CLPX - BACSU - GREMLIN Contacts

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CLPX - ATP-dependent Clp protease ATP-binding subunit ClpX

UniProt:	P50866	Sequences: MFKFNEEKGQLKCSFCGKTQDQVRKLVAGPGVYICDECIELCTEIVEEELGTEEEVEFKDVPKPQEIREILNEYVIGQDQAKKSLAVAVYNHYKRINSNSKVDDVELSKSNISLIGPTGSGKTLLAQTLARILNVPFAIADATSLTEAGYVGEDVENILLKLIQAADYDVEKAEKGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVASVPPQGGRKHPHQEFIQIDTTNILFICGGAFDGIEQIIKRRLGQKVIGFGADNKAADLEKEDLLSKVLPEDLLRFGLIPEFIGRLPVIASLEKLDEEALVAILTKPKNALVKQFKKMLELDNVELEFEEEALSEIAKKAIERKTGARGLRSIIEGIMLDVMFELPSRDDIEKCVITGATVTHGEPPRLLLKDGTEVSQDKTSA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	420 (336)
Sequences:	8247 (4198)
Seq/√Len:	229.0

ECOLI - CLPX CLPB CLPA
BACSU - CLPX CLPC CLPE

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
313_E	354_K	5.316	1.00
321_T	349_L	4.871	1.00
317_V	350_S	4.296	1.00
312_D	315_A	3.767	1.00
387_I	390_C	3.717	1.00
66_E	69_E	3.642	1.00
313_E	350_S	3.568	1.00
390_C	393_T	3.208	1.00
72_N	79_D	3.205	1.00
70_I	73_E	3.200	1.00
216_V	226_K	3.102	1.00
329_K	332_K	2.740	1.00
87_V	380_E	2.615	1.00
67_I	132_I	2.498	1.00
87_V	376_D	2.495	1.00
281_L	285_L	2.380	1.00
38_C	41_L	2.341	1.00
70_I	132_I	2.317	1.00
351_E	355_K	2.315	1.00
111_N	212_L	2.287	1.00
345_E	393_T	2.270	1.00
281_L	284_V	2.234	1.00
381_L	386_D	2.181	1.00
236_D	302_L	2.150	1.00
159_L	235_I	2.147	1.00
68_R	72_N	2.132	1.00
149_G	152_G	2.124	1.00
68_R	83_K	2.107	1.00
355_K	373_I	2.104	1.00
343_E	389_K	2.089	1.00
341_E	389_K	1.967	1.00
328_V	344_F	1.922	1.00
277_K	281_L	1.917	1.00
317_V	346_E	1.916	1.00
240_I	292_F	1.869	1.00
277_K	280_L	1.843	1.00
336_E	341_E	1.797	1.00
18_K	22_Q	1.787	1.00
136_P	173_A	1.785	1.00
74_Y	131_R	1.781	1.00
126_A	235_I	1.771	1.00
253_Q	256_K	1.769	1.00
387_I	393_T	1.719	1.00
333_K	336_E	1.711	1.00
369_I	373_I	1.697	1.00
113_S	302_L	1.671	1.00
17_G	20_Q	1.652	1.00
315_A	318_A	1.645	1.00
331_F	370_I	1.643	1.00
317_V	349_L	1.638	1.00
152_G	155_V	1.633	1.00
20_Q	27_V	1.622	1.00
72_N	82_K	1.619	1.00
351_E	354_K	1.605	1.00
171_E	174_E	1.604	1.00
15_F	19_T	1.582	1.00
327_L	367_R	1.566	1.00
58_F	66_E	1.559	1.00
74_Y	128_T	1.543	1.00
65_Q	383_S	1.540	1.00
327_L	330_Q	1.534	1.00
82_K	125_L	1.532	1.00
138_A	176_G	1.531	1.00
278_E	281_L	1.524	1.00
68_R	90_Y	1.522	1.00
309_E	315_A	1.518	1.00
80_Q	309_E	1.517	1.00
76_I	326_A	1.511	1.00
65_Q	380_E	1.503	1.00
92_H	97_N	1.498	1.00
211_I	234_Q	1.489	1.00
346_E	350_S	1.488	1.00
17_G	21_D	1.487	1.00
279_D	282_S	1.483	1.00
351_E	373_I	1.479	1.00
320_L	349_L	1.476	1.00
288_D	291_R	1.469	1.00
66_E	70_I	1.460	1.00
355_K	369_I	1.457	1.00
352_I	369_I	1.455	1.00
21_D	25_K	1.447	1.00
68_R	86_A	1.428	1.00
208_L	211_I	1.424	1.00
108_S	127_Q	1.423	1.00
148_A	189_K	1.420	1.00
332_K	341_E	1.410	1.00
74_Y	124_L	1.381	1.00
152_G	157_N	1.365	1.00
316_L	353_A	1.364	1.00
113_S	289_L	1.361	1.00
344_F	348_A	1.348	1.00
19_T	22_Q	1.345	1.00
19_T	27_V	1.337	1.00
99_N	334_M	1.333	1.00
154_D	157_N	1.332	1.00
155_V	207_A	1.330	1.00
240_I	289_L	1.327	1.00
282_S	285_L	1.326	1.00
20_Q	23_V	1.314	1.00
318_A	321_T	1.301	1.00
20_Q	24_R	1.297	1.00
321_T	346_E	1.293	1.00
387_I	391_V	1.281	1.00
332_K	336_E	1.262	1.00
22_Q	26_L	1.260	1.00
287_E	290_L	1.256	1.00
67_I	86_A	1.256	1.00
153_E	157_N	1.256	1.00
345_E	348_A	1.251	1.00
27_V	30_P	1.233	1.00
344_F	349_L	1.223	1.00
320_L	353_A	1.219	1.00
65_Q	384_R	1.217	1.00
373_I	377_V	1.216	1.00
115_I	238_T	1.209	1.00
128_T	131_R	1.208	1.00
146_T	150_Y	1.203	1.00
113_S	183_I	1.200	1.00
356_A	366_L	1.198	1.00
317_V	321_T	1.194	1.00
150_Y	153_E	1.189	1.00
85_L	125_L	1.183	1.00
150_Y	154_D	1.179	1.00
163_I	235_I	1.179	1.00
211_I	217_A	1.179	1.00
24_R	27_V	1.177	1.00
289_L	299_I	1.173	1.00
380_E	384_R	1.173	1.00
71_L	75_V	1.169	1.00
377_V	381_L	1.161	1.00
23_V	27_V	1.160	1.00
387_I	392_I	1.160	1.00
174_E	236_D	1.158	1.00
345_E	391_V	1.157	1.00
347_E	350_S	1.146	1.00
37_E	42_C	1.134	1.00
381_L	384_R	1.133	1.00
280_L	284_V	1.132	1.00
15_F	18_K	1.131	1.00
97_N	109_K	1.128	1.00
74_Y	134_N	1.125	1.00
19_T	23_V	1.121	1.00
45_I	49_E	1.120	1.00
23_V	26_L	1.120	1.00
317_V	353_A	1.119	1.00
21_D	24_R	1.116	1.00
149_G	153_E	1.116	1.00
114_L	235_I	1.116	1.00
356_A	369_I	1.108	1.00
276_E	279_D	1.104	1.00
69_E	72_N	1.103	1.00
328_V	370_I	1.103	1.00
19_T	26_L	1.101	1.00
44_E	54_E	1.098	1.00
24_R	28_A	1.097	1.00
159_L	178_I	1.092	1.00
332_K	342_L	1.088	1.00
213_E	367_R	1.084	1.00
62_P	66_E	1.078	1.00
163_I	170_V	1.072	1.00
90_Y	380_E	1.071	1.00
79_D	315_A	1.067	1.00
313_E	353_A	1.063	1.00
145_L	165_A	1.051	1.00
69_E	73_E	1.042	1.00
90_Y	376_D	1.041	1.00
59_K	62_P	1.039	1.00
280_L	285_L	1.036	1.00
320_L	370_I	1.036	1.00
84_S	306_A	1.032	1.00
386_D	390_C	1.026	1.00
83_K	87_V	0.999	1.00
17_G	27_V	0.999	1.00
314_E	317_V	0.993	1.00
314_E	350_S	0.990	1.00
330_Q	333_K	0.988	1.00
170_V	232_F	0.986	1.00
329_K	333_K	0.985	1.00
18_K	21_D	0.981	1.00
18_K	27_V	0.980	1.00
64_P	93_Y	0.978	1.00
137_F	177_I	0.968	1.00
388_E	391_V	0.967	1.00
278_E	284_V	0.966	1.00
146_T	192_N	0.965	1.00
133_L	233_I	0.960	1.00
170_V	229_H	0.959	1.00
150_Y	157_N	0.958	1.00
149_G	154_D	0.958	1.00
96_I	331_F	0.957	1.00
146_T	189_K	0.956	1.00
150_Y	155_V	0.946	1.00
148_A	153_E	0.942	1.00
22_Q	25_K	0.935	1.00
91_N	376_D	0.932	1.00
344_F	374_M	0.926	1.00
149_G	157_N	0.924	1.00
287_E	291_R	0.923	1.00
41_L	44_E	0.921	1.00
343_E	346_E	0.916	1.00
124_L	128_T	0.914	1.00
331_F	375_L	0.912	1.00
328_V	349_L	0.910	1.00
25_K	29_G	0.906	0.99
229_H	232_F	0.901	0.99
350_S	354_K	0.896	0.99
279_D	283_K	0.890	0.99
389_K	393_T	0.890	0.99
20_Q	26_L	0.889	0.99
36_D	41_L	0.888	0.99
298_F	302_L	0.885	0.99
79_D	83_K	0.884	0.99
294_L	298_F	0.883	0.99
321_T	332_K	0.881	0.99
375_L	379_F	0.877	0.99
16_C	20_Q	0.874	0.99
71_L	128_T	0.870	0.99
351_E	369_I	0.867	0.99
313_E	357_I	0.865	0.99
34_I	38_C	0.864	0.99
355_K	358_E	0.859	0.99
278_E	285_L	0.858	0.99
80_Q	281_L	0.858	0.99
140_A	178_I	0.855	0.99
328_V	332_K	0.855	0.99
358_E	365_G	0.854	0.99
327_L	370_I	0.852	0.99
138_A	170_V	0.850	0.99
278_E	282_S	0.850	0.99
334_M	375_L	0.848	0.99
327_L	366_L	0.840	0.99
16_C	27_V	0.840	0.99
344_F	370_I	0.839	0.99
58_F	62_P	0.838	0.99
99_N	337_L	0.837	0.99
316_L	357_I	0.835	0.99
107_L	367_R	0.835	0.99
290_L	361_T	0.834	0.99
343_E	391_V	0.832	0.99
321_T	329_K	0.832	0.99
277_K	309_E	0.830	0.99
98_S	106_E	0.828	0.99
340_V	387_I	0.826	0.99
17_G	26_L	0.820	0.99
68_R	379_F	0.815	0.99
72_N	315_A	0.808	0.99
76_I	318_A	0.807	0.99
146_T	207_A	0.802	0.99
86_A	90_Y	0.800	0.99
83_K	86_A	0.800	0.99
90_Y	383_S	0.800	0.99
168_Y	172_K	0.794	0.99
220_P	227_H	0.792	0.99
304_V	371_E	0.792	0.99
89_V	133_L	0.791	0.99
275_L	279_D	0.791	0.99
140_A	154_D	0.789	0.99
72_N	83_K	0.789	0.99
347_E	393_T	0.783	0.98
352_I	370_I	0.783	0.98
332_K	335_L	0.780	0.98
289_L	305_I	0.779	0.98
15_F	26_L	0.777	0.98
169_D	173_A	0.777	0.98
151_V	190_S	0.775	0.98
281_L	307_S	0.775	0.98
98_S	330_Q	0.773	0.98
280_L	283_K	0.769	0.98
32_V	35_C	0.768	0.98
114_L	308_L	0.766	0.98
316_L	320_L	0.762	0.98
127_Q	214_G	0.758	0.98
43_T	47_E	0.757	0.98
277_K	285_L	0.757	0.98
16_C	26_L	0.757	0.98
138_A	169_D	0.757	0.98
71_L	86_A	0.750	0.98
106_E	131_R	0.745	0.98
16_C	19_T	0.744	0.98
254_I	288_D	0.741	0.98
340_V	382_P	0.740	0.98
34_I	41_L	0.738	0.98
64_P	90_Y	0.738	0.98
376_D	380_E	0.735	0.98
340_V	381_L	0.734	0.98
209_L	297_E	0.734	0.98
18_K	23_V	0.731	0.98
24_R	36_D	0.729	0.98
313_E	317_V	0.729	0.98
183_I	240_I	0.727	0.98
300_G	368_S	0.726	0.98
218_S	232_F	0.724	0.98
142_A	180_I	0.724	0.98
171_E	175_K	0.717	0.97
96_I	126_A	0.717	0.97
144_S	229_H	0.717	0.97
47_E	53_E	0.717	0.97
149_G	155_V	0.714	0.97
98_S	107_L	0.714	0.97
328_V	374_M	0.713	0.97
228_P	231_E	0.710	0.97
332_K	344_F	0.710	0.97
125_L	308_L	0.707	0.97
180_I	211_I	0.706	0.97
124_L	327_L	0.705	0.97
138_A	178_I	0.705	0.97
151_V	207_A	0.702	0.97
73_E	329_K	0.697	0.97
139_I	214_G	0.695	0.97
352_I	374_M	0.694	0.97
26_L	30_P	0.694	0.97
17_G	23_V	0.693	0.97
115_I	240_I	0.691	0.97
80_Q	282_S	0.690	0.97
94_K	338_D	0.686	0.97
352_I	356_A	0.683	0.96
288_D	292_F	0.682	0.96
381_L	385_D	0.682	0.96
253_Q	257_R	0.682	0.96
75_V	128_T	0.681	0.96
348_A	374_M	0.679	0.96
304_V	372_G	0.678	0.96
97_N	375_L	0.677	0.96
352_I	373_I	0.675	0.96
139_I	213_E	0.672	0.96
71_L	77_G	0.671	0.96
167_D	227_H	0.671	0.96
370_I	374_M	0.669	0.96
106_E	135_V	0.668	0.96
240_I	288_D	0.664	0.96
153_E	220_P	0.664	0.96
87_V	372_G	0.664	0.96
15_F	21_D	0.662	0.96
367_R	371_E	0.662	0.96
180_I	236_D	0.662	0.96
253_Q	288_D	0.661	0.96
229_H	234_Q	0.660	0.96
18_K	24_R	0.657	0.96
81_A	306_A	0.657	0.96
207_A	217_A	0.656	0.96
59_K	134_N	0.654	0.95
153_E	218_S	0.652	0.95
106_E	330_Q	0.652	0.95
280_L	309_E	0.651	0.95
72_N	309_E	0.651	0.95
277_K	284_V	0.649	0.95
148_A	155_V	0.646	0.95
51_G	56_V	0.645	0.95
21_D	27_V	0.645	0.95
347_E	351_E	0.644	0.95
98_S	334_M	0.644	0.95
349_L	366_L	0.643	0.95
149_G	160_L	0.638	0.95
212_L	298_F	0.637	0.95
285_L	289_L	0.637	0.95
321_T	344_F	0.637	0.95
91_N	375_L	0.634	0.95
148_A	152_G	0.631	0.95
157_N	162_L	0.630	0.94
381_L	387_I	0.629	0.94
60_D	93_Y	0.629	0.94
336_E	339_N	0.627	0.94
132_I	326_A	0.627	0.94
75_V	139_I	0.627	0.94
276_E	284_V	0.626	0.94
39_I	55_E	0.624	0.94
115_I	289_L	0.623	0.94
98_S	230_Q	0.623	0.94
71_L	82_K	0.623	0.94
131_R	134_N	0.620	0.94
45_I	48_E	0.618	0.94
25_K	28_A	0.618	0.94
83_K	376_D	0.614	0.94
220_P	223_G	0.613	0.94
235_I	240_I	0.612	0.94
217_A	220_P	0.611	0.94
216_V	230_Q	0.611	0.94
326_A	329_K	0.611	0.94
80_Q	83_K	0.609	0.93
68_R	79_D	0.606	0.93
26_L	29_G	0.605	0.93
33_Y	36_D	0.605	0.93
188_R	295_I	0.604	0.93
16_C	23_V	0.603	0.93
282_S	287_E	0.603	0.93
114_L	306_A	0.603	0.93
167_D	217_A	0.602	0.93
183_I	294_L	0.602	0.93
23_V	30_P	0.602	0.93
346_E	349_L	0.599	0.93
157_N	180_I	0.597	0.93
267_G	270_N	0.597	0.93
146_T	375_L	0.596	0.93
134_N	172_K	0.596	0.93
276_E	281_L	0.592	0.92
62_P	65_Q	0.591	0.92
28_A	31_G	0.591	0.92
294_L	302_L	0.590	0.92
120_S	124_L	0.588	0.92
348_A	351_E	0.588	0.92
146_T	155_V	0.587	0.92
212_L	234_Q	0.585	0.92
355_K	372_G	0.585	0.92
33_Y	37_E	0.583	0.92
275_L	278_E	0.583	0.92
70_I	128_T	0.582	0.92
147_E	152_G	0.581	0.92
335_L	339_N	0.578	0.92
171_E	225_R	0.577	0.91
137_F	178_I	0.577	0.91
24_R	30_P	0.573	0.91
64_P	68_R	0.572	0.91
15_F	20_Q	0.571	0.91
53_E	56_V	0.571	0.91
40_E	43_T	0.570	0.91
87_V	90_Y	0.570	0.91
333_K	337_L	0.570	0.91
47_E	56_V	0.569	0.91
342_L	374_M	0.568	0.91
332_K	343_E	0.567	0.91
15_F	27_V	0.566	0.91
157_N	160_L	0.565	0.91
151_V	157_N	0.564	0.91
18_K	37_E	0.563	0.90
23_V	29_G	0.562	0.90
320_L	366_L	0.561	0.90
92_H	109_K	0.559	0.90
153_E	192_N	0.559	0.90
189_K	192_N	0.556	0.90
299_I	305_I	0.555	0.90
276_E	280_L	0.554	0.90
218_S	234_Q	0.552	0.90
339_N	389_K	0.552	0.90
88_A	109_K	0.550	0.89
163_I	168_Y	0.549	0.89
159_L	211_I	0.549	0.89
212_L	302_L	0.548	0.89
178_I	232_F	0.547	0.89
320_L	344_F	0.546	0.89
174_E	239_N	0.546	0.89
216_V	234_Q	0.545	0.89
159_L	163_I	0.545	0.89
314_E	347_E	0.543	0.89
163_I	166_A	0.542	0.89
94_K	382_P	0.542	0.89
384_R	387_I	0.540	0.89
32_V	37_E	0.538	0.88
388_E	393_T	0.538	0.88
47_E	50_L	0.536	0.88
15_F	23_V	0.536	0.88
28_A	33_Y	0.536	0.88
146_T	151_V	0.534	0.88
46_V	53_E	0.533	0.88
35_C	87_V	0.533	0.88
35_C	75_V	0.528	0.87
145_L	153_E	0.528	0.87
213_E	298_F	0.527	0.87
80_Q	84_S	0.527	0.87
321_T	326_A	0.526	0.87
46_V	49_E	0.523	0.87
126_A	188_R	0.523	0.87
332_K	340_V	0.523	0.87
153_E	165_A	0.522	0.87
285_L	290_L	0.521	0.87
178_I	217_A	0.519	0.87
27_V	31_G	0.519	0.87
137_F	176_G	0.517	0.86
181_D	301_R	0.516	0.86
140_A	207_A	0.515	0.86
85_L	114_L	0.514	0.86
173_A	176_G	0.514	0.86
27_V	32_V	0.514	0.86
152_G	220_P	0.511	0.86
61_V	65_Q	0.511	0.86
163_I	219_V	0.511	0.86
160_L	220_P	0.510	0.86
25_K	30_P	0.510	0.86
119_G	362_G	0.509	0.86
367_R	376_D	0.509	0.86
335_L	340_V	0.509	0.86
389_K	392_I	0.509	0.86
214_G	226_K	0.508	0.85
44_E	48_E	0.507	0.85
306_A	310_K	0.507	0.85
107_L	213_E	0.507	0.85
192_N	295_I	0.506	0.85
44_E	135_V	0.506	0.85
30_P	33_Y	0.506	0.85
146_T	220_P	0.505	0.85
22_Q	27_V	0.504	0.85
329_K	336_E	0.504	0.85
161_K	223_G	0.504	0.85
75_V	82_K	0.504	0.85
261_Q	269_D	0.503	0.85
48_E	61_V	0.503	0.85
17_G	24_R	0.503	0.85
89_V	129_L	0.502	0.85
223_G	340_V	0.502	0.85
311_L	316_L	0.501	0.85
61_V	376_D	0.501	0.85
317_V	320_L	0.501	0.85
164_Q	168_Y	0.501	0.85
254_I	259_L	0.500	0.85
264_I	268_A	0.500	0.85

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1r6bX	1	0.8095	100	0.494	Contact Map
1qvrA	3	0.8214	100	0.521	Contact Map
3pxiA	3	0.7452	100	0.537	Contact Map
4d2uA	3	0.8214	100	0.546	Contact Map
4ciuA	1	0.819	100	0.584	Contact Map
1um8A	1	0.7429	100	0.612	Contact Map
3hwsA	3	0.7976	100	0.634	Contact Map
4lj9A	1	0.769	100	0.637	Contact Map
1g41A	3	0.7119	100	0.674	Contact Map
1ofhA	3	0.7167	100	0.694	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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