GREMLIN Database
YPHB - Uncharacterized protein YphB
UniProt: P50742 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 297 (286)
Sequences: 153 (116)
Seq/√Len: 6.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
191_E195_K4.5590.98
12_V122_L3.8240.94
18_T66_I3.2000.87
97_S224_F3.0070.83
269_V273_S2.9360.81
127_A139_A2.7940.78
40_H110_F2.7440.77
91_D246_K2.7110.76
141_V213_I2.6750.75
163_E203_T2.4730.68
59_L63_F2.4190.67
195_K263_H2.3650.65
200_F272_I2.3520.64
189_K240_S2.3220.63
14_A140_A2.2360.60
157_K273_S2.2040.59
160_V213_I2.1810.58
116_I146_L2.1560.57
136_A140_A2.1390.57
141_V146_L2.1270.56
162_I273_S2.1200.56
126_S190_Q2.0870.55
53_I64_T2.0830.54
71_L273_S2.0800.54
121_A125_T2.0750.54
234_R242_T2.0570.53
121_A181_M2.0270.52
21_Y52_A2.0120.52
78_D270_Q1.9800.51
195_K266_E1.9240.48
105_G153_G1.9200.48
11_G282_I1.9120.48
59_L129_V1.9110.48
165_I177_D1.9030.48
22_M184_I1.8940.47
43_L64_T1.8590.46
142_V146_L1.8380.45
28_R44_G1.8230.45
8_I49_G1.8150.44
163_E198_M1.7920.43
79_V220_Q1.7770.43
161_D205_K1.7580.42
58_L133_I1.7400.42
62_E71_L1.7140.41
192_L238_E1.6880.40
58_L71_L1.6520.38
57_A121_A1.6450.38
13_I137_V1.6350.38
55_M123_L1.6330.38
43_L73_A1.6220.37
84_R104_E1.6040.37
62_E258_V1.6020.37
189_K238_E1.5940.36
57_A142_V1.5870.36
45_L254_V1.5850.36
48_A251_D1.5600.35
109_A247_R1.5580.35
123_L139_A1.5500.35
128_Y136_A1.4960.33
4_Y60_Q1.4890.33
73_A104_E1.4760.32
157_K162_I1.4700.32
27_Y46_I1.4660.32
226_V272_I1.4660.32
32_T118_I1.4400.31
16_I45_L1.4400.31
161_D203_T1.4380.31
27_Y40_H1.4160.30
38_V121_A1.4000.30
90_M157_K1.3950.30
38_V150_F1.3800.29
80_R98_R1.3700.29
160_V202_L1.3590.28
189_K281_A1.3580.28
74_T102_Y1.3510.28
222_I230_L1.3500.28
140_A188_E1.3440.28
110_F285_P1.3350.28
5_I32_T1.3330.28
130_F188_E1.3230.27
14_A170_D1.3180.27
125_T156_L1.3170.27
74_T108_I1.3150.27
21_Y41_I1.3150.27
179_I253_R1.3070.27
154_S194_L1.2830.26
52_A152_S1.2820.26
215_N232_V1.2810.26
158_D184_I1.2720.26
160_V272_I1.2670.26
35_H105_G1.2610.26
65_A83_E1.2570.25
60_Q142_V1.2550.25
188_E270_Q1.2510.25
199_G268_A1.2470.25
18_T277_T1.2440.25
79_V223_L1.2390.25
110_F252_G1.2190.24
20_L274_N1.2150.24
58_L61_E1.1980.24
164_Y198_M1.1960.24
77_R98_R1.1920.24
193_I257_F1.1900.24
164_Y266_E1.1890.23
165_I265_P1.1870.23
45_L158_D1.1710.23
202_L272_I1.1700.23
63_F122_L1.1520.23
53_I263_H1.1490.22
48_A171_G1.1450.22
189_K192_L1.1420.22
50_L210_A1.1410.22
13_I149_K1.1290.22
109_A280_N1.1250.22
122_L270_Q1.1250.22
84_R171_G1.1180.22
164_Y265_P1.1170.22
57_A159_I1.1150.22
34_V74_T1.1140.22
69_L75_Q1.1100.21
73_A243_P1.1080.21
166_K178_N1.1060.21
271_I287_E1.1010.21
265_P269_V1.0940.21
216_L236_S1.0940.21
156_L272_I1.0910.21
33_Y159_I1.0910.21
139_A142_V1.0890.21
146_L275_V1.0850.21
55_M112_S1.0750.21
4_Y177_D1.0750.21
77_R80_R1.0740.21
5_I277_T1.0700.20
52_A121_A1.0690.20
237_G259_L1.0660.20
96_V104_E1.0650.20
13_I155_V1.0640.20
141_V190_Q1.0620.20
162_I272_I1.0600.20
48_A159_I1.0480.20
91_D129_V1.0460.20
27_Y159_I1.0450.20
16_I238_E1.0400.20
78_D124_T1.0370.20
74_T210_A1.0340.20
166_K177_D1.0340.20
41_I270_Q1.0300.19
284_M287_E1.0280.19
110_F182_M1.0200.19
63_F195_K1.0170.19
102_Y279_E1.0160.19
120_T143_C1.0120.19
43_L243_P1.0080.19
54_I190_Q1.0060.19
71_L119_F1.0040.19
234_R268_A1.0030.19
81_N182_M1.0030.19
135_A258_V0.9950.19
120_T159_I0.9950.19
126_S288_F0.9930.19
7_P282_I0.9860.18
224_F262_I0.9830.18
166_K170_D0.9830.18
196_H233_Y0.9820.18
55_M122_L0.9810.18
90_M280_N0.9790.18
74_T93_Y0.9790.18
16_I55_M0.9790.18
49_G157_K0.9730.18
64_T118_I0.9720.18
145_L250_N0.9600.18
200_F268_A0.9590.18
61_E162_I0.9570.18
17_A123_L0.9500.18
223_L256_V0.9470.18
145_L248_D0.9470.18
101_T202_L0.9400.17
33_Y285_P0.9340.17
88_T208_N0.9330.17
44_G110_F0.9190.17
21_Y49_G0.9180.17
174_L257_F0.9170.17
27_Y285_P0.9140.17
214_A225_D0.9030.17
62_E173_G0.9020.17
137_V141_V0.9020.17
142_V250_N0.9010.17
151_M244_I0.8980.16
225_D283_R0.8950.16
150_F206_N0.8930.16
171_G267_T0.8930.16
7_P125_T0.8930.16
236_S240_S0.8910.16
18_T149_K0.8900.16
52_A57_A0.8900.16
57_A230_L0.8880.16
91_D248_D0.8820.16
42_A130_F0.8810.16
121_A141_V0.8780.16
64_T254_V0.8730.16
40_H44_G0.8680.16
142_V159_I0.8670.16
73_A95_L0.8650.16
138_I195_K0.8650.16
44_G80_R0.8610.16
26_D44_G0.8570.16
128_Y184_I0.8480.15
206_N216_L0.8460.15
18_T138_I0.8460.15
90_M277_T0.8440.15
173_G234_R0.8400.15
17_A170_D0.8390.15
126_S156_L0.8380.15
248_D253_R0.8350.15
73_A96_V0.8310.15
200_F226_V0.8300.15
136_A230_L0.8280.15
95_L104_E0.8270.15
13_I78_D0.8250.15
22_M123_L0.8210.15
26_D80_R0.8200.15
139_A146_L0.8120.15
39_I223_L0.8100.15
79_V91_D0.8050.15
180_Y223_L0.8050.15
135_A145_L0.8040.15
83_E102_Y0.7980.14
167_P277_T0.7960.14
104_E235_D0.7880.14
73_A84_R0.7850.14
137_V178_N0.7840.14
94_E285_P0.7810.14
37_K248_D0.7810.14
97_S119_F0.7800.14
199_G237_G0.7780.14
241_L246_K0.7740.14
26_D98_R0.7680.14
124_T127_A0.7640.14
126_S176_V0.7630.14
58_L97_S0.7620.14
69_L103_I0.7610.14
66_I183_N0.7590.14
50_L74_T0.7570.14
237_G249_L0.7570.14
190_Q256_V0.7500.14
14_A203_T0.7500.14
156_L213_I0.7450.14
184_I247_R0.7410.13
122_L201_I0.7370.13
27_Y102_Y0.7370.13
9_I205_K0.7370.13
48_A123_L0.7350.13
35_H42_A0.7340.13
66_I118_I0.7290.13
10_A140_A0.7260.13
34_V173_G0.7250.13
90_M158_D0.7250.13
122_L240_S0.7250.13
88_T109_A0.7220.13
65_A252_G0.7210.13
124_T143_C0.7200.13
20_L126_S0.7200.13
211_A238_E0.7180.13
153_G193_I0.7110.13
182_M258_V0.7080.13
24_K70_T0.7080.13
200_F284_M0.7070.13
34_V189_K0.7060.13
184_I271_I0.7040.13
152_S248_D0.7030.13
65_A102_Y0.7010.13
190_Q222_I0.7000.13
72_A230_L0.6940.13
54_I126_S0.6940.13
4_Y224_F0.6910.13
65_A221_A0.6900.13
74_T169_F0.6890.13
201_I253_R0.6890.13
116_I153_G0.6860.13
88_T213_I0.6840.12
32_T238_E0.6830.12
55_M139_A0.6820.12
17_A230_L0.6810.12
11_G73_A0.6800.12
18_T201_I0.6770.12
124_T264_H0.6770.12
248_D289_I0.6760.12
20_L41_I0.6750.12
109_A225_D0.6720.12
27_Y33_Y0.6710.12
198_M268_A0.6660.12
9_I122_L0.6660.12
58_L62_E0.6650.12
34_V200_F0.6630.12
154_S280_N0.6630.12
178_N254_V0.6620.12
7_P247_R0.6610.12
170_D250_N0.6590.12
139_A258_V0.6570.12
57_A271_I0.6570.12
116_I288_F0.6570.12
16_I41_I0.6550.12
43_L104_E0.6550.12
50_L284_M0.6540.12
83_E94_E0.6490.12
48_A131_L0.6490.12
88_T118_I0.6470.12
24_K54_I0.6460.12
40_H285_P0.6450.12
269_V289_I0.6440.12
109_A283_R0.6440.12
64_T263_H0.6400.12
146_L161_D0.6390.12
21_Y187_P0.6390.12
245_A254_V0.6380.12
58_L144_F0.6340.12
141_V170_D0.6280.12
32_T271_I0.6270.12
50_L85_N0.6230.11
166_K190_Q0.6200.11
91_D241_L0.6170.11
47_A53_I0.6130.11
145_L258_V0.6120.11
214_A247_R0.6120.11
54_I63_F0.6110.11
164_Y167_P0.6110.11
39_I237_G0.6110.11
73_A118_I0.6090.11
40_H252_G0.6080.11
30_Y72_A0.6070.11
26_D110_F0.6070.11
67_T185_G0.6040.11
127_A135_A0.6040.11
134_W287_E0.6040.11
61_E242_T0.6040.11
47_A114_N0.6020.11
210_A262_I0.6000.11
163_E266_E0.5990.11
26_D217_G0.5990.11
42_A64_T0.5960.11
63_F112_S0.5960.11
59_L226_V0.5960.11
121_A146_L0.5960.11
226_V247_R0.5950.11
246_K268_A0.5950.11
101_T257_F0.5940.11
188_E191_E0.5940.11
147_A282_I0.5920.11
79_V239_P0.5910.11
118_I143_C0.5900.11
62_E124_T0.5880.11
22_M129_V0.5870.11
123_L131_L0.5860.11
10_A213_I0.5860.11
119_F156_L0.5840.11
152_S239_P0.5790.11
235_D249_L0.5760.11
60_Q224_F0.5750.11
121_A249_L0.5740.11
125_T160_V0.5740.11
147_A193_I0.5740.11
52_A195_K0.5730.11
117_V179_I0.5730.11
151_M225_D0.5730.11
34_V238_E0.5730.11
17_A236_S0.5720.11
151_M158_D0.5720.11
132_S138_I0.5700.11
240_S267_T0.5690.11
134_W266_E0.5680.11
52_A137_V0.5680.11
90_M195_K0.5650.11
127_A166_K0.5640.11
11_G118_I0.5620.11
119_F246_K0.5620.11
58_L205_K0.5610.11
12_V97_S0.5590.11
52_A74_T0.5590.11
8_I208_N0.5570.11
9_I44_G0.5570.11
71_L268_A0.5560.10
63_F188_E0.5530.10
93_Y202_L0.5510.10
89_Q247_R0.5500.10
7_P57_A0.5490.10
8_I122_L0.5460.10
78_D254_V0.5460.10
135_A167_P0.5440.10
237_G268_A0.5410.10
212_T287_E0.5380.10
50_L228_N0.5380.10
13_I127_A0.5370.10
263_H267_T0.5370.10
234_R237_G0.5360.10
43_L84_R0.5350.10
225_D237_G0.5350.10
71_L122_L0.5340.10
253_R271_I0.5320.10
158_D169_F0.5320.10
104_E243_P0.5320.10
21_Y270_Q0.5310.10
43_L285_P0.5310.10
225_D235_D0.5310.10
36_G102_Y0.5310.10
136_A209_S0.5300.10
211_A258_V0.5290.10
130_F155_V0.5260.10
138_I162_I0.5260.10
26_D40_H0.5250.10
123_L146_L0.5230.10
92_S138_I0.5180.10
94_E136_A0.5160.10
36_G83_E0.5160.10
58_L191_E0.5150.10
178_N195_K0.5120.10
6_Y41_I0.5120.10
165_I198_M0.5120.10
122_L133_I0.5120.10
130_F270_Q0.5110.10
222_I258_V0.5100.10
141_V145_L0.5100.10
91_D108_I0.5090.10
263_H274_N0.5070.10
12_V188_E0.5060.10
191_E230_L0.5050.10
5_I234_R0.5050.10
49_G147_A0.5020.10
42_A118_I0.5020.10
160_V238_E0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2c7hA 1 0.2727 11.6 0.981 Contact Map
4xp4A 1 0.2626 9.2 0.981 Contact Map
4k0jA 3 0.1111 8.4 0.982 Contact Map
3af5A 1 0.431 8.3 0.982 Contact Map
4q4hB 1 0.9428 7.4 0.982 Contact Map
3qe7A 2 0.4276 6.7 0.983 Contact Map
2m8rA 1 0.2795 6 0.983 Contact Map
2micA 2 0.138 5.9 0.983 Contact Map
3vouA 4 0.2997 5.4 0.983 Contact Map
4px7A 1 0.2492 5.3 0.983 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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