KDGT - BACSU - GREMLIN Contacts

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KDGT - 2-keto-3-deoxygluconate permease

UniProt:	P50847	Sequences: MKIKATIERVPGGMMIIPLFLGAALNTFAPGTAEFFGGFTGALITGTLPILGVFIFCVGATIDFRSSGYIARKGITLLLGKIGFAALLGVIAAQFIPDDGIQSGFFAGLSVLAIVAVMNETNGGLYLALMNHMGRKEDAGAFAFISTESGPFMTMVTFGVTGLAAFPWETLAATVIPFLLGCILGNLDHDLRDLFSKVVPAIIPFFAFSLGNTLNFGMLIQSGLLGIFIGVSVVILSGSSLFLLDRFIARGDGVAGVAASSTAGAAVAVPYALAEANASFAPVAESATAIIATSVIVTSLLTPLATVWVDKKIKQKKRRTPPPKNQMTIN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	330 (310)
Sequences:	347 (218)
Seq/√Len:	12.4

ECOLI - KDGT
BACSU - KDGT

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
261_S	302_T	4.147	1.00
10_V	17_I	3.875	0.99
124_G	206_F	3.788	0.99
5_A	190_D	3.697	0.99
245_D	253_G	3.502	0.99
60_A	195_F	3.500	0.99
124_G	207_A	3.379	0.98
89_G	115_V	3.293	0.98
121_T	148_E	3.285	0.98
300_L	304_L	3.232	0.97
120_E	148_E	3.102	0.97
169_E	172_A	3.060	0.96
262_T	266_A	2.897	0.95
56_F	195_F	2.779	0.94
198_V	201_A	2.540	0.90
179_L	183_I	2.525	0.90
80_G	244_L	2.402	0.88
13_G	188_D	2.358	0.87
92_A	114_I	2.325	0.86
180_L	316_K	2.286	0.85
4_K	8_E	2.264	0.84
85_A	119_N	2.250	0.84
55_I	273_L	2.209	0.83
12_G	124_G	2.206	0.83
107_A	290_I	2.163	0.81
203_I	268_A	2.160	0.81
229_I	290_I	2.159	0.81
56_F	180_L	2.147	0.81
76_T	175_V	2.144	0.81
23_A	215_N	2.121	0.80
233_V	294_S	2.085	0.79
121_T	149_S	2.014	0.76
120_E	265_A	1.990	0.75
245_D	255_A	1.955	0.74
52_G	275_E	1.937	0.73
255_A	260_S	1.930	0.73
152_F	167_P	1.904	0.72
243_L	247_F	1.872	0.71
234_V	305_A	1.806	0.68
50_I	53_V	1.793	0.67
121_T	145_I	1.759	0.66
202_I	205_F	1.741	0.65
190_D	193_D	1.736	0.65
44_I	173_A	1.704	0.63
215_N	227_I	1.655	0.61
4_K	14_M	1.651	0.61
7_I	17_I	1.637	0.60
12_G	207_A	1.634	0.60
155_M	273_L	1.631	0.60
56_F	175_V	1.630	0.60
33_A	41_G	1.596	0.58
56_F	227_I	1.593	0.58
124_G	210_L	1.585	0.57
231_V	294_S	1.566	0.56
242_F	260_S	1.536	0.55
12_G	125_L	1.514	0.54
257_V	309_V	1.504	0.53
228_F	231_V	1.481	0.52
56_F	68_G	1.481	0.52
60_A	278_A	1.470	0.52
215_N	218_M	1.425	0.49
253_G	260_S	1.418	0.49
29_A	231_V	1.416	0.49
33_A	290_I	1.414	0.49
85_A	97_P	1.411	0.49
53_V	205_F	1.410	0.48
25_L	221_Q	1.403	0.48
16_I	89_G	1.402	0.48
237_S	240_S	1.396	0.48
120_E	266_A	1.375	0.47
219_L	296_I	1.364	0.46
52_G	116_A	1.350	0.45
116_A	207_A	1.346	0.45
15_M	264_G	1.346	0.45
245_D	261_S	1.344	0.45
230_G	234_V	1.342	0.45
150_G	162_G	1.342	0.45
44_I	296_I	1.340	0.45
225_L	290_I	1.328	0.44
36_F	172_A	1.325	0.44
43_L	116_A	1.325	0.44
153_M	265_A	1.316	0.44
144_F	296_I	1.315	0.44
72_R	260_S	1.310	0.43
180_L	197_K	1.302	0.43
171_L	237_S	1.297	0.43
123_G	149_S	1.294	0.43
5_A	300_L	1.288	0.42
24_A	91_I	1.280	0.42
4_K	7_I	1.277	0.42
232_S	295_V	1.273	0.42
127_L	269_V	1.272	0.42
171_L	175_V	1.271	0.41
63_D	189_H	1.268	0.41
56_F	220_I	1.265	0.41
153_M	156_V	1.264	0.41
83_G	115_V	1.236	0.40
3_I	182_C	1.221	0.39
116_A	269_V	1.218	0.39
7_I	228_F	1.217	0.39
24_A	32_T	1.215	0.39
84_F	215_N	1.214	0.39
193_D	197_K	1.214	0.39
227_I	283_V	1.214	0.39
128_A	194_L	1.210	0.38
242_F	255_A	1.210	0.38
153_M	215_N	1.206	0.38
15_M	204_P	1.205	0.38
160_V	215_N	1.205	0.38
78_L	86_A	1.203	0.38
227_I	235_I	1.199	0.38
236_L	311_K	1.197	0.38
22_G	124_G	1.193	0.38
291_I	294_S	1.185	0.37
23_A	114_I	1.176	0.37
9_R	175_V	1.168	0.36
56_F	60_A	1.161	0.36
135_R	138_D	1.160	0.36
120_E	149_S	1.143	0.35
225_L	297_V	1.128	0.35
90_V	171_L	1.126	0.35
118_M	237_S	1.123	0.34
10_V	278_A	1.118	0.34
34_E	41_G	1.115	0.34
179_L	217_G	1.110	0.34
223_G	256_G	1.107	0.34
9_R	305_A	1.103	0.33
156_V	160_V	1.100	0.33
154_T	273_L	1.097	0.33
310_D	314_K	1.097	0.33
47_T	222_S	1.088	0.33
96_I	107_A	1.087	0.33
183_I	227_I	1.086	0.33
101_I	180_L	1.081	0.32
261_S	278_A	1.079	0.32
62_I	127_L	1.073	0.32
115_V	295_V	1.072	0.32
78_L	127_L	1.070	0.32
14_M	128_A	1.056	0.31
111_V	253_G	1.055	0.31
130_M	255_A	1.052	0.31
16_I	74_G	1.049	0.31
19_L	208_F	1.048	0.31
114_I	126_Y	1.047	0.31
302_T	306_T	1.046	0.31
95_F	308_W	1.045	0.31
87_L	91_I	1.044	0.31
184_L	191_L	1.041	0.31
92_A	156_V	1.039	0.31
97_P	265_A	1.037	0.31
3_I	13_G	1.036	0.30
23_A	27_T	1.027	0.30
158_F	273_L	1.021	0.30
3_I	187_L	1.018	0.30
97_P	100_G	1.017	0.30
57_C	198_V	1.008	0.29
267_V	294_S	1.006	0.29
145_I	157_T	1.004	0.29
44_I	175_V	0.999	0.29
206_F	210_L	0.996	0.29
204_P	264_G	0.996	0.29
123_G	297_V	0.990	0.29
221_Q	247_F	0.980	0.28
82_I	157_T	0.977	0.28
8_E	190_D	0.974	0.28
52_G	124_G	0.971	0.28
28_F	220_I	0.969	0.28
20_F	83_G	0.967	0.28
89_G	154_T	0.954	0.27
9_R	28_F	0.950	0.27
83_G	296_I	0.949	0.27
76_T	248_I	0.946	0.27
67_S	269_V	0.943	0.27
130_M	260_S	0.942	0.27
121_T	259_A	0.941	0.27
112_L	288_T	0.939	0.26
54_F	74_G	0.937	0.26
154_T	233_V	0.934	0.26
63_D	231_V	0.932	0.26
49_P	175_V	0.932	0.26
91_I	228_F	0.930	0.26
9_R	193_D	0.929	0.26
110_S	147_T	0.928	0.26
160_V	273_L	0.926	0.26
175_V	228_F	0.926	0.26
232_S	236_L	0.921	0.26
73_K	254_V	0.918	0.26
31_G	215_N	0.913	0.25
89_G	114_I	0.912	0.25
159_G	167_P	0.912	0.25
116_A	175_V	0.910	0.25
273_L	293_T	0.910	0.25
95_F	227_I	0.910	0.25
180_L	301_L	0.909	0.25
245_D	260_S	0.908	0.25
23_A	125_L	0.907	0.25
44_I	133_M	0.907	0.25
41_G	277_N	0.906	0.25
150_G	238_G	0.905	0.25
220_I	307_V	0.900	0.25
82_I	280_F	0.897	0.25
123_G	230_G	0.896	0.25
7_I	191_L	0.890	0.25
272_A	275_E	0.887	0.24
55_I	257_V	0.879	0.24
114_I	213_T	0.876	0.24
182_C	280_F	0.875	0.24
85_A	259_A	0.874	0.24
219_L	293_T	0.872	0.24
76_T	80_G	0.870	0.24
171_L	304_L	0.869	0.24
15_M	19_L	0.868	0.24
77_L	166_F	0.868	0.24
71_A	83_G	0.858	0.23
9_R	65_R	0.858	0.23
38_G	293_T	0.854	0.23
25_L	219_L	0.853	0.23
135_R	166_F	0.848	0.23
130_M	159_G	0.848	0.23
84_F	235_I	0.844	0.23
73_K	137_E	0.837	0.23
79_L	246_R	0.836	0.23
9_R	228_F	0.832	0.22
172_A	179_L	0.830	0.22
24_A	219_L	0.827	0.22
36_F	40_T	0.826	0.22
197_K	228_F	0.818	0.22
22_G	208_F	0.815	0.22
15_M	123_G	0.815	0.22
26_N	212_N	0.813	0.22
123_G	152_F	0.811	0.22
117_V	229_I	0.811	0.22
210_L	293_T	0.806	0.22
16_I	174_T	0.803	0.21
223_G	293_T	0.802	0.21
83_G	87_L	0.801	0.21
25_L	106_F	0.795	0.21
76_T	91_I	0.795	0.21
29_A	91_I	0.793	0.21
172_A	175_V	0.792	0.21
225_L	300_L	0.788	0.21
232_S	235_I	0.787	0.21
14_M	191_L	0.787	0.21
33_A	36_F	0.787	0.21
156_V	170_T	0.784	0.21
89_G	157_T	0.783	0.21
30_P	223_G	0.783	0.21
32_T	172_A	0.782	0.21
64_F	182_C	0.780	0.21
115_V	233_V	0.778	0.21
47_T	203_I	0.775	0.20
118_M	252_D	0.773	0.20
267_V	289_A	0.771	0.20
45_T	130_M	0.771	0.20
236_L	316_K	0.771	0.20
91_I	96_I	0.769	0.20
143_A	178_F	0.766	0.20
147_T	190_D	0.752	0.20
47_T	210_L	0.749	0.20
138_D	265_A	0.742	0.19
25_L	32_T	0.740	0.19
165_A	277_N	0.734	0.19
41_G	269_V	0.733	0.19
110_S	280_F	0.733	0.19
162_G	256_G	0.732	0.19
27_T	129_L	0.731	0.19
31_G	171_L	0.724	0.19
189_H	201_A	0.722	0.19
51_L	276_A	0.720	0.19
12_G	269_V	0.720	0.19
304_L	311_K	0.715	0.19
41_G	290_I	0.714	0.19
207_A	210_L	0.713	0.19
73_K	146_S	0.711	0.18
31_G	34_E	0.710	0.18
21_L	111_V	0.709	0.18
112_L	183_I	0.705	0.18
39_F	150_G	0.704	0.18
40_T	223_G	0.704	0.18
61_T	133_M	0.701	0.18
15_M	159_G	0.701	0.18
73_K	252_D	0.701	0.18
166_F	277_N	0.700	0.18
310_D	315_Q	0.700	0.18
195_F	198_V	0.697	0.18
12_G	206_F	0.697	0.18
157_T	178_F	0.697	0.18
148_E	233_V	0.696	0.18
15_M	210_L	0.694	0.18
19_L	206_F	0.693	0.18
97_P	135_R	0.693	0.18
13_G	190_D	0.692	0.18
96_I	231_V	0.691	0.18
28_F	136_K	0.689	0.18
79_L	236_L	0.683	0.18
117_V	301_L	0.682	0.18
72_R	253_G	0.681	0.18
74_G	126_Y	0.678	0.17
57_C	178_F	0.677	0.17
150_G	288_T	0.676	0.17
145_I	149_S	0.676	0.17
29_A	179_L	0.673	0.17
17_I	180_L	0.672	0.17
237_S	241_L	0.665	0.17
44_I	212_N	0.661	0.17
101_I	106_F	0.659	0.17
306_T	313_I	0.657	0.17
32_T	36_F	0.656	0.17
46_G	55_I	0.655	0.17
32_T	231_V	0.653	0.17
245_D	256_G	0.653	0.17
138_D	290_I	0.651	0.17
65_R	156_V	0.649	0.17
114_I	229_I	0.647	0.17
65_R	190_D	0.647	0.17
70_I	110_S	0.644	0.16
47_T	207_A	0.644	0.16
162_G	238_G	0.642	0.16
138_D	173_A	0.642	0.16
60_A	182_C	0.641	0.16
107_A	225_L	0.641	0.16
117_V	190_D	0.640	0.16
95_F	99_D	0.639	0.16
68_G	237_S	0.639	0.16
56_F	184_L	0.636	0.16
49_P	141_A	0.636	0.16
28_F	279_S	0.635	0.16
158_F	209_S	0.634	0.16
73_K	245_D	0.634	0.16
9_R	217_G	0.634	0.16
219_L	289_A	0.634	0.16
93_A	167_P	0.633	0.16
219_L	307_V	0.632	0.16
20_F	64_F	0.632	0.16
17_I	77_L	0.631	0.16
199_V	210_L	0.627	0.16
14_M	116_A	0.627	0.16
16_I	233_V	0.627	0.16
184_L	189_H	0.626	0.16
237_S	260_S	0.625	0.16
29_A	281_A	0.625	0.16
43_L	128_A	0.625	0.16
125_L	141_A	0.623	0.16
22_G	203_I	0.621	0.16
282_P	285_E	0.618	0.16
260_S	306_T	0.617	0.16
228_F	243_L	0.614	0.16
150_G	230_G	0.614	0.16
242_F	309_V	0.612	0.16
314_K	317_K	0.612	0.16
161_T	248_I	0.612	0.16
296_I	301_L	0.610	0.16
124_G	241_L	0.609	0.16
10_V	40_T	0.608	0.15
54_F	144_F	0.608	0.15
10_V	304_L	0.607	0.15
142_F	269_V	0.607	0.15
203_I	206_F	0.606	0.15
113_A	204_P	0.606	0.15
288_T	291_I	0.605	0.15
38_G	173_A	0.604	0.15
112_L	276_A	0.603	0.15
214_L	295_V	0.602	0.15
64_F	183_I	0.602	0.15
312_K	315_Q	0.600	0.15
77_L	145_I	0.600	0.15
123_G	167_P	0.599	0.15
174_T	291_I	0.599	0.15
146_S	192_R	0.599	0.15
149_S	265_A	0.598	0.15
191_L	195_F	0.598	0.15
225_L	307_V	0.597	0.15
69_Y	178_F	0.596	0.15
106_F	180_L	0.594	0.15
68_G	170_T	0.592	0.15
193_D	300_L	0.590	0.15
16_I	85_A	0.590	0.15
227_I	308_W	0.590	0.15
64_F	91_I	0.589	0.15
19_L	67_S	0.589	0.15
292_A	306_T	0.588	0.15
126_Y	141_A	0.587	0.15
19_L	207_A	0.585	0.15
86_A	282_P	0.585	0.15
51_L	124_G	0.582	0.15
93_A	111_V	0.582	0.15
216_F	236_L	0.581	0.15
109_L	114_I	0.580	0.15
5_A	147_T	0.577	0.15
10_V	129_L	0.576	0.15
8_E	14_M	0.576	0.15
76_T	137_E	0.575	0.15
215_N	306_T	0.573	0.15
41_G	225_L	0.573	0.15
21_L	208_F	0.573	0.15
150_G	154_T	0.573	0.15
254_V	261_S	0.572	0.15
67_S	222_S	0.571	0.15
47_T	128_A	0.571	0.15
17_I	291_I	0.570	0.15
74_G	154_T	0.566	0.14
149_S	157_T	0.565	0.14
95_F	244_L	0.564	0.14
16_I	138_D	0.562	0.14
162_G	230_G	0.561	0.14
17_I	25_L	0.561	0.14
193_D	196_S	0.558	0.14
22_G	150_G	0.557	0.14
49_P	53_V	0.556	0.14
10_V	29_A	0.556	0.14
166_F	296_I	0.553	0.14
162_G	167_P	0.550	0.14
214_L	218_M	0.546	0.14
129_L	306_T	0.545	0.14
19_L	162_G	0.544	0.14
131_N	279_S	0.542	0.14
26_N	37_G	0.542	0.14
3_I	12_G	0.541	0.14
163_L	167_P	0.539	0.14
67_S	207_A	0.539	0.14
120_E	267_V	0.538	0.14
163_L	305_A	0.537	0.14
186_N	269_V	0.537	0.14
9_R	101_I	0.536	0.14
90_V	314_K	0.535	0.14
74_G	119_N	0.534	0.14
72_R	245_D	0.533	0.14
78_L	148_E	0.533	0.14
64_F	311_K	0.533	0.14
9_R	227_I	0.531	0.14
144_F	192_R	0.529	0.13
150_G	256_G	0.527	0.13
89_G	233_V	0.527	0.13
125_L	261_S	0.526	0.13
63_D	234_V	0.526	0.13
143_A	168_W	0.526	0.13
171_L	274_A	0.524	0.13
119_N	168_W	0.524	0.13
210_L	268_A	0.524	0.13
71_A	216_F	0.524	0.13
298_T	306_T	0.521	0.13
230_G	293_T	0.520	0.13
20_F	61_T	0.516	0.13
203_I	238_G	0.516	0.13
57_C	60_A	0.516	0.13
91_I	156_V	0.515	0.13
51_L	284_A	0.513	0.13
216_F	220_I	0.512	0.13
109_L	154_T	0.511	0.13
84_F	153_M	0.509	0.13
9_R	21_L	0.509	0.13
76_T	222_S	0.508	0.13
71_A	284_A	0.508	0.13
7_I	115_V	0.507	0.13
13_G	124_G	0.506	0.13
37_G	134_G	0.504	0.13
10_V	317_K	0.504	0.13
198_V	305_A	0.504	0.13
257_V	269_V	0.503	0.13
246_R	312_K	0.502	0.13
93_A	279_S	0.502	0.13
159_G	258_A	0.502	0.13
42_A	78_L	0.501	0.13
176_I	224_L	0.500	0.13
275_E	298_T	0.500	0.13

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3zuxA	1	0.8667	99.9	0.794	Contact Map
4n7wA	2	0.8697	99.6	0.866	Contact Map
4bwzA	2	0.9152	98.4	0.92	Contact Map
4czbA	2	0.9273	98.1	0.927	Contact Map
4cz8A	2	0.8909	97.2	0.939	Contact Map
1zcdA	1	0.8242	84.3	0.962	Contact Map
4rfsS	1	0.4788	39.2	0.972	Contact Map
2kv5A	1	0.0879	27.7	0.974	Contact Map
4ogqG	1	0.1121	23.2	0.975	Contact Map
4huqS	1	0.4606	22.2	0.975	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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