SALA - BACSU - GREMLIN Contacts

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SALA - Protein mrp homolog SalA

UniProt:	P50863	Sequences: MIREDEVRKLVGEMREPFLQRPLGELDAVKEIKIKPEKRHISVKVALAKTGTAEQMQIQQEIVNVLKGAGAETVGLRFEELPEETVAKFRAPSAEKKTLLNMDNPPVFLAVASGKGGVGKSTVSVNLAISLARLGKKVGLIDADIYGFSVPDMMGITVRPTIEGEKLLPVERFGVKVMSMGFFVEENAPVVWRGPMLGKMLNNFFHEVEWGEVDYIVLDLPPGTGDVALDVHTMLPSCKEIIVSTPHPTAAFVAARAGSMAIKTDHEVVGVIENMAYYESAKTGEREYVFGKGGGDKLAEELNVPLLGRIPLKQPDWDKDQFAPSVYDENHPIGEIYQDIAKKIDAKMSVQV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	352 (333)
Sequences:	2892 (1662)
Seq/√Len:	91.1

ECOLI - MRP
BACSU - SALA MIND SOJ YLXH
HALSA - Q9HQJ7 Q9HHZ7 Q9HQY5 Q9HNF1 Q9HHU2 O54573
SULSO - Q97ZW4 Q97YM8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
280_S	283_T	5.621	1.00
124_S	217_V	5.010	1.00
22_P	25_E	4.914	1.00
296_D	300_E	4.655	1.00
308_G	340_I	4.133	1.00
124_S	140_L	3.614	1.00
134_L	342_K	3.560	1.00
282_K	285_E	3.522	1.00
278_Y	287_E	3.261	1.00
177_V	182_F	3.203	1.00
123_V	337_Y	3.160	1.00
176_K	211_G	3.122	1.00
305_P	347_K	3.003	1.00
277_Y	286_R	2.933	1.00
306_L	309_R	2.890	1.00
244_S	295_G	2.850	1.00
9_K	12_G	2.825	1.00
59_Q	63_V	2.785	1.00
136_K	215_Y	2.641	1.00
125_V	154_M	2.632	1.00
134_L	338_Q	2.603	1.00
154_M	177_V	2.515	1.00
278_Y	281_A	2.482	1.00
111_V	217_V	2.425	1.00
139_G	213_V	2.411	1.00
296_D	309_R	2.401	1.00
30_K	46_A	2.272	1.00
23_L	29_V	2.265	1.00
171_E	176_K	2.224	1.00
125_V	150_V	2.211	1.00
41_I	71_A	2.188	1.00
151_P	181_G	2.159	1.00
12_G	22_P	2.133	1.00
288_Y	292_K	2.129	1.00
63_V	67_K	2.097	1.00
153_M	249_T	2.084	1.00
156_I	177_V	2.075	1.00
107_V	238_C	2.066	1.00
34_I	41_I	2.051	1.00
283_T	287_E	2.047	1.00
282_K	287_E	2.037	1.00
57_Q	61_E	1.982	1.00
197_L	227_V	1.967	1.00
272_I	340_I	1.954	1.00
43_V	62_I	1.925	1.00
31_E	44_K	1.912	1.00
56_M	59_Q	1.874	1.00
40_H	73_T	1.841	1.00
189_P	259_S	1.824	1.00
315_P	318_D	1.824	1.00
44_K	77_R	1.813	1.00
154_M	175_V	1.808	1.00
280_S	287_E	1.781	1.00
168_L	209_E	1.777	1.00
331_H	334_G	1.772	1.00
133_R	338_Q	1.748	1.00
297_K	300_E	1.734	1.00
296_D	306_L	1.718	1.00
8_R	24_G	1.702	1.00
125_V	153_M	1.621	1.00
158_V	170_V	1.602	1.00
202_N	206_H	1.593	1.00
146_Y	225_G	1.583	1.00
40_H	75_G	1.562	1.00
8_R	32_I	1.560	1.00
279_E	286_R	1.559	1.00
178_M	208_V	1.524	1.00
6_E	9_K	1.495	1.00
340_I	344_I	1.466	1.00
152_D	252_F	1.425	0.99
259_S	262_I	1.405	0.99
166_K	209_E	1.404	0.99
45_V	62_I	1.400	0.99
276_A	309_R	1.398	0.99
132_A	175_V	1.396	0.99
7_V	32_I	1.387	0.99
48_A	52_T	1.381	0.99
111_V	127_L	1.378	0.99
156_I	170_V	1.367	0.99
37_E	72_E	1.358	0.99
5_D	9_K	1.357	0.99
295_G	306_L	1.357	0.99
10_L	66_L	1.355	0.99
289_V	312_L	1.352	0.99
239_K	267_E	1.347	0.99
130_S	341_A	1.335	0.99
12_G	24_G	1.331	0.99
60_Q	64_N	1.325	0.99
129_I	175_V	1.324	0.99
157_T	160_P	1.316	0.99
281_A	287_E	1.308	0.99
255_A	301_E	1.295	0.99
112_A	257_A	1.293	0.99
305_P	343_K	1.292	0.99
339_D	343_K	1.291	0.99
198_G	230_D	1.290	0.99
33_K	42_S	1.289	0.99
15_R	20_Q	1.286	0.99
14_M	62_I	1.285	0.99
218_L	231_V	1.282	0.99
173_F	323_A	1.272	0.99
131_L	215_Y	1.262	0.99
11_V	24_G	1.258	0.99
277_Y	288_Y	1.241	0.98
325_S	331_H	1.239	0.98
65_V	68_G	1.239	0.98
16_E	26_L	1.224	0.98
203_N	207_E	1.218	0.98
7_V	41_I	1.218	0.98
66_L	74_V	1.216	0.98
35_K	40_H	1.207	0.98
56_M	60_Q	1.207	0.98
126_N	324_P	1.201	0.98
21_R	25_E	1.182	0.98
220_L	257_A	1.175	0.98
112_A	242_I	1.169	0.98
7_V	34_I	1.161	0.97
249_T	319_K	1.159	0.97
136_K	345_D	1.157	0.97
21_R	26_L	1.156	0.97
42_S	75_G	1.154	0.97
198_G	234_M	1.152	0.97
10_L	69_A	1.149	0.97
198_G	227_V	1.136	0.97
46_A	79_E	1.134	0.97
32_I	43_V	1.132	0.97
213_V	216_I	1.131	0.97
329_E	334_G	1.124	0.97
152_D	186_E	1.118	0.97
310_I	340_I	1.116	0.97
156_I	182_F	1.100	0.97
109_L	269_V	1.087	0.96
13_E	65_V	1.085	0.96
131_L	217_V	1.083	0.96
185_E	188_A	1.080	0.96
192_W	200_M	1.079	0.96
36_P	72_E	1.078	0.96
65_V	69_A	1.076	0.96
127_L	344_I	1.076	0.96
66_L	69_A	1.076	0.96
43_V	66_L	1.068	0.96
339_D	342_K	1.067	0.96
239_K	269_V	1.066	0.96
123_V	310_I	1.064	0.96
297_K	301_E	1.059	0.96
47_L	51_G	1.057	0.96
8_R	12_G	1.052	0.96
16_E	20_Q	1.046	0.95
335_E	339_D	1.044	0.95
313_K	333_I	1.044	0.95
29_V	45_V	1.040	0.95
140_L	177_V	1.037	0.95
47_L	52_T	1.036	0.95
19_L	26_L	1.026	0.95
14_M	61_E	1.021	0.95
330_N	335_E	1.018	0.95
317_W	320_D	1.004	0.94
28_A	53_A	0.999	0.94
121_S	149_S	0.999	0.94
217_V	344_I	0.997	0.94
18_F	26_L	0.995	0.94
111_V	241_I	0.981	0.93
280_S	285_E	0.977	0.93
293_G	296_D	0.975	0.93
332_P	335_E	0.974	0.93
7_V	66_L	0.968	0.93
343_K	346_A	0.959	0.93
241_I	340_I	0.950	0.92
37_E	71_A	0.945	0.92
332_P	336_I	0.945	0.92
318_D	321_Q	0.942	0.92
277_Y	309_R	0.938	0.92
184_V	190_V	0.933	0.92
18_F	28_A	0.929	0.91
298_L	301_E	0.925	0.91
16_E	49_K	0.914	0.91
336_I	339_D	0.913	0.91
24_G	28_A	0.910	0.91
16_E	19_L	0.906	0.90
123_V	243_V	0.906	0.90
276_A	279_E	0.905	0.90
335_E	338_Q	0.901	0.90
13_E	22_P	0.901	0.90
49_K	52_T	0.901	0.90
31_E	42_S	0.901	0.90
129_I	133_R	0.896	0.90
187_N	298_L	0.896	0.90
258_G	302_L	0.895	0.90
40_H	72_E	0.892	0.90
10_L	65_V	0.885	0.89
125_V	177_V	0.884	0.89
184_V	229_L	0.884	0.89
196_M	199_K	0.883	0.89
197_L	204_F	0.881	0.89
112_A	220_L	0.878	0.89
150_V	177_V	0.875	0.89
28_A	54_E	0.874	0.89
139_G	216_I	0.857	0.88
58_I	62_I	0.856	0.88
16_E	27_D	0.856	0.88
230_D	234_M	0.852	0.88
166_K	207_E	0.852	0.88
298_L	302_L	0.850	0.87
71_A	74_V	0.848	0.87
48_A	51_G	0.847	0.87
14_M	65_V	0.843	0.87
102_M	105_P	0.843	0.87
240_E	253_V	0.842	0.87
228_A	261_A	0.841	0.87
6_E	69_A	0.840	0.87
14_M	27_D	0.838	0.87
55_Q	59_Q	0.837	0.87
61_E	65_V	0.831	0.86
324_P	327_Y	0.829	0.86
107_V	136_K	0.826	0.86
326_V	334_G	0.825	0.86
50_T	345_D	0.822	0.86
240_E	261_A	0.821	0.86
258_G	268_V	0.819	0.85
18_F	54_E	0.818	0.85
109_L	215_Y	0.813	0.85
167_L	178_M	0.811	0.85
295_G	299_A	0.808	0.85
28_A	52_T	0.807	0.85
271_V	304_V	0.806	0.84
178_M	182_F	0.806	0.84
30_K	44_K	0.805	0.84
46_A	81_L	0.804	0.84
15_R	18_F	0.802	0.84
121_S	150_V	0.801	0.84
278_Y	282_K	0.797	0.84
63_V	73_T	0.792	0.83
201_L	227_V	0.791	0.83
228_A	257_A	0.790	0.83
61_E	64_N	0.783	0.83
242_I	254_A	0.782	0.83
26_L	58_I	0.780	0.83
204_F	208_V	0.776	0.82
157_T	161_T	0.773	0.82
323_A	328_D	0.771	0.82
43_V	46_A	0.770	0.82
249_T	253_V	0.764	0.81
48_A	53_A	0.763	0.81
129_I	327_Y	0.762	0.81
191_V	229_L	0.761	0.81
10_L	14_M	0.759	0.81
187_N	264_T	0.757	0.81
280_S	284_G	0.757	0.81
130_S	326_V	0.757	0.81
52_T	55_Q	0.752	0.80
28_A	48_A	0.747	0.80
149_S	253_V	0.747	0.80
276_A	286_R	0.747	0.80
171_E	174_G	0.745	0.80
23_L	28_A	0.745	0.80
29_V	32_I	0.741	0.79
310_I	336_I	0.740	0.79
253_V	261_A	0.740	0.79
37_E	40_H	0.739	0.79
64_N	68_G	0.738	0.79
149_S	264_T	0.737	0.79
41_I	66_L	0.733	0.78
137_K	212_E	0.732	0.78
110_A	237_S	0.732	0.78
167_L	208_V	0.727	0.78
148_F	253_V	0.724	0.78
188_A	263_K	0.722	0.77
44_K	79_E	0.722	0.77
287_E	314_Q	0.721	0.77
18_F	52_T	0.720	0.77
155_G	172_R	0.717	0.77
141_I	216_I	0.717	0.77
140_L	150_V	0.716	0.77
16_E	53_A	0.715	0.77
194_G	226_D	0.710	0.76
250_A	294_G	0.703	0.75
319_K	325_S	0.700	0.75
291_G	317_W	0.700	0.75
326_V	338_Q	0.699	0.75
59_Q	67_K	0.697	0.75
15_R	21_R	0.687	0.74
31_E	43_V	0.687	0.74
24_G	29_V	0.686	0.74
326_V	329_E	0.686	0.74
22_P	26_L	0.686	0.74
129_I	326_V	0.686	0.74
149_S	189_P	0.678	0.73
23_L	45_V	0.677	0.73
285_E	288_Y	0.677	0.73
152_D	157_T	0.676	0.73
155_G	173_F	0.672	0.72
288_Y	309_R	0.671	0.72
173_F	324_P	0.670	0.72
232_H	264_T	0.669	0.72
151_P	180_M	0.669	0.72
148_F	239_K	0.668	0.72
278_Y	289_V	0.667	0.72
232_H	266_H	0.667	0.72
70_G	74_V	0.667	0.72
22_P	27_D	0.666	0.72
342_K	346_A	0.666	0.72
286_R	309_R	0.666	0.72
19_L	28_A	0.664	0.71
6_E	32_I	0.662	0.71
126_N	129_I	0.661	0.71
10_L	13_E	0.659	0.71
153_M	319_K	0.655	0.70
279_E	332_P	0.648	0.69
30_K	43_V	0.647	0.69
131_L	138_V	0.647	0.69
143_A	218_L	0.646	0.69
124_S	134_L	0.645	0.69
176_K	213_V	0.644	0.69
314_Q	318_D	0.641	0.69
316_D	337_Y	0.639	0.68
176_K	212_E	0.639	0.68
130_S	134_L	0.638	0.68
271_V	295_G	0.637	0.68
340_I	343_K	0.636	0.68
41_I	74_V	0.636	0.68
197_L	208_V	0.635	0.68
151_P	179_S	0.634	0.68
196_M	200_M	0.629	0.67
9_K	33_K	0.628	0.67
202_N	234_M	0.628	0.67
146_Y	228_A	0.628	0.67
191_V	265_D	0.628	0.67
36_P	40_H	0.626	0.67
22_P	29_V	0.624	0.67
47_L	55_Q	0.624	0.67
215_Y	244_S	0.622	0.66
53_A	58_I	0.622	0.66
287_E	291_G	0.621	0.66
258_G	271_V	0.621	0.66
242_I	258_G	0.620	0.66
15_R	19_L	0.619	0.66
14_M	23_L	0.619	0.66
322_F	327_Y	0.619	0.66
323_A	327_Y	0.619	0.66
300_E	303_N	0.618	0.66
228_A	240_E	0.617	0.66
130_S	217_V	0.617	0.66
163_E	168_L	0.616	0.66
5_D	8_R	0.614	0.65
310_I	333_I	0.613	0.65
141_I	218_L	0.612	0.65
278_Y	285_E	0.610	0.65
106_P	137_K	0.610	0.65
205_F	235_L	0.610	0.65
248_P	251_A	0.608	0.65
52_T	58_I	0.605	0.64
190_V	256_R	0.602	0.64
60_Q	342_K	0.601	0.64
6_E	10_L	0.601	0.64
26_L	53_A	0.601	0.64
133_R	329_E	0.598	0.63
180_M	254_A	0.597	0.63
12_G	21_R	0.596	0.63
33_K	77_R	0.596	0.63
186_E	255_A	0.595	0.63
67_K	74_V	0.595	0.63
92_P	95_E	0.594	0.63
189_P	258_G	0.593	0.63
54_E	61_E	0.592	0.62
9_K	13_E	0.592	0.62
35_K	42_S	0.592	0.62
42_S	77_R	0.590	0.62
58_I	61_E	0.590	0.62
120_K	222_P	0.589	0.62
282_K	286_R	0.589	0.62
66_L	73_T	0.589	0.62
91_A	94_A	0.589	0.62
13_E	24_G	0.588	0.62
48_A	54_E	0.588	0.62
332_P	339_D	0.586	0.62
258_G	298_L	0.585	0.62
140_L	217_V	0.584	0.61
16_E	52_T	0.583	0.61
159_R	162_I	0.583	0.61
60_Q	73_T	0.581	0.61
28_A	49_K	0.580	0.61
54_E	58_I	0.579	0.61
254_A	312_L	0.579	0.61
245_T	275_M	0.578	0.61
149_S	227_V	0.578	0.61
48_A	58_I	0.576	0.60
325_S	334_G	0.576	0.60
158_V	161_T	0.576	0.60
64_N	67_K	0.575	0.60
30_K	79_E	0.572	0.60
162_I	165_E	0.570	0.60
162_I	166_K	0.568	0.59
129_I	173_F	0.568	0.59
19_L	22_P	0.567	0.59
198_G	202_N	0.565	0.59
110_A	266_H	0.565	0.59
15_R	61_E	0.565	0.59
149_S	254_A	0.564	0.59
262_I	303_N	0.564	0.59
242_I	268_V	0.564	0.59
191_V	260_M	0.563	0.59
47_L	53_A	0.562	0.59
18_F	48_A	0.562	0.59
193_R	245_T	0.562	0.59
197_L	200_M	0.561	0.58
187_N	259_S	0.561	0.58
143_A	201_L	0.560	0.58
60_Q	67_K	0.559	0.58
170_V	177_V	0.558	0.58
66_L	71_A	0.558	0.58
18_F	53_A	0.556	0.58
146_Y	257_A	0.556	0.58
51_G	55_Q	0.556	0.58
168_L	171_E	0.552	0.57
325_S	329_E	0.550	0.57
126_N	326_V	0.550	0.57
226_D	245_T	0.550	0.57
188_A	259_S	0.548	0.57
178_M	190_V	0.547	0.56
273_E	276_A	0.546	0.56
249_T	252_F	0.546	0.56
134_L	345_D	0.543	0.56
131_L	345_D	0.542	0.56
24_G	53_A	0.542	0.56
149_S	181_G	0.541	0.56
200_M	207_E	0.541	0.56
149_S	249_T	0.540	0.56
294_G	299_A	0.540	0.56
26_L	29_V	0.539	0.55
121_S	254_A	0.539	0.55
190_V	197_L	0.538	0.55
138_V	175_V	0.538	0.55
280_S	314_Q	0.537	0.55
26_L	52_T	0.536	0.55
102_M	108_F	0.535	0.55
112_A	201_L	0.531	0.54
285_E	316_D	0.531	0.54
6_E	12_G	0.531	0.54
252_F	256_R	0.530	0.54
93_S	96_K	0.529	0.54
201_L	205_F	0.528	0.54
179_S	275_M	0.527	0.54
31_E	168_L	0.526	0.54
12_G	33_K	0.526	0.54
167_L	207_E	0.526	0.54
36_P	73_T	0.525	0.53
57_Q	60_Q	0.525	0.53
157_T	186_E	0.525	0.53
158_V	172_R	0.525	0.53
168_L	262_I	0.525	0.53
47_L	50_T	0.525	0.53
113_S	223_G	0.524	0.53
322_F	326_V	0.523	0.53
11_V	14_M	0.522	0.53
147_G	275_M	0.522	0.53
147_G	224_T	0.522	0.53
13_E	68_G	0.521	0.53
146_Y	260_M	0.521	0.53
258_G	262_I	0.519	0.53
69_A	72_E	0.519	0.53
131_L	140_L	0.519	0.53
63_V	77_R	0.518	0.53
225_G	228_A	0.518	0.53
15_R	23_L	0.518	0.53
192_W	270_G	0.518	0.53
244_S	306_L	0.518	0.53
173_F	327_Y	0.517	0.52
164_G	264_T	0.516	0.52
231_V	267_E	0.516	0.52
19_L	52_T	0.515	0.52
148_F	261_A	0.515	0.52
109_L	241_I	0.514	0.52
223_G	226_D	0.513	0.52
243_V	274_N	0.513	0.52
215_Y	345_D	0.511	0.52
321_Q	324_P	0.511	0.52
16_E	47_L	0.510	0.51
14_M	18_F	0.510	0.51
133_R	335_E	0.510	0.51
145_I	210_W	0.510	0.51
321_Q	325_S	0.510	0.51
157_T	162_I	0.509	0.51
114_G	270_G	0.508	0.51
141_I	204_F	0.508	0.51
12_G	32_I	0.508	0.51
338_Q	342_K	0.506	0.51
324_P	328_D	0.506	0.51
139_G	226_D	0.506	0.51
50_T	53_A	0.506	0.51
169_P	275_M	0.504	0.51
74_V	78_F	0.503	0.50
31_E	73_T	0.503	0.50
220_L	232_H	0.502	0.50
45_V	58_I	0.502	0.50
67_K	73_T	0.502	0.50
292_K	300_E	0.502	0.50
237_S	261_A	0.501	0.50
325_S	328_D	0.501	0.50
18_F	49_K	0.501	0.50
275_M	312_L	0.500	0.50

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4pfsA	1	0.625	100	0.525	Contact Map
5aunB	2	0.679	100	0.526	Contact Map
3pg5A	2	0.6222	100	0.527	Contact Map
4v03A	2	0.6307	100	0.543	Contact Map
1g3qA	1	0.6392	100	0.544	Contact Map
2ph1A	2	0.6875	100	0.546	Contact Map
4rz3A	2	0.6506	100	0.548	Contact Map
3ea0A	2	0.6335	100	0.549	Contact Map
1hyqA	1	0.625	100	0.551	Contact Map
1wcv1	2	0.642	100	0.554	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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