GREMLIN Database
KDGT - 2-keto-3-deoxygluconate permease
UniProt: P50847 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 330 (310)
Sequences: 347 (218)
Seq/√Len: 12.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
261_S302_T4.1471.00
10_V17_I3.8750.99
124_G206_F3.7880.99
5_A190_D3.6970.99
245_D253_G3.5020.99
60_A195_F3.5000.99
124_G207_A3.3790.98
89_G115_V3.2930.98
121_T148_E3.2850.98
300_L304_L3.2320.97
120_E148_E3.1020.97
169_E172_A3.0600.96
262_T266_A2.8970.95
56_F195_F2.7790.94
198_V201_A2.5400.90
179_L183_I2.5250.90
80_G244_L2.4020.88
13_G188_D2.3580.87
92_A114_I2.3250.86
180_L316_K2.2860.85
4_K8_E2.2640.84
85_A119_N2.2500.84
55_I273_L2.2090.83
12_G124_G2.2060.83
107_A290_I2.1630.81
203_I268_A2.1600.81
229_I290_I2.1590.81
56_F180_L2.1470.81
76_T175_V2.1440.81
23_A215_N2.1210.80
233_V294_S2.0850.79
121_T149_S2.0140.76
120_E265_A1.9900.75
245_D255_A1.9550.74
52_G275_E1.9370.73
255_A260_S1.9300.73
152_F167_P1.9040.72
243_L247_F1.8720.71
234_V305_A1.8060.68
50_I53_V1.7930.67
121_T145_I1.7590.66
202_I205_F1.7410.65
190_D193_D1.7360.65
44_I173_A1.7040.63
215_N227_I1.6550.61
4_K14_M1.6510.61
7_I17_I1.6370.60
12_G207_A1.6340.60
155_M273_L1.6310.60
56_F175_V1.6300.60
33_A41_G1.5960.58
56_F227_I1.5930.58
124_G210_L1.5850.57
231_V294_S1.5660.56
242_F260_S1.5360.55
12_G125_L1.5140.54
257_V309_V1.5040.53
228_F231_V1.4810.52
56_F68_G1.4810.52
60_A278_A1.4700.52
215_N218_M1.4250.49
253_G260_S1.4180.49
29_A231_V1.4160.49
33_A290_I1.4140.49
85_A97_P1.4110.49
53_V205_F1.4100.48
25_L221_Q1.4030.48
16_I89_G1.4020.48
237_S240_S1.3960.48
120_E266_A1.3750.47
219_L296_I1.3640.46
52_G116_A1.3500.45
116_A207_A1.3460.45
15_M264_G1.3460.45
245_D261_S1.3440.45
230_G234_V1.3420.45
150_G162_G1.3420.45
44_I296_I1.3400.45
225_L290_I1.3280.44
36_F172_A1.3250.44
43_L116_A1.3250.44
153_M265_A1.3160.44
144_F296_I1.3150.44
72_R260_S1.3100.43
180_L197_K1.3020.43
171_L237_S1.2970.43
123_G149_S1.2940.43
5_A300_L1.2880.42
24_A91_I1.2800.42
4_K7_I1.2770.42
232_S295_V1.2730.42
127_L269_V1.2720.42
171_L175_V1.2710.41
63_D189_H1.2680.41
56_F220_I1.2650.41
153_M156_V1.2640.41
83_G115_V1.2360.40
3_I182_C1.2210.39
116_A269_V1.2180.39
7_I228_F1.2170.39
24_A32_T1.2150.39
84_F215_N1.2140.39
193_D197_K1.2140.39
227_I283_V1.2140.39
128_A194_L1.2100.38
242_F255_A1.2100.38
153_M215_N1.2060.38
15_M204_P1.2050.38
160_V215_N1.2050.38
78_L86_A1.2030.38
227_I235_I1.1990.38
236_L311_K1.1970.38
22_G124_G1.1930.38
291_I294_S1.1850.37
23_A114_I1.1760.37
9_R175_V1.1680.36
56_F60_A1.1610.36
135_R138_D1.1600.36
120_E149_S1.1430.35
225_L297_V1.1280.35
90_V171_L1.1260.35
118_M237_S1.1230.34
10_V278_A1.1180.34
34_E41_G1.1150.34
179_L217_G1.1100.34
223_G256_G1.1070.34
9_R305_A1.1030.33
156_V160_V1.1000.33
154_T273_L1.0970.33
310_D314_K1.0970.33
47_T222_S1.0880.33
96_I107_A1.0870.33
183_I227_I1.0860.33
101_I180_L1.0810.32
261_S278_A1.0790.32
62_I127_L1.0730.32
115_V295_V1.0720.32
78_L127_L1.0700.32
14_M128_A1.0560.31
111_V253_G1.0550.31
130_M255_A1.0520.31
16_I74_G1.0490.31
19_L208_F1.0480.31
114_I126_Y1.0470.31
302_T306_T1.0460.31
95_F308_W1.0450.31
87_L91_I1.0440.31
184_L191_L1.0410.31
92_A156_V1.0390.31
97_P265_A1.0370.31
3_I13_G1.0360.30
23_A27_T1.0270.30
158_F273_L1.0210.30
3_I187_L1.0180.30
97_P100_G1.0170.30
57_C198_V1.0080.29
267_V294_S1.0060.29
145_I157_T1.0040.29
44_I175_V0.9990.29
206_F210_L0.9960.29
204_P264_G0.9960.29
123_G297_V0.9900.29
221_Q247_F0.9800.28
82_I157_T0.9770.28
8_E190_D0.9740.28
52_G124_G0.9710.28
28_F220_I0.9690.28
20_F83_G0.9670.28
89_G154_T0.9540.27
9_R28_F0.9500.27
83_G296_I0.9490.27
76_T248_I0.9460.27
67_S269_V0.9430.27
130_M260_S0.9420.27
121_T259_A0.9410.27
112_L288_T0.9390.26
54_F74_G0.9370.26
154_T233_V0.9340.26
63_D231_V0.9320.26
49_P175_V0.9320.26
91_I228_F0.9300.26
9_R193_D0.9290.26
110_S147_T0.9280.26
160_V273_L0.9260.26
175_V228_F0.9260.26
232_S236_L0.9210.26
73_K254_V0.9180.26
31_G215_N0.9130.25
89_G114_I0.9120.25
159_G167_P0.9120.25
116_A175_V0.9100.25
273_L293_T0.9100.25
95_F227_I0.9100.25
180_L301_L0.9090.25
245_D260_S0.9080.25
23_A125_L0.9070.25
44_I133_M0.9070.25
41_G277_N0.9060.25
150_G238_G0.9050.25
220_I307_V0.9000.25
82_I280_F0.8970.25
123_G230_G0.8960.25
7_I191_L0.8900.25
272_A275_E0.8870.24
55_I257_V0.8790.24
114_I213_T0.8760.24
182_C280_F0.8750.24
85_A259_A0.8740.24
219_L293_T0.8720.24
76_T80_G0.8700.24
171_L304_L0.8690.24
15_M19_L0.8680.24
77_L166_F0.8680.24
71_A83_G0.8580.23
9_R65_R0.8580.23
38_G293_T0.8540.23
25_L219_L0.8530.23
135_R166_F0.8480.23
130_M159_G0.8480.23
84_F235_I0.8440.23
73_K137_E0.8370.23
79_L246_R0.8360.23
9_R228_F0.8320.22
172_A179_L0.8300.22
24_A219_L0.8270.22
36_F40_T0.8260.22
197_K228_F0.8180.22
22_G208_F0.8150.22
15_M123_G0.8150.22
26_N212_N0.8130.22
123_G152_F0.8110.22
117_V229_I0.8110.22
210_L293_T0.8060.22
16_I174_T0.8030.21
223_G293_T0.8020.21
83_G87_L0.8010.21
25_L106_F0.7950.21
76_T91_I0.7950.21
29_A91_I0.7930.21
172_A175_V0.7920.21
225_L300_L0.7880.21
232_S235_I0.7870.21
14_M191_L0.7870.21
33_A36_F0.7870.21
156_V170_T0.7840.21
89_G157_T0.7830.21
30_P223_G0.7830.21
32_T172_A0.7820.21
64_F182_C0.7800.21
115_V233_V0.7780.21
47_T203_I0.7750.20
118_M252_D0.7730.20
267_V289_A0.7710.20
45_T130_M0.7710.20
236_L316_K0.7710.20
91_I96_I0.7690.20
143_A178_F0.7660.20
147_T190_D0.7520.20
47_T210_L0.7490.20
138_D265_A0.7420.19
25_L32_T0.7400.19
165_A277_N0.7340.19
41_G269_V0.7330.19
110_S280_F0.7330.19
162_G256_G0.7320.19
27_T129_L0.7310.19
31_G171_L0.7240.19
189_H201_A0.7220.19
51_L276_A0.7200.19
12_G269_V0.7200.19
304_L311_K0.7150.19
41_G290_I0.7140.19
207_A210_L0.7130.19
73_K146_S0.7110.18
31_G34_E0.7100.18
21_L111_V0.7090.18
112_L183_I0.7050.18
39_F150_G0.7040.18
40_T223_G0.7040.18
61_T133_M0.7010.18
15_M159_G0.7010.18
73_K252_D0.7010.18
166_F277_N0.7000.18
310_D315_Q0.7000.18
195_F198_V0.6970.18
12_G206_F0.6970.18
157_T178_F0.6970.18
148_E233_V0.6960.18
15_M210_L0.6940.18
19_L206_F0.6930.18
97_P135_R0.6930.18
13_G190_D0.6920.18
96_I231_V0.6910.18
28_F136_K0.6890.18
79_L236_L0.6830.18
117_V301_L0.6820.18
72_R253_G0.6810.18
74_G126_Y0.6780.17
57_C178_F0.6770.17
150_G288_T0.6760.17
145_I149_S0.6760.17
29_A179_L0.6730.17
17_I180_L0.6720.17
237_S241_L0.6650.17
44_I212_N0.6610.17
101_I106_F0.6590.17
306_T313_I0.6570.17
32_T36_F0.6560.17
46_G55_I0.6550.17
32_T231_V0.6530.17
245_D256_G0.6530.17
138_D290_I0.6510.17
65_R156_V0.6490.17
114_I229_I0.6470.17
65_R190_D0.6470.17
70_I110_S0.6440.16
47_T207_A0.6440.16
162_G238_G0.6420.16
138_D173_A0.6420.16
60_A182_C0.6410.16
107_A225_L0.6410.16
117_V190_D0.6400.16
95_F99_D0.6390.16
68_G237_S0.6390.16
56_F184_L0.6360.16
49_P141_A0.6360.16
28_F279_S0.6350.16
158_F209_S0.6340.16
73_K245_D0.6340.16
9_R217_G0.6340.16
219_L289_A0.6340.16
93_A167_P0.6330.16
219_L307_V0.6320.16
20_F64_F0.6320.16
17_I77_L0.6310.16
199_V210_L0.6270.16
14_M116_A0.6270.16
16_I233_V0.6270.16
184_L189_H0.6260.16
237_S260_S0.6250.16
29_A281_A0.6250.16
43_L128_A0.6250.16
125_L141_A0.6230.16
22_G203_I0.6210.16
282_P285_E0.6180.16
260_S306_T0.6170.16
228_F243_L0.6140.16
150_G230_G0.6140.16
242_F309_V0.6120.16
314_K317_K0.6120.16
161_T248_I0.6120.16
296_I301_L0.6100.16
124_G241_L0.6090.16
10_V40_T0.6080.15
54_F144_F0.6080.15
10_V304_L0.6070.15
142_F269_V0.6070.15
203_I206_F0.6060.15
113_A204_P0.6060.15
288_T291_I0.6050.15
38_G173_A0.6040.15
112_L276_A0.6030.15
214_L295_V0.6020.15
64_F183_I0.6020.15
312_K315_Q0.6000.15
77_L145_I0.6000.15
123_G167_P0.5990.15
174_T291_I0.5990.15
146_S192_R0.5990.15
149_S265_A0.5980.15
191_L195_F0.5980.15
225_L307_V0.5970.15
69_Y178_F0.5960.15
106_F180_L0.5940.15
68_G170_T0.5920.15
193_D300_L0.5900.15
16_I85_A0.5900.15
227_I308_W0.5900.15
64_F91_I0.5890.15
19_L67_S0.5890.15
292_A306_T0.5880.15
126_Y141_A0.5870.15
19_L207_A0.5850.15
86_A282_P0.5850.15
51_L124_G0.5820.15
93_A111_V0.5820.15
216_F236_L0.5810.15
109_L114_I0.5800.15
5_A147_T0.5770.15
10_V129_L0.5760.15
8_E14_M0.5760.15
76_T137_E0.5750.15
215_N306_T0.5730.15
41_G225_L0.5730.15
21_L208_F0.5730.15
150_G154_T0.5730.15
254_V261_S0.5720.15
67_S222_S0.5710.15
47_T128_A0.5710.15
17_I291_I0.5700.15
74_G154_T0.5660.14
149_S157_T0.5650.14
95_F244_L0.5640.14
16_I138_D0.5620.14
162_G230_G0.5610.14
17_I25_L0.5610.14
193_D196_S0.5580.14
22_G150_G0.5570.14
49_P53_V0.5560.14
10_V29_A0.5560.14
166_F296_I0.5530.14
162_G167_P0.5500.14
214_L218_M0.5460.14
129_L306_T0.5450.14
19_L162_G0.5440.14
131_N279_S0.5420.14
26_N37_G0.5420.14
3_I12_G0.5410.14
163_L167_P0.5390.14
67_S207_A0.5390.14
120_E267_V0.5380.14
163_L305_A0.5370.14
186_N269_V0.5370.14
9_R101_I0.5360.14
90_V314_K0.5350.14
74_G119_N0.5340.14
72_R245_D0.5330.14
78_L148_E0.5330.14
64_F311_K0.5330.14
9_R227_I0.5310.14
144_F192_R0.5290.13
150_G256_G0.5270.13
89_G233_V0.5270.13
125_L261_S0.5260.13
63_D234_V0.5260.13
143_A168_W0.5260.13
171_L274_A0.5240.13
119_N168_W0.5240.13
210_L268_A0.5240.13
71_A216_F0.5240.13
298_T306_T0.5210.13
230_G293_T0.5200.13
20_F61_T0.5160.13
203_I238_G0.5160.13
57_C60_A0.5160.13
91_I156_V0.5150.13
51_L284_A0.5130.13
216_F220_I0.5120.13
109_L154_T0.5110.13
84_F153_M0.5090.13
9_R21_L0.5090.13
76_T222_S0.5080.13
71_A284_A0.5080.13
7_I115_V0.5070.13
13_G124_G0.5060.13
37_G134_G0.5040.13
10_V317_K0.5040.13
198_V305_A0.5040.13
257_V269_V0.5030.13
246_R312_K0.5020.13
93_A279_S0.5020.13
159_G258_A0.5020.13
42_A78_L0.5010.13
176_I224_L0.5000.13
275_E298_T0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zuxA 1 0.8667 99.9 0.794 Contact Map
4n7wA 2 0.8697 99.6 0.866 Contact Map
4bwzA 2 0.9152 98.4 0.92 Contact Map
4czbA 2 0.9273 98.1 0.927 Contact Map
4cz8A 2 0.8909 97.2 0.939 Contact Map
1zcdA 1 0.8242 84.3 0.962 Contact Map
4rfsS 1 0.4788 39.2 0.972 Contact Map
2kv5A 1 0.0879 27.7 0.974 Contact Map
4ogqG 1 0.1121 23.2 0.975 Contact Map
4huqS 1 0.4606 22.2 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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