GREMLIN Database
YPHA - Uncharacterized protein YphA
UniProt: P50741 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 199 (190)
Sequences: 114 (98)
Seq/√Len: 7.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
3_Q162_N5.4511.00
94_A105_P4.9980.99
51_L74_F3.3970.91
14_W35_L3.2290.88
141_V145_V2.9060.82
81_L84_V2.8260.80
96_Y174_I2.6760.76
15_V88_A2.5820.73
11_W19_F2.2820.63
139_E156_G2.2170.61
59_F63_C2.1840.60
87_Y97_D2.1740.59
20_I164_C2.1400.58
31_S81_L2.1210.57
3_Q6_Y2.0710.56
63_C137_Q2.0250.54
6_Y58_F1.9860.52
122_R139_E1.9780.52
38_I47_L1.9510.51
99_V174_I1.8910.49
116_L129_V1.8820.48
100_W142_Y1.8730.48
133_L184_I1.8180.46
31_S92_L1.8120.46
82_T115_L1.7080.42
3_Q134_G1.6960.41
1_M11_W1.6570.40
21_F58_F1.6350.39
93_F149_L1.6290.39
32_V56_L1.6020.38
26_R161_L1.5760.37
82_T94_A1.5710.37
4_F180_L1.5510.36
6_Y10_M1.5300.35
34_I139_E1.5040.34
90_V109_A1.5020.34
5_Y122_R1.4530.32
51_L66_A1.4510.32
13_L82_T1.4340.32
18_T96_Y1.4330.32
122_R145_V1.4010.31
20_I167_G1.3900.30
39_I166_A1.3820.30
115_L120_V1.3780.30
14_W18_T1.3770.30
23_K35_L1.3700.30
59_F140_L1.3690.30
84_V167_G1.3670.30
5_Y16_L1.3610.29
134_G162_N1.3500.29
6_Y174_I1.3410.29
11_W98_P1.3390.29
1_M19_F1.3250.28
70_G135_M1.3200.28
108_A120_V1.3140.28
97_D104_K1.2860.27
86_A142_Y1.2740.27
50_S78_M1.2690.27
45_I56_L1.2650.26
93_F97_D1.2650.26
52_N133_L1.2640.26
17_T31_S1.2570.26
60_V114_V1.2500.26
83_L169_I1.2490.26
15_V170_L1.2400.26
142_Y146_I1.2360.26
10_M38_I1.2360.26
9_S160_W1.2300.25
59_F139_E1.2270.25
2_E95_L1.2150.25
55_Y96_Y1.1940.24
18_T156_G1.1850.24
89_F128_L1.1790.24
135_M164_C1.1710.24
103_I185_G1.1690.24
41_S161_L1.1490.23
18_T31_S1.1430.23
85_A101_F1.1300.23
29_A123_N1.1210.22
18_T41_S1.1200.22
6_Y162_N1.1190.22
7_Y127_Q1.1070.22
96_Y110_V1.1040.22
19_F98_P1.0980.22
54_A165_S1.0980.22
21_F28_I1.0980.22
84_V91_Y1.0960.22
91_Y151_G1.0870.21
101_F110_V1.0750.21
2_E93_F1.0610.21
21_F112_L1.0470.20
55_Y136_C1.0430.20
11_W14_W1.0420.20
66_A152_A1.0300.20
51_L165_S1.0210.20
82_T90_V1.0200.20
93_F146_I1.0170.20
61_C169_I1.0090.19
50_S159_Q0.9870.19
16_L20_I0.9790.19
73_R83_L0.9780.19
35_L38_I0.9770.19
109_A173_G0.9740.19
53_A158_F0.9740.19
66_A130_L0.9720.19
100_W143_S0.9600.18
31_S166_A0.9590.18
84_V104_K0.9590.18
116_L184_I0.9470.18
36_T44_D0.9460.18
12_F15_V0.9460.18
53_A106_E0.9460.18
15_V20_I0.9330.18
88_A128_L0.9310.18
170_L178_E0.9260.18
95_L142_Y0.9220.17
12_F180_L0.9150.17
155_V160_W0.9020.17
118_A127_Q0.8970.17
24_T55_Y0.8930.17
162_N166_A0.8890.17
16_L93_F0.8890.17
107_W110_V0.8810.17
17_T45_I0.8790.16
58_F119_S0.8770.16
117_T149_L0.8710.16
28_I136_C0.8660.16
82_T184_I0.8630.16
113_I164_C0.8610.16
103_I189_K0.8570.16
86_A106_E0.8530.16
56_L78_M0.8520.16
8_W102_I0.8490.16
70_G171_L0.8460.16
73_R107_W0.8460.16
137_Q165_S0.8430.16
108_A119_S0.8380.16
81_L92_L0.8370.16
64_V74_F0.8290.15
55_Y69_L0.8290.15
161_L173_G0.8280.15
83_L133_L0.8260.15
53_A60_V0.8160.15
69_L84_V0.8150.15
45_I115_L0.8120.15
54_A119_S0.8100.15
50_S70_G0.8080.15
42_I100_W0.8020.15
31_S77_I0.7910.15
90_V97_D0.7910.15
45_I127_Q0.7900.15
110_V159_Q0.7760.14
8_W80_Y0.7750.14
110_V174_I0.7710.14
101_F107_W0.7660.14
53_A135_M0.7650.14
27_R98_P0.7590.14
45_I112_L0.7590.14
8_W24_T0.7580.14
89_F99_V0.7580.14
29_A118_A0.7580.14
86_A90_V0.7530.14
45_I128_L0.7520.14
37_N176_K0.7520.14
160_W166_A0.7490.14
96_Y156_G0.7390.14
131_F157_G0.7370.14
119_S131_F0.7340.14
7_Y41_S0.7330.14
30_V59_F0.7300.14
93_F173_G0.7290.14
86_A97_D0.7260.13
86_A92_L0.7230.13
36_T112_L0.7200.13
125_E181_A0.7190.13
158_F171_L0.7130.13
30_V96_Y0.7110.13
31_S102_I0.7070.13
61_C126_K0.6980.13
104_K136_C0.6980.13
61_C144_F0.6970.13
96_Y178_E0.6940.13
27_R138_G0.6900.13
51_L174_I0.6870.13
7_Y55_Y0.6850.13
160_W185_G0.6840.13
2_E5_Y0.6790.13
7_Y171_L0.6730.13
45_I78_M0.6710.13
1_M98_P0.6700.12
66_A113_I0.6620.12
72_Y169_I0.6610.12
4_F10_M0.6600.12
104_K149_L0.6560.12
68_Y84_V0.6560.12
20_I110_V0.6550.12
107_W140_L0.6540.12
98_P138_G0.6500.12
7_Y11_W0.6430.12
58_F165_S0.6360.12
127_Q165_S0.6350.12
117_T120_V0.6350.12
83_L89_F0.6300.12
53_A161_L0.6290.12
23_K37_N0.6280.12
121_E161_L0.6210.12
2_E128_L0.6200.12
20_I90_V0.6200.12
1_M92_L0.6190.12
14_W19_F0.6190.12
34_I115_L0.6150.12
167_G172_F0.6100.12
118_A185_G0.6080.11
13_L36_T0.6060.11
158_F161_L0.6020.11
6_Y112_L0.6020.11
78_M122_R0.6000.11
90_V108_A0.5980.11
149_L155_V0.5980.11
153_M183_Q0.5960.11
37_N54_A0.5950.11
70_G77_I0.5930.11
48_Y112_L0.5920.11
8_W11_W0.5920.11
101_F130_L0.5920.11
95_L146_I0.5900.11
28_I96_Y0.5900.11
14_W161_L0.5890.11
23_K87_Y0.5880.11
31_S160_W0.5880.11
76_Y107_W0.5880.11
99_V138_G0.5870.11
135_M160_W0.5870.11
111_I158_F0.5860.11
83_L170_L0.5820.11
23_K97_D0.5790.11
49_F112_L0.5780.11
58_F171_L0.5750.11
59_F95_L0.5660.11
45_I176_K0.5640.11
13_L63_C0.5640.11
12_F20_I0.5630.11
97_D137_Q0.5600.11
118_A175_S0.5590.11
34_I164_C0.5590.11
14_W23_K0.5560.11
96_Y149_L0.5550.11
96_Y139_E0.5550.11
49_F62_G0.5530.11
115_L153_M0.5520.11
32_V158_F0.5520.11
57_M75_R0.5490.11
116_L122_R0.5460.11
31_S131_F0.5460.11
90_V96_Y0.5450.11
81_L132_V0.5440.11
48_Y51_L0.5440.11
20_I70_G0.5410.10
55_Y124_F0.5400.10
62_G65_Y0.5400.10
85_A130_L0.5340.10
22_E153_M0.5330.10
107_W158_F0.5330.10
20_I168_M0.5320.10
61_C90_V0.5320.10
164_C173_G0.5320.10
143_S146_I0.5310.10
68_Y165_S0.5290.10
43_H160_W0.5280.10
117_T140_L0.5270.10
20_I53_A0.5240.10
80_Y120_V0.5230.10
100_W153_M0.5200.10
75_R162_N0.5200.10
49_F154_A0.5200.10
11_W27_R0.5190.10
97_D149_L0.5170.10
40_L57_M0.5160.10
116_L176_K0.5110.10
37_N73_R0.5090.10
47_L168_M0.5030.10
12_F124_F0.5030.10
66_A133_L0.5030.10
89_F162_N0.5020.10
67_G177_Y0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rfsS 1 0.7638 23.5 0.95 Contact Map
4hzuS 1 0.7538 23.5 0.95 Contact Map
4huqS 1 0.799 21.7 0.951 Contact Map
3p5nA 2 0.7538 13.8 0.955 Contact Map
2kncB 1 0.2764 5 0.964 Contact Map
3rkoN 1 0.5176 3.3 0.967 Contact Map
1r48A 2 0.1407 2.9 0.968 Contact Map
4he8A 1 0.1508 2.7 0.968 Contact Map
2yufA 1 0.2412 2.7 0.968 Contact Map
3dinC 1 0.4221 2.3 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0074 seconds.