GREMLIN Database
KDUI - 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase
UniProt: P50843 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 275 (273)
Sequences: 714 (441)
Seq/√Len: 26.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_N53_G4.1331.00
27_D232_Q3.7301.00
126_V255_A3.6791.00
89_V108_N3.4321.00
85_G123_F3.4311.00
11_Q15_F3.3851.00
69_F72_E3.0061.00
145_T162_K2.8011.00
104_I136_T2.7451.00
81_V203_L2.7251.00
122_K231_E2.7020.99
12_V20_L2.5980.99
89_V104_I2.5460.99
16_T19_E2.4660.99
76_I104_I2.4430.99
31_T34_K2.4100.99
270_P273_G2.3920.99
178_I251_S2.3920.99
115_S120_K2.3750.99
212_K229_G2.3360.98
86_A114_S2.3350.98
98_T206_D2.2430.98
18_E22_S2.1620.97
214_F227_V2.1470.97
226_L234_V2.1260.97
76_I125_F2.1090.97
153_A183_Q2.1020.97
63_D66_K2.0970.97
186_N245_A2.0360.96
37_M125_F2.0300.96
15_F19_E2.0220.96
155_S186_N1.9920.96
146_P161_Y1.9590.95
37_M46_V1.9530.95
88_R114_S1.9370.95
157_V182_D1.9120.95
147_D162_K1.8820.94
115_S121_A1.8640.94
35_L57_L1.8430.93
207_L211_S1.8370.93
8_H11_Q1.8120.93
19_E23_H1.8080.93
50_A57_L1.7630.92
37_M48_G1.7540.92
164_I171_S1.7440.91
26_M235_L1.7410.91
68_D72_E1.7310.91
33_N56_E1.6950.90
139_A169_I1.6920.90
105_G135_P1.6910.90
71_L76_I1.6810.90
84_P97_Q1.6700.89
56_E114_S1.6450.89
26_M47_I1.6320.88
14_R19_E1.6170.88
33_N54_Q1.6090.88
151_D154_A1.5860.87
132_K170_K1.5780.87
45_V201_A1.5750.86
84_P116_L1.5630.86
8_H23_H1.5470.85
165_H168_G1.5410.85
151_D157_V1.5270.85
128_A257_A1.5250.85
51_A122_K1.5070.84
77_G176_M1.4650.82
86_A116_L1.4570.82
152_D157_V1.4240.80
13_K16_T1.4140.80
228_V232_Q1.4110.80
33_N51_A1.3890.78
153_A185_N1.3740.78
93_E114_S1.3710.78
6_S42_E1.3470.76
25_L228_V1.3440.76
140_A143_E1.3260.75
45_V257_A1.3240.75
148_R157_V1.3240.75
147_D264_T1.3200.75
164_I168_G1.3110.74
178_I253_V1.3110.74
2_E38_Y1.3090.74
30_F203_L1.3070.74
58_K110_D1.3030.74
7_V12_V1.2860.73
28_S31_T1.2680.72
78_I102_L1.2520.71
79_I253_V1.2510.71
51_A203_L1.2460.70
86_A93_E1.2460.70
208_E248_S1.2410.70
41_H238_A1.2340.70
139_A168_G1.2260.69
162_K167_D1.2140.68
84_P95_V1.2120.68
40_S235_L1.2080.68
18_E222_E1.1980.67
28_S232_Q1.1890.67
145_T167_D1.1880.67
263_F266_M1.1880.67
134_Y170_K1.1840.66
96_L100_D1.1750.66
137_Q171_S1.1740.66
5_Y219_Q1.1730.66
212_K227_V1.1650.65
81_V253_V1.1630.65
105_G136_T1.1630.65
183_Q249_N1.1610.65
263_F268_L1.1600.65
100_D141_L1.1500.64
32_E51_A1.1370.63
30_F51_A1.1360.63
161_Y180_M1.1290.63
152_D185_N1.1250.62
89_V136_T1.1200.62
189_T243_S1.1180.62
101_F168_G1.1140.61
146_P163_V1.1140.61
101_F163_V1.1130.61
162_K165_H1.1110.61
88_R93_E1.1080.61
96_L102_L1.0960.60
42_E238_A1.0890.60
10_E22_S1.0770.59
96_L138_K1.0760.59
117_N120_K1.0600.58
78_I87_V1.0600.58
12_V24_F1.0590.58
7_V24_F1.0520.57
95_V116_L1.0510.57
106_M133_S1.0410.56
76_I87_V1.0410.56
27_D49_G1.0160.54
175_M263_F1.0060.54
61_A67_T0.9890.52
90_G109_Q0.9890.52
141_L180_M0.9890.52
68_D262_T0.9840.52
101_F169_I0.9820.52
77_G164_I0.9800.52
100_D140_A0.9760.51
144_L159_S0.9720.51
81_V231_E0.9700.51
99_K180_M0.9650.51
4_R235_L0.9630.50
148_R182_D0.9620.50
220_P269_I0.9570.50
33_N55_S0.9490.49
15_F23_H0.9460.49
94_Y136_T0.9430.49
137_Q143_E0.9410.49
152_D155_S0.9380.49
13_K222_E0.9360.48
11_Q19_E0.9340.48
238_A264_T0.9320.48
175_M261_Y0.9320.48
180_M251_S0.9290.48
168_G175_M0.9220.47
46_V70_F0.9190.47
105_G133_S0.9180.47
7_V23_H0.9130.47
46_V65_L0.9120.47
5_Y196_D0.9110.46
208_E211_S0.9090.46
92_D108_N0.9050.46
79_I176_M0.9010.46
228_V234_V0.8810.44
146_P162_K0.8810.44
148_R159_S0.8800.44
8_H15_F0.8660.43
35_L106_M0.8650.43
159_S182_D0.8640.43
46_V257_A0.8640.43
66_K166_Q0.8640.43
90_G108_N0.8580.43
214_F262_T0.8570.43
99_K178_I0.8560.42
35_L50_A0.8560.42
137_Q170_K0.8520.42
88_R110_D0.8480.42
87_V104_I0.8470.42
196_D238_A0.8390.41
189_T213_V0.8350.41
29_L84_P0.8290.40
51_A57_L0.8270.40
4_R38_Y0.8250.40
12_V128_A0.8220.40
43_D199_M0.8210.40
33_N57_L0.8200.40
25_L232_Q0.8160.40
263_F267_D0.8140.39
41_H196_D0.8130.39
69_F109_Q0.8100.39
28_S36_T0.8100.39
7_V15_F0.8090.39
42_E261_Y0.8090.39
162_K166_Q0.8040.39
154_A184_N0.8040.39
165_H171_S0.8040.39
66_K262_T0.8030.39
79_I101_F0.7970.38
147_D168_G0.7880.38
94_Y224_R0.7860.37
32_E56_E0.7840.37
194_V238_A0.7820.37
149_L160_L0.7810.37
139_A166_Q0.7810.37
89_V102_L0.7770.37
11_Q14_R0.7760.37
131_H173_Q0.7750.37
24_F42_E0.7690.36
147_D263_F0.7690.36
43_D194_V0.7690.36
128_A199_M0.7660.36
171_S175_M0.7660.36
60_D67_T0.7620.36
104_I111_V0.7570.35
227_V271_M0.7560.35
10_E23_H0.7510.35
229_G271_M0.7510.35
13_K251_S0.7480.35
10_E19_E0.7470.35
101_F165_H0.7460.35
65_L259_E0.7430.34
53_G120_K0.7430.34
201_A235_L0.7330.34
129_C203_L0.7320.34
123_F201_A0.7320.34
32_E53_G0.7300.34
166_Q175_M0.7220.33
25_L226_L0.7170.33
151_D186_N0.7130.32
24_F81_V0.7130.32
153_A184_N0.7130.32
42_E201_A0.7080.32
17_T223_T0.7040.32
115_S122_K0.7010.32
182_D266_M0.6950.31
194_V264_T0.6950.31
100_D163_V0.6930.31
139_A164_I0.6930.31
115_S118_G0.6910.31
66_K261_Y0.6900.31
97_Q142_S0.6890.31
97_Q100_D0.6870.31
192_A271_M0.6870.31
213_V228_V0.6860.31
162_K264_T0.6850.31
105_G108_N0.6790.30
99_K104_I0.6770.30
108_N133_S0.6760.30
61_A65_L0.6680.30
6_S37_M0.6680.30
220_P241_I0.6640.29
101_F126_V0.6630.29
11_Q23_H0.6620.29
53_G56_E0.6620.29
269_I273_G0.6590.29
165_H264_T0.6580.29
165_H261_Y0.6560.29
5_Y9_P0.6530.29
83_Q115_S0.6520.29
216_F226_L0.6480.28
107_G133_S0.6460.28
135_P203_L0.6460.28
149_L263_F0.6450.28
33_N203_L0.6450.28
167_D228_V0.6440.28
56_E88_R0.6440.28
175_M194_V0.6430.28
189_T228_V0.6420.28
67_T76_I0.6420.28
209_K272_D0.6390.28
164_I176_M0.6390.28
57_L203_L0.6380.28
203_L234_V0.6370.28
31_T49_G0.6340.27
9_P48_G0.6330.27
67_T261_Y0.6330.27
192_A269_I0.6320.27
145_T264_T0.6300.27
155_S184_N0.6270.27
101_F139_A0.6260.27
208_E212_K0.6240.27
152_D183_Q0.6210.27
87_V90_G0.6200.27
130_A172_C0.6190.27
50_A167_D0.6160.26
12_V220_P0.6160.26
42_E257_A0.6160.26
154_A185_N0.6140.26
147_D159_S0.6130.26
186_N219_Q0.6120.26
241_I274_L0.6120.26
141_L163_V0.6110.26
85_G115_S0.6110.26
101_F171_S0.6090.26
32_E54_Q0.6060.26
91_D108_N0.6050.26
152_D182_D0.6040.26
49_G253_V0.6030.26
206_D228_V0.6020.26
9_P219_Q0.6020.26
45_V199_M0.6000.26
152_D160_L0.5990.25
38_Y232_Q0.5960.25
78_I113_F0.5950.25
166_Q169_I0.5930.25
129_C154_A0.5920.25
180_M206_D0.5920.25
18_E119_E0.5900.25
213_V244_G0.5900.25
73_R106_M0.5900.25
45_V126_V0.5870.25
22_S86_A0.5870.25
13_K224_R0.5850.25
48_G212_K0.5850.25
271_M274_L0.5820.24
145_T165_H0.5820.24
18_E221_D0.5810.24
155_S245_A0.5810.24
210_D227_V0.5760.24
63_D166_Q0.5710.24
66_K196_D0.5710.24
27_D83_Q0.5690.24
21_R25_L0.5670.24
79_I83_Q0.5660.24
194_V267_D0.5650.24
87_V136_T0.5650.24
112_S116_L0.5640.24
165_H175_M0.5630.23
71_L199_M0.5610.23
167_D170_K0.5600.23
71_L104_I0.5600.23
104_I140_A0.5580.23
8_H163_V0.5580.23
128_A171_S0.5570.23
61_A111_V0.5570.23
211_S271_M0.5540.23
5_Y132_K0.5540.23
14_R35_L0.5530.23
83_Q96_L0.5510.23
89_V92_D0.5500.23
136_T233_A0.5500.23
72_E108_N0.5500.23
60_D90_G0.5490.23
126_V203_L0.5490.23
3_N196_D0.5490.23
146_P159_S0.5490.23
87_V137_Q0.5480.23
176_M266_M0.5480.23
87_V119_E0.5480.23
207_L251_S0.5480.23
207_L248_S0.5480.23
87_V96_L0.5480.23
29_L54_Q0.5460.23
199_M257_A0.5450.22
147_D186_N0.5440.22
228_V246_G0.5440.22
138_K143_E0.5430.22
66_K214_F0.5430.22
133_S207_L0.5420.22
91_D110_D0.5410.22
166_Q263_F0.5380.22
100_D269_I0.5360.22
31_T36_T0.5360.22
141_L161_Y0.5340.22
83_Q120_K0.5330.22
37_M76_I0.5330.22
63_D67_T0.5330.22
47_I201_A0.5320.22
69_F106_M0.5310.22
29_L36_T0.5300.22
86_A112_S0.5290.22
43_D223_T0.5280.22
6_S19_E0.5270.22
108_N136_T0.5250.21
56_E111_V0.5240.21
24_F67_T0.5240.21
45_V66_K0.5230.21
148_R216_F0.5230.21
100_D138_K0.5230.21
147_D160_L0.5210.21
243_S251_S0.5210.21
85_G121_A0.5190.21
99_K126_V0.5190.21
41_H128_A0.5170.21
86_A95_V0.5160.21
229_G272_D0.5160.21
35_L176_M0.5150.21
4_R233_A0.5120.21
214_F225_H0.5120.21
96_L141_L0.5100.21
201_A217_M0.5100.21
78_I123_F0.5080.21
89_V98_T0.5070.21
53_G83_Q0.5060.21
169_I175_M0.5050.20
99_K206_D0.5050.20
43_D147_D0.5050.20
88_R91_D0.5040.20
56_E84_P0.5040.20
35_L46_V0.5030.20
100_D142_S0.5030.20
165_H212_K0.5020.20
133_S136_T0.5020.20
24_F246_G0.5020.20
12_V41_H0.5010.20
70_F99_K0.5010.20
194_V261_Y0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ywkA 1 0.9164 100 0.296 Contact Map
1xruA 3 1 100 0.298 Contact Map
2qjvA 4 0.8182 100 0.608 Contact Map
2vqaA 3 0.9055 96.8 0.952 Contact Map
3rnsA 1 0.7345 96.6 0.954 Contact Map
1uijA 3 0.8909 96.6 0.954 Contact Map
1sq4A 5 0.9018 96.6 0.954 Contact Map
1rc6A 4 0.8109 96.6 0.954 Contact Map
1sefA 5 0.8327 96.4 0.955 Contact Map
3h7jA 1 0.7927 96 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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