GREMLIN Database
CSPD - Cold shock protein CspD
UniProt: P51777 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 66 (62)
Sequences: 4500 (1688)
Seq/√Len: 214.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_V63_V3.5041.00
52_V61_S3.4341.00
50_E62_N2.6261.00
21_E46_E2.1411.00
48_S64_V2.1341.00
3_N48_S2.0491.00
5_K46_E2.0141.00
11_N42_E1.8711.00
3_N46_E1.8301.00
34_E64_V1.8141.00
42_E45_Q1.7081.00
28_V41_L1.6821.00
20_V24_D1.6531.00
54_G59_Q1.5381.00
34_E62_N1.5231.00
20_V23_G1.4911.00
11_N38_Y1.4851.00
32_A61_S1.4831.00
53_E58_P1.4701.00
9_F30_F1.3651.00
54_G58_P1.3201.00
20_V49_F1.3051.00
26_V51_I1.2621.00
33_I38_Y1.2551.00
11_N40_S1.2341.00
5_K19_E1.2121.00
51_I58_P1.1951.00
54_G57_G1.1541.00
3_N21_E1.1301.00
30_F39_K1.0951.00
18_I49_F1.0941.00
52_V59_Q1.0781.00
24_D58_P1.0501.00
33_I39_K0.9300.99
4_G60_A0.9200.99
41_L47_V0.9120.99
33_I36_D0.8910.99
32_A62_N0.8910.99
4_G18_I0.8540.99
32_A52_V0.8330.99
18_I60_A0.8060.98
49_F60_A0.7960.98
7_K25_D0.7700.98
33_I41_L0.7660.98
8_W28_V0.7560.98
5_K21_E0.7480.97
7_K13_K0.7440.97
35_G39_K0.7190.97
30_F33_I0.7140.97
18_I28_V0.7120.97
30_F56_R0.7110.97
33_I63_V0.7020.96
19_E44_G0.6990.96
30_F38_Y0.6900.96
36_D64_V0.6770.95
20_V51_I0.6750.95
10_N27_F0.6750.95
35_G38_Y0.6590.95
8_W43_E0.6510.94
26_V60_A0.6290.93
4_G49_F0.6190.93
14_G25_D0.6160.93
53_E56_R0.5980.92
51_I61_S0.5940.91
13_K25_D0.5940.91
50_E61_S0.5920.91
41_L45_Q0.5860.91
34_E39_K0.5840.91
18_I47_V0.5640.89
55_N58_P0.5630.89
17_F27_F0.5630.89
40_S45_Q0.5590.89
32_A59_Q0.5570.88
14_G33_I0.5560.88
55_N59_Q0.5520.88
36_D39_K0.5510.88
4_G47_V0.5490.88
18_I31_T0.5490.88
8_W13_K0.5470.88
38_Y42_E0.5440.87
26_V52_V0.5400.87
11_N36_D0.5400.87
15_F41_L0.5350.86
17_F44_G0.5310.86
31_T56_R0.5310.86
12_E45_Q0.5300.86
36_D47_V0.5270.86
16_G28_V0.5260.85
13_K37_G0.5260.85
38_Y63_V0.5230.85
24_D53_E0.5150.84
53_E59_Q0.5120.84
3_N42_E0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2lxjA 1 1 99.8 0.128 Contact Map
1c9oA 2 1 99.8 0.139 Contact Map
3camA 2 1 99.8 0.139 Contact Map
3a0jA 1 1 99.8 0.154 Contact Map
1g6pA 1 0.9848 99.8 0.164 Contact Map
3i2zB 2 1 99.8 0.165 Contact Map
3uljA 3 1 99.7 0.176 Contact Map
2mqhA 1 0.9697 99.7 0.182 Contact Map
2lssA 1 1 99.7 0.189 Contact Map
3ts2A 1 1 99.7 0.19 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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