GREMLIN Database
PRSW - Protease PrsW
UniProt: P50738 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 218 (206)
Sequences: 1329 (1052)
Seq/√Len: 73.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
168_L172_S4.1571.00
99_G146_G3.7481.00
23_D28_E3.7401.00
137_C141_I3.6591.00
77_S168_L3.5991.00
201_W205_R2.9811.00
103_G107_S2.9211.00
28_E94_D2.9101.00
80_W145_M2.7731.00
82_I106_V2.6591.00
146_G150_G2.6421.00
167_S171_P2.6411.00
28_E102_Y2.5891.00
122_H126_H2.5841.00
142_G145_M2.4221.00
41_V113_L2.2301.00
134_P178_Y2.1781.00
77_S172_S2.1711.00
72_G172_S2.1401.00
68_F176_G2.0821.00
28_E98_D2.0441.00
98_D102_Y2.0431.00
119_L127_A2.0221.00
83_L106_V2.0041.00
196_M200_W1.9541.00
200_W204_L1.9231.00
72_G179_D1.8571.00
23_D98_D1.8271.00
15_L108_L1.8031.00
33_V105_S1.7461.00
19_F104_A1.7451.00
70_S73_F1.7401.00
73_F172_S1.7261.00
162_K166_L1.7011.00
181_I184_A1.6651.00
17_S21_L1.6451.00
199_L206_K1.5920.99
196_M207_A1.5560.99
76_E175_H1.5130.99
10_A14_A1.4990.99
93_F102_Y1.4960.99
114_E175_H1.4910.99
40_G109_G1.4770.99
29_P32_M1.4630.99
111_A137_C1.4440.99
76_E79_K1.4380.99
67_S71_S1.4210.99
12_G112_T1.4060.99
23_D26_D1.4010.98
135_V178_Y1.4010.98
94_D102_Y1.4000.98
51_Q55_E1.3720.98
194_P198_F1.3710.98
36_S106_V1.3710.98
199_L204_L1.3560.98
75_E138_H1.3430.98
145_M171_P1.3220.98
29_P102_Y1.3150.98
111_A115_N1.3110.98
83_L142_G1.3050.98
192_M198_F1.2420.97
16_L105_S1.2330.97
93_F150_G1.2310.97
200_W206_K1.2190.96
194_P200_W1.2120.96
23_D29_P1.1930.96
92_H102_Y1.1890.96
8_G116_I1.1760.95
29_P93_F1.1640.95
76_E114_E1.1630.95
80_W142_G1.1610.95
23_D32_M1.1580.95
50_I54_L1.1450.95
82_I86_S1.1430.95
71_S179_D1.1370.95
145_M148_Y1.1330.94
8_G115_N1.1310.94
99_G103_G1.1290.94
192_M195_F1.1260.94
118_Y138_H1.1160.94
148_Y178_Y1.1060.94
107_S152_A1.0900.93
99_G104_A1.0790.93
144_I171_P1.0680.93
11_P14_A1.0670.93
4_I11_P1.0610.92
40_G106_V1.0560.92
36_S87_V1.0520.92
19_F143_V1.0440.92
9_I15_L1.0240.91
58_N62_G1.0180.91
98_D101_V1.0140.90
23_D94_D1.0110.90
93_F153_R1.0040.90
70_S74_L0.9910.89
188_W197_V0.9890.89
16_L20_Y0.9820.89
75_E175_H0.9820.89
141_I178_Y0.9780.89
95_E150_G0.9670.88
26_D94_D0.9660.88
7_A137_C0.9660.88
147_F151_K0.9650.88
195_F202_F0.9630.88
190_Y197_V0.9630.88
104_A143_V0.9620.88
30_V47_I0.9600.88
103_G141_I0.9570.88
43_L48_M0.9530.88
69_L84_M0.9500.87
165_T169_V0.9490.87
10_A193_L0.9480.87
113_L181_I0.9470.87
148_Y167_S0.9450.87
79_K175_H0.9440.87
194_P206_K0.9410.87
138_H175_H0.9390.87
190_Y194_P0.9360.87
104_A107_S0.9330.86
199_L203_G0.9320.86
43_L92_H0.9290.86
49_F117_L0.9280.86
34_L38_F0.9260.86
51_Q54_L0.9230.86
6_S57_E0.9200.86
111_A134_P0.9130.85
11_P15_L0.9120.85
192_M200_W0.9070.85
68_F181_I0.9030.85
29_P98_D0.8950.84
192_M196_M0.8940.84
120_I191_Y0.8760.83
137_C181_I0.8760.83
29_P101_V0.8740.83
11_P111_A0.8730.82
130_R138_H0.8690.82
176_G179_D0.8680.82
119_L135_V0.8670.82
192_M199_L0.8620.82
9_I112_T0.8600.82
6_S63_S0.8570.81
157_D173_L0.8510.81
118_Y130_R0.8210.78
25_Y42_V0.8060.77
5_I105_S0.8040.77
8_G11_P0.8030.77
26_D102_Y0.8000.77
59_V121_G0.7960.76
192_M207_A0.7930.76
96_H151_K0.7910.76
11_P135_V0.7870.75
47_I78_L0.7860.75
166_L171_P0.7840.75
25_Y95_E0.7840.75
84_M89_P0.7810.75
52_Y55_E0.7810.75
96_H147_F0.7800.75
134_P153_R0.7800.75
160_R165_T0.7710.74
148_Y164_L0.7650.73
127_A150_G0.7650.73
59_V63_S0.7600.73
140_L179_D0.7570.73
135_V142_G0.7550.72
9_I22_K0.7520.72
71_S95_E0.7500.72
141_I174_L0.7490.72
202_F208_K0.7440.71
23_D101_V0.7400.71
86_S149_L0.7390.71
83_L146_G0.7370.71
107_S143_V0.7360.70
68_F177_S0.7340.70
11_P112_T0.7320.70
44_V48_M0.7290.70
111_A131_A0.7260.69
131_A135_V0.7260.69
14_A17_S0.7250.69
119_L131_A0.7230.69
140_L174_L0.7200.69
75_E114_E0.7200.69
96_H150_G0.7170.68
79_K138_H0.7140.68
56_K190_Y0.7130.68
80_W149_L0.7120.68
197_V201_W0.7080.68
107_S178_Y0.7040.67
71_S172_S0.7000.67
203_G208_K0.6990.67
156_A193_L0.6930.66
8_G111_A0.6880.65
206_K209_K0.6840.65
38_F50_I0.6800.64
68_F143_V0.6790.64
197_V207_A0.6780.64
17_S38_F0.6730.64
56_K183_T0.6710.63
58_N61_G0.6660.63
200_W207_A0.6650.63
202_F205_R0.6640.63
16_L33_V0.6630.62
192_M203_G0.6610.62
112_T115_N0.6590.62
11_P115_N0.6560.62
50_I55_E0.6560.62
78_L113_L0.6530.61
48_M74_L0.6510.61
172_S176_G0.6490.61
168_L171_P0.6480.61
23_D102_Y0.6480.61
69_L126_H0.6480.61
167_S179_D0.6480.61
193_L207_A0.6460.60
136_S142_G0.6420.60
199_L207_A0.6410.60
190_Y202_F0.6340.59
123_G161_V0.6330.59
56_K132_L0.6320.59
160_R171_P0.6300.59
185_L191_Y0.6290.58
56_K169_V0.6290.58
80_W107_S0.6270.58
108_L139_A0.6230.58
76_E138_H0.6220.58
99_G150_G0.6220.58
204_L207_A0.6220.58
93_F149_L0.6190.57
138_H179_D0.6190.57
68_F72_G0.6180.57
116_I165_T0.6180.57
203_G206_K0.6170.57
136_S140_L0.6150.57
50_I177_S0.6140.57
115_N139_A0.6110.56
140_L199_L0.6110.56
77_S80_W0.6080.56
27_N95_E0.6080.56
142_G171_P0.6080.56
34_L162_K0.6040.55
192_M208_K0.6030.55
64_F68_F0.5990.55
19_F37_F0.5970.54
7_A127_A0.5970.54
201_W207_A0.5930.54
108_L112_T0.5920.54
73_F166_L0.5910.54
41_V112_T0.5900.54
66_V73_F0.5890.54
77_S82_I0.5880.53
79_K114_E0.5860.53
87_V205_R0.5850.53
48_M188_W0.5840.53
96_H154_F0.5820.53
181_I191_Y0.5810.53
203_G207_A0.5810.53
75_E130_R0.5800.52
95_E153_R0.5790.52
129_V132_L0.5790.52
66_V69_L0.5770.52
93_F98_D0.5730.52
51_Q56_K0.5730.52
44_V47_I0.5720.51
33_V93_F0.5710.51
29_P34_L0.5690.51
198_F201_W0.5640.50
198_F209_K0.5630.50
187_N200_W0.5620.50
72_G180_F0.5610.50
41_V48_M0.5600.50
13_I85_I0.5580.50
43_L85_I0.5580.50
72_G103_G0.5570.50
195_F199_L0.5550.49
107_S145_M0.5550.49
25_Y108_L0.5520.49
14_A30_V0.5480.48
62_G67_S0.5480.48
68_F148_Y0.5480.48
29_P94_D0.5460.48
24_Q71_S0.5460.48
28_E101_V0.5460.48
192_M197_V0.5460.48
83_L87_V0.5440.48
15_L135_V0.5440.48
36_S39_L0.5440.48
112_T116_I0.5430.48
5_I9_I0.5380.47
30_V34_L0.5340.47
46_P51_Q0.5330.47
114_E130_R0.5260.46
41_V47_I0.5250.46
50_I205_R0.5240.45
111_A174_L0.5210.45
64_F87_V0.5190.45
5_I162_K0.5170.45
52_Y72_G0.5160.44
80_W106_V0.5150.44
68_F180_F0.5130.44
95_E98_D0.5110.44
104_A153_R0.5110.44
54_L173_L0.5080.43
187_N190_Y0.5080.43
10_A21_L0.5050.43
156_A162_K0.5050.43
28_E92_H0.5040.43
107_S119_L0.5030.43
176_G180_F0.5020.43
67_S172_S0.5020.43
199_L208_K0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cadC 1 0.8991 97 0.844 Contact Map
5a63C 1 0.8853 33.5 0.93 Contact Map
4px7A 1 0.8853 8.6 0.946 Contact Map
4n7wA 2 0.8991 8.3 0.947 Contact Map
2rddB 1 0.1468 7.4 0.948 Contact Map
2m20A 2 0.1835 6.1 0.95 Contact Map
3giaA 1 0.9083 6 0.95 Contact Map
2nq2A 2 0.8991 5.9 0.95 Contact Map
4eneA 2 0.8945 5.3 0.951 Contact Map
3l1lA 2 0.9128 5.3 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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