GREMLIN Database
YLXY - Uncharacterized protein YlxY
UniProt: P50850 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 319 (299)
Sequences: 896 (830)
Seq/√Len: 48.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
177_K181_D5.0281.00
155_H296_T4.9071.00
150_P177_K4.7141.00
215_E221_K4.6891.00
153_Q181_D4.6411.00
184_E309_T4.4341.00
155_H299_K4.3371.00
205_E209_K3.9311.00
203_I236_V3.4071.00
273_I298_I3.1081.00
152_L159_A3.0801.00
292_E296_T2.9911.00
132_V279_I2.8481.00
211_N245_M2.8311.00
274_H277_A2.7431.00
157_V295_I2.7271.00
270_L297_Q2.6081.00
158_K183_H2.5921.00
163_L175_A2.5871.00
148_M288_A2.5241.00
191_N206_Q2.5121.00
230_G250_W2.4591.00
265_L290_S2.4331.00
163_L178_I2.4181.00
255_I258_Q2.3791.00
194_D231_S2.3421.00
269_V294_L2.3001.00
290_S294_L2.2321.00
148_M291_L2.2161.00
200_T235_A2.0901.00
165_G190_Y2.0831.00
196_S231_S2.0751.00
193_P206_Q2.0741.00
208_D212_E2.0641.00
151_I288_A2.0461.00
296_T299_K2.0140.99
194_D197_K2.0080.99
138_V283_P1.9310.99
141_G144_Y1.8920.99
176_K180_K1.8850.99
132_V273_I1.8710.99
187_N207_L1.8340.99
145_L149_L1.8140.99
133_A306_G1.8060.99
199_T202_R1.8040.99
150_P181_D1.8000.99
149_L181_D1.7450.99
234_K238_D1.7290.98
135_L278_M1.6760.98
179_A218_I1.6630.98
267_T271_S1.6490.98
253_D257_W1.6320.98
190_Y209_K1.6130.97
188_H192_H1.6030.97
192_H206_Q1.5990.97
19_F22_M1.5900.97
184_E308_V1.5830.97
189_S245_M1.5800.97
266_Q293_A1.5670.97
172_V217_T1.5630.97
202_R206_Q1.5230.96
266_Q270_L1.5090.96
140_W283_P1.5020.96
161_F183_H1.4770.96
145_L283_P1.4720.96
295_I299_K1.4530.95
251_T274_H1.4380.95
155_H292_E1.4270.95
179_A220_V1.4240.95
149_L177_K1.4190.95
297_Q300_D1.4170.95
168_V213_Q1.4070.94
19_F28_L1.3990.94
168_V217_T1.3920.94
162_F224_W1.3750.94
273_I279_I1.3570.93
214_I222_P1.3410.93
147_K289_E1.3310.93
266_Q297_Q1.3240.92
238_D242_E1.3040.92
136_I152_L1.2970.92
163_L214_I1.2950.92
207_L240_A1.2850.91
295_I305_L1.2840.91
206_Q210_T1.2790.91
164_E189_S1.2670.91
263_S293_A1.2610.90
190_Y206_Q1.2470.90
175_A217_T1.2300.89
194_D229_S1.2270.89
288_A292_E1.2250.89
133_A249_M1.2060.88
138_V164_E1.1910.88
130_P303_Y1.1670.87
140_W226_A1.1580.86
171_N174_L1.1580.86
204_S242_E1.1480.86
140_W145_L1.1300.85
291_L295_I1.1240.85
195_M206_Q1.1200.84
10_V14_L1.0970.83
145_L174_L1.0840.82
229_S253_D1.0750.82
18_S22_M1.0710.82
293_A297_Q1.0680.81
146_E177_K1.0660.81
137_N188_H1.0640.81
22_M25_P1.0610.81
133_A160_T1.0600.81
149_L178_I1.0580.81
210_T214_I1.0540.80
145_L177_K1.0540.80
239_I243_K1.0510.80
141_G146_E1.0510.80
189_S206_Q1.0500.80
187_N210_T1.0460.80
98_F101_K1.0440.80
153_Q158_K1.0420.80
227_P249_M1.0350.79
30_Y34_M1.0340.79
154_K292_E1.0340.79
30_Y35_K1.0290.79
46_D54_Q1.0230.78
192_H228_P1.0130.78
200_T238_D1.0090.77
264_V268_R1.0070.77
10_V15_F1.0070.77
151_I292_E1.0060.77
249_M254_T0.9980.77
281_M287_T0.9970.77
266_Q294_L0.9850.76
136_I139_A0.9840.76
212_E221_K0.9790.75
14_L18_S0.9730.75
266_Q290_S0.9720.75
198_L206_Q0.9660.74
13_F30_Y0.9650.74
296_T300_D0.9600.74
291_L305_L0.9540.73
29_D32_G0.9510.73
138_V229_S0.9380.72
10_V19_F0.9380.72
188_H282_H0.9310.72
47_P50_E0.9290.71
131_M306_G0.9190.71
10_V23_E0.9190.71
133_A253_D0.9170.70
178_I225_F0.9150.70
12_L28_L0.9140.70
217_T220_V0.9120.70
16_F39_V0.9100.70
229_S257_W0.9030.69
227_P232_F0.9020.69
195_M247_T0.8990.69
212_E216_Q0.8810.67
138_V188_H0.8730.67
155_H295_I0.8690.66
17_V39_V0.8670.66
17_V26_H0.8570.65
15_F22_M0.8530.65
139_A229_S0.8530.65
285_D288_A0.8510.65
133_A305_L0.8510.65
28_L32_G0.8470.64
176_K219_G0.8460.64
200_T239_I0.8440.64
28_L31_I0.8410.64
149_L183_H0.8400.64
189_S290_S0.8390.63
237_I245_M0.8370.63
169_R213_Q0.8370.63
24_N28_L0.8370.63
145_L226_A0.8360.63
149_L161_F0.8360.63
262_P293_A0.8350.63
213_Q217_T0.8350.63
16_F22_M0.8330.63
168_V214_I0.8330.63
23_E33_A0.8320.63
15_F23_E0.8290.63
15_F19_F0.8270.62
188_H280_L0.8260.62
180_K218_I0.8230.62
164_E283_P0.8230.62
160_T308_V0.8220.62
11_F18_S0.8210.62
20_E23_E0.8180.61
190_Y213_Q0.8170.61
230_G249_M0.8150.61
139_A145_L0.8140.61
188_H228_P0.8110.61
15_F18_S0.8100.61
297_Q301_K0.8090.61
175_A178_I0.8080.61
261_A286_P0.8060.60
227_P276_G0.8020.60
151_I291_L0.8010.60
187_N211_N0.7990.60
21_M27_A0.7960.59
257_W276_G0.7960.59
12_L33_A0.7960.59
133_A308_V0.7930.59
31_I35_K0.7930.59
157_V299_K0.7910.59
28_L33_A0.7900.59
151_I295_I0.7900.59
227_P231_S0.7890.59
53_L156_Q0.7890.59
146_E292_E0.7870.58
77_G80_G0.7830.58
184_E307_T0.7770.58
227_P248_V0.7760.57
137_N226_A0.7750.57
18_S24_N0.7730.57
189_S247_T0.7710.57
169_R172_V0.7690.57
253_D258_Q0.7660.56
261_A264_V0.7600.56
203_I235_A0.7590.56
276_G306_G0.7580.56
195_M203_I0.7570.56
129_K304_A0.7550.55
171_N291_L0.7530.55
302_G305_L0.7510.55
26_H38_T0.7470.55
162_F192_H0.7470.55
248_V251_T0.7470.55
161_F186_G0.7460.54
281_M291_L0.7460.54
250_W256_D0.7450.54
37_D46_D0.7420.54
232_F236_V0.7420.54
33_A42_T0.7370.54
22_M38_T0.7370.54
137_N140_W0.7370.54
25_P29_D0.7370.54
14_L17_V0.7360.53
10_V36_K0.7360.53
253_D256_D0.7360.53
234_K237_I0.7340.53
259_K265_L0.7340.53
17_V23_E0.7320.53
233_R248_V0.7300.53
266_Q271_S0.7280.53
136_I148_M0.7270.53
16_F20_E0.7260.52
161_F256_D0.7260.52
256_D280_L0.7220.52
133_A198_L0.7220.52
131_M304_A0.7200.52
273_I297_Q0.7180.52
175_A185_I0.7140.51
46_D49_Y0.7130.51
226_A282_H0.7130.51
19_F39_V0.7130.51
31_I37_D0.7120.51
227_P240_A0.7100.51
16_F52_L0.7090.51
132_V298_I0.7080.51
195_M276_G0.7070.51
226_A251_T0.7060.50
13_F36_K0.7030.50
292_E299_K0.7010.50
250_W257_W0.7010.50
198_L202_R0.6990.50
137_N283_P0.6970.50
23_E34_M0.6940.49
16_F37_D0.6920.49
278_M308_V0.6910.49
196_S206_Q0.6890.49
166_N189_S0.6890.49
19_F35_K0.6880.49
45_K51_E0.6880.49
38_T41_V0.6870.49
160_T184_E0.6850.48
149_L152_L0.6850.48
168_V172_V0.6830.48
23_E26_H0.6830.48
235_A239_I0.6810.48
137_N228_P0.6810.48
15_F33_A0.6790.48
174_L291_L0.6780.48
13_F17_V0.6780.48
144_Y288_A0.6770.48
175_A218_I0.6740.47
12_L23_E0.6740.47
21_M29_D0.6730.47
16_F19_F0.6710.47
10_V33_A0.6610.46
177_K183_H0.6610.46
250_W254_T0.6610.46
10_V20_E0.6610.46
20_E28_L0.6600.46
47_P53_L0.6580.46
26_H30_Y0.6550.45
135_L189_S0.6540.45
14_L26_H0.6500.45
135_L226_A0.6480.45
258_Q265_L0.6480.45
193_P229_S0.6480.45
153_Q177_K0.6470.45
37_D43_A0.6430.44
254_T281_M0.6420.44
17_V24_N0.6410.44
192_H282_H0.6410.44
262_P286_P0.6410.44
279_I298_I0.6390.44
152_L161_F0.6380.44
207_L245_M0.6370.44
192_H226_A0.6360.43
15_F31_I0.6360.43
28_L37_D0.6340.43
168_V175_A0.6330.43
229_S249_M0.6320.43
140_W167_W0.6300.43
135_L269_V0.6250.42
168_V222_P0.6210.42
15_F20_E0.6210.42
139_A226_A0.6200.42
27_A32_G0.6170.42
148_M284_T0.6160.41
287_T291_L0.6130.41
227_P284_T0.6130.41
37_D40_T0.6100.41
33_A39_V0.6100.41
250_W280_L0.6090.41
140_W164_E0.6080.41
140_W229_S0.6060.41
29_D33_A0.6050.40
192_H250_W0.6030.40
51_E55_K0.6020.40
247_T254_T0.6020.40
13_F24_N0.6020.40
13_F37_D0.6010.40
133_A184_E0.6000.40
20_E43_A0.6000.40
27_A30_Y0.6000.40
137_N192_H0.5990.40
133_A307_T0.5990.40
15_F37_D0.5980.40
253_D287_T0.5970.40
175_A183_H0.5960.40
207_L243_K0.5950.39
54_Q62_K0.5950.39
13_F22_M0.5920.39
96_G99_R0.5910.39
34_M37_D0.5900.39
192_H280_L0.5900.39
277_A303_Y0.5890.39
188_H230_G0.5860.39
47_P58_E0.5860.39
261_A279_I0.5860.39
126_N129_K0.5860.39
249_M253_D0.5850.38
35_K47_P0.5840.38
103_L107_Q0.5810.38
14_L39_V0.5810.38
38_T53_L0.5810.38
177_K180_K0.5800.38
165_G279_I0.5770.38
146_E291_L0.5770.38
22_M42_T0.5770.38
10_V21_M0.5770.38
205_E289_E0.5750.38
12_L27_A0.5750.38
16_F31_I0.5750.38
13_F26_H0.5740.37
53_L60_E0.5730.37
138_V287_T0.5700.37
211_N218_I0.5700.37
101_K157_V0.5690.37
249_M257_W0.5680.37
292_E295_I0.5660.37
164_E210_T0.5630.36
147_K151_I0.5620.36
213_Q216_Q0.5600.36
26_H29_D0.5560.36
250_W282_H0.5530.35
25_P33_A0.5510.35
16_F26_H0.5500.35
39_V58_E0.5500.35
260_P285_D0.5500.35
254_T257_W0.5490.35
10_V24_N0.5490.35
78_Y81_L0.5490.35
16_F32_G0.5490.35
179_A185_I0.5480.35
139_A188_H0.5480.35
235_A238_D0.5470.35
269_V298_I0.5460.35
126_N131_M0.5440.35
19_F26_H0.5440.35
144_Y147_K0.5410.34
24_N34_M0.5410.34
23_E39_V0.5400.34
28_L41_V0.5390.34
226_A256_D0.5390.34
198_L203_I0.5370.34
73_K79_N0.5360.34
138_V228_P0.5350.34
18_S34_M0.5320.34
44_S201_G0.5320.34
13_F44_S0.5300.33
226_A280_L0.5300.33
24_N35_K0.5300.33
263_S267_T0.5300.33
258_Q264_V0.5280.33
203_I233_R0.5270.33
232_F237_I0.5270.33
227_P247_T0.5270.33
225_F247_T0.5270.33
284_T291_L0.5260.33
14_L25_P0.5260.33
22_M28_L0.5260.33
204_S208_D0.5240.33
18_S61_V0.5210.33
22_M26_H0.5210.33
43_A46_D0.5200.33
21_M33_A0.5190.32
13_F16_F0.5180.32
10_V43_A0.5170.32
17_V36_K0.5170.32
224_W309_T0.5160.32
37_D53_L0.5160.32
25_P30_Y0.5150.32
20_E32_G0.5150.32
57_P62_K0.5140.32
154_K300_D0.5140.32
36_K44_S0.5140.32
11_F27_A0.5130.32
156_Q238_D0.5130.32
210_T253_D0.5100.32
227_P257_W0.5100.32
153_Q156_Q0.5090.32
187_N214_I0.5090.32
22_M50_E0.5080.31
21_M39_V0.5070.31
279_I287_T0.5070.31
227_P233_R0.5070.31
285_D295_I0.5060.31
60_E64_Q0.5050.31
284_T288_A0.5050.31
236_V254_T0.5050.31
174_L303_Y0.5050.31
91_K95_H0.5030.31
138_V254_T0.5020.31
133_A229_S0.5010.31
164_E229_S0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4l1gA 1 0.652 100 0.292 Contact Map
2w3zA 1 0.6677 100 0.345 Contact Map
2c1iA 1 0.884 100 0.35 Contact Map
4m1bA 1 0.6144 100 0.368 Contact Map
1ny1A 1 0.7179 100 0.378 Contact Map
2j13A 1 0.6364 100 0.379 Contact Map
2y8uA 1 0.6364 100 0.38 Contact Map
2cc0A 2 0.6019 100 0.381 Contact Map
2vyoA 1 0.6207 100 0.393 Contact Map
2iw0A 1 0.6332 100 0.395 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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