GREMLIN Database
KDGR - HTH-type transcriptional regulator KdgR
UniProt: P50844 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 339 (324)
Sequences: 34647 (25425)
Seq/√Len: 1412.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
169_R209_E3.3361.00
184_Y249_K3.2221.00
17_C50_E3.0891.00
272_R275_Q3.0701.00
175_I280_A2.6481.00
204_A208_Q2.5701.00
184_Y278_G2.5691.00
126_G313_V2.5401.00
284_D299_A2.4701.00
173_K213_V2.3311.00
162_D316_R2.3111.00
38_P42_K2.2701.00
46_K50_E2.2091.00
234_K268_E2.2081.00
42_K46_K2.1681.00
92_V95_Q2.1421.00
238_R269_L2.1251.00
92_V311_E2.1241.00
180_Y214_Q2.0451.00
308_T311_E2.0271.00
170_W174_E2.0161.00
173_K209_E2.0011.00
238_R265_C1.9931.00
173_K210_M1.9921.00
177_Q210_M1.9921.00
28_Y44_I1.9781.00
93_C310_M1.9521.00
41_V45_K1.9131.00
177_Q181_S1.8861.00
29_I48_I1.8841.00
169_R205_A1.8831.00
172_T176_L1.8681.00
171_I282_F1.8581.00
88_G306_G1.8501.00
12_K22_K1.8461.00
32_K35_A1.8441.00
266_M277_I1.8241.00
92_V307_R1.8121.00
233_L261_K1.8101.00
299_A332_K1.7911.00
242_K269_L1.7901.00
172_T252_L1.7891.00
179_V250_A1.7861.00
176_L207_Y1.7831.00
177_Q214_Q1.7531.00
315_K320_D1.7401.00
91_E303_H1.7201.00
17_C47_A1.7151.00
18_A47_A1.7011.00
294_G337_K1.6951.00
173_K177_Q1.6921.00
308_T327_I1.6751.00
301_P304_D1.6661.00
234_K265_C1.6531.00
237_L262_I1.6371.00
71_G124_V1.6321.00
189_L254_L1.6271.00
188_A248_K1.6201.00
174_E331_A1.6191.00
88_G303_H1.6191.00
253_A262_I1.6131.00
271_L276_D1.6091.00
178_K182_K1.5881.00
92_V96_Y1.5761.00
272_R276_D1.5751.00
265_C269_L1.5561.00
152_I309_A1.5491.00
45_K49_A1.5461.00
186_D219_L1.5301.00
267_E292_G1.5301.00
96_Y314_L1.4991.00
304_D308_T1.4961.00
205_A209_E1.4861.00
170_W173_K1.4851.00
186_D247_Q1.4781.00
28_Y48_I1.4701.00
265_C268_E1.4571.00
178_K181_S1.4571.00
167_D170_W1.4411.00
180_Y210_M1.4401.00
224_E239_S1.4371.00
45_K48_I1.4331.00
280_A296_T1.4301.00
14_V47_A1.4101.00
304_D307_R1.4031.00
68_K125_E1.3951.00
202_E205_A1.3841.00
208_Q212_S1.3661.00
178_K335_M1.3621.00
92_V310_M1.3551.00
171_I331_A1.3401.00
284_D336_R1.3351.00
266_M271_L1.3301.00
227_V232_Q1.3261.00
210_M213_V1.3141.00
188_A240_F1.3011.00
12_K16_E1.2991.00
234_K238_R1.2961.00
238_R268_E1.2961.00
176_L180_Y1.2861.00
176_L206_V1.2821.00
238_R242_K1.2751.00
237_L266_M1.2741.00
172_T206_V1.2711.00
244_M247_Q1.2711.00
38_P41_V1.2691.00
176_L210_M1.2691.00
13_D16_E1.2681.00
70_I93_C1.2671.00
186_D249_K1.2641.00
237_L251_I1.2631.00
184_Y250_A1.2601.00
234_K264_S1.2571.00
68_K98_Y1.2521.00
17_C51_L1.2521.00
206_V210_M1.2461.00
311_E315_K1.2441.00
314_L318_E1.2421.00
43_N47_A1.2371.00
140_R144_E1.2371.00
219_L222_L1.2351.00
47_A50_E1.2331.00
37_S40_K1.2181.00
27_R32_K1.2141.00
263_I279_I1.2061.00
177_Q213_V1.2051.00
103_C115_M1.2001.00
103_C119_L1.1991.00
14_V18_A1.1981.00
245_P248_K1.1961.00
11_I22_K1.1871.00
174_E177_Q1.1861.00
72_F89_V1.1851.00
9_T51_L1.1771.00
169_R173_K1.1751.00
93_C100_I1.1671.00
71_G119_L1.1631.00
40_K43_N1.1631.00
128_I309_A1.1621.00
239_S243_E1.1611.00
185_T249_K1.1551.00
89_V128_I1.1531.00
169_R202_E1.1501.00
47_A51_L1.1471.00
89_V310_M1.1411.00
207_Y211_A1.1221.00
211_A216_V1.1181.00
303_H307_R1.1071.00
28_Y36_I1.1071.00
14_V51_L1.1061.00
190_F262_I1.1011.00
231_E235_A1.1001.00
46_K49_A1.1001.00
236_E239_S1.0991.00
187_V211_A1.0921.00
42_K45_K1.0861.00
261_K265_C1.0821.00
210_M214_Q1.0791.00
306_G310_M1.0751.00
96_Y311_E1.0751.00
182_K335_M1.0721.00
31_G41_V1.0691.00
209_E213_V1.0621.00
251_I262_I1.0601.00
189_L204_A1.0581.00
169_R206_V1.0571.00
308_T312_R1.0551.00
175_I252_L1.0521.00
256_G297_T1.0501.00
94_D111_K1.0481.00
244_M248_K1.0461.00
11_I25_V1.0451.00
69_L101_M1.0421.00
117_L141_A1.0341.00
181_S214_Q1.0341.00
72_F100_I1.0301.00
256_G281_G1.0301.00
56_S62_L1.0251.00
180_Y216_V1.0241.00
69_L99_S1.0211.00
90_E94_D1.0171.00
96_Y318_E1.0091.00
307_R311_E1.0081.00
113_R117_L1.0051.00
58_M61_G1.0021.00
229_D232_Q1.0011.00
178_K296_T1.0001.00
98_Y314_L0.9951.00
312_R327_I0.9931.00
205_A208_Q0.9931.00
170_W330_E0.9791.00
253_A259_M0.9781.00
308_T329_L0.9691.00
313_V317_I0.9661.00
253_A258_I0.9651.00
235_A239_S0.9601.00
48_I51_L0.9601.00
18_A25_V0.9571.00
263_I273_I0.9521.00
232_Q235_A0.9461.00
263_I291_I0.9431.00
233_L237_L0.9431.00
185_T216_V0.9421.00
230_K264_S0.9331.00
207_Y252_L0.9311.00
237_L241_H0.9301.00
187_V250_A0.9301.00
175_I298_I0.9291.00
201_A205_A0.9271.00
182_K278_G0.9271.00
111_K114_E0.9241.00
117_L121_A0.9201.00
95_Q307_R0.9141.00
224_E236_E0.9041.00
180_Y185_T0.9041.00
176_L211_A0.9021.00
332_K335_M0.8991.00
31_G45_K0.8941.00
208_Q218_G0.8931.00
166_T301_P0.8881.00
163_T326_T0.8831.00
198_S202_E0.8831.00
55_P60_Q0.8801.00
267_E294_G0.8761.00
56_S59_A0.8711.00
87_R91_E0.8701.00
162_D312_R0.8691.00
128_I313_V0.8681.00
31_G34_D0.8671.00
194_I225_I0.8661.00
301_P329_L0.8651.00
192_E228_K0.8651.00
91_E307_R0.8621.00
170_W331_A0.8561.00
59_A62_L0.8531.00
136_K140_R0.8521.00
167_D328_E0.8511.00
89_V306_G0.8491.00
271_L277_I0.8491.00
312_R315_K0.8481.00
70_I128_I0.8411.00
72_F86_F0.8411.00
301_P332_K0.8391.00
241_H265_C0.8381.00
28_Y45_K0.8371.00
164_V312_R0.8361.00
211_A218_G0.8351.00
85_A152_I0.8341.00
251_I277_I0.8341.00
299_A334_I0.8331.00
188_A251_I0.8331.00
235_A238_R0.8331.00
166_T331_A0.8311.00
165_T328_E0.8261.00
247_Q271_L0.8231.00
167_D330_E0.8231.00
81_F302_S0.8111.00
226_D258_I0.8081.00
266_M279_I0.8051.00
10_T13_D0.8031.00
256_G284_D0.8021.00
67_S125_E0.8011.00
39_E42_K0.8001.00
165_T326_T0.7981.00
168_N203_R0.7981.00
209_E212_S0.7971.00
162_D325_Q0.7941.00
310_M314_L0.7941.00
166_T300_Q0.7931.00
191_T204_A0.7911.00
222_L243_E0.7911.00
281_G297_T0.7891.00
186_D222_L0.7881.00
126_G317_I0.7871.00
20_V44_I0.7831.00
284_D334_I0.7801.00
190_F253_A0.7801.00
27_R34_D0.7771.00
141_A144_E0.7721.00
39_E43_N0.7701.00
218_G221_R0.7701.00
179_V280_A0.7681.00
86_F90_E0.7661.00
69_L122_H0.7641.00
237_L265_C0.7631.00
108_S111_K0.7631.00
84_A303_H0.7631.00
88_G92_V0.7631.00
23_S27_R0.7611.00
66_K125_E0.7611.00
232_Q236_E0.7571.00
57_K60_Q0.7561.00
89_V100_I0.7541.00
284_D288_Y0.7541.00
88_G307_R0.7521.00
249_K278_G0.7451.00
75_A82_S0.7441.00
237_L240_F0.7421.00
189_L252_L0.7391.00
70_I310_M0.7371.00
24_T27_R0.7361.00
91_E95_Q0.7351.00
241_H269_L0.7311.00
174_E298_I0.7301.00
202_E206_V0.7301.00
155_K326_T0.7281.00
114_E117_L0.7251.00
260_L291_I0.7241.00
178_K333_V0.7221.00
120_E145_Q0.7221.00
252_L280_A0.7211.00
266_M273_I0.7191.00
71_G127_L0.7191.00
86_F102_V0.7161.00
243_E247_Q0.7131.00
140_R143_A0.7121.00
87_R90_E0.7071.00
27_R35_A0.7061.00
195_S201_A0.7011.00
101_M124_V0.6981.00
283_D300_Q0.6981.00
264_S267_E0.6981.00
54_R121_A0.6971.00
264_S294_G0.6951.00
315_K319_G0.6881.00
143_A160_K0.6871.00
243_E248_K0.6851.00
151_L156_L0.6851.00
28_Y41_V0.6841.00
42_K49_A0.6831.00
90_E104_N0.6831.00
187_V249_K0.6811.00
226_D232_Q0.6781.00
256_G259_M0.6771.00
90_E100_I0.6751.00
239_S242_K0.6731.00
151_L161_L0.6731.00
173_K206_V0.6691.00
66_K318_E0.6691.00
143_A149_T0.6691.00
180_Y211_A0.6651.00
264_S268_E0.6641.00
111_K115_M0.6631.00
200_R228_K0.6621.00
9_T47_A0.6621.00
174_E178_K0.6581.00
233_L236_E0.6541.00
106_D111_K0.6531.00
149_T161_L0.6531.00
126_G150_I0.6511.00
224_E240_F0.6501.00
128_I152_I0.6481.00
110_E114_E0.6471.00
259_M281_G0.6461.00
204_A223_H0.6441.00
216_V220_V0.6421.00
9_T52_N0.6401.00
294_G336_R0.6371.00
179_V252_L0.6361.00
207_Y218_G0.6311.00
264_S292_G0.6311.00
153_D199_P0.6301.00
150_I313_V0.6291.00
291_I294_G0.6291.00
237_L261_K0.6291.00
54_R117_L0.6291.00
315_K325_Q0.6281.00
116_L127_L0.6241.00
162_D324_P0.6231.00
20_V40_K0.6231.00
186_D245_P0.6231.00
12_K63_K0.6221.00
143_A161_L0.6211.00
43_N46_K0.6201.00
84_A302_S0.6181.00
150_I316_R0.6151.00
35_A40_K0.6151.00
224_E243_E0.6141.00
79_N257_L0.6141.00
142_F149_T0.6131.00
189_L207_Y0.6121.00
263_I267_E0.6111.00
49_A52_N0.6111.00
14_V25_V0.6081.00
255_N283_D0.6071.00
25_V28_Y0.6071.00
120_E147_I0.6061.00
98_Y317_I0.6041.00
230_K287_W0.6021.00
316_R319_G0.6011.00
87_R303_H0.6011.00
126_G309_A0.6011.00
187_V207_Y0.6011.00
288_Y297_T0.6001.00
113_R138_V0.6001.00
168_N202_E0.6001.00
153_D168_N0.5971.00
260_L287_W0.5961.00
88_G302_S0.5961.00
73_V115_M0.5941.00
228_K254_L0.5941.00
173_K176_L0.5931.00
137_D140_R0.5911.00
85_A302_S0.5871.00
260_L285_T0.5851.00
266_M269_L0.5841.00
178_K280_A0.5841.00
296_T333_V0.5841.00
36_I41_V0.5831.00
101_M122_H0.5821.00
192_E200_R0.5801.00
186_D248_K0.5781.00
150_I164_V0.5781.00
27_R36_I0.5771.00
303_H306_G0.5761.00
25_V48_I0.5751.00
32_K36_I0.5751.00
70_I126_G0.5751.00
81_F85_A0.5721.00
138_V141_A0.5701.00
282_F300_Q0.5661.00
127_L147_I0.5651.00
289_K294_G0.5611.00
267_E272_R0.5611.00
292_G337_K0.5601.00
54_R58_M0.5561.00
117_L120_E0.5561.00
255_N258_I0.5551.00
98_Y125_E0.5551.00
93_C314_L0.5521.00
230_K261_K0.5511.00
298_I331_A0.5491.00
218_G223_H0.5491.00
312_R316_R0.5481.00
70_I317_I0.5481.00
208_Q220_V0.5471.00
150_I309_A0.5471.00
155_K163_T0.5471.00
105_T112_E0.5461.00
252_L282_F0.5451.00
87_R106_D0.5451.00
175_I250_A0.5431.00
231_E234_K0.5411.00
248_K251_I0.5401.00
150_I312_R0.5391.00
200_R254_L0.5381.00
67_S99_S0.5381.00
268_E292_G0.5371.00
308_T315_K0.5371.00
70_I98_Y0.5351.00
271_L274_P0.5351.00
60_Q64_I0.5351.00
248_K271_L0.5341.00
164_V308_T0.5341.00
262_I266_M0.5321.00
234_K261_K0.5301.00
109_P113_R0.5301.00
221_R243_E0.5291.00
93_C98_Y0.5291.00
204_A218_G0.5231.00
84_A286_E0.5221.00
20_V25_V0.5221.00
18_A28_Y0.5211.00
236_E240_F0.5201.00
228_K258_I0.5171.00
253_A281_G0.5161.00
234_K237_L0.5151.00
103_C118_K0.5141.00
166_T282_F0.5131.00
328_E331_A0.5121.00
23_S32_K0.5121.00
288_Y295_I0.5111.00
25_V44_I0.5111.00
305_M329_L0.5101.00
119_L124_V0.5101.00
204_A225_I0.5101.00
113_R141_A0.5091.00
69_L125_E0.5081.00
301_P305_M0.5081.00
80_P257_L0.5061.00
141_A145_Q0.5031.00
273_I276_D0.5031.00
191_T225_I0.5021.00
165_T168_N0.5011.00
61_G64_I0.5001.00
13_D17_C0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kjxA 2 0.9764 100 0.062 Contact Map
2hsgA 1 0.9617 100 0.068 Contact Map
2o20A 2 0.8083 100 0.069 Contact Map
3dbiA 2 0.8024 100 0.071 Contact Map
3bilA 2 0.7463 100 0.071 Contact Map
1qpzA 2 0.9676 100 0.073 Contact Map
3e3mA 2 0.7817 100 0.075 Contact Map
4o5aA 2 0.7817 100 0.083 Contact Map
3h5oA 2 0.7906 100 0.085 Contact Map
3ctpA 2 0.7788 100 0.093 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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