IDI2 - BACSU - GREMLIN Contacts

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IDI2 - Isopentenyl-diphosphate delta-isomerase

UniProt:	P50740	Sequences: MTRAERKRQHINHALSIGQKRETGLDDITFVHVSLPDLALEQVDISTKIGELSSSSPIFINAMTGGGGKLTYEINKSLARAASQAGIPLAVGSQMSALKDPSERLSYEIVRKENPNGLIFANLGSEATAAQAKEAVEMIGANALQIHLNVIQEIVMPEGDRSFSGALKRIEQICSRVSVPVIVKEVGFGMSKASAGKLYEAGAAAVDIGGYGGTNFSKIENLRRQRQISFFNSWGISTAASLAEIRSEFPASTMIASGGLQDALDVAKAIALGASCTGMAGHFLKALTDSGEEGLLEEIQLILEELKLIMTVLGARTIADLQKAPLVIKGETHHWLTERGVNTSSYSVR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	349 (322)
Sequences:	1072 (812)
Seq/√Len:	45.3

BACSU - IDI2
HALSA - IDI2
SULSO - IDI2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
267_A	306_L	4.739	1.00
317_T	320_D	4.435	1.00
83_S	116_N	3.844	1.00
94_Q	138_M	3.657	1.00
195_A	245_I	3.259	1.00
190_M	206_V	3.249	1.00
168_K	171_E	3.182	1.00
54_S	88_P	2.973	1.00
133_K	178_S	2.827	1.00
39_A	162_S	2.650	1.00
84_Q	296_L	2.580	1.00
209_G	257_S	2.539	1.00
97_A	138_M	2.499	1.00
80_R	292_E	2.453	1.00
190_M	195_A	2.377	1.00
151_I	312_V	2.343	1.00
174_C	203_A	2.254	1.00
167_L	201_A	2.253	1.00
29_T	240_A	2.241	1.00
283_F	299_I	2.166	1.00
56_S	303_L	2.084	1.00
76_K	113_E	2.020	0.99
52_L	142_N	2.014	0.99
80_R	113_E	2.005	0.99
30_F	271_A	1.976	0.99
14_A	219_I	1.970	0.99
85_A	296_L	1.963	0.99
24_G	239_A	1.937	0.99
72_Y	105_L	1.913	0.99
103_E	106_S	1.887	0.99
260_L	277_T	1.887	0.99
11_I	71_T	1.875	0.99
61_N	145_Q	1.868	0.99
123_L	146_I	1.850	0.99
96_S	107_Y	1.843	0.99
12_N	16_S	1.823	0.99
60_I	82_A	1.780	0.98
174_C	201_A	1.764	0.98
205_A	253_T	1.752	0.98
266_V	277_T	1.749	0.98
77_S	287_L	1.745	0.98
146_I	170_I	1.727	0.98
25_L	239_A	1.720	0.98
91_V	94_Q	1.718	0.98
89_L	119_I	1.714	0.98
183_V	198_L	1.710	0.98
196_G	200_E	1.707	0.98
110_V	119_I	1.704	0.98
85_A	299_I	1.697	0.98
33_V	194_S	1.684	0.98
242_L	256_A	1.684	0.98
195_A	206_V	1.673	0.98
37_D	314_G	1.667	0.98
262_D	265_D	1.658	0.97
171_E	175_S	1.642	0.97
271_A	326_L	1.637	0.97
42_Q	164_S	1.619	0.97
132_A	144_L	1.605	0.97
129_A	176_R	1.601	0.97
81_A	299_I	1.593	0.97
81_A	292_E	1.592	0.97
54_S	118_L	1.587	0.97
192_K	244_E	1.574	0.97
114_N	117_G	1.570	0.96
23_T	239_A	1.563	0.96
34_S	190_M	1.553	0.96
136_V	179_V	1.539	0.96
22_E	26_D	1.529	0.96
39_A	42_Q	1.519	0.96
11_I	74_I	1.501	0.95
9_Q	12_N	1.492	0.95
279_M	302_I	1.482	0.95
199_Y	252_S	1.475	0.95
35_L	148_L	1.468	0.95
133_K	137_E	1.454	0.95
261_Q	282_H	1.449	0.94
104_R	134_E	1.436	0.94
316_R	320_D	1.423	0.94
174_C	181_V	1.419	0.94
91_V	139_I	1.417	0.94
148_L	183_V	1.409	0.94
96_S	103_E	1.401	0.93
310_M	318_I	1.388	0.93
230_F	264_L	1.380	0.93
43_V	311_T	1.378	0.93
267_A	313_L	1.359	0.92
151_I	217_S	1.354	0.92
62_A	90_A	1.352	0.92
134_E	137_E	1.343	0.92
120_F	145_Q	1.342	0.92
206_V	252_S	1.339	0.92
32_H	234_W	1.337	0.92
129_A	177_V	1.336	0.92
77_S	292_E	1.335	0.92
275_S	322_Q	1.319	0.91
78_L	82_A	1.317	0.91
263_A	309_I	1.316	0.91
130_A	133_K	1.316	0.91
155_V	217_S	1.312	0.91
87_I	299_I	1.310	0.91
260_L	269_A	1.309	0.91
81_A	295_L	1.294	0.90
61_N	257_S	1.288	0.90
172_Q	176_R	1.287	0.90
95_M	127_A	1.286	0.90
104_R	108_E	1.284	0.90
193_A	244_E	1.278	0.90
25_L	269_A	1.278	0.90
112_K	140_G	1.270	0.89
125_S	170_I	1.263	0.89
286_A	295_L	1.258	0.89
136_V	144_L	1.253	0.89
255_I	276_C	1.252	0.89
143_A	182_I	1.247	0.89
42_Q	316_R	1.246	0.88
293_E	297_E	1.243	0.88
281_G	285_K	1.240	0.88
61_N	278_G	1.228	0.88
282_H	298_E	1.212	0.87
72_Y	106_S	1.207	0.87
59_F	276_C	1.206	0.87
34_S	194_S	1.204	0.87
263_A	302_I	1.202	0.87
120_F	143_A	1.200	0.87
59_F	255_I	1.185	0.86
256_A	269_A	1.184	0.86
61_N	207_D	1.184	0.86
30_F	326_L	1.173	0.85
190_M	241_S	1.164	0.85
32_H	236_I	1.162	0.85
91_V	110_V	1.160	0.85
46_S	53_S	1.153	0.84
111_R	119_I	1.152	0.84
97_A	135_A	1.149	0.84
62_A	145_Q	1.144	0.84
158_E	223_R	1.135	0.83
286_A	298_E	1.133	0.83
124_G	127_A	1.131	0.83
76_K	112_K	1.119	0.82
38_L	311_T	1.116	0.82
76_K	80_R	1.113	0.82
130_A	134_E	1.109	0.82
237_S	240_A	1.103	0.81
170_I	203_A	1.100	0.81
261_Q	265_D	1.096	0.81
48_K	53_S	1.094	0.81
72_Y	76_K	1.093	0.81
11_I	154_I	1.092	0.81
23_T	26_D	1.089	0.81
183_V	203_A	1.080	0.80
94_Q	135_A	1.079	0.80
48_K	51_E	1.079	0.80
60_I	78_L	1.079	0.80
260_L	279_M	1.078	0.80
55_S	86_G	1.060	0.79
24_G	237_S	1.057	0.79
126_E	146_I	1.046	0.78
132_A	146_I	1.045	0.78
85_A	283_F	1.044	0.78
58_I	302_I	1.036	0.77
61_N	280_A	1.031	0.77
85_A	300_Q	1.028	0.77
73_E	76_K	1.026	0.76
26_D	262_D	1.021	0.76
128_T	156_M	1.020	0.76
191_S	194_S	1.015	0.76
95_M	156_M	1.012	0.75
121_A	144_L	1.005	0.75
298_E	302_I	1.005	0.75
90_A	145_Q	0.996	0.74
287_L	290_S	0.995	0.74
146_I	173_I	0.994	0.74
38_L	43_V	0.994	0.74
173_I	181_V	0.991	0.74
45_I	310_M	0.986	0.74
271_A	324_A	0.976	0.73
145_Q	156_M	0.974	0.73
283_F	295_L	0.971	0.72
38_L	42_Q	0.967	0.72
4_A	103_E	0.963	0.72
123_L	127_A	0.962	0.72
25_L	238_T	0.962	0.72
170_I	198_L	0.962	0.72
85_A	303_L	0.958	0.71
33_V	197_K	0.958	0.71
190_M	245_I	0.957	0.71
5_E	9_Q	0.954	0.71
123_L	135_A	0.948	0.71
266_V	302_I	0.947	0.70
287_L	295_L	0.946	0.70
182_I	255_I	0.940	0.70
211_Y	237_S	0.933	0.69
253_T	275_S	0.933	0.69
94_Q	139_I	0.929	0.69
49_I	276_C	0.928	0.69
14_A	281_G	0.920	0.68
319_A	322_Q	0.919	0.68
267_A	309_I	0.917	0.68
118_L	142_N	0.915	0.68
239_A	260_L	0.914	0.68
61_N	156_M	0.912	0.68
151_I	188_F	0.905	0.67
171_E	201_A	0.903	0.67
26_D	261_Q	0.897	0.66
266_V	306_L	0.897	0.66
58_I	303_L	0.895	0.66
52_L	118_L	0.894	0.66
61_N	90_A	0.890	0.66
9_Q	223_R	0.887	0.65
245_I	249_F	0.886	0.65
114_N	216_F	0.885	0.65
38_L	316_R	0.884	0.65
54_S	276_C	0.884	0.65
186_V	209_G	0.883	0.65
209_G	280_A	0.875	0.64
127_A	131_Q	0.870	0.64
173_I	177_V	0.868	0.64
25_L	268_K	0.867	0.64
77_S	80_R	0.867	0.64
125_S	166_A	0.866	0.64
310_M	321_L	0.858	0.63
81_A	86_G	0.856	0.63
192_K	247_S	0.856	0.63
80_R	84_Q	0.855	0.63
120_F	182_I	0.854	0.62
8_R	69_K	0.852	0.62
80_R	83_S	0.849	0.62
230_F	305_E	0.840	0.61
124_G	157_P	0.837	0.61
242_L	275_S	0.834	0.61
73_E	77_S	0.834	0.61
37_D	165_G	0.834	0.61
145_Q	207_D	0.831	0.60
263_A	305_E	0.829	0.60
269_A	277_T	0.823	0.60
27_D	328_I	0.818	0.59
260_L	266_V	0.818	0.59
77_S	290_S	0.809	0.58
256_A	274_A	0.804	0.58
242_L	246_R	0.804	0.58
270_I	318_I	0.801	0.57
230_F	263_A	0.796	0.57
263_A	267_A	0.794	0.57
236_I	241_S	0.793	0.57
74_I	135_A	0.790	0.56
33_V	325_P	0.789	0.56
247_S	250_P	0.789	0.56
163_F	186_V	0.788	0.56
91_V	97_A	0.787	0.56
126_E	156_M	0.787	0.56
79_A	110_V	0.786	0.56
271_A	305_E	0.785	0.56
28_I	239_A	0.784	0.56
95_M	126_E	0.783	0.56
50_G	205_A	0.781	0.56
85_A	88_P	0.781	0.56
31_V	191_S	0.779	0.55
94_Q	97_A	0.776	0.55
8_R	71_T	0.774	0.55
94_Q	121_A	0.769	0.54
154_I	161_R	0.767	0.54
89_L	110_V	0.766	0.54
188_F	312_V	0.766	0.54
85_A	295_L	0.764	0.54
166_A	169_R	0.764	0.54
208_I	276_C	0.763	0.54
9_Q	89_L	0.763	0.54
67_G	71_T	0.762	0.54
8_R	67_G	0.760	0.54
106_S	110_V	0.759	0.53
68_G	73_E	0.758	0.53
146_I	166_A	0.758	0.53
40_L	311_T	0.757	0.53
117_G	216_F	0.756	0.53
155_V	224_R	0.756	0.53
84_Q	300_Q	0.753	0.53
167_L	197_K	0.753	0.53
23_T	237_S	0.750	0.53
219_I	222_L	0.749	0.52
41_E	161_R	0.749	0.52
133_K	176_R	0.745	0.52
156_M	216_F	0.743	0.52
132_A	136_V	0.740	0.52
79_A	89_L	0.738	0.51
45_I	56_S	0.737	0.51
117_G	156_M	0.736	0.51
11_I	280_A	0.735	0.51
127_A	156_M	0.734	0.51
300_Q	304_E	0.733	0.51
28_I	268_K	0.733	0.51
129_A	172_Q	0.727	0.50
103_E	107_Y	0.726	0.50
151_I	155_V	0.722	0.50
95_M	99_K	0.722	0.50
296_L	300_Q	0.718	0.49
25_L	260_L	0.713	0.49
108_E	254_M	0.711	0.49
15_L	288_T	0.708	0.48
14_A	216_F	0.703	0.48
81_A	287_L	0.702	0.48
193_A	325_P	0.701	0.48
150_V	312_V	0.701	0.48
35_L	198_L	0.698	0.47
290_S	294_G	0.698	0.47
40_L	307_K	0.696	0.47
30_F	324_A	0.694	0.47
246_R	275_S	0.692	0.47
292_E	295_L	0.691	0.47
4_A	100_D	0.689	0.47
126_E	216_F	0.689	0.47
60_I	299_I	0.679	0.46
17_I	218_K	0.679	0.46
12_N	17_I	0.679	0.46
132_A	135_A	0.676	0.45
7_K	10_H	0.675	0.45
60_I	272_L	0.673	0.45
11_I	288_T	0.673	0.45
131_Q	169_R	0.670	0.45
178_S	293_E	0.669	0.45
79_A	121_A	0.668	0.45
118_L	143_A	0.666	0.44
83_S	114_N	0.665	0.44
30_F	313_L	0.664	0.44
199_Y	206_V	0.663	0.44
67_G	91_V	0.662	0.44
164_S	170_I	0.662	0.44
231_F	309_I	0.656	0.43
12_N	15_L	0.656	0.43
107_Y	295_L	0.654	0.43
249_F	252_S	0.651	0.43
168_K	175_S	0.651	0.43
170_I	183_V	0.650	0.43
114_N	156_M	0.647	0.43
161_R	311_T	0.645	0.42
98_L	135_A	0.645	0.42
53_S	319_A	0.641	0.42
44_D	317_T	0.641	0.42
13_H	222_L	0.641	0.42
111_R	117_G	0.639	0.42
198_L	206_V	0.638	0.42
39_A	164_S	0.638	0.42
148_L	170_I	0.637	0.42
59_F	166_A	0.636	0.42
294_G	297_E	0.635	0.41
6_R	10_H	0.633	0.41
128_T	146_I	0.631	0.41
33_V	193_A	0.631	0.41
56_S	87_I	0.631	0.41
244_E	327_V	0.629	0.41
158_E	219_I	0.628	0.41
221_N	224_R	0.627	0.41
101_P	104_R	0.626	0.41
133_K	177_V	0.624	0.40
139_I	195_A	0.624	0.40
128_T	131_Q	0.623	0.40
6_R	223_R	0.623	0.40
283_F	298_E	0.622	0.40
31_V	244_E	0.622	0.40
320_D	323_K	0.622	0.40
174_C	204_A	0.622	0.40
215_N	233_S	0.621	0.40
9_Q	13_H	0.620	0.40
242_L	254_M	0.617	0.40
192_K	196_G	0.616	0.40
94_Q	150_V	0.615	0.40
15_L	285_K	0.614	0.39
85_A	139_I	0.613	0.39
11_I	96_S	0.607	0.39
185_E	257_S	0.607	0.39
98_L	138_M	0.606	0.39
215_N	305_E	0.606	0.39
58_I	279_M	0.605	0.39
128_T	216_F	0.596	0.38
145_Q	188_F	0.595	0.38
105_L	108_E	0.595	0.38
194_S	241_S	0.595	0.38
237_S	242_L	0.593	0.38
45_I	318_I	0.591	0.37
251_A	322_Q	0.591	0.37
301_L	305_E	0.591	0.37
319_A	327_V	0.591	0.37
45_I	307_K	0.590	0.37
90_A	156_M	0.589	0.37
157_P	223_R	0.589	0.37
208_I	254_M	0.588	0.37
151_I	231_F	0.588	0.37
52_L	117_G	0.588	0.37
126_E	169_R	0.588	0.37
45_I	306_L	0.587	0.37
36_P	150_V	0.585	0.37
98_L	177_V	0.585	0.37
234_W	278_G	0.581	0.36
35_L	233_S	0.579	0.36
228_I	305_E	0.578	0.36
29_T	233_S	0.575	0.36
50_G	276_C	0.575	0.36
14_A	67_G	0.574	0.36
21_R	29_T	0.573	0.36
174_C	177_V	0.572	0.36
315_A	324_A	0.572	0.36
148_L	190_M	0.571	0.36
313_L	324_A	0.570	0.35
121_A	141_A	0.569	0.35
61_N	216_F	0.568	0.35
52_L	146_I	0.567	0.35
97_A	104_R	0.567	0.35
38_L	314_G	0.565	0.35
111_R	143_A	0.564	0.35
136_V	186_V	0.564	0.35
217_S	312_V	0.563	0.35
67_G	107_Y	0.562	0.35
204_A	251_A	0.561	0.35
61_N	126_E	0.561	0.35
55_S	303_L	0.561	0.35
154_I	312_V	0.559	0.34
96_S	106_S	0.557	0.34
108_E	134_E	0.557	0.34
36_P	60_I	0.556	0.34
145_Q	216_F	0.555	0.34
174_C	202_G	0.555	0.34
260_L	306_L	0.553	0.34
300_Q	303_L	0.552	0.34
15_L	284_L	0.552	0.34
134_E	140_G	0.549	0.34
267_A	271_A	0.549	0.34
165_G	168_K	0.547	0.33
62_A	216_F	0.545	0.33
118_L	205_A	0.545	0.33
79_A	113_E	0.544	0.33
299_I	303_L	0.544	0.33
127_A	287_L	0.544	0.33
182_I	205_A	0.544	0.33
111_R	115_P	0.542	0.33
40_L	304_E	0.542	0.33
171_E	293_E	0.542	0.33
83_S	113_E	0.540	0.33
156_M	263_A	0.539	0.33
28_I	243_A	0.538	0.33
99_K	107_Y	0.537	0.33
67_G	103_E	0.534	0.32
62_A	238_T	0.534	0.32
279_M	298_E	0.533	0.32
95_M	124_G	0.532	0.32
116_N	140_G	0.531	0.32
136_V	139_I	0.531	0.32
29_T	327_V	0.530	0.32
156_M	309_I	0.529	0.32
67_G	224_R	0.529	0.32
123_L	177_V	0.528	0.32
112_K	285_K	0.527	0.32
270_I	324_A	0.527	0.32
33_V	37_D	0.526	0.32
72_Y	107_Y	0.526	0.32
196_G	319_A	0.525	0.32
203_A	206_V	0.524	0.31
137_E	175_S	0.520	0.31
154_I	311_T	0.520	0.31
110_V	218_K	0.519	0.31
303_L	307_K	0.518	0.31
49_I	264_L	0.518	0.31
267_A	270_I	0.516	0.31
13_H	17_I	0.516	0.31
9_Q	225_Q	0.515	0.31
116_N	319_A	0.514	0.31
155_V	308_L	0.514	0.31
54_S	280_A	0.513	0.31
8_R	12_N	0.512	0.30
95_M	128_T	0.512	0.30
156_M	311_T	0.512	0.30
18_G	285_K	0.511	0.30
206_V	245_I	0.511	0.30
285_K	289_D	0.510	0.30
205_A	208_I	0.509	0.30
131_Q	208_I	0.509	0.30
78_L	283_F	0.506	0.30
266_V	270_I	0.505	0.30
131_Q	134_E	0.504	0.30
11_I	295_L	0.503	0.30
139_I	242_L	0.503	0.30
245_I	254_M	0.503	0.30
53_S	134_E	0.501	0.30
127_A	145_Q	0.501	0.30
126_E	166_A	0.500	0.29

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3vkjA	4	0.9885	100	0.465	Contact Map
1p0kA	4	0.8854	100	0.5	Contact Map
3sr7A	3	0.7908	100	0.5	Contact Map
4n02A	3	0.9513	100	0.504	Contact Map
1vcfA	3	0.8539	100	0.558	Contact Map
1ofdA	1	0.9427	100	0.671	Contact Map
1ea0A	1	0.914	100	0.673	Contact Map
2qr6A	3	0.851	100	0.681	Contact Map
1p4cA	3	0.8252	100	0.71	Contact Map
2c6qA	4	0.7822	100	0.718	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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