GREMLIN Database
YPQE - Putative phosphotransferase enzyme IIA component YpqE
UniProt: P50829 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 168 (149)
Sequences: 3811 (3179)
Seq/√Len: 260.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_K46_E2.9891.00
66_I78_R2.7001.00
61_A79_T2.5251.00
56_E116_P2.4181.00
104_H119_T2.3611.00
62_E112_K2.2951.00
106_K109_D2.2511.00
104_H116_P2.2241.00
25_D54_S2.2131.00
89_V118_I2.1751.00
64_E110_K2.1251.00
102_T119_T2.1031.00
80_R110_K2.0381.00
95_N130_S2.0311.00
100_G124_L2.0261.00
124_L128_K1.9881.00
72_K103_A1.9691.00
35_P131_S1.8861.00
99_E128_K1.8641.00
21_Y113_V1.8341.00
27_T51_E1.8221.00
34_V49_A1.8181.00
32_S42_K1.7171.00
56_E119_T1.7121.00
55_G122_L1.6621.00
62_E113_V1.6551.00
51_E131_S1.6071.00
112_K115_D1.5721.00
57_I87_I1.5601.00
24_A57_I1.5401.00
37_P41_Q1.5341.00
29_M133_V1.4941.00
89_V120_C1.4711.00
58_V157_K1.4701.00
64_E78_R1.4611.00
99_E124_L1.4281.00
156_R159_E1.4041.00
122_L132_T1.3791.00
58_V116_P1.3731.00
122_L126_K1.3671.00
35_P133_V1.3671.00
75_V118_I1.3581.00
109_D115_D1.3551.00
18_E81_S1.3331.00
123_E127_E1.2841.00
25_D156_R1.2811.00
24_A134_I1.2701.00
123_E126_K1.2661.00
25_D157_K1.2621.00
65_V75_V1.2461.00
25_D53_S1.2411.00
124_L127_E1.2351.00
49_A133_V1.2261.00
59_S77_I1.2251.00
96_M124_L1.2111.00
30_D33_D1.2071.00
62_E80_R1.2031.00
51_E132_T1.2011.00
53_S154_A1.1951.00
116_P119_T1.1761.00
27_T154_A1.1721.00
19_V160_S1.1691.00
28_V48_I1.1661.00
65_V105_I1.1601.00
120_C125_I1.1531.00
63_G77_I1.1511.00
132_T135_P1.1501.00
38_V43_M1.1361.00
83_I144_V1.1251.00
68_I103_A1.1111.00
29_M49_A1.1021.00
92_E95_N1.1011.00
103_A118_I1.0991.00
84_E140_N1.0861.00
78_R84_E1.0711.00
51_E126_K1.0671.00
18_E79_T1.0661.00
61_A77_I1.0601.00
141_G144_V1.0521.00
91_L135_P1.0461.00
121_D124_L1.0401.00
29_M51_E1.0351.00
48_I136_I1.0251.00
76_G139_M1.0021.00
68_I107_E0.9951.00
96_M100_G0.9891.00
57_I120_C0.9751.00
20_I61_A0.9741.00
65_V77_I0.9681.00
67_Q107_E0.9621.00
100_G128_K0.9601.00
75_V117_L0.9421.00
126_K132_T0.9411.00
89_V134_I0.9271.00
31_L47_G0.9251.00
96_M125_I0.9201.00
28_V155_A0.9151.00
140_N144_V0.9081.00
61_A85_L0.9001.00
72_K102_T0.8991.00
22_S50_V0.8961.00
22_S155_A0.8951.00
44_M139_M0.8901.00
46_E141_G0.8841.00
105_I109_D0.8831.00
51_E133_V0.8701.00
31_L34_V0.8671.00
18_E83_I0.8661.00
96_M99_E0.8651.00
50_V136_I0.8641.00
68_I72_K0.8591.00
79_T83_I0.8551.00
34_V133_V0.8500.99
23_P136_I0.8400.99
145_G148_V0.8370.99
150_A153_K0.8320.99
68_I118_I0.8290.99
100_G130_S0.8280.99
105_I115_D0.8260.99
75_V87_I0.8250.99
29_M34_V0.8200.99
70_H107_E0.8130.99
67_Q76_G0.7970.99
48_I161_K0.7840.99
77_I117_L0.7840.99
96_M130_S0.7760.99
35_P91_L0.7750.99
103_A107_E0.7660.99
59_S62_E0.7660.99
138_I141_G0.7640.99
49_A135_P0.7630.99
27_T53_S0.7580.99
55_G119_T0.7440.99
65_V68_I0.7360.99
31_L42_K0.7260.98
64_E108_G0.7200.98
70_H97_N0.7180.98
113_V116_P0.7170.98
125_I130_S0.7110.98
29_M33_D0.7100.98
56_E104_H0.7070.98
21_Y160_S0.7020.98
68_I75_V0.7010.98
48_I138_I0.6950.98
85_L138_I0.6900.98
65_V111_V0.6860.98
57_I134_I0.6820.98
38_V44_M0.6790.98
48_I149_S0.6780.98
55_G123_E0.6720.97
44_M137_V0.6700.97
67_Q70_H0.6660.97
155_A160_S0.6660.97
84_E139_M0.6650.97
141_G147_M0.6650.97
28_V150_A0.6650.97
34_V135_P0.6640.97
93_T125_I0.6620.97
24_A50_V0.6580.97
46_E146_S0.6500.97
43_M70_H0.6490.97
24_A52_P0.6480.97
68_I105_I0.6420.97
72_K104_H0.6400.96
54_S122_L0.6400.96
87_I136_I0.6400.96
31_L137_V0.6350.96
136_I161_K0.6340.96
52_P120_C0.6330.96
18_E21_Y0.6320.96
27_T153_K0.6310.96
125_I132_T0.6240.96
138_I144_V0.6140.96
124_L129_A0.6130.96
24_A120_C0.6050.95
38_V41_Q0.6050.95
33_D152_E0.6050.95
91_L137_V0.6030.95
48_I162_L0.6000.95
28_V152_E0.5960.95
83_I138_I0.5960.95
66_I76_G0.5930.95
89_V103_A0.5920.95
20_I138_I0.5900.94
140_N143_A0.5870.94
30_D42_K0.5860.94
77_I87_I0.5830.94
73_H88_H0.5800.94
37_P92_E0.5800.94
76_G84_E0.5790.94
92_E130_S0.5770.94
91_L131_S0.5740.94
91_L133_V0.5730.94
104_H118_I0.5660.93
34_V47_G0.5660.93
22_S25_D0.5580.93
105_I117_L0.5550.93
55_G121_D0.5540.92
42_K47_G0.5530.92
67_Q75_V0.5520.92
63_G79_T0.5480.92
15_V18_E0.5460.92
87_I117_L0.5440.92
62_E110_K0.5390.91
14_K145_G0.5380.91
55_G120_C0.5370.91
25_D158_G0.5350.91
93_T98_G0.5310.91
66_I84_E0.5310.91
28_V153_K0.5290.91
56_E157_K0.5280.91
75_V105_I0.5280.91
75_V103_A0.5250.90
78_R82_G0.5160.90
48_I83_I0.5140.89
21_Y158_G0.5130.89
88_H94_V0.5120.89
155_A159_E0.5080.89
85_L136_I0.5040.88
96_M132_T0.5040.88
151_G160_S0.5020.88
44_M67_Q0.5020.88
87_I135_P0.5010.88
20_I161_K0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ourB 1 0.8929 100 0.062 Contact Map
1f3zA 2 0.8929 100 0.071 Contact Map
2gprA 1 0.9167 100 0.091 Contact Map
1ax3A 1 0.9643 100 0.105 Contact Map
2d5dA 1 0.4167 98.1 0.835 Contact Map
1dczA 1 0.4583 98 0.839 Contact Map
1z6hA 1 0.4048 96.9 0.87 Contact Map
3bg3A 4 0.8988 96.7 0.872 Contact Map
1bdoA 2 0.4167 96.7 0.872 Contact Map
3hblA 4 0.7262 96.6 0.873 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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