GREMLIN Database
YPRB - Uncharacterized protein YprB
UniProt: P50837 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 413 (400)
Sequences: 204 (175)
Seq/√Len: 8.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
342_V364_L5.6421.00
298_M310_L4.9331.00
403_R406_R4.4720.99
379_L404_I3.9140.98
134_V267_I3.8380.97
166_Y218_V3.7030.97
334_K337_R3.3720.94
62_E133_R3.3240.94
60_E137_K3.2390.93
170_A229_E3.2350.93
114_G119_N3.1640.92
72_Y272_H3.0260.90
140_L252_L2.9660.89
231_T239_L2.9440.89
127_A134_V2.8900.88
80_V274_S2.8680.88
337_R340_E2.8580.87
198_L204_R2.6570.83
188_P198_L2.6560.83
141_L178_T2.6520.83
382_A404_I2.6060.82
77_L271_I2.5900.81
277_I297_F2.5630.81
403_R410_K2.4650.78
126_H139_H2.4540.78
9_R13_H2.3380.74
345_W367_Y2.3350.74
218_V236_A2.2400.71
51_F54_E2.1990.69
178_T182_L2.1960.69
333_K363_E2.1580.68
77_L103_L2.1330.67
406_R410_K2.1270.66
115_G182_L2.1020.66
141_L182_L2.0270.63
173_W296_W2.0260.62
365_A382_A2.0110.62
329_S344_L1.9230.58
125_G264_L1.9180.58
41_W260_E1.9020.57
130_Y275_K1.8900.57
214_S239_L1.8830.57
135_T382_A1.8720.56
4_K9_R1.8130.54
5_G10_M1.8090.53
154_F180_H1.8030.53
276_K293_M1.7940.53
233_G236_A1.7910.53
121_I175_Q1.7770.52
265_S383_E1.7500.51
41_W296_W1.7180.50
202_A273_M1.7150.49
129_V267_I1.7140.49
142_P146_N1.7060.49
403_R407_L1.7050.49
202_A210_M1.6920.48
121_I181_T1.6880.48
240_Y333_K1.6760.48
205_L213_V1.6530.47
233_G259_N1.6040.45
234_Y334_K1.5930.44
384_Q387_S1.5830.44
334_K404_I1.5720.43
292_A295_K1.5610.43
214_S244_I1.5540.43
60_E135_T1.5490.42
231_T248_E1.5380.42
141_L198_L1.5350.42
151_Y193_F1.5340.42
136_V263_V1.5330.42
206_W272_H1.5310.42
139_H153_S1.5300.42
182_L259_N1.5140.41
155_L194_G1.5120.41
166_Y329_S1.5090.41
175_Q181_T1.5080.41
37_F243_F1.5080.41
59_R260_E1.4990.40
263_V331_L1.4820.40
405_A409_R1.4800.39
56_C104_F1.4720.39
114_G345_W1.4670.39
144_P260_E1.4510.38
367_Y372_K1.4480.38
180_H274_S1.4400.38
106_F123_L1.4340.38
157_E259_N1.4300.37
154_F196_F1.4250.37
148_V170_A1.4240.37
326_L330_L1.4220.37
119_N175_Q1.4140.37
46_M57_L1.4080.37
209_K222_E1.3700.35
70_G365_A1.3620.35
62_E130_Y1.3510.34
390_A405_A1.3470.34
364_L368_F1.3440.34
126_H259_N1.3390.34
149_A222_E1.3370.34
67_H277_I1.3370.34
363_E366_K1.3290.33
69_H225_I1.3260.33
334_K379_L1.3240.33
4_K7_L1.3140.33
129_V265_S1.3110.33
190_L204_R1.3110.33
115_G175_Q1.3100.33
127_A136_V1.3090.33
126_H153_S1.2970.32
231_T259_N1.2940.32
57_L65_L1.2940.32
206_W363_E1.2880.32
144_P296_W1.2870.32
103_L289_E1.2860.32
184_R295_K1.2770.32
142_P183_I1.2740.31
151_Y180_H1.2700.31
150_L335_Q1.2680.31
302_E337_R1.2660.31
294_A328_L1.2630.31
228_L349_S1.2620.31
182_L220_K1.2520.31
300_H313_L1.2430.30
338_L371_K1.2330.30
362_I382_A1.2330.30
294_A301_K1.2310.30
239_L254_G1.2270.30
10_M15_A1.2260.30
267_I382_A1.2240.30
165_T178_T1.2150.29
41_W249_P1.2120.29
140_L263_V1.2110.29
377_K380_Q1.2090.29
114_G145_G1.2070.29
54_E187_L1.2040.29
140_L295_K1.1930.29
129_V329_S1.1910.28
407_L410_K1.1890.28
166_Y297_F1.1880.28
58_I137_K1.1860.28
199_L213_V1.1850.28
112_G168_G1.1840.28
145_G231_T1.1810.28
136_V294_A1.1770.28
255_V282_H1.1760.28
155_L180_H1.1750.28
92_T214_S1.1710.28
104_F145_G1.1600.27
198_L366_K1.1580.27
139_H209_K1.1560.27
114_G344_L1.1520.27
149_A271_I1.1480.27
383_E408_K1.1480.27
375_F382_A1.1280.26
325_R347_K1.1240.26
231_T277_I1.1200.26
17_D22_K1.1160.26
254_G334_K1.1150.26
199_L246_A1.1140.26
140_L329_S1.1100.26
137_K243_F1.1090.26
69_H261_M1.1060.26
77_L80_V1.1060.26
151_Y154_F1.1030.25
123_L184_R1.0990.25
212_R217_T1.0960.25
216_G231_T1.0930.25
84_W106_F1.0920.25
10_M19_G1.0910.25
193_F196_F1.0880.25
366_K370_H1.0800.25
151_Y155_L1.0720.24
104_F213_V1.0720.24
22_K43_A1.0710.24
20_E26_G1.0670.24
236_A296_W1.0650.24
144_P270_Y1.0610.24
177_K194_G1.0600.24
202_A218_V1.0570.24
97_G202_A1.0570.24
63_Y175_Q1.0560.24
212_R240_Y1.0530.24
49_F216_G1.0500.24
206_W225_I1.0500.24
267_I306_A1.0470.24
46_M243_F1.0430.24
293_M329_S1.0370.23
295_K327_D1.0360.23
75_S308_K1.0330.23
93_L191_P1.0290.23
144_P175_Q1.0230.23
232_P365_A1.0220.23
76_E275_K1.0210.23
70_G264_L1.0210.23
3_L340_E1.0190.23
255_V304_D1.0140.23
151_Y183_I1.0090.23
215_L265_S1.0060.22
181_T260_E1.0050.22
70_G223_L0.9970.22
121_I154_F0.9960.22
76_E271_I0.9960.22
74_F259_N0.9890.22
137_K295_K0.9880.22
151_Y158_V0.9870.22
206_W333_K0.9870.22
128_R214_S0.9830.22
260_E296_W0.9830.22
294_A298_M0.9820.22
103_L164_V0.9820.22
166_Y309_Q0.9810.22
104_F220_K0.9800.22
154_F270_Y0.9720.21
208_H216_G0.9680.21
53_D158_V0.9660.21
225_I261_M0.9650.21
45_G294_A0.9620.21
118_G122_F0.9600.21
113_L168_G0.9600.21
123_L198_L0.9590.21
248_E389_A0.9580.21
155_L191_P0.9580.21
141_L150_L0.9570.21
106_F124_L0.9520.21
119_N254_G0.9510.21
117_A375_F0.9460.21
115_G178_T0.9450.21
22_K26_G0.9440.21
180_H238_M0.9420.21
121_I296_W0.9420.21
41_W144_P0.9410.21
24_E42_E0.9400.21
142_P151_Y0.9390.21
232_P265_S0.9390.21
177_K191_P0.9310.20
136_V377_K0.9300.20
325_R381_V0.9230.20
35_I38_L0.9190.20
3_L7_L0.9190.20
215_L370_H0.9180.20
151_Y270_Y0.9090.20
163_L306_A0.9080.20
166_Y348_L0.9070.20
142_P191_P0.9070.20
3_L114_G0.9060.20
45_G52_E0.9060.20
121_I190_L0.9050.20
17_D243_F0.9040.20
229_E287_H0.9020.19
104_F120_T0.9020.19
103_L194_G0.9010.19
80_V271_I0.9010.19
127_A263_V0.8990.19
401_H404_I0.8960.19
54_E183_I0.8890.19
329_S359_A0.8860.19
223_L259_N0.8840.19
101_N373_K0.8830.19
132_D365_A0.8820.19
124_L151_Y0.8810.19
101_N375_F0.8800.19
20_E25_A0.8760.19
61_V243_F0.8730.19
76_E297_F0.8720.19
108_T269_L0.8680.19
74_F265_S0.8670.19
79_E228_L0.8630.18
202_A256_L0.8620.18
209_K366_K0.8550.18
106_F169_K0.8520.18
166_Y260_E0.8510.18
384_Q405_A0.8510.18
386_L400_L0.8490.18
124_L150_L0.8470.18
18_E22_K0.8460.18
329_S368_F0.8450.18
92_T191_P0.8430.18
199_L203_R0.8420.18
129_V313_L0.8400.18
180_H194_G0.8380.18
218_V277_I0.8370.18
91_H296_W0.8330.18
93_L154_F0.8320.18
128_R157_E0.8300.18
137_K362_I0.8290.18
139_H324_A0.8270.18
329_S366_K0.8260.18
65_L194_G0.8240.17
154_F190_L0.8220.17
336_N402_V0.8210.17
254_G379_L0.8210.17
36_P48_P0.8200.17
295_K301_K0.8190.17
329_S345_W0.8150.17
177_K193_F0.8120.17
136_V329_S0.8080.17
222_E276_K0.8070.17
198_L273_M0.8010.17
242_H247_Q0.7980.17
212_R403_R0.7980.17
93_L193_F0.7970.17
322_D362_I0.7960.17
59_R103_L0.7900.17
256_L264_L0.7900.17
343_P346_E0.7880.17
379_L407_L0.7820.16
116_G370_H0.7810.16
152_Q252_L0.7810.16
154_F194_G0.7810.16
15_A117_A0.7780.16
244_I345_W0.7770.16
51_F259_N0.7760.16
214_S242_H0.7760.16
376_G404_I0.7760.16
12_K15_A0.7750.16
5_G86_Q0.7710.16
31_H67_H0.7710.16
386_L389_A0.7690.16
56_C244_I0.7680.16
12_K52_E0.7670.16
143_K163_L0.7650.16
210_M363_E0.7610.16
216_G361_V0.7600.16
374_E377_K0.7560.16
151_Y196_F0.7560.16
326_L359_A0.7550.16
23_I90_S0.7550.16
62_E135_T0.7530.16
228_L275_K0.7500.16
104_F199_L0.7440.16
201_G278_L0.7420.16
169_K204_R0.7410.16
157_E183_I0.7410.16
235_L239_L0.7400.15
91_H155_L0.7400.15
91_H190_L0.7400.15
239_L251_L0.7370.15
104_F183_I0.7350.15
365_A373_K0.7340.15
9_R195_H0.7310.15
155_L270_Y0.7310.15
114_G224_G0.7290.15
304_D339_E0.7270.15
153_S164_V0.7270.15
84_W274_S0.7270.15
137_K313_L0.7260.15
346_E377_K0.7250.15
142_P154_F0.7240.15
332_Y337_R0.7230.15
207_K240_Y0.7200.15
74_F241_F0.7200.15
194_G235_L0.7190.15
18_E24_E0.7170.15
4_K13_H0.7160.15
204_R270_Y0.7160.15
255_V322_D0.7140.15
342_V372_K0.7130.15
75_S409_R0.7100.15
134_V316_K0.7100.15
204_R366_K0.7090.15
31_H42_E0.7090.15
165_T294_A0.7090.15
52_E242_H0.7090.15
155_L177_K0.7090.15
36_P182_L0.7080.15
216_G254_G0.7070.15
207_K372_K0.7060.15
44_F166_Y0.7030.15
10_M338_L0.7010.15
173_W235_L0.7010.15
177_K180_H0.6990.15
135_T303_T0.6980.15
239_L253_K0.6970.15
74_F176_V0.6960.15
120_T366_K0.6910.14
41_W63_Y0.6890.14
201_G222_E0.6890.14
104_F153_S0.6890.14
100_K408_K0.6880.14
82_T101_N0.6860.14
46_M56_C0.6840.14
240_Y363_E0.6830.14
104_F276_K0.6820.14
91_H270_Y0.6810.14
183_I217_T0.6780.14
6_K13_H0.6780.14
5_G248_E0.6770.14
75_S275_K0.6740.14
212_R363_E0.6730.14
150_L201_G0.6720.14
193_F270_Y0.6710.14
34_D382_A0.6680.14
103_L188_P0.6680.14
78_E202_A0.6680.14
67_H117_A0.6670.14
81_I255_V0.6650.14
244_I332_Y0.6640.14
144_P173_W0.6610.14
344_L348_L0.6590.14
225_I368_F0.6580.14
22_K376_G0.6580.14
114_G143_K0.6570.14
131_E408_K0.6570.14
310_L327_D0.6560.14
173_W240_Y0.6560.14
287_H409_R0.6540.14
157_E246_A0.6530.14
26_G30_N0.6530.14
153_S156_S0.6530.14
170_A373_K0.6520.14
177_K206_W0.6500.14
115_G139_H0.6490.14
207_K221_E0.6470.14
123_L256_L0.6470.14
183_I267_I0.6440.13
91_H180_H0.6440.13
202_A354_Q0.6430.13
214_S331_L0.6420.13
108_T150_L0.6400.13
199_L347_K0.6390.13
273_M301_K0.6390.13
104_F139_H0.6380.13
101_N220_K0.6360.13
101_N316_K0.6350.13
127_A209_K0.6350.13
98_Y335_Q0.6340.13
106_F121_I0.6340.13
310_L390_A0.6320.13
224_G247_Q0.6320.13
103_L155_L0.6310.13
70_G215_L0.6260.13
15_A21_Q0.6260.13
94_S177_K0.6250.13
151_Y238_M0.6230.13
304_D395_K0.6200.13
150_L182_L0.6200.13
363_E385_S0.6200.13
235_L296_W0.6180.13
231_T250_D0.6170.13
26_G373_K0.6170.13
326_L334_K0.6160.13
71_L214_S0.6160.13
91_H191_P0.6140.13
166_Y379_L0.6130.13
339_E358_Y0.6130.13
379_L409_R0.6110.13
228_L381_V0.6080.13
177_K333_K0.6060.13
349_S361_V0.6060.13
132_D255_V0.6040.13
114_G236_A0.6030.13
393_S401_H0.6030.13
84_W270_Y0.6030.13
109_E138_Q0.6020.13
109_E167_N0.6020.13
107_D227_R0.6020.13
138_Q172_D0.6020.13
109_E262_D0.6020.13
109_E172_D0.6020.13
107_D138_Q0.6020.13
138_Q197_D0.6020.13
107_D172_D0.6020.13
109_E197_D0.6020.13
138_Q167_N0.6020.13
107_D197_D0.6020.13
107_D262_D0.6020.13
138_Q258_H0.6020.13
109_E227_R0.6020.13
107_D167_N0.6020.13
138_Q262_D0.6020.13
138_Q227_R0.6020.13
258_H262_D0.6020.13
107_D258_H0.6020.13
227_R262_D0.6020.13
227_R258_H0.6020.13
172_D262_D0.6020.13
172_D227_R0.6020.13
172_D197_D0.6020.13
172_D258_H0.6020.13
109_E258_H0.6020.13
197_D258_H0.6020.13
167_N262_D0.6020.13
167_N258_H0.6020.13
167_N227_R0.6020.13
197_D262_D0.6020.13
167_N172_D0.6020.13
167_N197_D0.6020.13
197_D227_R0.6020.13
39_E388_D0.6020.13
165_T309_Q0.6020.13
341_A345_W0.6020.13
145_G213_V0.6010.13
26_G31_H0.6000.13
312_R387_S0.6000.13
53_D180_H0.5980.13
229_E338_L0.5970.13
183_I187_L0.5960.13
183_I297_F0.5930.12
53_D151_Y0.5920.12
101_N131_E0.5910.12
119_N199_L0.5910.12
293_M297_F0.5910.12
348_L379_L0.5880.12
386_L394_E0.5870.12
34_D216_G0.5840.12
212_R406_R0.5820.12
43_A132_D0.5820.12
170_A225_I0.5820.12
175_Q268_S0.5790.12
251_L294_A0.5790.12
151_Y165_T0.5780.12
25_A362_I0.5770.12
265_S335_Q0.5770.12
164_V241_F0.5760.12
177_K183_I0.5740.12
169_K184_R0.5720.12
345_W348_L0.5720.12
31_H352_Q0.5720.12
255_V324_A0.5710.12
121_I263_V0.5710.12
61_V135_T0.5700.12
144_P249_P0.5660.12
313_L358_Y0.5660.12
132_D265_S0.5660.12
215_L369_E0.5650.12
201_G274_S0.5650.12
41_W91_H0.5650.12
57_L170_A0.5640.12
108_T204_R0.5630.12
11_K14_M0.5620.12
54_E255_V0.5620.12
74_F217_T0.5600.12
182_L345_W0.5590.12
325_R400_L0.5590.12
151_Y252_L0.5580.12
18_E26_G0.5570.12
67_H76_E0.5560.12
389_A400_L0.5560.12
363_E403_R0.5560.12
131_E383_E0.5550.12
6_K11_K0.5550.12
200_H294_A0.5520.12
199_L245_K0.5510.12
154_F191_P0.5500.12
160_I196_F0.5500.12
17_D315_E0.5490.12
191_P194_G0.5460.12
218_V329_S0.5450.12
126_H401_H0.5410.12
391_C397_T0.5400.12
199_L237_P0.5360.11
210_M310_L0.5360.11
9_R254_G0.5360.11
181_T292_A0.5360.11
287_H352_Q0.5350.11
305_Q399_K0.5350.11
391_C408_K0.5350.11
91_H200_H0.5340.11
22_K387_S0.5330.11
212_R298_M0.5330.11
151_Y191_P0.5320.11
22_K315_E0.5320.11
83_L246_A0.5310.11
195_H363_E0.5310.11
9_R76_E0.5290.11
188_P204_R0.5280.11
170_A182_L0.5270.11
94_S272_H0.5270.11
106_F188_P0.5270.11
91_H154_F0.5260.11
340_E395_K0.5250.11
71_L224_G0.5250.11
340_E382_A0.5230.11
185_D244_I0.5230.11
337_R342_V0.5220.11
191_P207_K0.5210.11
84_W150_L0.5200.11
280_E382_A0.5190.11
20_E384_Q0.5190.11
10_M329_S0.5180.11
144_P240_Y0.5170.11
92_T270_Y0.5160.11
69_H257_H0.5150.11
201_G255_V0.5150.11
26_G304_D0.5130.11
234_Y377_K0.5120.11
96_K256_L0.5110.11
18_E49_F0.5110.11
259_N263_V0.5100.11
151_Y177_K0.5090.11
77_L129_V0.5080.11
175_Q234_Y0.5060.11
395_K399_K0.5050.11
124_L270_Y0.5050.11
329_S407_L0.5050.11
120_T236_A0.5030.11
65_L397_T0.5020.11
212_R252_L0.5020.11
124_L193_F0.5010.11
46_M241_F0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4m8oA 1 0.8547 99.8 0.873 Contact Map
4qclA 1 0.9201 99.8 0.874 Contact Map
1qhtA 1 0.8644 99.7 0.878 Contact Map
1s5jA 1 0.77 99.7 0.884 Contact Map
3iayA 1 0.9395 99.6 0.888 Contact Map
4fvmA 1 0.9225 99.6 0.889 Contact Map
1noyA 2 0.6392 99.5 0.896 Contact Map
3mxmB 2 0.4189 99.5 0.898 Contact Map
2qxfA 1 0.6295 99.5 0.899 Contact Map
1y97A 2 0.414 99.4 0.903 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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