GREMLIN Database
DER - GTPase Der
UniProt: P50743 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 436 (430)
Sequences: 3204 (1778)
Seq/√Len: 85.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
262_A292_V4.4261.00
158_A161_E4.0441.00
225_F344_I3.8461.00
87_I117_A3.7661.00
223_Q344_I3.6581.00
219_T224_E3.3431.00
179_C258_S3.3061.00
180_L192_V3.1591.00
416_R419_D3.1461.00
194_A333_K2.9641.00
181_I282_A2.9441.00
92_G121_L2.7811.00
24_A44_S2.7701.00
363_I385_A2.7671.00
258_S261_V2.7641.00
219_T222_Q2.7461.00
101_E135_S2.7371.00
310_E314_R2.7341.00
233_M251_A2.7201.00
175_V226_V2.6711.00
394_S431_F2.6481.00
87_I159_V2.6411.00
92_G118_V2.6361.00
192_V201_V2.6311.00
402_P434_A2.6021.00
22_R149_G2.5651.00
24_A28_I2.5551.00
68_F72_I2.4811.00
340_M343_I2.4561.00
7_A83_A2.3461.00
282_A289_V2.3111.00
307_K311_E2.2951.00
410_E432_A2.2371.00
6_V159_V2.2101.00
233_M248_V2.1881.00
227_I343_I2.1791.00
394_S429_K2.1711.00
228_V257_R2.1551.00
349_N422_G2.1521.00
290_V346_A2.1471.00
178_F343_I2.1251.00
405_M432_A2.0431.00
47_E50_N2.0411.00
263_V279_A2.0341.00
215_D257_R1.9781.00
276_K316_H1.9621.00
6_V85_V1.9581.00
41_R75_Q1.9561.00
85_V159_V1.9391.00
45_S52_D1.9211.00
116_L141_P1.9191.00
29_S42_I1.9131.00
90_V116_L1.9111.00
288_A346_A1.9081.00
362_V421_F1.9061.00
177_Q228_V1.9011.00
351_S391_K1.8741.00
256_D285_A1.8371.00
362_V420_A1.8301.00
89_M144_I1.8301.00
388_V396_V1.8261.00
385_A397_V1.8031.00
23_I46_A1.8001.00
293_V327_F1.7891.00
288_A350_H1.7721.00
85_V115_V1.7201.00
19_I146_G1.6991.00
292_V339_L1.6871.00
286_G429_K1.6621.00
234_R244_E1.6611.00
292_V326_L1.6571.00
142_Y158_A1.6561.00
352_L422_G1.6481.00
217_S226_V1.6391.00
252_L281_Y1.6331.00
347_S351_S1.6311.00
181_I255_I1.6261.00
255_I261_V1.6261.00
386_T398_F1.6171.00
213_A254_A1.6051.00
339_L343_I1.6041.00
80_M110_T1.5921.00
177_Q226_V1.5821.00
356_T360_N1.5791.00
19_I89_M1.5771.00
158_A162_H1.5731.00
80_M86_I1.5711.00
397_V432_A1.5611.00
324_P346_A1.5431.00
279_A320_L1.5351.00
105_K109_R1.5341.00
307_K310_E1.5241.00
178_F227_I1.5211.00
382_I397_V1.5141.00
122_D150_L1.5111.00
6_V46_A1.5010.99
32_E37_V1.5000.99
366_A416_R1.4990.99
326_L342_A1.4960.99
333_K336_I1.4860.99
356_T384_Y1.4840.99
362_V366_A1.4760.99
311_E315_D1.4750.99
385_A395_F1.4710.99
292_V328_M1.4590.99
43_Y82_E1.4550.99
352_L423_F1.4540.99
233_M278_I1.4530.99
85_V163_F1.4530.99
314_R325_I1.4440.99
359_L385_A1.4320.99
175_V217_S1.4190.99
91_N94_E1.4140.99
4_P163_F1.4120.99
48_W156_L1.4040.99
194_A336_I1.4000.99
289_V320_L1.3890.99
74_Q199_E1.3830.99
28_I44_S1.3790.99
221_N341_P1.3710.99
196_L218_F1.3640.99
130_I143_P1.3570.99
345_K422_G1.3520.99
262_A343_I1.3510.99
71_Q74_Q1.3440.99
217_S224_E1.3430.99
176_I347_S1.3430.99
191_L264_V1.3380.99
46_A53_F1.3360.99
138_F141_P1.3350.99
280_G284_E1.3250.99
24_A55_L1.3210.99
5_V54_N1.3180.99
308_E312_N1.3150.99
204_S209_T1.3130.99
399_V402_P1.3130.99
267_G299_V1.2990.99
51_Y165_N1.2980.99
85_V162_H1.2960.99
350_H391_K1.2820.98
263_V291_I1.2800.98
354_V423_F1.2780.98
115_V142_Y1.2690.98
380_L399_V1.2690.98
176_I225_F1.2640.98
45_S54_N1.2570.98
18_T146_G1.2470.98
153_G157_D1.2450.98
342_A345_K1.2430.98
117_A144_I1.2400.98
80_M106_I1.2350.98
366_A412_F1.2350.98
105_K108_Y1.2320.98
149_G152_L1.2290.98
93_R126_M1.2140.98
263_V282_A1.2100.98
8_I87_I1.2060.98
95_G132_D1.2020.98
263_V289_V1.1930.97
180_L201_V1.1910.97
191_L336_I1.1890.97
308_E311_E1.1800.97
366_A413_L1.1790.97
46_A55_L1.1770.97
41_R79_A1.1770.97
6_V53_F1.1760.97
346_A426_T1.1700.97
196_L201_V1.1690.97
68_F71_Q1.1640.97
223_Q348_E1.1640.97
140_E158_A1.1630.97
90_V133_F1.1610.97
6_V160_A1.1440.97
268_E298_A1.1430.97
48_W153_G1.1400.97
62_D72_I1.1310.96
123_N126_M1.1290.96
107_L114_V1.1220.96
380_L401_D1.1200.96
47_E52_D1.1180.96
271_I317_F1.1180.96
48_W157_D1.1130.96
372_T409_Y1.1120.96
75_Q79_A1.1090.96
283_H322_Y1.1090.96
101_E105_K1.1000.96
349_N425_G1.1000.96
19_I152_L1.0920.96
239_V248_V1.0870.96
115_V158_A1.0820.95
51_Y160_A1.0730.95
265_L270_G1.0560.95
324_P345_K1.0550.95
115_V162_H1.0540.95
92_G129_N1.0530.95
370_N412_F1.0510.95
221_N344_I1.0480.95
273_E277_R1.0480.95
181_I278_I1.0430.94
262_A339_L1.0330.94
294_N330_A1.0310.94
389_S394_S1.0290.94
220_Y340_M1.0240.94
72_I76_A1.0240.94
382_I405_M1.0230.94
290_V326_L1.0160.94
37_V243_T1.0160.94
363_I382_I1.0130.94
334_K338_T1.0120.93
365_D420_A1.0100.93
354_V421_F1.0050.93
360_N384_Y1.0040.93
218_F227_I1.0030.93
115_V159_V0.9990.93
363_I417_I0.9920.93
324_P424_E0.9880.93
104_A138_F0.9880.93
267_G293_V0.9860.93
73_R77_E0.9840.93
280_G323_A0.9830.92
280_G319_F0.9820.92
269_E272_I0.9790.92
19_I155_L0.9790.92
43_Y54_N0.9760.92
293_V313_I0.9750.92
349_N352_L0.9700.92
328_M339_L0.9700.92
291_I325_I0.9660.92
218_F340_M0.9660.92
51_Y164_K0.9650.92
195_M340_M0.9620.92
353_R386_T0.9530.91
213_A228_V0.9530.91
396_V431_F0.9530.91
191_L328_M0.9520.91
62_D69_L0.9510.91
23_I53_F0.9430.91
255_I282_A0.9380.91
77_E106_I0.9350.90
409_Y412_F0.9320.90
192_V227_I0.9310.90
69_L72_I0.9260.90
303_E306_M0.9240.90
82_E357_N0.9210.90
378_S401_D0.9190.90
380_L405_M0.9170.90
61_I76_A0.9130.89
67_P206_V0.9090.89
215_D226_V0.9080.89
117_A155_L0.9050.89
345_K349_N0.9000.89
348_E352_L0.8980.89
225_F340_M0.8970.89
220_Y225_F0.8960.88
34_T37_V0.8940.88
78_I81_D0.8920.88
32_E242_T0.8910.88
201_V214_V0.8880.88
96_V135_S0.8860.88
271_I313_I0.8860.88
338_T341_P0.8850.88
373_P377_G0.8850.88
195_M218_F0.8850.88
132_D135_S0.8810.88
69_L99_A0.8780.87
151_G276_K0.8750.87
11_R97_T0.8750.87
369_M416_R0.8740.87
186_V269_E0.8730.87
294_N297_D0.8720.87
358_V361_D0.8710.87
407_F410_E0.8700.87
286_G392_P0.8690.87
10_G15_G0.8650.87
71_Q202_I0.8610.86
246_Y250_R0.8580.86
355_Q358_V0.8520.86
260_V288_A0.8510.86
395_F417_I0.8510.86
309_F313_I0.8510.86
347_S350_H0.8510.86
220_Y223_Q0.8490.86
171_Y226_V0.8460.85
201_V216_T0.8430.85
357_N361_D0.8430.85
375_H404_L0.8410.85
290_V342_A0.8410.85
248_V252_L0.8410.85
192_V216_T0.8370.85
367_V372_T0.8340.85
34_T243_T0.8330.85
378_S404_L0.8310.84
401_D404_L0.8290.84
6_V87_I0.8190.84
344_I348_E0.8190.84
27_R31_V0.8180.84
44_S55_L0.8180.84
53_F156_L0.8180.84
312_N315_D0.8170.83
77_E80_M0.8150.83
374_T377_G0.8120.83
266_D269_E0.8110.83
259_E391_K0.8080.83
306_M335_R0.8060.83
104_A139_G0.8010.82
353_R390_V0.7970.82
131_Y134_Y0.7960.82
380_L404_L0.7940.82
88_F107_L0.7940.82
118_V133_F0.7940.82
43_Y75_Q0.7910.81
310_E327_F0.7900.81
250_R253_K0.7900.81
77_E81_D0.7880.81
192_V233_M0.7850.81
178_F218_F0.7850.81
345_K424_E0.7820.81
94_E98_A0.7820.81
287_K350_H0.7800.80
176_I344_I0.7790.80
397_V413_L0.7790.80
156_L160_A0.7770.80
396_V433_R0.7760.80
26_E44_S0.7750.80
59_G72_I0.7740.80
9_V86_I0.7720.80
62_D73_R0.7710.80
236_K252_L0.7700.80
49_L160_A0.7680.79
93_R123_N0.7670.79
173_E224_E0.7670.79
301_K304_S0.7670.79
183_R272_I0.7640.79
414_E418_R0.7640.79
82_E253_K0.7640.79
415_N419_D0.7600.79
225_F343_I0.7590.79
234_R239_V0.7570.78
410_E414_E0.7560.78
134_Y293_V0.7550.78
302_D307_K0.7540.78
8_I20_F0.7530.78
293_V309_F0.7520.78
98_A101_E0.7520.78
417_I421_F0.7510.78
124_T150_L0.7480.78
76_A80_M0.7480.78
248_V251_A0.7480.78
11_R14_V0.7460.77
326_L339_L0.7450.77
116_L136_L0.7430.77
41_R82_E0.7430.77
264_V292_V0.7420.77
41_R56_I0.7380.77
30_I250_R0.7360.77
312_N316_H0.7350.76
118_V139_G0.7340.76
188_K229_D0.7330.76
234_R274_Q0.7300.76
105_K135_S0.7290.76
7_A56_I0.7280.76
421_F425_G0.7270.76
115_V131_Y0.7250.75
356_T386_T0.7250.75
22_R152_L0.7250.75
262_A328_M0.7240.75
349_N424_E0.7240.75
384_Y398_F0.7220.75
288_A297_D0.7200.75
195_M336_I0.7190.75
377_G380_L0.7190.75
281_Y284_E0.7170.75
153_G156_L0.7170.75
46_A49_L0.7130.74
268_E293_V0.7130.74
311_E325_I0.7120.74
156_L159_V0.7100.74
79_A83_A0.7090.74
10_G16_K0.7070.74
407_F411_R0.7070.74
194_A332_T0.7070.74
211_R243_T0.7010.73
237_G277_R0.6980.73
121_L129_N0.6970.73
352_L358_V0.6970.73
268_E299_V0.6960.72
387_Q393_P0.6950.72
118_V143_P0.6940.72
157_D160_A0.6920.72
58_T79_A0.6920.72
145_S150_L0.6900.72
50_N105_K0.6890.72
187_G229_D0.6870.71
346_A349_N0.6860.71
323_A426_T0.6850.71
406_H415_N0.6840.71
399_V432_A0.6830.71
55_L159_V0.6830.71
304_S308_E0.6830.71
328_M331_L0.6820.71
174_E224_E0.6810.71
193_N210_T0.6800.71
262_A290_V0.6770.70
159_V162_H0.6760.70
194_A264_V0.6760.70
161_E165_N0.6720.70
387_Q390_V0.6710.70
41_R58_T0.6710.70
41_R78_I0.6680.69
102_E105_K0.6630.69
144_I152_L0.6610.69
291_I317_F0.6600.68
227_I340_M0.6600.68
413_L432_A0.6570.68
29_S44_S0.6550.68
50_N156_L0.6540.68
342_A346_A0.6530.68
393_P426_T0.6490.67
190_S203_V0.6480.67
48_W53_F0.6460.67
28_I42_I0.6440.67
374_T380_L0.6410.66
114_V138_F0.6410.66
373_P406_H0.6390.66
296_W335_R0.6370.66
42_I214_V0.6370.66
118_V141_P0.6370.66
7_A79_A0.6360.66
304_S307_K0.6350.65
111_K217_S0.6350.65
365_D368_A0.6350.65
353_R357_N0.6350.65
167_P170_K0.6330.65
335_R338_T0.6330.65
191_L339_L0.6320.65
116_L139_G0.6290.65
127_R150_L0.6280.65
272_I278_I0.6280.65
68_F206_V0.6270.64
149_G153_G0.6270.64
362_V417_I0.6240.64
122_D145_S0.6230.64
5_V43_Y0.6190.63
299_V309_F0.6180.63
62_D71_Q0.6170.63
394_S399_V0.6160.63
351_S390_V0.6160.63
320_L323_A0.6150.63
416_R420_A0.6140.63
76_A204_S0.6140.63
122_D141_P0.6130.63
302_D308_E0.6130.63
176_I223_Q0.6120.63
8_I89_M0.6120.63
51_Y163_F0.6120.63
353_R433_R0.6120.63
376_N403_E0.6120.63
66_E70_A0.6110.62
244_E247_S0.6110.62
271_I276_K0.6100.62
276_K280_G0.6090.62
360_N386_T0.6090.62
290_V347_S0.6080.62
306_M309_F0.6070.62
27_R256_D0.6060.62
353_R360_N0.6040.62
239_V274_Q0.6040.62
359_L395_F0.6040.62
196_L216_T0.6040.62
242_T245_K0.6020.61
376_N404_L0.6000.61
115_V155_L0.5990.61
284_E320_L0.5980.61
190_S330_A0.5970.61
23_I55_L0.5950.60
86_I114_V0.5950.60
53_F157_D0.5940.60
142_Y151_G0.5930.60
271_I355_Q0.5920.60
189_S210_T0.5920.60
183_R269_E0.5920.60
87_I166_I0.5920.60
194_A330_A0.5920.60
374_T378_S0.5910.60
356_T387_Q0.5910.60
152_L163_F0.5910.60
192_V196_L0.5900.60
411_R414_E0.5890.60
88_F138_F0.5890.60
237_G248_V0.5880.60
245_K379_R0.5870.59
18_T144_I0.5870.59
216_T227_I0.5870.59
63_I69_L0.5850.59
361_D364_M0.5850.59
349_N423_F0.5840.59
220_Y344_I0.5830.59
177_Q259_E0.5820.59
89_M420_A0.5810.59
335_R361_D0.5810.59
45_S130_I0.5800.59
84_D112_K0.5800.59
96_V136_L0.5800.59
242_T246_Y0.5790.58
148_H412_F0.5790.58
177_Q257_R0.5790.58
46_A50_N0.5780.58
413_L423_F0.5780.58
84_D180_L0.5770.58
353_R396_V0.5770.58
258_S359_L0.5760.58
302_D306_M0.5760.58
192_V340_M0.5740.58
407_F415_N0.5740.58
22_R148_H0.5740.58
46_A163_F0.5730.58
171_Y174_E0.5720.57
5_V56_I0.5720.57
227_I255_I0.5710.57
121_L150_L0.5710.57
112_K201_V0.5710.57
10_G13_N0.5700.57
51_Y166_I0.5700.57
246_Y256_D0.5700.57
23_I44_S0.5690.57
69_L73_R0.5680.57
319_F406_H0.5680.57
260_V350_H0.5680.57
388_V399_V0.5670.57
27_R253_K0.5670.57
383_Y399_V0.5660.57
53_F163_F0.5660.57
287_K297_D0.5650.57
22_R29_S0.5640.56
397_V405_M0.5630.56
23_I52_D0.5620.56
102_E178_F0.5620.56
289_V297_D0.5610.56
93_R96_V0.5610.56
337_H341_P0.5610.56
265_L272_I0.5600.56
245_K249_L0.5600.56
394_S433_R0.5590.56
57_D60_G0.5580.56
237_G317_F0.5580.56
377_G382_I0.5580.56
161_E164_K0.5570.55
184_P208_G0.5570.55
58_T75_Q0.5570.55
7_A58_T0.5570.55
67_P70_A0.5560.55
48_W160_A0.5560.55
190_S332_T0.5560.55
259_E347_S0.5550.55
220_Y341_P0.5550.55
185_N210_T0.5550.55
95_G133_F0.5550.55
397_V430_I0.5550.55
127_R143_P0.5530.55
185_N208_G0.5520.55
218_F320_L0.5500.55
38_T210_T0.5500.55
72_I204_S0.5500.55
65_D109_R0.5490.54
98_A102_E0.5480.54
401_D406_H0.5480.54
249_L285_A0.5450.54
101_E132_D0.5450.54
117_A343_I0.5440.54
192_V242_T0.5440.54
334_K341_P0.5440.54
186_V298_A0.5420.53
303_E307_K0.5420.53
20_F44_S0.5410.53
7_A76_A0.5410.53
165_N172_N0.5410.53
223_Q226_V0.5400.53
6_V117_A0.5390.53
286_G350_H0.5380.53
136_L139_G0.5380.53
311_E314_R0.5350.53
353_R392_P0.5350.53
25_G28_I0.5350.53
368_A407_F0.5350.53
264_V330_A0.5340.52
62_D207_A0.5320.52
98_A121_L0.5320.52
152_L156_L0.5320.52
414_E430_I0.5320.52
410_E430_I0.5310.52
113_P162_H0.5300.52
117_A152_L0.5300.52
72_I150_L0.5290.52
236_K239_V0.5290.52
30_I211_R0.5280.52
143_P236_K0.5270.51
317_F320_L0.5260.51
180_L262_A0.5260.51
355_Q361_D0.5240.51
128_A167_P0.5230.51
23_I152_L0.5230.51
26_E37_V0.5220.51
62_D99_A0.5210.51
283_H320_L0.5210.51
122_D149_G0.5200.51
301_K335_R0.5200.51
175_V224_E0.5200.51
115_V161_E0.5190.50
242_T250_R0.5180.50
367_V370_N0.5180.50
395_F398_F0.5170.50
112_K122_D0.5170.50
363_I372_T0.5170.50
19_I144_I0.5170.50
353_R387_Q0.5150.50
213_A233_M0.5150.50
397_V414_E0.5130.50
122_D203_V0.5130.50
366_A420_A0.5120.49
52_D167_P0.5120.49
237_G281_Y0.5110.49
128_A385_A0.5110.49
268_E309_F0.5110.49
371_P411_R0.5100.49
261_V287_K0.5100.49
291_I320_L0.5090.49
263_V312_N0.5090.49
209_T250_R0.5090.49
263_V278_I0.5080.49
255_I285_A0.5080.49
302_D335_R0.5080.49
239_V244_E0.5070.49
215_D383_Y0.5060.49
50_N207_A0.5060.49
108_Y214_V0.5050.49
180_L336_I0.5050.49
117_A130_I0.5050.49
16_K21_N0.5050.49
353_R388_V0.5040.48
248_V426_T0.5040.48
35_P272_I0.5030.48
10_G17_S0.5030.48
399_V405_M0.5010.48
89_M248_V0.5010.48
306_M325_I0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1mkyA 1 0.9151 100 0.248 Contact Map
4dcuA 1 0.9174 100 0.249 Contact Map
3j8gX 1 0.9358 100 0.27 Contact Map
3j65o 1 0.7133 100 0.66 Contact Map
4fidA 1 0.5894 100 0.715 Contact Map
1egaA 2 0.617 100 0.724 Contact Map
4xc8A 2 0.8761 100 0.727 Contact Map
3ec1A 1 0.6674 100 0.737 Contact Map
2yv5A 1 0.6261 100 0.751 Contact Map
3h2yA 1 0.6628 100 0.753 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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