GREMLIN Database
CLPX - ATP-dependent Clp protease ATP-binding subunit ClpX
UniProt: P50866 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 420 (336)
Sequences: 8247 (4198)
Seq/√Len: 229.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
313_E354_K5.3161.00
321_T349_L4.8711.00
317_V350_S4.2961.00
312_D315_A3.7671.00
387_I390_C3.7171.00
66_E69_E3.6421.00
313_E350_S3.5681.00
390_C393_T3.2081.00
72_N79_D3.2051.00
70_I73_E3.2001.00
216_V226_K3.1021.00
329_K332_K2.7401.00
87_V380_E2.6151.00
67_I132_I2.4981.00
87_V376_D2.4951.00
281_L285_L2.3801.00
38_C41_L2.3411.00
70_I132_I2.3171.00
351_E355_K2.3151.00
111_N212_L2.2871.00
345_E393_T2.2701.00
281_L284_V2.2341.00
381_L386_D2.1811.00
236_D302_L2.1501.00
159_L235_I2.1471.00
68_R72_N2.1321.00
149_G152_G2.1241.00
68_R83_K2.1071.00
355_K373_I2.1041.00
343_E389_K2.0891.00
341_E389_K1.9671.00
328_V344_F1.9221.00
277_K281_L1.9171.00
317_V346_E1.9161.00
240_I292_F1.8691.00
277_K280_L1.8431.00
336_E341_E1.7971.00
18_K22_Q1.7871.00
136_P173_A1.7851.00
74_Y131_R1.7811.00
126_A235_I1.7711.00
253_Q256_K1.7691.00
387_I393_T1.7191.00
333_K336_E1.7111.00
369_I373_I1.6971.00
113_S302_L1.6711.00
17_G20_Q1.6521.00
315_A318_A1.6451.00
331_F370_I1.6431.00
317_V349_L1.6381.00
152_G155_V1.6331.00
20_Q27_V1.6221.00
72_N82_K1.6191.00
351_E354_K1.6051.00
171_E174_E1.6041.00
15_F19_T1.5821.00
327_L367_R1.5661.00
58_F66_E1.5591.00
74_Y128_T1.5431.00
65_Q383_S1.5401.00
327_L330_Q1.5341.00
82_K125_L1.5321.00
138_A176_G1.5311.00
278_E281_L1.5241.00
68_R90_Y1.5221.00
309_E315_A1.5181.00
80_Q309_E1.5171.00
76_I326_A1.5111.00
65_Q380_E1.5031.00
92_H97_N1.4981.00
211_I234_Q1.4891.00
346_E350_S1.4881.00
17_G21_D1.4871.00
279_D282_S1.4831.00
351_E373_I1.4791.00
320_L349_L1.4761.00
288_D291_R1.4691.00
66_E70_I1.4601.00
355_K369_I1.4571.00
352_I369_I1.4551.00
21_D25_K1.4471.00
68_R86_A1.4281.00
208_L211_I1.4241.00
108_S127_Q1.4231.00
148_A189_K1.4201.00
332_K341_E1.4101.00
74_Y124_L1.3811.00
152_G157_N1.3651.00
316_L353_A1.3641.00
113_S289_L1.3611.00
344_F348_A1.3481.00
19_T22_Q1.3451.00
19_T27_V1.3371.00
99_N334_M1.3331.00
154_D157_N1.3321.00
155_V207_A1.3301.00
240_I289_L1.3271.00
282_S285_L1.3261.00
20_Q23_V1.3141.00
318_A321_T1.3011.00
20_Q24_R1.2971.00
321_T346_E1.2931.00
387_I391_V1.2811.00
332_K336_E1.2621.00
22_Q26_L1.2601.00
287_E290_L1.2561.00
67_I86_A1.2561.00
153_E157_N1.2561.00
345_E348_A1.2511.00
27_V30_P1.2331.00
344_F349_L1.2231.00
320_L353_A1.2191.00
65_Q384_R1.2171.00
373_I377_V1.2161.00
115_I238_T1.2091.00
128_T131_R1.2081.00
146_T150_Y1.2031.00
113_S183_I1.2001.00
356_A366_L1.1981.00
317_V321_T1.1941.00
150_Y153_E1.1891.00
85_L125_L1.1831.00
150_Y154_D1.1791.00
163_I235_I1.1791.00
211_I217_A1.1791.00
24_R27_V1.1771.00
289_L299_I1.1731.00
380_E384_R1.1731.00
71_L75_V1.1691.00
377_V381_L1.1611.00
23_V27_V1.1601.00
387_I392_I1.1601.00
174_E236_D1.1581.00
345_E391_V1.1571.00
347_E350_S1.1461.00
37_E42_C1.1341.00
381_L384_R1.1331.00
280_L284_V1.1321.00
15_F18_K1.1311.00
97_N109_K1.1281.00
74_Y134_N1.1251.00
19_T23_V1.1211.00
45_I49_E1.1201.00
23_V26_L1.1201.00
317_V353_A1.1191.00
21_D24_R1.1161.00
149_G153_E1.1161.00
114_L235_I1.1161.00
356_A369_I1.1081.00
276_E279_D1.1041.00
69_E72_N1.1031.00
328_V370_I1.1031.00
19_T26_L1.1011.00
44_E54_E1.0981.00
24_R28_A1.0971.00
159_L178_I1.0921.00
332_K342_L1.0881.00
213_E367_R1.0841.00
62_P66_E1.0781.00
163_I170_V1.0721.00
90_Y380_E1.0711.00
79_D315_A1.0671.00
313_E353_A1.0631.00
145_L165_A1.0511.00
69_E73_E1.0421.00
90_Y376_D1.0411.00
59_K62_P1.0391.00
280_L285_L1.0361.00
320_L370_I1.0361.00
84_S306_A1.0321.00
386_D390_C1.0261.00
83_K87_V0.9991.00
17_G27_V0.9991.00
314_E317_V0.9931.00
314_E350_S0.9901.00
330_Q333_K0.9881.00
170_V232_F0.9861.00
329_K333_K0.9851.00
18_K21_D0.9811.00
18_K27_V0.9801.00
64_P93_Y0.9781.00
137_F177_I0.9681.00
388_E391_V0.9671.00
278_E284_V0.9661.00
146_T192_N0.9651.00
133_L233_I0.9601.00
170_V229_H0.9591.00
150_Y157_N0.9581.00
149_G154_D0.9581.00
96_I331_F0.9571.00
146_T189_K0.9561.00
150_Y155_V0.9461.00
148_A153_E0.9421.00
22_Q25_K0.9351.00
91_N376_D0.9321.00
344_F374_M0.9261.00
149_G157_N0.9241.00
287_E291_R0.9231.00
41_L44_E0.9211.00
343_E346_E0.9161.00
124_L128_T0.9141.00
331_F375_L0.9121.00
328_V349_L0.9101.00
25_K29_G0.9060.99
229_H232_F0.9010.99
350_S354_K0.8960.99
279_D283_K0.8900.99
389_K393_T0.8900.99
20_Q26_L0.8890.99
36_D41_L0.8880.99
298_F302_L0.8850.99
79_D83_K0.8840.99
294_L298_F0.8830.99
321_T332_K0.8810.99
375_L379_F0.8770.99
16_C20_Q0.8740.99
71_L128_T0.8700.99
351_E369_I0.8670.99
313_E357_I0.8650.99
34_I38_C0.8640.99
355_K358_E0.8590.99
278_E285_L0.8580.99
80_Q281_L0.8580.99
140_A178_I0.8550.99
328_V332_K0.8550.99
358_E365_G0.8540.99
327_L370_I0.8520.99
138_A170_V0.8500.99
278_E282_S0.8500.99
334_M375_L0.8480.99
327_L366_L0.8400.99
16_C27_V0.8400.99
344_F370_I0.8390.99
58_F62_P0.8380.99
99_N337_L0.8370.99
316_L357_I0.8350.99
107_L367_R0.8350.99
290_L361_T0.8340.99
343_E391_V0.8320.99
321_T329_K0.8320.99
277_K309_E0.8300.99
98_S106_E0.8280.99
340_V387_I0.8260.99
17_G26_L0.8200.99
68_R379_F0.8150.99
72_N315_A0.8080.99
76_I318_A0.8070.99
146_T207_A0.8020.99
86_A90_Y0.8000.99
83_K86_A0.8000.99
90_Y383_S0.8000.99
168_Y172_K0.7940.99
220_P227_H0.7920.99
304_V371_E0.7920.99
89_V133_L0.7910.99
275_L279_D0.7910.99
140_A154_D0.7890.99
72_N83_K0.7890.99
347_E393_T0.7830.98
352_I370_I0.7830.98
332_K335_L0.7800.98
289_L305_I0.7790.98
15_F26_L0.7770.98
169_D173_A0.7770.98
151_V190_S0.7750.98
281_L307_S0.7750.98
98_S330_Q0.7730.98
280_L283_K0.7690.98
32_V35_C0.7680.98
114_L308_L0.7660.98
316_L320_L0.7620.98
127_Q214_G0.7580.98
43_T47_E0.7570.98
277_K285_L0.7570.98
16_C26_L0.7570.98
138_A169_D0.7570.98
71_L86_A0.7500.98
106_E131_R0.7450.98
16_C19_T0.7440.98
254_I288_D0.7410.98
340_V382_P0.7400.98
34_I41_L0.7380.98
64_P90_Y0.7380.98
376_D380_E0.7350.98
340_V381_L0.7340.98
209_L297_E0.7340.98
18_K23_V0.7310.98
24_R36_D0.7290.98
313_E317_V0.7290.98
183_I240_I0.7270.98
300_G368_S0.7260.98
218_S232_F0.7240.98
142_A180_I0.7240.98
171_E175_K0.7170.97
96_I126_A0.7170.97
144_S229_H0.7170.97
47_E53_E0.7170.97
149_G155_V0.7140.97
98_S107_L0.7140.97
328_V374_M0.7130.97
228_P231_E0.7100.97
332_K344_F0.7100.97
125_L308_L0.7070.97
180_I211_I0.7060.97
124_L327_L0.7050.97
138_A178_I0.7050.97
151_V207_A0.7020.97
73_E329_K0.6970.97
139_I214_G0.6950.97
352_I374_M0.6940.97
26_L30_P0.6940.97
17_G23_V0.6930.97
115_I240_I0.6910.97
80_Q282_S0.6900.97
94_K338_D0.6860.97
352_I356_A0.6830.96
288_D292_F0.6820.96
381_L385_D0.6820.96
253_Q257_R0.6820.96
75_V128_T0.6810.96
348_A374_M0.6790.96
304_V372_G0.6780.96
97_N375_L0.6770.96
352_I373_I0.6750.96
139_I213_E0.6720.96
71_L77_G0.6710.96
167_D227_H0.6710.96
370_I374_M0.6690.96
106_E135_V0.6680.96
240_I288_D0.6640.96
153_E220_P0.6640.96
87_V372_G0.6640.96
15_F21_D0.6620.96
367_R371_E0.6620.96
180_I236_D0.6620.96
253_Q288_D0.6610.96
229_H234_Q0.6600.96
18_K24_R0.6570.96
81_A306_A0.6570.96
207_A217_A0.6560.96
59_K134_N0.6540.95
153_E218_S0.6520.95
106_E330_Q0.6520.95
280_L309_E0.6510.95
72_N309_E0.6510.95
277_K284_V0.6490.95
148_A155_V0.6460.95
51_G56_V0.6450.95
21_D27_V0.6450.95
347_E351_E0.6440.95
98_S334_M0.6440.95
349_L366_L0.6430.95
149_G160_L0.6380.95
212_L298_F0.6370.95
285_L289_L0.6370.95
321_T344_F0.6370.95
91_N375_L0.6340.95
148_A152_G0.6310.95
157_N162_L0.6300.94
381_L387_I0.6290.94
60_D93_Y0.6290.94
336_E339_N0.6270.94
132_I326_A0.6270.94
75_V139_I0.6270.94
276_E284_V0.6260.94
39_I55_E0.6240.94
115_I289_L0.6230.94
98_S230_Q0.6230.94
71_L82_K0.6230.94
131_R134_N0.6200.94
45_I48_E0.6180.94
25_K28_A0.6180.94
83_K376_D0.6140.94
220_P223_G0.6130.94
235_I240_I0.6120.94
217_A220_P0.6110.94
216_V230_Q0.6110.94
326_A329_K0.6110.94
80_Q83_K0.6090.93
68_R79_D0.6060.93
26_L29_G0.6050.93
33_Y36_D0.6050.93
188_R295_I0.6040.93
16_C23_V0.6030.93
282_S287_E0.6030.93
114_L306_A0.6030.93
167_D217_A0.6020.93
183_I294_L0.6020.93
23_V30_P0.6020.93
346_E349_L0.5990.93
157_N180_I0.5970.93
267_G270_N0.5970.93
146_T375_L0.5960.93
134_N172_K0.5960.93
276_E281_L0.5920.92
62_P65_Q0.5910.92
28_A31_G0.5910.92
294_L302_L0.5900.92
120_S124_L0.5880.92
348_A351_E0.5880.92
146_T155_V0.5870.92
212_L234_Q0.5850.92
355_K372_G0.5850.92
33_Y37_E0.5830.92
275_L278_E0.5830.92
70_I128_T0.5820.92
147_E152_G0.5810.92
335_L339_N0.5780.92
171_E225_R0.5770.91
137_F178_I0.5770.91
24_R30_P0.5730.91
64_P68_R0.5720.91
15_F20_Q0.5710.91
53_E56_V0.5710.91
40_E43_T0.5700.91
87_V90_Y0.5700.91
333_K337_L0.5700.91
47_E56_V0.5690.91
342_L374_M0.5680.91
332_K343_E0.5670.91
15_F27_V0.5660.91
157_N160_L0.5650.91
151_V157_N0.5640.91
18_K37_E0.5630.90
23_V29_G0.5620.90
320_L366_L0.5610.90
92_H109_K0.5590.90
153_E192_N0.5590.90
189_K192_N0.5560.90
299_I305_I0.5550.90
276_E280_L0.5540.90
218_S234_Q0.5520.90
339_N389_K0.5520.90
88_A109_K0.5500.89
163_I168_Y0.5490.89
159_L211_I0.5490.89
212_L302_L0.5480.89
178_I232_F0.5470.89
320_L344_F0.5460.89
174_E239_N0.5460.89
216_V234_Q0.5450.89
159_L163_I0.5450.89
314_E347_E0.5430.89
163_I166_A0.5420.89
94_K382_P0.5420.89
384_R387_I0.5400.89
32_V37_E0.5380.88
388_E393_T0.5380.88
47_E50_L0.5360.88
15_F23_V0.5360.88
28_A33_Y0.5360.88
146_T151_V0.5340.88
46_V53_E0.5330.88
35_C87_V0.5330.88
35_C75_V0.5280.87
145_L153_E0.5280.87
213_E298_F0.5270.87
80_Q84_S0.5270.87
321_T326_A0.5260.87
46_V49_E0.5230.87
126_A188_R0.5230.87
332_K340_V0.5230.87
153_E165_A0.5220.87
285_L290_L0.5210.87
178_I217_A0.5190.87
27_V31_G0.5190.87
137_F176_G0.5170.86
181_D301_R0.5160.86
140_A207_A0.5150.86
85_L114_L0.5140.86
173_A176_G0.5140.86
27_V32_V0.5140.86
152_G220_P0.5110.86
61_V65_Q0.5110.86
163_I219_V0.5110.86
160_L220_P0.5100.86
25_K30_P0.5100.86
119_G362_G0.5090.86
367_R376_D0.5090.86
335_L340_V0.5090.86
389_K392_I0.5090.86
214_G226_K0.5080.85
44_E48_E0.5070.85
306_A310_K0.5070.85
107_L213_E0.5070.85
192_N295_I0.5060.85
44_E135_V0.5060.85
30_P33_Y0.5060.85
146_T220_P0.5050.85
22_Q27_V0.5040.85
329_K336_E0.5040.85
161_K223_G0.5040.85
75_V82_K0.5040.85
261_Q269_D0.5030.85
48_E61_V0.5030.85
17_G24_R0.5030.85
89_V129_L0.5020.85
223_G340_V0.5020.85
311_L316_L0.5010.85
61_V376_D0.5010.85
317_V320_L0.5010.85
164_Q168_Y0.5010.85
254_I259_L0.5000.85
264_I268_A0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1r6bX 1 0.8095 100 0.494 Contact Map
1qvrA 3 0.8214 100 0.521 Contact Map
3pxiA 3 0.7452 100 0.537 Contact Map
4d2uA 3 0.8214 100 0.546 Contact Map
4ciuA 1 0.819 100 0.584 Contact Map
1um8A 1 0.7429 100 0.612 Contact Map
3hwsA 3 0.7976 100 0.634 Contact Map
4lj9A 1 0.769 100 0.637 Contact Map
1g41A 3 0.7119 100 0.674 Contact Map
1ofhA 3 0.7167 100 0.694 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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