YLXY - BACSU - GREMLIN Contacts

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YLXY - Uncharacterized protein YlxY

UniProt:	P50850	Sequences: MYKKFVPFAVFLFLFFVSFEMMENPHALDYIGAMKKDTVTVTASKDPLYEELLQKAPEYEVKPQNARIDKVWKSIPGYNGLKVNIEQSYKKMKQHGKFREKDLVYSQVKPSVHLESLQPEPIYKGNPDKPMVAFLINVAWGNEYLEKMLPILQKHQVKATFFLEGNWVRNNVQLAKKIAKDGHEIGNHSYNHPDMSKLTTGRISEQLDKTNEQIEQTIGVKPKWFAPPSGSFRKAVIDIAAEKQMGTVMWTVDTIDWQKPAPSVLQTRVLSKIHNGAMILMHPTDPTAESLEALITQIKDKGYALGTVTELMDETRLLK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	319 (299)
Sequences:	896 (830)
Seq/√Len:	48.0

BACSU - YLXY PDAC YHEN PDAA PDAB YXKH

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
177_K	181_D	5.028	1.00
155_H	296_T	4.907	1.00
150_P	177_K	4.714	1.00
215_E	221_K	4.689	1.00
153_Q	181_D	4.641	1.00
184_E	309_T	4.434	1.00
155_H	299_K	4.337	1.00
205_E	209_K	3.931	1.00
203_I	236_V	3.407	1.00
273_I	298_I	3.108	1.00
152_L	159_A	3.080	1.00
292_E	296_T	2.991	1.00
132_V	279_I	2.848	1.00
211_N	245_M	2.831	1.00
274_H	277_A	2.743	1.00
157_V	295_I	2.727	1.00
270_L	297_Q	2.608	1.00
158_K	183_H	2.592	1.00
163_L	175_A	2.587	1.00
148_M	288_A	2.524	1.00
191_N	206_Q	2.512	1.00
230_G	250_W	2.459	1.00
265_L	290_S	2.433	1.00
163_L	178_I	2.418	1.00
255_I	258_Q	2.379	1.00
194_D	231_S	2.342	1.00
269_V	294_L	2.300	1.00
290_S	294_L	2.232	1.00
148_M	291_L	2.216	1.00
200_T	235_A	2.090	1.00
165_G	190_Y	2.083	1.00
196_S	231_S	2.075	1.00
193_P	206_Q	2.074	1.00
208_D	212_E	2.064	1.00
151_I	288_A	2.046	1.00
296_T	299_K	2.014	0.99
194_D	197_K	2.008	0.99
138_V	283_P	1.931	0.99
141_G	144_Y	1.892	0.99
176_K	180_K	1.885	0.99
132_V	273_I	1.871	0.99
187_N	207_L	1.834	0.99
145_L	149_L	1.814	0.99
133_A	306_G	1.806	0.99
199_T	202_R	1.804	0.99
150_P	181_D	1.800	0.99
149_L	181_D	1.745	0.99
234_K	238_D	1.729	0.98
135_L	278_M	1.676	0.98
179_A	218_I	1.663	0.98
267_T	271_S	1.649	0.98
253_D	257_W	1.632	0.98
190_Y	209_K	1.613	0.97
188_H	192_H	1.603	0.97
192_H	206_Q	1.599	0.97
19_F	22_M	1.590	0.97
184_E	308_V	1.583	0.97
189_S	245_M	1.580	0.97
266_Q	293_A	1.567	0.97
172_V	217_T	1.563	0.97
202_R	206_Q	1.523	0.96
266_Q	270_L	1.509	0.96
140_W	283_P	1.502	0.96
161_F	183_H	1.477	0.96
145_L	283_P	1.472	0.96
295_I	299_K	1.453	0.95
251_T	274_H	1.438	0.95
155_H	292_E	1.427	0.95
179_A	220_V	1.424	0.95
149_L	177_K	1.419	0.95
297_Q	300_D	1.417	0.95
168_V	213_Q	1.407	0.94
19_F	28_L	1.399	0.94
168_V	217_T	1.392	0.94
162_F	224_W	1.375	0.94
273_I	279_I	1.357	0.93
214_I	222_P	1.341	0.93
147_K	289_E	1.331	0.93
266_Q	297_Q	1.324	0.92
238_D	242_E	1.304	0.92
136_I	152_L	1.297	0.92
163_L	214_I	1.295	0.92
207_L	240_A	1.285	0.91
295_I	305_L	1.284	0.91
206_Q	210_T	1.279	0.91
164_E	189_S	1.267	0.91
263_S	293_A	1.261	0.90
190_Y	206_Q	1.247	0.90
175_A	217_T	1.230	0.89
194_D	229_S	1.227	0.89
288_A	292_E	1.225	0.89
133_A	249_M	1.206	0.88
138_V	164_E	1.191	0.88
130_P	303_Y	1.167	0.87
140_W	226_A	1.158	0.86
171_N	174_L	1.158	0.86
204_S	242_E	1.148	0.86
140_W	145_L	1.130	0.85
291_L	295_I	1.124	0.85
195_M	206_Q	1.120	0.84
10_V	14_L	1.097	0.83
145_L	174_L	1.084	0.82
229_S	253_D	1.075	0.82
18_S	22_M	1.071	0.82
293_A	297_Q	1.068	0.81
146_E	177_K	1.066	0.81
137_N	188_H	1.064	0.81
22_M	25_P	1.061	0.81
133_A	160_T	1.060	0.81
149_L	178_I	1.058	0.81
210_T	214_I	1.054	0.80
145_L	177_K	1.054	0.80
239_I	243_K	1.051	0.80
141_G	146_E	1.051	0.80
189_S	206_Q	1.050	0.80
187_N	210_T	1.046	0.80
98_F	101_K	1.044	0.80
153_Q	158_K	1.042	0.80
227_P	249_M	1.035	0.79
30_Y	34_M	1.034	0.79
154_K	292_E	1.034	0.79
30_Y	35_K	1.029	0.79
46_D	54_Q	1.023	0.78
192_H	228_P	1.013	0.78
200_T	238_D	1.009	0.77
264_V	268_R	1.007	0.77
10_V	15_F	1.007	0.77
151_I	292_E	1.006	0.77
249_M	254_T	0.998	0.77
281_M	287_T	0.997	0.77
266_Q	294_L	0.985	0.76
136_I	139_A	0.984	0.76
212_E	221_K	0.979	0.75
14_L	18_S	0.973	0.75
266_Q	290_S	0.972	0.75
198_L	206_Q	0.966	0.74
13_F	30_Y	0.965	0.74
296_T	300_D	0.960	0.74
291_L	305_L	0.954	0.73
29_D	32_G	0.951	0.73
138_V	229_S	0.938	0.72
10_V	19_F	0.938	0.72
188_H	282_H	0.931	0.72
47_P	50_E	0.929	0.71
131_M	306_G	0.919	0.71
10_V	23_E	0.919	0.71
133_A	253_D	0.917	0.70
178_I	225_F	0.915	0.70
12_L	28_L	0.914	0.70
217_T	220_V	0.912	0.70
16_F	39_V	0.910	0.70
229_S	257_W	0.903	0.69
227_P	232_F	0.902	0.69
195_M	247_T	0.899	0.69
212_E	216_Q	0.881	0.67
138_V	188_H	0.873	0.67
155_H	295_I	0.869	0.66
17_V	39_V	0.867	0.66
17_V	26_H	0.857	0.65
15_F	22_M	0.853	0.65
139_A	229_S	0.853	0.65
285_D	288_A	0.851	0.65
133_A	305_L	0.851	0.65
28_L	32_G	0.847	0.64
176_K	219_G	0.846	0.64
200_T	239_I	0.844	0.64
28_L	31_I	0.841	0.64
149_L	183_H	0.840	0.64
189_S	290_S	0.839	0.63
237_I	245_M	0.837	0.63
169_R	213_Q	0.837	0.63
24_N	28_L	0.837	0.63
145_L	226_A	0.836	0.63
149_L	161_F	0.836	0.63
262_P	293_A	0.835	0.63
213_Q	217_T	0.835	0.63
16_F	22_M	0.833	0.63
168_V	214_I	0.833	0.63
23_E	33_A	0.832	0.63
15_F	23_E	0.829	0.63
15_F	19_F	0.827	0.62
188_H	280_L	0.826	0.62
180_K	218_I	0.823	0.62
164_E	283_P	0.823	0.62
160_T	308_V	0.822	0.62
11_F	18_S	0.821	0.62
20_E	23_E	0.818	0.61
190_Y	213_Q	0.817	0.61
230_G	249_M	0.815	0.61
139_A	145_L	0.814	0.61
188_H	228_P	0.811	0.61
15_F	18_S	0.810	0.61
297_Q	301_K	0.809	0.61
175_A	178_I	0.808	0.61
261_A	286_P	0.806	0.60
227_P	276_G	0.802	0.60
151_I	291_L	0.801	0.60
187_N	211_N	0.799	0.60
21_M	27_A	0.796	0.59
257_W	276_G	0.796	0.59
12_L	33_A	0.796	0.59
133_A	308_V	0.793	0.59
31_I	35_K	0.793	0.59
157_V	299_K	0.791	0.59
28_L	33_A	0.790	0.59
151_I	295_I	0.790	0.59
227_P	231_S	0.789	0.59
53_L	156_Q	0.789	0.59
146_E	292_E	0.787	0.58
77_G	80_G	0.783	0.58
184_E	307_T	0.777	0.58
227_P	248_V	0.776	0.57
137_N	226_A	0.775	0.57
18_S	24_N	0.773	0.57
189_S	247_T	0.771	0.57
169_R	172_V	0.769	0.57
253_D	258_Q	0.766	0.56
261_A	264_V	0.760	0.56
203_I	235_A	0.759	0.56
276_G	306_G	0.758	0.56
195_M	203_I	0.757	0.56
129_K	304_A	0.755	0.55
171_N	291_L	0.753	0.55
302_G	305_L	0.751	0.55
26_H	38_T	0.747	0.55
162_F	192_H	0.747	0.55
248_V	251_T	0.747	0.55
161_F	186_G	0.746	0.54
281_M	291_L	0.746	0.54
250_W	256_D	0.745	0.54
37_D	46_D	0.742	0.54
232_F	236_V	0.742	0.54
33_A	42_T	0.737	0.54
22_M	38_T	0.737	0.54
137_N	140_W	0.737	0.54
25_P	29_D	0.737	0.54
14_L	17_V	0.736	0.53
10_V	36_K	0.736	0.53
253_D	256_D	0.736	0.53
234_K	237_I	0.734	0.53
259_K	265_L	0.734	0.53
17_V	23_E	0.732	0.53
233_R	248_V	0.730	0.53
266_Q	271_S	0.728	0.53
136_I	148_M	0.727	0.53
16_F	20_E	0.726	0.52
161_F	256_D	0.726	0.52
256_D	280_L	0.722	0.52
133_A	198_L	0.722	0.52
131_M	304_A	0.720	0.52
273_I	297_Q	0.718	0.52
175_A	185_I	0.714	0.51
46_D	49_Y	0.713	0.51
226_A	282_H	0.713	0.51
19_F	39_V	0.713	0.51
31_I	37_D	0.712	0.51
227_P	240_A	0.710	0.51
16_F	52_L	0.709	0.51
132_V	298_I	0.708	0.51
195_M	276_G	0.707	0.51
226_A	251_T	0.706	0.50
13_F	36_K	0.703	0.50
292_E	299_K	0.701	0.50
250_W	257_W	0.701	0.50
198_L	202_R	0.699	0.50
137_N	283_P	0.697	0.50
23_E	34_M	0.694	0.49
16_F	37_D	0.692	0.49
278_M	308_V	0.691	0.49
196_S	206_Q	0.689	0.49
166_N	189_S	0.689	0.49
19_F	35_K	0.688	0.49
45_K	51_E	0.688	0.49
38_T	41_V	0.687	0.49
160_T	184_E	0.685	0.48
149_L	152_L	0.685	0.48
168_V	172_V	0.683	0.48
23_E	26_H	0.683	0.48
235_A	239_I	0.681	0.48
137_N	228_P	0.681	0.48
15_F	33_A	0.679	0.48
174_L	291_L	0.678	0.48
13_F	17_V	0.678	0.48
144_Y	288_A	0.677	0.48
175_A	218_I	0.674	0.47
12_L	23_E	0.674	0.47
21_M	29_D	0.673	0.47
16_F	19_F	0.671	0.47
10_V	33_A	0.661	0.46
177_K	183_H	0.661	0.46
250_W	254_T	0.661	0.46
10_V	20_E	0.661	0.46
20_E	28_L	0.660	0.46
47_P	53_L	0.658	0.46
26_H	30_Y	0.655	0.45
135_L	189_S	0.654	0.45
14_L	26_H	0.650	0.45
135_L	226_A	0.648	0.45
258_Q	265_L	0.648	0.45
193_P	229_S	0.648	0.45
153_Q	177_K	0.647	0.45
37_D	43_A	0.643	0.44
254_T	281_M	0.642	0.44
17_V	24_N	0.641	0.44
192_H	282_H	0.641	0.44
262_P	286_P	0.641	0.44
279_I	298_I	0.639	0.44
152_L	161_F	0.638	0.44
207_L	245_M	0.637	0.44
192_H	226_A	0.636	0.43
15_F	31_I	0.636	0.43
28_L	37_D	0.634	0.43
168_V	175_A	0.633	0.43
229_S	249_M	0.632	0.43
140_W	167_W	0.630	0.43
135_L	269_V	0.625	0.42
168_V	222_P	0.621	0.42
15_F	20_E	0.621	0.42
139_A	226_A	0.620	0.42
27_A	32_G	0.617	0.42
148_M	284_T	0.616	0.41
287_T	291_L	0.613	0.41
227_P	284_T	0.613	0.41
37_D	40_T	0.610	0.41
33_A	39_V	0.610	0.41
250_W	280_L	0.609	0.41
140_W	164_E	0.608	0.41
140_W	229_S	0.606	0.41
29_D	33_A	0.605	0.40
192_H	250_W	0.603	0.40
51_E	55_K	0.602	0.40
247_T	254_T	0.602	0.40
13_F	24_N	0.602	0.40
13_F	37_D	0.601	0.40
133_A	184_E	0.600	0.40
20_E	43_A	0.600	0.40
27_A	30_Y	0.600	0.40
137_N	192_H	0.599	0.40
133_A	307_T	0.599	0.40
15_F	37_D	0.598	0.40
253_D	287_T	0.597	0.40
175_A	183_H	0.596	0.40
207_L	243_K	0.595	0.39
54_Q	62_K	0.595	0.39
13_F	22_M	0.592	0.39
96_G	99_R	0.591	0.39
34_M	37_D	0.590	0.39
192_H	280_L	0.590	0.39
277_A	303_Y	0.589	0.39
188_H	230_G	0.586	0.39
47_P	58_E	0.586	0.39
261_A	279_I	0.586	0.39
126_N	129_K	0.586	0.39
249_M	253_D	0.585	0.38
35_K	47_P	0.584	0.38
103_L	107_Q	0.581	0.38
14_L	39_V	0.581	0.38
38_T	53_L	0.581	0.38
177_K	180_K	0.580	0.38
165_G	279_I	0.577	0.38
146_E	291_L	0.577	0.38
22_M	42_T	0.577	0.38
10_V	21_M	0.577	0.38
205_E	289_E	0.575	0.38
12_L	27_A	0.575	0.38
16_F	31_I	0.575	0.38
13_F	26_H	0.574	0.37
53_L	60_E	0.573	0.37
138_V	287_T	0.570	0.37
211_N	218_I	0.570	0.37
101_K	157_V	0.569	0.37
249_M	257_W	0.568	0.37
292_E	295_I	0.566	0.37
164_E	210_T	0.563	0.36
147_K	151_I	0.562	0.36
213_Q	216_Q	0.560	0.36
26_H	29_D	0.556	0.36
250_W	282_H	0.553	0.35
25_P	33_A	0.551	0.35
16_F	26_H	0.550	0.35
39_V	58_E	0.550	0.35
260_P	285_D	0.550	0.35
254_T	257_W	0.549	0.35
10_V	24_N	0.549	0.35
78_Y	81_L	0.549	0.35
16_F	32_G	0.549	0.35
179_A	185_I	0.548	0.35
139_A	188_H	0.548	0.35
235_A	238_D	0.547	0.35
269_V	298_I	0.546	0.35
126_N	131_M	0.544	0.35
19_F	26_H	0.544	0.35
144_Y	147_K	0.541	0.34
24_N	34_M	0.541	0.34
23_E	39_V	0.540	0.34
28_L	41_V	0.539	0.34
226_A	256_D	0.539	0.34
198_L	203_I	0.537	0.34
73_K	79_N	0.536	0.34
138_V	228_P	0.535	0.34
18_S	34_M	0.532	0.34
44_S	201_G	0.532	0.34
13_F	44_S	0.530	0.33
226_A	280_L	0.530	0.33
24_N	35_K	0.530	0.33
263_S	267_T	0.530	0.33
258_Q	264_V	0.528	0.33
203_I	233_R	0.527	0.33
232_F	237_I	0.527	0.33
227_P	247_T	0.527	0.33
225_F	247_T	0.527	0.33
284_T	291_L	0.526	0.33
14_L	25_P	0.526	0.33
22_M	28_L	0.526	0.33
204_S	208_D	0.524	0.33
18_S	61_V	0.521	0.33
22_M	26_H	0.521	0.33
43_A	46_D	0.520	0.33
21_M	33_A	0.519	0.32
13_F	16_F	0.518	0.32
10_V	43_A	0.517	0.32
17_V	36_K	0.517	0.32
224_W	309_T	0.516	0.32
37_D	53_L	0.516	0.32
25_P	30_Y	0.515	0.32
20_E	32_G	0.515	0.32
57_P	62_K	0.514	0.32
154_K	300_D	0.514	0.32
36_K	44_S	0.514	0.32
11_F	27_A	0.513	0.32
156_Q	238_D	0.513	0.32
210_T	253_D	0.510	0.32
227_P	257_W	0.510	0.32
153_Q	156_Q	0.509	0.32
187_N	214_I	0.509	0.32
22_M	50_E	0.508	0.31
21_M	39_V	0.507	0.31
279_I	287_T	0.507	0.31
227_P	233_R	0.507	0.31
285_D	295_I	0.506	0.31
60_E	64_Q	0.505	0.31
284_T	288_A	0.505	0.31
236_V	254_T	0.505	0.31
174_L	303_Y	0.505	0.31
91_K	95_H	0.503	0.31
138_V	254_T	0.502	0.31
133_A	229_S	0.501	0.31
164_E	229_S	0.500	0.31

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4l1gA	1	0.652	100	0.292	Contact Map
2w3zA	1	0.6677	100	0.345	Contact Map
2c1iA	1	0.884	100	0.35	Contact Map
4m1bA	1	0.6144	100	0.368	Contact Map
1ny1A	1	0.7179	100	0.378	Contact Map
2j13A	1	0.6364	100	0.379	Contact Map
2y8uA	1	0.6364	100	0.38	Contact Map
2cc0A	2	0.6019	100	0.381	Contact Map
2vyoA	1	0.6207	100	0.393	Contact Map
2iw0A	1	0.6332	100	0.395	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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