_V	0.952	0.90
221_I	231_F	0.947	0.90
149_A	191_T	0.945	0.90
265_D	274_T	0.944	0.90
335_E	369_D	0.943	0.90
276_L	279_L	0.939	0.89
191_T	226_P	0.938	0.89
543_Y	547_V	0.936	0.89
533_P	541_A	0.935	0.89
316_E	320_E	0.931	0.89
226_P	230_E	0.930	0.89
534_K	538_G	0.930	0.89
493_P	525_K	0.927	0.89
268_L	327_A	0.926	0.89
247_I	251_D	0.918	0.88
92_Y	109_S	0.916	0.88
329_N	332_S	0.913	0.88
141_I	235_S	0.912	0.88
23_R	32_F	0.911	0.88
431_V	503_I	0.911	0.88
405_E	513_D	0.910	0.88
381_L	390_A	0.909	0.88
514_V	517_P	0.907	0.88
211_L	261_A	0.907	0.88
153_T	184_L	0.906	0.88
100_I	128_G	0.903	0.87
13_I	171_Y	0.903	0.87
400_G	462_P	0.900	0.87
215_L	238_Q	0.900	0.87
257_A	343_L	0.899	0.87
102_D	542_R	0.898	0.87
433_I	514_V	0.895	0.87
61_K	73_E	0.882	0.86
62_E	66_E	0.882	0.86
230_E	234_K	0.881	0.86
491_G	528_W	0.874	0.86
481_I	505_V	0.872	0.85
240_M	244_R	0.869	0.85
362_Y	367_P	0.869	0.85
51_V	192_C	0.868	0.85
332_S	355_A	0.868	0.85
34_K	70_V	0.867	0.85
255_V	287_V	0.866	0.85
409_V	425_K	0.864	0.85
99_I	106_T	0.863	0.85
99_I	539_Y	0.863	0.85
306_K	313_V	0.860	0.85
401_I	404_H	0.860	0.85
252_I	343_L	0.859	0.85
36_F	70_V	0.857	0.84
330_E	369_D	0.854	0.84
40_C	104_V	0.852	0.84
53_L	145_G	0.852	0.84
214_A	235_S	0.847	0.84
57_G	73_E	0.844	0.84
52_H	145_G	0.842	0.83
299_E	510_R	0.841	0.83
134_M	258_I	0.840	0.83
528_W	532_E	0.840	0.83
145_G	194_S	0.838	0.83
336_G	368_L	0.838	0.83
304_L	368_L	0.835	0.83
392_I	507_I	0.835	0.83
542_R	546_L	0.833	0.83
213_L	252_I	0.832	0.83
434_I	437_E	0.832	0.83
426_V	499_N	0.831	0.83
238_Q	247_I	0.831	0.83
328_L	338_L	0.829	0.82
312_D	363_D	0.828	0.82
321_A	362_Y	0.828	0.82
537_T	541_A	0.828	0.82
404_H	431_V	0.827	0.82
236_A	239_L	0.825	0.82
104_V	129_M	0.824	0.82
69_G	236_A	0.822	0.82
301_V	337_A	0.819	0.82
421_I	451_P	0.817	0.82
504_I	511_I	0.815	0.81
149_A	222_L	0.815	0.81
158_K	316_E	0.814	0.81
519_E	523_K	0.813	0.81
350_L	354_I	0.808	0.81
264_L	324_V	0.806	0.81
79_V	106_T	0.806	0.81
117_V	143_V	0.804	0.81
28_K	31_D	0.804	0.81
227_E	230_E	0.803	0.80
351_G	355_A	0.802	0.80
318_L	365_I	0.801	0.80
120_P	142_F	0.801	0.80
250_R	286_G	0.799	0.80
217_G	319_H	0.798	0.80
379_A	394_T	0.795	0.80
329_N	334_K	0.794	0.80
343_L	353_T	0.790	0.79
467_I	497_V	0.790	0.79
34_K	66_E	0.790	0.79
38_A	113_F	0.789	0.79
207_L	265_D	0.783	0.79
254_T	257_A	0.781	0.79
64_I	117_V	0.781	0.79
306_K	366_H	0.779	0.78
80_D	84_A	0.779	0.78
436_Y	495_A	0.778	0.78
321_A	359_V	0.778	0.78
42_S	76_T	0.775	0.78
78_G	125_I	0.775	0.78
332_S	336_G	0.773	0.78
39_V	61_K	0.772	0.78
88_I	535_V	0.772	0.78
53_L	73_E	0.772	0.78
41_N	53_L	0.769	0.77
242_T	345_V	0.768	0.77
206_C	268_L	0.767	0.77
63_A	233_R	0.767	0.77
340_L	354_I	0.764	0.77
297_V	300_R	0.764	0.77
343_L	348_K	0.763	0.77
412_D	531_F	0.762	0.77
283_N	288_E	0.761	0.77
529_K	532_E	0.761	0.77
106_T	539_Y	0.759	0.77
351_G	354_I	0.758	0.76
240_M	243_I	0.758	0.76
258_I	287_V	0.756	0.76
130_L	253_V	0.755	0.76
433_I	484_V	0.754	0.76
481_I	484_V	0.750	0.76
167_G	184_L	0.749	0.76
295_N	379_A	0.747	0.75
39_V	60_V	0.744	0.75
35_P	69_G	0.742	0.75
79_V	93_S	0.742	0.75
247_I	343_L	0.740	0.75
256_K	342_A	0.740	0.75
516_V	524_R	0.739	0.75
342_A	349_T	0.737	0.74
418_L	450_A	0.737	0.74
300_R	337_A	0.735	0.74
267_A	304_L	0.734	0.74
484_V	494_L	0.734	0.74
263_A	337_A	0.731	0.74
45_D	73_E	0.731	0.74
412_D	499_N	0.730	0.74
134_M	257_A	0.730	0.74
153_T	183_E	0.729	0.74
247_I	353_T	0.728	0.74
275_V	294_I	0.727	0.73
343_L	346_T	0.725	0.73
398_Q	401_I	0.725	0.73
198_M	268_L	0.724	0.73
542_R	556_M	0.723	0.73
531_F	534_K	0.723	0.73
229_K	233_R	0.723	0.73
476_S	480_S	0.722	0.73
15_R	18_H	0.722	0.73
206_C	219_G	0.721	0.73
64_I	71_P	0.719	0.73
161_L	165_F	0.718	0.72
67_A	236_A	0.717	0.72
548_T	555_I	0.716	0.72
232_V	235_S	0.715	0.72
10_T	36_F	0.714	0.72
337_A	368_L	0.713	0.72
406_G	431_V	0.713	0.72
159_I	163_S	0.712	0.72
385_L	435_R	0.712	0.72
116_M	140_T	0.712	0.72
239_L	243_I	0.712	0.72
445_M	550_A	0.712	0.72
426_V	430_D	0.710	0.72
536_K	541_A	0.710	0.72
341_D	351_G	0.710	0.72
49_G	80_D	0.710	0.72
178_E	182_Q	0.710	0.72
262_F	278_T	0.710	0.72
170_A	176_I	0.708	0.71
250_R	537_T	0.707	0.71
42_S	120_P	0.705	0.71
144_S	205_N	0.704	0.71
39_V	116_M	0.704	0.71
518_E	521_W	0.701	0.71
442_G	446_P	0.699	0.70
516_V	522_E	0.699	0.70
336_G	340_L	0.697	0.70
64_I	239_L	0.696	0.70
120_P	129_M	0.696	0.70
385_L	513_D	0.695	0.70
305_A	327_A	0.695	0.70
517_P	523_K	0.694	0.70
489_A	530_G	0.690	0.69
63_A	67_A	0.688	0.69
144_S	228_R	0.688	0.69
283_N	555_I	0.687	0.69
490_E	549_S	0.687	0.69
213_L	254_T	0.685	0.69
339_H	342_A	0.683	0.69
242_T	245_K	0.682	0.69
518_E	524_R	0.682	0.69
85_M	197_G	0.681	0.68
67_A	240_M	0.680	0.68
152_R	158_K	0.680	0.68
207_L	278_T	0.680	0.68
40_C	74_F	0.680	0.68
407_P	431_V	0.679	0.68
53_L	57_G	0.678	0.68
334_K	351_G	0.675	0.68
407_P	504_I	0.673	0.68
425_K	430_D	0.673	0.68
165_F	197_G	0.672	0.67
207_L	211_L	0.672	0.67
137_N	249_P	0.672	0.67
507_I	510_R	0.672	0.67
325_S	353_T	0.671	0.67
28_K	32_F	0.670	0.67
159_I	162_S	0.670	0.67
503_I	514_V	0.669	0.67
495_A	531_F	0.669	0.67
22_L	27_V	0.667	0.67
253_V	289_Y	0.667	0.67
153_T	159_I	0.667	0.67
86_G	450_A	0.666	0.67
286_G	537_T	0.665	0.67
258_I	289_Y	0.664	0.67
275_V	391_I	0.664	0.67
291_L	551_N	0.664	0.67
506_D	511_I	0.664	0.67
31_D	237_A	0.663	0.66
422_I	475_A	0.662	0.66
416_E	420_G	0.662	0.66
60_V	119_I	0.661	0.66
410_V	514_V	0.661	0.66
47_V	107_V	0.661	0.66
148_M	189_C	0.660	0.66
76_T	103_S	0.660	0.66
533_P	538_G	0.659	0.66
517_P	521_W	0.658	0.66
259_D	341_D	0.658	0.66
44_I	107_V	0.657	0.66
348_K	356_G	0.657	0.66
141_I	242_T	0.656	0.66
162_S	308_A	0.656	0.66
313_V	364_V	0.653	0.65
235_S	239_L	0.653	0.65
221_I	319_H	0.653	0.65
489_A	547_V	0.653	0.65
427_K	460_L	0.652	0.65
242_T	252_I	0.652	0.65
382_F	388_D	0.652	0.65
59_I	63_A	0.651	0.65
411_F	426_V	0.649	0.65
20_S	164_V	0.647	0.65
192_C	224_T	0.645	0.64
257_A	287_V	0.644	0.64
160_S	163_S	0.644	0.64
30_E	234_K	0.641	0.64
398_Q	402_T	0.641	0.64
289_Y	294_I	0.640	0.64
431_V	465_A	0.640	0.64
295_N	298_A	0.640	0.64
282_A	287_V	0.638	0.63
252_I	344_T	0.638	0.63
310_A	395_G	0.637	0.63
11_Q	33_G	0.637	0.63
519_E	522_E	0.636	0.63
428_E	460_L	0.636	0.63
250_R	285_A	0.634	0.63
254_T	342_A	0.634	0.63
63_A	237_A	0.633	0.63
375_K	402_T	0.632	0.63
153_T	176_I	0.631	0.63
140_T	249_P	0.630	0.62
138_I	249_P	0.629	0.62
210_A	324_V	0.629	0.62
342_A	351_G	0.629	0.62
538_G	541_A	0.628	0.62
38_A	74_F	0.628	0.62
164_V	184_L	0.628	0.62
44_I	78_G	0.626	0.62
230_E	233_R	0.626	0.62
262_F	297_V	0.625	0.62
257_A	285_A	0.625	0.62
116_M	136_I	0.624	0.62
299_E	379_A	0.624	0.62
520_E	524_R	0.622	0.62
210_A	342_A	0.622	0.62
346_T	349_T	0.622	0.62
425_K	499_N	0.621	0.61
42_S	78_G	0.621	0.61
22_L	72_F	0.621	0.61
170_A	180_E	0.621	0.61
54_Q	61_K	0.620	0.61
160_S	475_A	0.620	0.61
76_T	129_M	0.620	0.61
363_D	366_H	0.619	0.61
508_E	511_I	0.618	0.61
152_R	157_R	0.618	0.61
22_L	32_F	0.615	0.61
208_S	281_L	0.615	0.61
310_A	396_G	0.615	0.61
379_A	392_I	0.614	0.61
163_S	475_A	0.614	0.61
108_V	138_I	0.614	0.61
39_V	57_G	0.614	0.61
385_L	514_V	0.613	0.60
166_E	477_R	0.612	0.60
397_V	507_I	0.611	0.60
54_Q	73_E	0.611	0.60
303_H	395_G	0.610	0.60
157_R	180_E	0.609	0.60
46_I	107_V	0.609	0.60
263_A	331_L	0.608	0.60
50_H	148_M	0.608	0.60
16_A	181_L	0.608	0.60
490_E	551_N	0.606	0.60
225_S	319_H	0.604	0.59
326_A	365_I	0.604	0.59
217_G	325_S	0.604	0.59
307_L	318_L	0.604	0.59
17_P	165_F	0.603	0.59
166_E	169_G	0.602	0.59
152_R	320_E	0.602	0.59
340_L	355_A	0.601	0.59
408_A	431_V	0.601	0.59
295_N	375_K	0.600	0.59
417_A	432_V	0.600	0.59
164_V	188_G	0.599	0.59
99_I	103_S	0.598	0.59
171_Y	181_L	0.598	0.59
233_R	237_A	0.597	0.58
18_H	86_G	0.596	0.58
23_R	182_Q	0.596	0.58
150_A	196_S	0.595	0.58
330_E	368_L	0.595	0.58
37_I	239_L	0.595	0.58
491_G	496_F	0.594	0.58
121_N	145_G	0.594	0.58
304_L	366_H	0.593	0.58
88_I	109_S	0.593	0.58
208_S	213_L	0.593	0.58
191_T	224_T	0.592	0.58
95_P	539_Y	0.592	0.58
363_D	370_Q	0.592	0.58
213_L	257_A	0.591	0.58
419_D	425_K	0.590	0.57
295_N	382_F	0.590	0.57
513_D	516_V	0.589	0.57
238_Q	345_V	0.588	0.57
490_E	528_W	0.587	0.57
38_A	73_E	0.587	0.57
420_G	499_N	0.586	0.57
304_L	327_A	0.585	0.57
228_R	231_F	0.584	0.57
407_P	514_V	0.584	0.57
25_A	51_V	0.582	0.56
12_G	19_R	0.581	0.56
65_R	70_V	0.581	0.56
421_I	454_Q	0.580	0.56
303_H	372_F	0.579	0.56
304_L	330_E	0.579	0.56
420_G	425_K	0.577	0.56
171_Y	177_N	0.577	0.56
418_L	454_Q	0.576	0.56
522_E	527_N	0.576	0.56
241_E	247_I	0.576	0.56
60_V	239_L	0.575	0.56
222_L	319_H	0.574	0.55
205_N	219_G	0.574	0.55
56_F	119_I	0.574	0.55
56_F	59_I	0.573	0.55
109_S	112_W	0.573	0.55
234_K	238_Q	0.573	0.55
334_K	369_D	0.573	0.55
290_S	551_N	0.573	0.55
58_K	61_K	0.570	0.55
134_M	250_R	0.570	0.55
263_A	339_H	0.570	0.55
392_I	397_V	0.569	0.55
416_E	425_K	0.568	0.55
321_A	365_I	0.567	0.55
329_N	358_E	0.567	0.55
41_N	199_F	0.567	0.55
470_G	554_G	0.567	0.55
272_T	483_H	0.567	0.55
516_V	523_K	0.567	0.55
266_M	298_A	0.566	0.54
84_A	87_H	0.566	0.54
196_S	308_A	0.566	0.54
176_I	184_L	0.565	0.54
330_E	367_P	0.563	0.54
453_S	457_G	0.560	0.54
231_F	235_S	0.557	0.53
23_R	230_E	0.556	0.53
60_V	64_I	0.556	0.53
49_G	125_I	0.555	0.53
346_T	352_E	0.554	0.53
334_K	340_L	0.554	0.53
502_H	514_V	0.554	0.53
191_T	225_S	0.554	0.53
475_A	480_S	0.554	0.53
40_C	78_G	0.554	0.53
135_R	284_E	0.553	0.53
262_F	290_S	0.553	0.53
172_Q	422_I	0.551	0.52
269_G	395_G	0.550	0.52
268_L	318_L	0.550	0.52
12_G	15_R	0.550	0.52
35_P	240_M	0.549	0.52
210_A	338_L	0.548	0.52
130_L	211_L	0.548	0.52
253_V	281_L	0.548	0.52
25_A	70_V	0.548	0.52
344_T	353_T	0.548	0.52
50_H	80_D	0.546	0.52
217_G	221_I	0.546	0.52
132_A	138_I	0.545	0.52
133_A	142_F	0.545	0.52
206_C	315_I	0.544	0.52
411_F	499_N	0.544	0.52
398_Q	479_L	0.544	0.52
385_L	494_L	0.543	0.51
275_V	380_V	0.542	0.51
196_S	314_F	0.542	0.51
44_I	75_N	0.541	0.51
168_V	181_L	0.540	0.51
38_A	107_V	0.540	0.51
434_I	476_S	0.540	0.51
222_L	225_S	0.539	0.51
103_S	107_V	0.538	0.51
389_G	551_N	0.538	0.51
547_V	554_G	0.537	0.51
329_N	354_I	0.536	0.51
409_V	428_E	0.536	0.51
108_V	113_F	0.536	0.51
291_L	389_G	0.535	0.50
239_L	242_T	0.534	0.50
488_A	494_L	0.533	0.50
120_P	189_C	0.533	0.50
303_H	376_G	0.532	0.50
523_K	529_K	0.532	0.50
207_L	219_G	0.532	0.50
392_I	481_I	0.531	0.50
152_R	156_G	0.531	0.50
404_H	479_L	0.531	0.50
157_R	312_D	0.531	0.50
525_K	529_K	0.531	0.50
467_I	503_I	0.530	0.50
267_A	301_V	0.529	0.50
58_K	73_E	0.529	0.50
541_A	546_L	0.528	0.49
289_Y	292_E	0.528	0.49
465_A	479_L	0.528	0.49
243_I	246_D	0.527	0.49
14_D	172_Q	0.527	0.49
327_A	365_I	0.526	0.49
257_A	278_T	0.526	0.49
45_D	51_V	0.526	0.49
379_A	507_I	0.526	0.49
331_L	338_L	0.526	0.49
180_E	183_E	0.524	0.49
294_I	380_V	0.524	0.49
39_V	73_E	0.524	0.49
24_A	29_E	0.523	0.49
384_N	493_P	0.523	0.49
85_M	199_F	0.523	0.49
104_V	118_C	0.522	0.49
401_I	479_L	0.522	0.49
234_K	241_E	0.522	0.49
197_G	449_L	0.520	0.48
179_N	183_E	0.520	0.48
326_A	362_Y	0.520	0.48
75_N	119_I	0.520	0.48
290_S	296_E	0.518	0.48
242_T	251_D	0.518	0.48
138_I	433_I	0.518	0.48
52_H	223_A	0.518	0.48
40_C	75_N	0.518	0.48
84_A	93_S	0.517	0.48
100_I	103_S	0.516	0.48
170_A	173_A	0.516	0.48
147_P	228_R	0.516	0.48
205_N	228_R	0.515	0.48
160_S	164_V	0.514	0.48
168_V	450_A	0.514	0.48
434_I	451_P	0.514	0.48
43_Y	57_G	0.514	0.48
409_V	416_E	0.513	0.48
77_I	107_V	0.513	0.48
495_A	514_V	0.513	0.48
218_N	228_R	0.513	0.48
157_R	160_S	0.512	0.47
397_V	479_L	0.510	0.47
169_G	457_G	0.510	0.47
342_A	353_T	0.510	0.47
275_V	378_L	0.510	0.47
219_G	222_L	0.510	0.47
10_T	72_F	0.509	0.47
128_G	142_F	0.509	0.47
306_K	372_F	0.509	0.47
144_S	214_A	0.509	0.47
140_T	213_L	0.508	0.47
163_S	308_A	0.508	0.47
254_T	287_V	0.508	0.47
61_K	71_P	0.507	0.47
496_F	529_K	0.507	0.47
255_V	339_H	0.507	0.47
404_H	465_A	0.506	0.47
259_D	289_Y	0.506	0.47
222_L	316_E	0.506	0.47
505_V	512_L	0.505	0.46
85_M	165_F	0.504	0.46
373_T	402_T	0.504	0.46
132_A	140_T	0.504	0.46
88_I	112_W	0.503	0.46
266_M	376_G	0.503	0.46
64_I	240_M	0.503	0.46
418_L	422_I	0.503	0.46
88_I	91_R	0.503	0.46
161_L	314_F	0.502	0.46
524_R	527_N	0.502	0.46
27_V	32_F	0.501	0.46
93_S	449_L	0.501	0.46
256_K	296_E	0.501	0.46
313_V	372_F	0.500	0.46
340_L	349_T	0.500	0.46

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2gp4A	2	0.8548	100	0.09	Contact Map
2pcnA	3	0.2527	76.1	0.981	Contact Map
1q5xA	3	0.2509	69.1	0.982	Contact Map
3rfqA	5	0.233	65.9	0.982	Contact Map
1nxjA	3	0.2419	60.1	0.983	Contact Map
1j3lA	3	0.2581	57.1	0.983	Contact Map
3nojA	5	0.3602	55.9	0.983	Contact Map
1vi4A	1	0.2527	45.7	0.984	Contact Map
4lhbA	4	0.2366	44.5	0.984	Contact Map
3c8oA	4	0.2527	44	0.984	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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