GREMLIN Database
ALKH - KHG/KDPG aldolase
UniProt: P50846 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 196 (181)
Sequences: 3687 (2506)
Seq/√Len: 186.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_R86_Q3.7941.00
95_A120_E2.7171.00
73_S76_Q2.6121.00
33_S37_K2.4871.00
53_D56_E2.4831.00
32_E61_R2.4631.00
94_S123_T2.3921.00
31_I58_F2.3671.00
81_A106_T2.3091.00
52_S79_E2.1931.00
46_Y52_S2.0821.00
28_C61_R2.0651.00
78_G100_H2.0421.00
166_P170_R1.9441.00
56_E60_N1.9401.00
98_A108_Y1.9261.00
121_A129_L1.9241.00
118_I152_V1.8811.00
90_S108_Y1.8721.00
113_L137_F1.8501.00
35_L64_I1.8461.00
99_E124_F1.8351.00
23_D26_E1.8321.00
78_G82_K1.8311.00
122_L152_V1.8011.00
137_F141_F1.7931.00
28_C57_S1.7851.00
32_E36_D1.7831.00
141_F145_L1.7601.00
112_V118_I1.7531.00
71_V88_I1.7511.00
55_I68_A1.7381.00
92_G119_M1.7261.00
75_Q79_E1.6851.00
80_A85_A1.6721.00
114_T117_E1.6661.00
102_S127_T1.6411.00
161_H164_E1.6331.00
88_I101_L1.6311.00
112_V129_L1.6301.00
93_F98_A1.6221.00
100_H104_V1.6201.00
101_L108_Y1.6121.00
76_Q79_E1.5751.00
77_A88_I1.5731.00
67_G87_F1.5731.00
93_F124_F1.5171.00
96_D123_T1.5051.00
24_K50_G1.5001.00
44_V58_F1.4871.00
50_G53_D1.4521.00
131_L154_F1.4461.00
115_P145_L1.4381.00
118_I149_F1.4171.00
122_L151_Q1.4041.00
96_D99_E1.3731.00
142_M173_A1.3711.00
16_I155_I1.3461.00
89_V109_I1.3301.00
135_G144_N1.3301.00
19_I42_V1.3051.00
131_L137_F1.2941.00
95_A124_F1.2871.00
100_H103_F1.2811.00
55_I66_I1.2631.00
136_V141_F1.2601.00
77_A100_H1.2341.00
135_G140_P1.2211.00
77_A97_L1.2201.00
11_K153_T1.2021.00
93_F112_V1.1971.00
35_L40_R1.1931.00
90_S110_P1.1851.00
78_G104_V1.1821.00
53_D57_S1.1781.00
119_M149_F1.1671.00
95_A99_E1.1591.00
31_I42_V1.1521.00
46_Y80_A1.1421.00
57_S60_N1.1381.00
13_A40_R1.1271.00
118_I145_L1.1231.00
135_G168_W1.1131.00
184_S187_K1.1091.00
57_S61_R1.0991.00
68_A80_A1.0971.00
65_L86_Q1.0951.00
99_E103_F1.0771.00
72_I76_Q1.0701.00
134_S160_I1.0611.00
81_A100_H1.0301.00
113_L141_F1.0281.00
136_V144_N1.0201.00
80_A88_I1.0191.00
8_N11_K1.0161.00
79_E82_K1.0100.99
81_A104_V1.0000.99
156_P173_A1.0000.99
165_V176_V1.0000.99
8_N12_E0.9970.99
74_A100_H0.9940.99
167_D170_R0.9900.99
13_A39_I0.9820.99
24_K54_I0.9630.99
116_S120_E0.9500.99
25_Q57_S0.9490.99
94_S119_M0.9450.99
18_V89_V0.9420.99
72_I151_Q0.9340.99
52_S80_A0.9320.99
22_K185_C0.9300.99
88_I106_T0.9290.99
131_L141_F0.9270.99
56_E82_K0.9260.99
28_C32_E0.9240.99
120_E124_F0.9190.99
112_V121_A0.9170.99
155_I175_A0.9030.99
59_R83_A0.8950.99
108_Y126_F0.8940.99
77_A101_L0.8910.99
50_G54_I0.8900.99
21_S54_I0.8880.99
140_P144_N0.8880.99
41_A65_L0.8840.99
75_Q78_G0.8720.99
73_S123_T0.8680.98
93_F121_A0.8600.98
74_A96_D0.8570.98
164_E167_D0.8560.98
98_A126_F0.8530.98
28_C58_F0.8460.98
34_L183_G0.8180.98
15_L39_I0.8170.98
80_A83_A0.8160.98
18_V157_T0.8120.98
93_F120_E0.7940.97
118_I154_F0.7880.97
161_H181_Q0.7830.97
13_A41_A0.7820.97
52_S83_A0.7810.97
24_K57_S0.7810.97
78_G81_A0.7780.97
12_E40_R0.7770.97
29_Q32_E0.7750.97
35_L63_D0.7570.96
156_P174_G0.7560.96
113_L145_L0.7510.96
9_R12_E0.7440.96
142_M154_F0.7420.96
47_T150_P0.7380.96
26_E29_Q0.7380.96
68_A88_I0.7360.96
26_E188_E0.7330.96
92_G97_L0.7300.96
21_S47_T0.7230.95
157_T177_G0.7230.95
54_I57_S0.7210.95
41_A87_F0.7180.95
101_L106_T0.7100.95
146_A174_G0.7090.95
42_V64_I0.7060.95
74_A78_G0.7050.95
48_T51_A0.7040.95
28_C54_I0.7030.95
158_G179_G0.6940.94
12_E65_L0.6920.94
18_V45_T0.6830.94
121_A124_F0.6820.94
46_Y76_Q0.6820.94
98_A124_F0.6810.94
139_I171_A0.6780.93
59_R66_I0.6760.93
88_I108_Y0.6740.93
126_F129_L0.6690.93
109_I128_T0.6680.93
47_T157_T0.6670.93
140_P167_D0.6660.93
161_H165_V0.6660.93
120_E123_T0.6640.93
117_E149_F0.6630.93
9_R65_L0.6620.93
31_I66_I0.6580.92
56_E59_R0.6550.92
39_I182_L0.6530.92
165_V169_L0.6520.92
99_E123_T0.6520.92
10_L175_A0.6480.92
58_F66_I0.6470.92
14_K169_L0.6470.92
144_N157_T0.6460.92
19_I183_G0.6430.92
157_T178_V0.6380.91
15_L165_V0.6350.91
21_S26_E0.6350.91
146_A154_F0.6280.91
27_A58_F0.6280.91
82_K104_V0.6270.91
46_Y51_A0.6260.90
131_L142_M0.6240.90
40_R63_D0.6170.90
128_T175_A0.6160.90
140_P143_K0.6120.89
90_S101_L0.6070.89
94_S116_S0.6070.89
27_A54_I0.6020.89
55_I83_A0.6000.89
163_S167_D0.6000.89
24_K27_A0.5990.88
77_A106_T0.5940.88
143_K171_A0.5940.88
45_T147_G0.5930.88
162_P165_V0.5910.88
29_Q33_S0.5900.88
149_F152_V0.5880.88
56_E83_A0.5870.87
129_L152_V0.5870.87
138_G141_F0.5860.87
30_Q183_G0.5850.87
44_V51_A0.5840.87
52_S56_E0.5810.87
29_Q34_L0.5800.87
139_I173_A0.5790.87
70_T91_P0.5780.87
17_A39_I0.5770.87
134_S168_W0.5740.86
89_V111_G0.5720.86
70_T130_K0.5710.86
184_S188_E0.5710.86
94_S97_L0.5700.86
75_Q103_F0.5690.86
115_P149_F0.5650.85
20_R185_C0.5650.85
147_G173_A0.5630.85
93_F126_F0.5590.85
160_I164_E0.5580.85
21_S30_Q0.5530.84
149_F177_G0.5510.84
44_V55_I0.5490.84
24_K53_D0.5480.84
115_P141_F0.5480.84
118_I129_L0.5470.84
17_A182_L0.5470.84
18_V47_T0.5450.83
20_R172_G0.5450.83
161_H166_P0.5400.83
103_F123_T0.5360.82
94_S98_A0.5330.82
172_G177_G0.5310.82
29_Q36_D0.5290.81
73_S103_F0.5280.81
110_P126_F0.5270.81
90_S94_S0.5240.81
17_A47_T0.5240.81
135_G143_K0.5230.81
113_L117_E0.5230.81
112_V145_L0.5200.80
140_P163_S0.5180.80
44_V68_A0.5180.80
82_K99_E0.5160.80
169_L176_V0.5130.79
45_T148_P0.5120.79
72_I119_M0.5120.79
185_C188_E0.5090.79
32_E63_D0.5080.79
145_L149_F0.5070.79
98_A102_S0.5050.78
79_E83_A0.5050.78
40_R65_L0.5040.78
74_A97_L0.5020.78
77_A81_A0.5010.78
77_A104_V0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vhcA 3 1 100 0.459 Contact Map
3vcrA 3 0.9898 100 0.464 Contact Map
1wbhA 3 1 100 0.473 Contact Map
2yw3A 4 0.9796 100 0.478 Contact Map
1mxsA 3 1 100 0.479 Contact Map
4bk9A 3 0.9796 100 0.493 Contact Map
4e38A 3 0.9898 100 0.514 Contact Map
1wa3A 3 0.9847 100 0.541 Contact Map
2v82A 3 0.9643 99.9 0.596 Contact Map
4qccA 6 0.949 99.9 0.605 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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