GREMLIN Database
IDI2 - Isopentenyl-diphosphate delta-isomerase
UniProt: P50740 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 349 (322)
Sequences: 1072 (812)
Seq/√Len: 45.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
267_A306_L4.7391.00
317_T320_D4.4351.00
83_S116_N3.8441.00
94_Q138_M3.6571.00
195_A245_I3.2591.00
190_M206_V3.2491.00
168_K171_E3.1821.00
54_S88_P2.9731.00
133_K178_S2.8271.00
39_A162_S2.6501.00
84_Q296_L2.5801.00
209_G257_S2.5391.00
97_A138_M2.4991.00
80_R292_E2.4531.00
190_M195_A2.3771.00
151_I312_V2.3431.00
174_C203_A2.2541.00
167_L201_A2.2531.00
29_T240_A2.2411.00
283_F299_I2.1661.00
56_S303_L2.0841.00
76_K113_E2.0200.99
52_L142_N2.0140.99
80_R113_E2.0050.99
30_F271_A1.9760.99
14_A219_I1.9700.99
85_A296_L1.9630.99
24_G239_A1.9370.99
72_Y105_L1.9130.99
103_E106_S1.8870.99
260_L277_T1.8870.99
11_I71_T1.8750.99
61_N145_Q1.8680.99
123_L146_I1.8500.99
96_S107_Y1.8430.99
12_N16_S1.8230.99
60_I82_A1.7800.98
174_C201_A1.7640.98
205_A253_T1.7520.98
266_V277_T1.7490.98
77_S287_L1.7450.98
146_I170_I1.7270.98
25_L239_A1.7200.98
91_V94_Q1.7180.98
89_L119_I1.7140.98
183_V198_L1.7100.98
196_G200_E1.7070.98
110_V119_I1.7040.98
85_A299_I1.6970.98
33_V194_S1.6840.98
242_L256_A1.6840.98
195_A206_V1.6730.98
37_D314_G1.6670.98
262_D265_D1.6580.97
171_E175_S1.6420.97
271_A326_L1.6370.97
42_Q164_S1.6190.97
132_A144_L1.6050.97
129_A176_R1.6010.97
81_A299_I1.5930.97
81_A292_E1.5920.97
54_S118_L1.5870.97
192_K244_E1.5740.97
114_N117_G1.5700.96
23_T239_A1.5630.96
34_S190_M1.5530.96
136_V179_V1.5390.96
22_E26_D1.5290.96
39_A42_Q1.5190.96
11_I74_I1.5010.95
9_Q12_N1.4920.95
279_M302_I1.4820.95
199_Y252_S1.4750.95
35_L148_L1.4680.95
133_K137_E1.4540.95
261_Q282_H1.4490.94
104_R134_E1.4360.94
316_R320_D1.4230.94
174_C181_V1.4190.94
91_V139_I1.4170.94
148_L183_V1.4090.94
96_S103_E1.4010.93
310_M318_I1.3880.93
230_F264_L1.3800.93
43_V311_T1.3780.93
267_A313_L1.3590.92
151_I217_S1.3540.92
62_A90_A1.3520.92
134_E137_E1.3430.92
120_F145_Q1.3420.92
206_V252_S1.3390.92
32_H234_W1.3370.92
129_A177_V1.3360.92
77_S292_E1.3350.92
275_S322_Q1.3190.91
78_L82_A1.3170.91
263_A309_I1.3160.91
130_A133_K1.3160.91
155_V217_S1.3120.91
87_I299_I1.3100.91
260_L269_A1.3090.91
81_A295_L1.2940.90
61_N257_S1.2880.90
172_Q176_R1.2870.90
95_M127_A1.2860.90
104_R108_E1.2840.90
193_A244_E1.2780.90
25_L269_A1.2780.90
112_K140_G1.2700.89
125_S170_I1.2630.89
286_A295_L1.2580.89
136_V144_L1.2530.89
255_I276_C1.2520.89
143_A182_I1.2470.89
42_Q316_R1.2460.88
293_E297_E1.2430.88
281_G285_K1.2400.88
61_N278_G1.2280.88
282_H298_E1.2120.87
72_Y106_S1.2070.87
59_F276_C1.2060.87
34_S194_S1.2040.87
263_A302_I1.2020.87
120_F143_A1.2000.87
59_F255_I1.1850.86
256_A269_A1.1840.86
61_N207_D1.1840.86
30_F326_L1.1730.85
190_M241_S1.1640.85
32_H236_I1.1620.85
91_V110_V1.1600.85
46_S53_S1.1530.84
111_R119_I1.1520.84
97_A135_A1.1490.84
62_A145_Q1.1440.84
158_E223_R1.1350.83
286_A298_E1.1330.83
124_G127_A1.1310.83
76_K112_K1.1190.82
38_L311_T1.1160.82
76_K80_R1.1130.82
130_A134_E1.1090.82
237_S240_A1.1030.81
170_I203_A1.1000.81
261_Q265_D1.0960.81
48_K53_S1.0940.81
72_Y76_K1.0930.81
11_I154_I1.0920.81
23_T26_D1.0890.81
183_V203_A1.0800.80
94_Q135_A1.0790.80
48_K51_E1.0790.80
60_I78_L1.0790.80
260_L279_M1.0780.80
55_S86_G1.0600.79
24_G237_S1.0570.79
126_E146_I1.0460.78
132_A146_I1.0450.78
85_A283_F1.0440.78
58_I302_I1.0360.77
61_N280_A1.0310.77
85_A300_Q1.0280.77
73_E76_K1.0260.76
26_D262_D1.0210.76
128_T156_M1.0200.76
191_S194_S1.0150.76
95_M156_M1.0120.75
121_A144_L1.0050.75
298_E302_I1.0050.75
90_A145_Q0.9960.74
287_L290_S0.9950.74
146_I173_I0.9940.74
38_L43_V0.9940.74
173_I181_V0.9910.74
45_I310_M0.9860.74
271_A324_A0.9760.73
145_Q156_M0.9740.73
283_F295_L0.9710.72
38_L42_Q0.9670.72
4_A103_E0.9630.72
123_L127_A0.9620.72
25_L238_T0.9620.72
170_I198_L0.9620.72
85_A303_L0.9580.71
33_V197_K0.9580.71
190_M245_I0.9570.71
5_E9_Q0.9540.71
123_L135_A0.9480.71
266_V302_I0.9470.70
287_L295_L0.9460.70
182_I255_I0.9400.70
211_Y237_S0.9330.69
253_T275_S0.9330.69
94_Q139_I0.9290.69
49_I276_C0.9280.69
14_A281_G0.9200.68
319_A322_Q0.9190.68
267_A309_I0.9170.68
118_L142_N0.9150.68
239_A260_L0.9140.68
61_N156_M0.9120.68
151_I188_F0.9050.67
171_E201_A0.9030.67
26_D261_Q0.8970.66
266_V306_L0.8970.66
58_I303_L0.8950.66
52_L118_L0.8940.66
61_N90_A0.8900.66
9_Q223_R0.8870.65
245_I249_F0.8860.65
114_N216_F0.8850.65
38_L316_R0.8840.65
54_S276_C0.8840.65
186_V209_G0.8830.65
209_G280_A0.8750.64
127_A131_Q0.8700.64
173_I177_V0.8680.64
25_L268_K0.8670.64
77_S80_R0.8670.64
125_S166_A0.8660.64
310_M321_L0.8580.63
81_A86_G0.8560.63
192_K247_S0.8560.63
80_R84_Q0.8550.63
120_F182_I0.8540.62
8_R69_K0.8520.62
80_R83_S0.8490.62
230_F305_E0.8400.61
124_G157_P0.8370.61
242_L275_S0.8340.61
73_E77_S0.8340.61
37_D165_G0.8340.61
145_Q207_D0.8310.60
263_A305_E0.8290.60
269_A277_T0.8230.60
27_D328_I0.8180.59
260_L266_V0.8180.59
77_S290_S0.8090.58
256_A274_A0.8040.58
242_L246_R0.8040.58
270_I318_I0.8010.57
230_F263_A0.7960.57
263_A267_A0.7940.57
236_I241_S0.7930.57
74_I135_A0.7900.56
33_V325_P0.7890.56
247_S250_P0.7890.56
163_F186_V0.7880.56
91_V97_A0.7870.56
126_E156_M0.7870.56
79_A110_V0.7860.56
271_A305_E0.7850.56
28_I239_A0.7840.56
95_M126_E0.7830.56
50_G205_A0.7810.56
85_A88_P0.7810.56
31_V191_S0.7790.55
94_Q97_A0.7760.55
8_R71_T0.7740.55
94_Q121_A0.7690.54
154_I161_R0.7670.54
89_L110_V0.7660.54
188_F312_V0.7660.54
85_A295_L0.7640.54
166_A169_R0.7640.54
208_I276_C0.7630.54
9_Q89_L0.7630.54
67_G71_T0.7620.54
8_R67_G0.7600.54
106_S110_V0.7590.53
68_G73_E0.7580.53
146_I166_A0.7580.53
40_L311_T0.7570.53
117_G216_F0.7560.53
155_V224_R0.7560.53
84_Q300_Q0.7530.53
167_L197_K0.7530.53
23_T237_S0.7500.53
219_I222_L0.7490.52
41_E161_R0.7490.52
133_K176_R0.7450.52
156_M216_F0.7430.52
132_A136_V0.7400.52
79_A89_L0.7380.51
45_I56_S0.7370.51
117_G156_M0.7360.51
11_I280_A0.7350.51
127_A156_M0.7340.51
300_Q304_E0.7330.51
28_I268_K0.7330.51
129_A172_Q0.7270.50
103_E107_Y0.7260.50
151_I155_V0.7220.50
95_M99_K0.7220.50
296_L300_Q0.7180.49
25_L260_L0.7130.49
108_E254_M0.7110.49
15_L288_T0.7080.48
14_A216_F0.7030.48
81_A287_L0.7020.48
193_A325_P0.7010.48
150_V312_V0.7010.48
35_L198_L0.6980.47
290_S294_G0.6980.47
40_L307_K0.6960.47
30_F324_A0.6940.47
246_R275_S0.6920.47
292_E295_L0.6910.47
4_A100_D0.6890.47
126_E216_F0.6890.47
60_I299_I0.6790.46
17_I218_K0.6790.46
12_N17_I0.6790.46
132_A135_A0.6760.45
7_K10_H0.6750.45
60_I272_L0.6730.45
11_I288_T0.6730.45
131_Q169_R0.6700.45
178_S293_E0.6690.45
79_A121_A0.6680.45
118_L143_A0.6660.44
83_S114_N0.6650.44
30_F313_L0.6640.44
199_Y206_V0.6630.44
67_G91_V0.6620.44
164_S170_I0.6620.44
231_F309_I0.6560.43
12_N15_L0.6560.43
107_Y295_L0.6540.43
249_F252_S0.6510.43
168_K175_S0.6510.43
170_I183_V0.6500.43
114_N156_M0.6470.43
161_R311_T0.6450.42
98_L135_A0.6450.42
53_S319_A0.6410.42
44_D317_T0.6410.42
13_H222_L0.6410.42
111_R117_G0.6390.42
198_L206_V0.6380.42
39_A164_S0.6380.42
148_L170_I0.6370.42
59_F166_A0.6360.42
294_G297_E0.6350.41
6_R10_H0.6330.41
128_T146_I0.6310.41
33_V193_A0.6310.41
56_S87_I0.6310.41
244_E327_V0.6290.41
158_E219_I0.6280.41
221_N224_R0.6270.41
101_P104_R0.6260.41
133_K177_V0.6240.40
139_I195_A0.6240.40
128_T131_Q0.6230.40
6_R223_R0.6230.40
283_F298_E0.6220.40
31_V244_E0.6220.40
320_D323_K0.6220.40
174_C204_A0.6220.40
215_N233_S0.6210.40
9_Q13_H0.6200.40
242_L254_M0.6170.40
192_K196_G0.6160.40
94_Q150_V0.6150.40
15_L285_K0.6140.39
85_A139_I0.6130.39
11_I96_S0.6070.39
185_E257_S0.6070.39
98_L138_M0.6060.39
215_N305_E0.6060.39
58_I279_M0.6050.39
128_T216_F0.5960.38
145_Q188_F0.5950.38
105_L108_E0.5950.38
194_S241_S0.5950.38
237_S242_L0.5930.38
45_I318_I0.5910.37
251_A322_Q0.5910.37
301_L305_E0.5910.37
319_A327_V0.5910.37
45_I307_K0.5900.37
90_A156_M0.5890.37
157_P223_R0.5890.37
208_I254_M0.5880.37
151_I231_F0.5880.37
52_L117_G0.5880.37
126_E169_R0.5880.37
45_I306_L0.5870.37
36_P150_V0.5850.37
98_L177_V0.5850.37
234_W278_G0.5810.36
35_L233_S0.5790.36
228_I305_E0.5780.36
29_T233_S0.5750.36
50_G276_C0.5750.36
14_A67_G0.5740.36
21_R29_T0.5730.36
174_C177_V0.5720.36
315_A324_A0.5720.36
148_L190_M0.5710.36
313_L324_A0.5700.35
121_A141_A0.5690.35
61_N216_F0.5680.35
52_L146_I0.5670.35
97_A104_R0.5670.35
38_L314_G0.5650.35
111_R143_A0.5640.35
136_V186_V0.5640.35
217_S312_V0.5630.35
67_G107_Y0.5620.35
204_A251_A0.5610.35
61_N126_E0.5610.35
55_S303_L0.5610.35
154_I312_V0.5590.34
96_S106_S0.5570.34
108_E134_E0.5570.34
36_P60_I0.5560.34
145_Q216_F0.5550.34
174_C202_G0.5550.34
260_L306_L0.5530.34
300_Q303_L0.5520.34
15_L284_L0.5520.34
134_E140_G0.5490.34
267_A271_A0.5490.34
165_G168_K0.5470.33
62_A216_F0.5450.33
118_L205_A0.5450.33
79_A113_E0.5440.33
299_I303_L0.5440.33
127_A287_L0.5440.33
182_I205_A0.5440.33
111_R115_P0.5420.33
40_L304_E0.5420.33
171_E293_E0.5420.33
83_S113_E0.5400.33
156_M263_A0.5390.33
28_I243_A0.5380.33
99_K107_Y0.5370.33
67_G103_E0.5340.32
62_A238_T0.5340.32
279_M298_E0.5330.32
95_M124_G0.5320.32
116_N140_G0.5310.32
136_V139_I0.5310.32
29_T327_V0.5300.32
156_M309_I0.5290.32
67_G224_R0.5290.32
123_L177_V0.5280.32
112_K285_K0.5270.32
270_I324_A0.5270.32
33_V37_D0.5260.32
72_Y107_Y0.5260.32
196_G319_A0.5250.32
203_A206_V0.5240.31
137_E175_S0.5200.31
154_I311_T0.5200.31
110_V218_K0.5190.31
303_L307_K0.5180.31
49_I264_L0.5180.31
267_A270_I0.5160.31
13_H17_I0.5160.31
9_Q225_Q0.5150.31
116_N319_A0.5140.31
155_V308_L0.5140.31
54_S280_A0.5130.31
8_R12_N0.5120.30
95_M128_T0.5120.30
156_M311_T0.5120.30
18_G285_K0.5110.30
206_V245_I0.5110.30
285_K289_D0.5100.30
205_A208_I0.5090.30
131_Q208_I0.5090.30
78_L283_F0.5060.30
266_V270_I0.5050.30
131_Q134_E0.5040.30
11_I295_L0.5030.30
139_I242_L0.5030.30
245_I254_M0.5030.30
53_S134_E0.5010.30
127_A145_Q0.5010.30
126_E166_A0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3vkjA 4 0.9885 100 0.465 Contact Map
1p0kA 4 0.8854 100 0.5 Contact Map
3sr7A 3 0.7908 100 0.5 Contact Map
4n02A 3 0.9513 100 0.504 Contact Map
1vcfA 3 0.8539 100 0.558 Contact Map
1ofdA 1 0.9427 100 0.671 Contact Map
1ea0A 1 0.914 100 0.673 Contact Map
2qr6A 3 0.851 100 0.681 Contact Map
1p4cA 3 0.8252 100 0.71 Contact Map
2c6qA 4 0.7822 100 0.718 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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