GREMLIN Database
SALA - Protein mrp homolog SalA
UniProt: P50863 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 352 (333)
Sequences: 2892 (1662)
Seq/√Len: 91.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
280_S283_T5.6211.00
124_S217_V5.0101.00
22_P25_E4.9141.00
296_D300_E4.6551.00
308_G340_I4.1331.00
124_S140_L3.6141.00
134_L342_K3.5601.00
282_K285_E3.5221.00
278_Y287_E3.2611.00
177_V182_F3.2031.00
123_V337_Y3.1601.00
176_K211_G3.1221.00
305_P347_K3.0031.00
277_Y286_R2.9331.00
306_L309_R2.8901.00
244_S295_G2.8501.00
9_K12_G2.8251.00
59_Q63_V2.7851.00
136_K215_Y2.6411.00
125_V154_M2.6321.00
134_L338_Q2.6031.00
154_M177_V2.5151.00
278_Y281_A2.4821.00
111_V217_V2.4251.00
139_G213_V2.4111.00
296_D309_R2.4011.00
30_K46_A2.2721.00
23_L29_V2.2651.00
171_E176_K2.2241.00
125_V150_V2.2111.00
41_I71_A2.1881.00
151_P181_G2.1591.00
12_G22_P2.1331.00
288_Y292_K2.1291.00
63_V67_K2.0971.00
153_M249_T2.0841.00
156_I177_V2.0751.00
107_V238_C2.0661.00
34_I41_I2.0511.00
283_T287_E2.0471.00
282_K287_E2.0371.00
57_Q61_E1.9821.00
197_L227_V1.9671.00
272_I340_I1.9541.00
43_V62_I1.9251.00
31_E44_K1.9121.00
56_M59_Q1.8741.00
40_H73_T1.8411.00
189_P259_S1.8241.00
315_P318_D1.8241.00
44_K77_R1.8131.00
154_M175_V1.8081.00
280_S287_E1.7811.00
168_L209_E1.7771.00
331_H334_G1.7721.00
133_R338_Q1.7481.00
297_K300_E1.7341.00
296_D306_L1.7181.00
8_R24_G1.7021.00
125_V153_M1.6211.00
158_V170_V1.6021.00
202_N206_H1.5931.00
146_Y225_G1.5831.00
40_H75_G1.5621.00
8_R32_I1.5601.00
279_E286_R1.5591.00
178_M208_V1.5241.00
6_E9_K1.4951.00
340_I344_I1.4661.00
152_D252_F1.4250.99
259_S262_I1.4050.99
166_K209_E1.4040.99
45_V62_I1.4000.99
276_A309_R1.3980.99
132_A175_V1.3960.99
7_V32_I1.3870.99
48_A52_T1.3810.99
111_V127_L1.3780.99
156_I170_V1.3670.99
37_E72_E1.3580.99
5_D9_K1.3570.99
295_G306_L1.3570.99
10_L66_L1.3550.99
289_V312_L1.3520.99
239_K267_E1.3470.99
130_S341_A1.3350.99
12_G24_G1.3310.99
60_Q64_N1.3250.99
129_I175_V1.3240.99
157_T160_P1.3160.99
281_A287_E1.3080.99
255_A301_E1.2950.99
112_A257_A1.2930.99
305_P343_K1.2920.99
339_D343_K1.2910.99
198_G230_D1.2900.99
33_K42_S1.2890.99
15_R20_Q1.2860.99
14_M62_I1.2850.99
218_L231_V1.2820.99
173_F323_A1.2720.99
131_L215_Y1.2620.99
11_V24_G1.2580.99
277_Y288_Y1.2410.98
325_S331_H1.2390.98
65_V68_G1.2390.98
16_E26_L1.2240.98
203_N207_E1.2180.98
7_V41_I1.2180.98
66_L74_V1.2160.98
35_K40_H1.2070.98
56_M60_Q1.2070.98
126_N324_P1.2010.98
21_R25_E1.1820.98
220_L257_A1.1750.98
112_A242_I1.1690.98
7_V34_I1.1610.97
249_T319_K1.1590.97
136_K345_D1.1570.97
21_R26_L1.1560.97
42_S75_G1.1540.97
198_G234_M1.1520.97
10_L69_A1.1490.97
198_G227_V1.1360.97
46_A79_E1.1340.97
32_I43_V1.1320.97
213_V216_I1.1310.97
329_E334_G1.1240.97
152_D186_E1.1180.97
310_I340_I1.1160.97
156_I182_F1.1000.97
109_L269_V1.0870.96
13_E65_V1.0850.96
131_L217_V1.0830.96
185_E188_A1.0800.96
192_W200_M1.0790.96
36_P72_E1.0780.96
65_V69_A1.0760.96
127_L344_I1.0760.96
66_L69_A1.0760.96
43_V66_L1.0680.96
339_D342_K1.0670.96
239_K269_V1.0660.96
123_V310_I1.0640.96
297_K301_E1.0590.96
47_L51_G1.0570.96
8_R12_G1.0520.96
16_E20_Q1.0460.95
335_E339_D1.0440.95
313_K333_I1.0440.95
29_V45_V1.0400.95
140_L177_V1.0370.95
47_L52_T1.0360.95
19_L26_L1.0260.95
14_M61_E1.0210.95
330_N335_E1.0180.95
317_W320_D1.0040.94
28_A53_A0.9990.94
121_S149_S0.9990.94
217_V344_I0.9970.94
18_F26_L0.9950.94
111_V241_I0.9810.93
280_S285_E0.9770.93
293_G296_D0.9750.93
332_P335_E0.9740.93
7_V66_L0.9680.93
343_K346_A0.9590.93
241_I340_I0.9500.92
37_E71_A0.9450.92
332_P336_I0.9450.92
318_D321_Q0.9420.92
277_Y309_R0.9380.92
184_V190_V0.9330.92
18_F28_A0.9290.91
298_L301_E0.9250.91
16_E49_K0.9140.91
336_I339_D0.9130.91
24_G28_A0.9100.91
16_E19_L0.9060.90
123_V243_V0.9060.90
276_A279_E0.9050.90
335_E338_Q0.9010.90
13_E22_P0.9010.90
49_K52_T0.9010.90
31_E42_S0.9010.90
129_I133_R0.8960.90
187_N298_L0.8960.90
258_G302_L0.8950.90
40_H72_E0.8920.90
10_L65_V0.8850.89
125_V177_V0.8840.89
184_V229_L0.8840.89
196_M199_K0.8830.89
197_L204_F0.8810.89
112_A220_L0.8780.89
150_V177_V0.8750.89
28_A54_E0.8740.89
139_G216_I0.8570.88
58_I62_I0.8560.88
16_E27_D0.8560.88
230_D234_M0.8520.88
166_K207_E0.8520.88
298_L302_L0.8500.87
71_A74_V0.8480.87
48_A51_G0.8470.87
14_M65_V0.8430.87
102_M105_P0.8430.87
240_E253_V0.8420.87
228_A261_A0.8410.87
6_E69_A0.8400.87
14_M27_D0.8380.87
55_Q59_Q0.8370.87
61_E65_V0.8310.86
324_P327_Y0.8290.86
107_V136_K0.8260.86
326_V334_G0.8250.86
50_T345_D0.8220.86
240_E261_A0.8210.86
258_G268_V0.8190.85
18_F54_E0.8180.85
109_L215_Y0.8130.85
167_L178_M0.8110.85
295_G299_A0.8080.85
28_A52_T0.8070.85
271_V304_V0.8060.84
178_M182_F0.8060.84
30_K44_K0.8050.84
46_A81_L0.8040.84
15_R18_F0.8020.84
121_S150_V0.8010.84
278_Y282_K0.7970.84
63_V73_T0.7920.83
201_L227_V0.7910.83
228_A257_A0.7900.83
61_E64_N0.7830.83
242_I254_A0.7820.83
26_L58_I0.7800.83
204_F208_V0.7760.82
157_T161_T0.7730.82
323_A328_D0.7710.82
43_V46_A0.7700.82
249_T253_V0.7640.81
48_A53_A0.7630.81
129_I327_Y0.7620.81
191_V229_L0.7610.81
10_L14_M0.7590.81
187_N264_T0.7570.81
280_S284_G0.7570.81
130_S326_V0.7570.81
52_T55_Q0.7520.80
28_A48_A0.7470.80
149_S253_V0.7470.80
276_A286_R0.7470.80
171_E174_G0.7450.80
23_L28_A0.7450.80
29_V32_I0.7410.79
310_I336_I0.7400.79
253_V261_A0.7400.79
37_E40_H0.7390.79
64_N68_G0.7380.79
149_S264_T0.7370.79
41_I66_L0.7330.78
137_K212_E0.7320.78
110_A237_S0.7320.78
167_L208_V0.7270.78
148_F253_V0.7240.78
188_A263_K0.7220.77
44_K79_E0.7220.77
287_E314_Q0.7210.77
18_F52_T0.7200.77
155_G172_R0.7170.77
141_I216_I0.7170.77
140_L150_V0.7160.77
16_E53_A0.7150.77
194_G226_D0.7100.76
250_A294_G0.7030.75
319_K325_S0.7000.75
291_G317_W0.7000.75
326_V338_Q0.6990.75
59_Q67_K0.6970.75
15_R21_R0.6870.74
31_E43_V0.6870.74
24_G29_V0.6860.74
326_V329_E0.6860.74
22_P26_L0.6860.74
129_I326_V0.6860.74
149_S189_P0.6780.73
23_L45_V0.6770.73
285_E288_Y0.6770.73
152_D157_T0.6760.73
155_G173_F0.6720.72
288_Y309_R0.6710.72
173_F324_P0.6700.72
232_H264_T0.6690.72
151_P180_M0.6690.72
148_F239_K0.6680.72
278_Y289_V0.6670.72
232_H266_H0.6670.72
70_G74_V0.6670.72
22_P27_D0.6660.72
342_K346_A0.6660.72
286_R309_R0.6660.72
19_L28_A0.6640.71
6_E32_I0.6620.71
126_N129_I0.6610.71
10_L13_E0.6590.71
153_M319_K0.6550.70
279_E332_P0.6480.69
30_K43_V0.6470.69
131_L138_V0.6470.69
143_A218_L0.6460.69
124_S134_L0.6450.69
176_K213_V0.6440.69
314_Q318_D0.6410.69
316_D337_Y0.6390.68
176_K212_E0.6390.68
130_S134_L0.6380.68
271_V295_G0.6370.68
340_I343_K0.6360.68
41_I74_V0.6360.68
197_L208_V0.6350.68
151_P179_S0.6340.68
196_M200_M0.6290.67
9_K33_K0.6280.67
202_N234_M0.6280.67
146_Y228_A0.6280.67
191_V265_D0.6280.67
36_P40_H0.6260.67
22_P29_V0.6240.67
47_L55_Q0.6240.67
215_Y244_S0.6220.66
53_A58_I0.6220.66
287_E291_G0.6210.66
258_G271_V0.6210.66
242_I258_G0.6200.66
15_R19_L0.6190.66
14_M23_L0.6190.66
322_F327_Y0.6190.66
323_A327_Y0.6190.66
300_E303_N0.6180.66
228_A240_E0.6170.66
130_S217_V0.6170.66
163_E168_L0.6160.66
5_D8_R0.6140.65
310_I333_I0.6130.65
141_I218_L0.6120.65
278_Y285_E0.6100.65
106_P137_K0.6100.65
205_F235_L0.6100.65
248_P251_A0.6080.65
52_T58_I0.6050.64
190_V256_R0.6020.64
60_Q342_K0.6010.64
6_E10_L0.6010.64
26_L53_A0.6010.64
133_R329_E0.5980.63
180_M254_A0.5970.63
12_G21_R0.5960.63
33_K77_R0.5960.63
186_E255_A0.5950.63
67_K74_V0.5950.63
92_P95_E0.5940.63
189_P258_G0.5930.63
54_E61_E0.5920.62
9_K13_E0.5920.62
35_K42_S0.5920.62
42_S77_R0.5900.62
58_I61_E0.5900.62
120_K222_P0.5890.62
282_K286_R0.5890.62
66_L73_T0.5890.62
91_A94_A0.5890.62
13_E24_G0.5880.62
48_A54_E0.5880.62
332_P339_D0.5860.62
258_G298_L0.5850.62
140_L217_V0.5840.61
16_E52_T0.5830.61
159_R162_I0.5830.61
60_Q73_T0.5810.61
28_A49_K0.5800.61
54_E58_I0.5790.61
254_A312_L0.5790.61
245_T275_M0.5780.61
149_S227_V0.5780.61
48_A58_I0.5760.60
325_S334_G0.5760.60
158_V161_T0.5760.60
64_N67_K0.5750.60
30_K79_E0.5720.60
162_I165_E0.5700.60
162_I166_K0.5680.59
129_I173_F0.5680.59
19_L22_P0.5670.59
198_G202_N0.5650.59
110_A266_H0.5650.59
15_R61_E0.5650.59
149_S254_A0.5640.59
262_I303_N0.5640.59
242_I268_V0.5640.59
191_V260_M0.5630.59
47_L53_A0.5620.59
18_F48_A0.5620.59
193_R245_T0.5620.59
197_L200_M0.5610.58
187_N259_S0.5610.58
143_A201_L0.5600.58
60_Q67_K0.5590.58
170_V177_V0.5580.58
66_L71_A0.5580.58
18_F53_A0.5560.58
146_Y257_A0.5560.58
51_G55_Q0.5560.58
168_L171_E0.5520.57
325_S329_E0.5500.57
126_N326_V0.5500.57
226_D245_T0.5500.57
188_A259_S0.5480.57
178_M190_V0.5470.56
273_E276_A0.5460.56
249_T252_F0.5460.56
134_L345_D0.5430.56
131_L345_D0.5420.56
24_G53_A0.5420.56
149_S181_G0.5410.56
200_M207_E0.5410.56
149_S249_T0.5400.56
294_G299_A0.5400.56
26_L29_V0.5390.55
121_S254_A0.5390.55
190_V197_L0.5380.55
138_V175_V0.5380.55
280_S314_Q0.5370.55
26_L52_T0.5360.55
102_M108_F0.5350.55
112_A201_L0.5310.54
285_E316_D0.5310.54
6_E12_G0.5310.54
252_F256_R0.5300.54
93_S96_K0.5290.54
201_L205_F0.5280.54
179_S275_M0.5270.54
31_E168_L0.5260.54
12_G33_K0.5260.54
167_L207_E0.5260.54
36_P73_T0.5250.53
57_Q60_Q0.5250.53
157_T186_E0.5250.53
158_V172_R0.5250.53
168_L262_I0.5250.53
47_L50_T0.5250.53
113_S223_G0.5240.53
322_F326_V0.5230.53
11_V14_M0.5220.53
147_G275_M0.5220.53
147_G224_T0.5220.53
13_E68_G0.5210.53
146_Y260_M0.5210.53
258_G262_I0.5190.53
69_A72_E0.5190.53
131_L140_L0.5190.53
63_V77_R0.5180.53
225_G228_A0.5180.53
15_R23_L0.5180.53
192_W270_G0.5180.53
244_S306_L0.5180.53
173_F327_Y0.5170.52
164_G264_T0.5160.52
231_V267_E0.5160.52
19_L52_T0.5150.52
148_F261_A0.5150.52
109_L241_I0.5140.52
223_G226_D0.5130.52
243_V274_N0.5130.52
215_Y345_D0.5110.52
321_Q324_P0.5110.52
16_E47_L0.5100.51
14_M18_F0.5100.51
133_R335_E0.5100.51
145_I210_W0.5100.51
321_Q325_S0.5100.51
157_T162_I0.5090.51
114_G270_G0.5080.51
141_I204_F0.5080.51
12_G32_I0.5080.51
338_Q342_K0.5060.51
324_P328_D0.5060.51
139_G226_D0.5060.51
50_T53_A0.5060.51
169_P275_M0.5040.51
74_V78_F0.5030.50
31_E73_T0.5030.50
220_L232_H0.5020.50
45_V58_I0.5020.50
67_K73_T0.5020.50
292_K300_E0.5020.50
237_S261_A0.5010.50
325_S328_D0.5010.50
18_F49_K0.5010.50
275_M312_L0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pfsA 1 0.625 100 0.525 Contact Map
5aunB 2 0.679 100 0.526 Contact Map
3pg5A 2 0.6222 100 0.527 Contact Map
4v03A 2 0.6307 100 0.543 Contact Map
1g3qA 1 0.6392 100 0.544 Contact Map
2ph1A 2 0.6875 100 0.546 Contact Map
4rz3A 2 0.6506 100 0.548 Contact Map
3ea0A 2 0.6335 100 0.549 Contact Map
1hyqA 1 0.625 100 0.551 Contact Map
1wcv1 2 0.642 100 0.554 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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