GREMLIN Database
KDGK - 2-dehydro-3-deoxygluconokinase
UniProt: P50845 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 324 (282)
Sequences: 22368 (16503)
Seq/√Len: 982.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_F269_S3.2411.00
229_L235_Y2.6251.00
67_L82_R2.5971.00
52_G76_D2.5691.00
236_F281_V2.4901.00
6_V129_A2.4341.00
270_G275_L2.4051.00
133_H164_S2.3321.00
276_S279_D2.2461.00
234_A263_F2.1861.00
154_N190_L2.1201.00
243_G278_K2.0611.00
64_T82_R2.0581.00
198_I229_L2.0141.00
218_L237_K2.0051.00
270_G283_R1.9731.00
71_K77_V1.9581.00
42_C73_E1.9491.00
164_S268_I1.9411.00
162_T192_D1.9291.00
56_K83_S1.9171.00
153_M163_I1.9041.00
303_T306_K1.8911.00
156_M161_K1.8591.00
44_L49_F1.8541.00
7_T41_A1.8531.00
131_H162_T1.8411.00
56_K120_E1.8361.00
83_S86_E1.8201.00
123_R155_D1.8141.00
46_R73_E1.8101.00
214_A237_K1.7971.00
262_G287_I1.7911.00
235_Y244_F1.7771.00
195_F264_A1.7591.00
275_L279_D1.7461.00
43_G265_V1.7351.00
150_Y186_D1.7281.00
273_D304_R1.6781.00
192_D223_S1.6751.00
193_W224_F1.6501.00
226_A267_V1.6501.00
69_E72_K1.6481.00
67_L71_K1.6471.00
234_A285_N1.6451.00
224_F238_T1.6451.00
131_H164_S1.6071.00
278_K282_Q1.6051.00
267_V280_A1.5861.00
216_Y220_K1.5831.00
229_L232_E1.5741.00
87_N115_T1.5711.00
236_F243_G1.5701.00
155_D159_A1.5691.00
266_G287_I1.5691.00
288_G292_V1.5671.00
5_A44_L1.5351.00
248_C286_A1.5281.00
236_F277_Y1.5221.00
150_Y154_N1.5221.00
216_Y219_K1.5211.00
31_K65_F1.5121.00
131_H268_I1.5121.00
259_A292_V1.5091.00
68_Q72_K1.5011.00
11_S55_S1.4951.00
229_L244_F1.4861.00
151_H154_N1.4681.00
294_A306_K1.4391.00
151_H155_D1.4331.00
202_E208_K1.4231.00
44_L269_S1.4151.00
245_L281_V1.4101.00
238_T241_S1.3981.00
155_D158_N1.3911.00
245_L285_N1.3901.00
269_S273_D1.3871.00
207_E216_Y1.3811.00
33_L66_I1.3781.00
162_T193_W1.3771.00
59_N82_R1.3771.00
266_G283_R1.3741.00
64_T68_Q1.3561.00
69_E73_E1.3551.00
248_C282_Q1.3441.00
59_N64_T1.3431.00
209_T212_G1.3221.00
38_S70_L1.3031.00
127_Q159_A1.2971.00
50_R76_D1.2951.00
157_R190_L1.2941.00
117_T120_E1.2751.00
157_R192_D1.2691.00
211_E215_D1.2661.00
33_L69_E1.2651.00
118_T151_H1.2611.00
15_F29_F1.2571.00
65_F68_Q1.2521.00
185_N220_K1.2511.00
255_D296_G1.2481.00
224_F277_Y1.2471.00
13_A65_F1.2381.00
218_L239_G1.2381.00
250_V293_Q1.2381.00
211_E242_E1.2201.00
63_G89_T1.2161.00
270_G280_A1.2131.00
191_A194_F1.2081.00
270_G273_D1.2011.00
167_P196_P1.1961.00
234_A281_V1.1951.00
67_L80_V1.1901.00
126_F129_A1.1891.00
49_F272_L1.1811.00
207_E212_G1.1811.00
215_D219_K1.1761.00
215_D237_K1.1741.00
224_F271_I1.1671.00
83_S87_N1.1591.00
64_T67_L1.1441.00
49_F273_D1.1401.00
162_T223_S1.1331.00
267_V284_G1.1301.00
290_L293_Q1.1261.00
132_L156_M1.1261.00
253_V292_V1.1201.00
266_G284_G1.1141.00
248_C285_N1.1131.00
166_D228_K1.1131.00
154_N158_N1.1121.00
15_F31_K1.1081.00
133_H268_I1.1051.00
224_F236_F1.1051.00
290_L294_A1.1001.00
41_A51_M1.0991.00
279_D282_Q1.0981.00
253_V256_T1.0981.00
267_V271_I1.0941.00
52_G129_A1.0901.00
65_F69_E1.0891.00
224_F267_V1.0891.00
193_W271_I1.0861.00
229_L233_G1.0801.00
44_L51_M1.0771.00
123_R159_A1.0751.00
47_L266_G1.0701.00
40_V133_H1.0681.00
11_S66_I1.0671.00
45_A75_V1.0671.00
201_G227_I1.0651.00
134_V163_I1.0641.00
195_F228_K1.0511.00
165_F191_A1.0491.00
248_C289_A1.0481.00
250_V292_V1.0431.00
59_N86_E1.0341.00
52_G79_R1.0331.00
198_I232_E1.0291.00
193_W267_V1.0291.00
212_G215_D1.0271.00
61_Q64_T1.0271.00
45_A74_G1.0241.00
42_C46_R1.0201.00
228_K263_F1.0161.00
67_L77_V1.0131.00
15_F91_L1.0041.00
68_Q71_K1.0031.00
250_V253_V1.0001.00
262_G291_Q0.9981.00
132_L161_K0.9961.00
201_G213_I0.9951.00
237_K242_E0.9941.00
267_V277_Y0.9911.00
83_S115_T0.9861.00
33_L65_F0.9811.00
11_S38_S0.9801.00
254_V295_P0.9741.00
282_Q286_A0.9601.00
214_A227_I0.9591.00
147_D151_H0.9591.00
245_L282_Q0.9581.00
285_N288_G0.9511.00
44_L265_V0.9491.00
8_F132_L0.9441.00
43_G262_G0.9411.00
129_A161_K0.9371.00
134_V153_M0.9361.00
52_G125_Y0.9351.00
113_A116_L0.9341.00
122_P151_H0.9341.00
104_V107_Y0.9311.00
181_V185_N0.9311.00
133_H264_A0.9251.00
280_A284_G0.9231.00
241_S278_K0.9231.00
11_S53_W0.9191.00
57_V67_L0.9171.00
223_S239_G0.9151.00
195_F267_V0.9081.00
5_A272_L0.9031.00
77_V80_V0.9031.00
57_V63_G0.9021.00
47_L287_I0.9011.00
247_G285_N0.9011.00
56_K81_I0.8931.00
269_S304_R0.8921.00
6_V54_M0.8921.00
269_S283_R0.8911.00
275_L283_R0.8891.00
238_T277_Y0.8881.00
15_F62_L0.8861.00
271_I280_A0.8861.00
95_S103_Q0.8811.00
45_A50_R0.8731.00
198_I202_E0.8731.00
150_Y190_L0.8721.00
67_L81_I0.8681.00
215_D242_E0.8661.00
16_Y32_G0.8631.00
189_G221_G0.8611.00
134_V149_T0.8561.00
31_K62_L0.8531.00
66_I89_T0.8531.00
58_G89_T0.8521.00
276_S280_A0.8511.00
154_N186_D0.8421.00
253_V293_Q0.8371.00
205_T213_I0.8371.00
215_D218_L0.8351.00
8_F152_V0.8321.00
57_V80_V0.8311.00
126_F161_K0.8251.00
45_A51_M0.8211.00
146_K183_T0.8211.00
144_E147_D0.8191.00
186_D189_G0.8171.00
212_G216_Y0.8161.00
52_G78_S0.8071.00
263_F285_N0.8061.00
7_T37_E0.8031.00
6_V52_G0.8011.00
245_L278_K0.7951.00
211_E214_A0.7921.00
266_G270_G0.7891.00
13_A31_K0.7881.00
124_D127_Q0.7871.00
214_A225_V0.7871.00
57_V82_R0.7841.00
210_P229_L0.7781.00
40_V264_A0.7731.00
188_A191_A0.7681.00
232_E244_F0.7681.00
233_G247_G0.7661.00
181_V184_I0.7641.00
148_F152_V0.7641.00
81_I120_E0.7641.00
38_S298_M0.7631.00
286_A290_L0.7601.00
196_P201_G0.7591.00
166_D195_F0.7561.00
12_M90_G0.7541.00
5_A131_H0.7531.00
262_G288_G0.7471.00
214_A218_L0.7451.00
239_G242_E0.7391.00
131_H272_L0.7381.00
42_C298_M0.7371.00
79_R82_R0.7361.00
250_V289_A0.7351.00
102_P106_Y0.7341.00
103_Q107_Y0.7331.00
60_D89_T0.7321.00
41_A53_W0.7321.00
94_K104_V0.7301.00
79_R125_Y0.7291.00
285_N289_A0.7281.00
47_L283_R0.7241.00
123_R158_N0.7201.00
13_A62_L0.7141.00
182_H185_N0.7121.00
197_G200_E0.7121.00
189_G220_K0.7121.00
201_G217_Y0.7051.00
136_G165_F0.7051.00
238_T243_G0.7051.00
125_Y129_A0.7021.00
62_L91_L0.6991.00
123_R127_Q0.6971.00
69_E298_M0.6971.00
146_K150_Y0.6951.00
164_S195_F0.6911.00
30_S295_P0.6901.00
132_L152_V0.6901.00
153_M190_L0.6881.00
226_A236_F0.6851.00
6_V125_Y0.6821.00
147_D150_Y0.6801.00
251_D293_Q0.6801.00
41_A75_V0.6791.00
210_P213_I0.6791.00
180_M183_T0.6781.00
166_D196_P0.6771.00
47_L269_S0.6751.00
164_S193_W0.6741.00
61_Q65_F0.6731.00
263_F284_G0.6711.00
251_D254_V0.6711.00
262_G266_G0.6711.00
211_E235_Y0.6691.00
283_R307_L0.6691.00
283_R304_R0.6681.00
263_F288_G0.6651.00
233_G244_F0.6641.00
288_G291_Q0.6621.00
103_Q106_Y0.6591.00
95_S105_T0.6581.00
213_I217_Y0.6571.00
211_E237_K0.6491.00
231_K249_R0.6471.00
47_L307_L0.6461.00
183_T186_D0.6441.00
116_L121_Y0.6371.00
164_S264_A0.6361.00
97_V101_D0.6331.00
218_L238_T0.6301.00
275_L280_A0.6301.00
185_N189_G0.6291.00
290_L306_K0.6291.00
125_Y128_C0.6281.00
243_G281_V0.6271.00
83_S120_E0.6261.00
118_T147_D0.6241.00
211_E244_F0.6201.00
210_P214_A0.6181.00
20_Y97_V0.6151.00
59_N83_S0.6121.00
101_D104_V0.6101.00
119_A122_P0.6091.00
192_D224_F0.6081.00
55_S80_V0.6071.00
94_K257_V0.6061.00
78_S125_Y0.6021.00
156_M163_I0.6021.00
101_D105_T0.6021.00
234_A245_L0.6011.00
50_R272_L0.5981.00
199_A203_L0.5971.00
226_A263_F0.5951.00
290_L307_L0.5891.00
195_F226_A0.5881.00
238_T242_E0.5881.00
26_V105_T0.5881.00
263_F281_V0.5871.00
281_V285_N0.5821.00
73_E303_T0.5811.00
207_E213_I0.5741.00
279_D283_R0.5691.00
153_M187_L0.5651.00
194_F225_V0.5651.00
274_G280_A0.5631.00
218_L240_T0.5631.00
88_P107_Y0.5621.00
182_H186_D0.5621.00
235_Y242_E0.5611.00
198_I230_G0.5601.00
70_L77_V0.5601.00
277_Y280_A0.5591.00
100_G104_V0.5591.00
70_L75_V0.5581.00
226_A281_V0.5541.00
102_P105_T0.5521.00
50_R130_G0.5511.00
287_I307_L0.5511.00
130_G161_K0.5471.00
18_N28_T0.5451.00
44_L268_I0.5451.00
201_G210_P0.5431.00
116_L120_E0.5421.00
87_N112_A0.5411.00
90_G95_S0.5381.00
7_T44_L0.5371.00
38_S53_W0.5371.00
94_K102_P0.5361.00
150_Y153_M0.5361.00
270_G304_R0.5351.00
107_Y111_S0.5341.00
40_V268_I0.5341.00
118_T148_F0.5341.00
15_F93_L0.5331.00
45_A73_E0.5321.00
163_I191_A0.5321.00
11_S70_L0.5311.00
152_V155_D0.5301.00
218_L225_V0.5301.00
7_T51_M0.5291.00
118_T122_P0.5291.00
150_Y183_T0.5271.00
223_S238_T0.5261.00
53_W70_L0.5261.00
270_G279_D0.5261.00
112_A115_T0.5241.00
131_H271_I0.5241.00
265_V269_S0.5231.00
270_G274_G0.5221.00
32_G298_M0.5211.00
231_K253_V0.5181.00
145_M148_F0.5171.00
191_A222_A0.5151.00
165_F187_L0.5151.00
60_D63_G0.5131.00
245_L248_C0.5111.00
88_P91_L0.5101.00
14_M34_A0.5091.00
257_V297_D0.5081.00
218_L222_A0.5081.00
17_A20_Y0.5081.00
188_A222_A0.5081.00
108_R114_S0.5081.00
131_H193_W0.5071.00
19_E22_G0.5061.00
130_G272_L0.5031.00
205_T216_Y0.5001.00
179_T183_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ljsA 2 0.9506 100 0.183 Contact Map
2v78A 5 0.9475 100 0.192 Contact Map
4du5A 2 0.9074 100 0.197 Contact Map
2dcnA 5 0.9383 100 0.197 Contact Map
3iq0A 2 0.9475 100 0.2 Contact Map
1tyyA 2 0.9074 100 0.205 Contact Map
3pl2A 2 0.9506 100 0.206 Contact Map
3ktnA 5 0.9815 100 0.21 Contact Map
1v1aA 5 0.9228 100 0.212 Contact Map
3hj6A 2 0.8549 100 0.212 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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