PRSW - BACSU - GREMLIN Contacts

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PRSW - Protease PrsW

UniProt:	P50738	Sequences: MFAIISAGIAPGIALLSYFYLKDQYDNEPVHMVLRSFFLGVVLVFPIMFIQYVLEKENVGGGSFFVSFLSSGFLEESLKWFILMISVYPHAHFDEHYDGIVYGASVSLGFATLENILYLIGHGVEHAFVRALLPVSCHALIGVIMGFYLGKARFSADKARVKWLTLSLVVPSLLHGSYDFILTALSNWIYYMLPFMVFLWWFGLRKAKKARSVNMMQV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	218 (206)
Sequences:	1329 (1052)
Seq/√Len:	73.3

BACSU - PRSW
HALSA - Q9HMB1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
168_L	172_S	4.157	1.00
99_G	146_G	3.748	1.00
23_D	28_E	3.740	1.00
137_C	141_I	3.659	1.00
77_S	168_L	3.599	1.00
201_W	205_R	2.981	1.00
103_G	107_S	2.921	1.00
28_E	94_D	2.910	1.00
80_W	145_M	2.773	1.00
82_I	106_V	2.659	1.00
146_G	150_G	2.642	1.00
167_S	171_P	2.641	1.00
28_E	102_Y	2.589	1.00
122_H	126_H	2.584	1.00
142_G	145_M	2.422	1.00
41_V	113_L	2.230	1.00
134_P	178_Y	2.178	1.00
77_S	172_S	2.171	1.00
72_G	172_S	2.140	1.00
68_F	176_G	2.082	1.00
28_E	98_D	2.044	1.00
98_D	102_Y	2.043	1.00
119_L	127_A	2.022	1.00
83_L	106_V	2.004	1.00
196_M	200_W	1.954	1.00
200_W	204_L	1.923	1.00
72_G	179_D	1.857	1.00
23_D	98_D	1.827	1.00
15_L	108_L	1.803	1.00
33_V	105_S	1.746	1.00
19_F	104_A	1.745	1.00
70_S	73_F	1.740	1.00
73_F	172_S	1.726	1.00
162_K	166_L	1.701	1.00
181_I	184_A	1.665	1.00
17_S	21_L	1.645	1.00
199_L	206_K	1.592	0.99
196_M	207_A	1.556	0.99
76_E	175_H	1.513	0.99
10_A	14_A	1.499	0.99
93_F	102_Y	1.496	0.99
114_E	175_H	1.491	0.99
40_G	109_G	1.477	0.99
29_P	32_M	1.463	0.99
111_A	137_C	1.444	0.99
76_E	79_K	1.438	0.99
67_S	71_S	1.421	0.99
12_G	112_T	1.406	0.99
23_D	26_D	1.401	0.98
135_V	178_Y	1.401	0.98
94_D	102_Y	1.400	0.98
51_Q	55_E	1.372	0.98
194_P	198_F	1.371	0.98
36_S	106_V	1.371	0.98
199_L	204_L	1.356	0.98
75_E	138_H	1.343	0.98
145_M	171_P	1.322	0.98
29_P	102_Y	1.315	0.98
111_A	115_N	1.311	0.98
83_L	142_G	1.305	0.98
192_M	198_F	1.242	0.97
16_L	105_S	1.233	0.97
93_F	150_G	1.231	0.97
200_W	206_K	1.219	0.96
194_P	200_W	1.212	0.96
23_D	29_P	1.193	0.96
92_H	102_Y	1.189	0.96
8_G	116_I	1.176	0.95
29_P	93_F	1.164	0.95
76_E	114_E	1.163	0.95
80_W	142_G	1.161	0.95
23_D	32_M	1.158	0.95
50_I	54_L	1.145	0.95
82_I	86_S	1.143	0.95
71_S	179_D	1.137	0.95
145_M	148_Y	1.133	0.94
8_G	115_N	1.131	0.94
99_G	103_G	1.129	0.94
192_M	195_F	1.126	0.94
118_Y	138_H	1.116	0.94
148_Y	178_Y	1.106	0.94
107_S	152_A	1.090	0.93
99_G	104_A	1.079	0.93
144_I	171_P	1.068	0.93
11_P	14_A	1.067	0.93
4_I	11_P	1.061	0.92
40_G	106_V	1.056	0.92
36_S	87_V	1.052	0.92
19_F	143_V	1.044	0.92
9_I	15_L	1.024	0.91
58_N	62_G	1.018	0.91
98_D	101_V	1.014	0.90
23_D	94_D	1.011	0.90
93_F	153_R	1.004	0.90
70_S	74_L	0.991	0.89
188_W	197_V	0.989	0.89
16_L	20_Y	0.982	0.89
75_E	175_H	0.982	0.89
141_I	178_Y	0.978	0.89
95_E	150_G	0.967	0.88
26_D	94_D	0.966	0.88
7_A	137_C	0.966	0.88
147_F	151_K	0.965	0.88
195_F	202_F	0.963	0.88
190_Y	197_V	0.963	0.88
104_A	143_V	0.962	0.88
30_V	47_I	0.960	0.88
103_G	141_I	0.957	0.88
43_L	48_M	0.953	0.88
69_L	84_M	0.950	0.87
165_T	169_V	0.949	0.87
10_A	193_L	0.948	0.87
113_L	181_I	0.947	0.87
148_Y	167_S	0.945	0.87
79_K	175_H	0.944	0.87
194_P	206_K	0.941	0.87
138_H	175_H	0.939	0.87
190_Y	194_P	0.936	0.87
104_A	107_S	0.933	0.86
199_L	203_G	0.932	0.86
43_L	92_H	0.929	0.86
49_F	117_L	0.928	0.86
34_L	38_F	0.926	0.86
51_Q	54_L	0.923	0.86
6_S	57_E	0.920	0.86
111_A	134_P	0.913	0.85
11_P	15_L	0.912	0.85
192_M	200_W	0.907	0.85
68_F	181_I	0.903	0.85
29_P	98_D	0.895	0.84
192_M	196_M	0.894	0.84
120_I	191_Y	0.876	0.83
137_C	181_I	0.876	0.83
29_P	101_V	0.874	0.83
11_P	111_A	0.873	0.82
130_R	138_H	0.869	0.82
176_G	179_D	0.868	0.82
119_L	135_V	0.867	0.82
192_M	199_L	0.862	0.82
9_I	112_T	0.860	0.82
6_S	63_S	0.857	0.81
157_D	173_L	0.851	0.81
118_Y	130_R	0.821	0.78
25_Y	42_V	0.806	0.77
5_I	105_S	0.804	0.77
8_G	11_P	0.803	0.77
26_D	102_Y	0.800	0.77
59_V	121_G	0.796	0.76
192_M	207_A	0.793	0.76
96_H	151_K	0.791	0.76
11_P	135_V	0.787	0.75
47_I	78_L	0.786	0.75
166_L	171_P	0.784	0.75
25_Y	95_E	0.784	0.75
84_M	89_P	0.781	0.75
52_Y	55_E	0.781	0.75
96_H	147_F	0.780	0.75
134_P	153_R	0.780	0.75
160_R	165_T	0.771	0.74
148_Y	164_L	0.765	0.73
127_A	150_G	0.765	0.73
59_V	63_S	0.760	0.73
140_L	179_D	0.757	0.73
135_V	142_G	0.755	0.72
9_I	22_K	0.752	0.72
71_S	95_E	0.750	0.72
141_I	174_L	0.749	0.72
202_F	208_K	0.744	0.71
23_D	101_V	0.740	0.71
86_S	149_L	0.739	0.71
83_L	146_G	0.737	0.71
107_S	143_V	0.736	0.70
68_F	177_S	0.734	0.70
11_P	112_T	0.732	0.70
44_V	48_M	0.729	0.70
111_A	131_A	0.726	0.69
131_A	135_V	0.726	0.69
14_A	17_S	0.725	0.69
119_L	131_A	0.723	0.69
140_L	174_L	0.720	0.69
75_E	114_E	0.720	0.69
96_H	150_G	0.717	0.68
79_K	138_H	0.714	0.68
56_K	190_Y	0.713	0.68
80_W	149_L	0.712	0.68
197_V	201_W	0.708	0.68
107_S	178_Y	0.704	0.67
71_S	172_S	0.700	0.67
203_G	208_K	0.699	0.67
156_A	193_L	0.693	0.66
8_G	111_A	0.688	0.65
206_K	209_K	0.684	0.65
38_F	50_I	0.680	0.64
68_F	143_V	0.679	0.64
197_V	207_A	0.678	0.64
17_S	38_F	0.673	0.64
56_K	183_T	0.671	0.63
58_N	61_G	0.666	0.63
200_W	207_A	0.665	0.63
202_F	205_R	0.664	0.63
16_L	33_V	0.663	0.62
192_M	203_G	0.661	0.62
112_T	115_N	0.659	0.62
11_P	115_N	0.656	0.62
50_I	55_E	0.656	0.62
78_L	113_L	0.653	0.61
48_M	74_L	0.651	0.61
172_S	176_G	0.649	0.61
168_L	171_P	0.648	0.61
23_D	102_Y	0.648	0.61
69_L	126_H	0.648	0.61
167_S	179_D	0.648	0.61
193_L	207_A	0.646	0.60
136_S	142_G	0.642	0.60
199_L	207_A	0.641	0.60
190_Y	202_F	0.634	0.59
123_G	161_V	0.633	0.59
56_K	132_L	0.632	0.59
160_R	171_P	0.630	0.59
185_L	191_Y	0.629	0.58
56_K	169_V	0.629	0.58
80_W	107_S	0.627	0.58
108_L	139_A	0.623	0.58
76_E	138_H	0.622	0.58
99_G	150_G	0.622	0.58
204_L	207_A	0.622	0.58
93_F	149_L	0.619	0.57
138_H	179_D	0.619	0.57
68_F	72_G	0.618	0.57
116_I	165_T	0.618	0.57
203_G	206_K	0.617	0.57
136_S	140_L	0.615	0.57
50_I	177_S	0.614	0.57
115_N	139_A	0.611	0.56
140_L	199_L	0.611	0.56
77_S	80_W	0.608	0.56
27_N	95_E	0.608	0.56
142_G	171_P	0.608	0.56
34_L	162_K	0.604	0.55
192_M	208_K	0.603	0.55
64_F	68_F	0.599	0.55
19_F	37_F	0.597	0.54
7_A	127_A	0.597	0.54
201_W	207_A	0.593	0.54
108_L	112_T	0.592	0.54
73_F	166_L	0.591	0.54
41_V	112_T	0.590	0.54
66_V	73_F	0.589	0.54
77_S	82_I	0.588	0.53
79_K	114_E	0.586	0.53
87_V	205_R	0.585	0.53
48_M	188_W	0.584	0.53
96_H	154_F	0.582	0.53
181_I	191_Y	0.581	0.53
203_G	207_A	0.581	0.53
75_E	130_R	0.580	0.52
95_E	153_R	0.579	0.52
129_V	132_L	0.579	0.52
66_V	69_L	0.577	0.52
93_F	98_D	0.573	0.52
51_Q	56_K	0.573	0.52
44_V	47_I	0.572	0.51
33_V	93_F	0.571	0.51
29_P	34_L	0.569	0.51
198_F	201_W	0.564	0.50
198_F	209_K	0.563	0.50
187_N	200_W	0.562	0.50
72_G	180_F	0.561	0.50
41_V	48_M	0.560	0.50
13_I	85_I	0.558	0.50
43_L	85_I	0.558	0.50
72_G	103_G	0.557	0.50
195_F	199_L	0.555	0.49
107_S	145_M	0.555	0.49
25_Y	108_L	0.552	0.49
14_A	30_V	0.548	0.48
62_G	67_S	0.548	0.48
68_F	148_Y	0.548	0.48
29_P	94_D	0.546	0.48
24_Q	71_S	0.546	0.48
28_E	101_V	0.546	0.48
192_M	197_V	0.546	0.48
83_L	87_V	0.544	0.48
15_L	135_V	0.544	0.48
36_S	39_L	0.544	0.48
112_T	116_I	0.543	0.48
5_I	9_I	0.538	0.47
30_V	34_L	0.534	0.47
46_P	51_Q	0.533	0.47
114_E	130_R	0.526	0.46
41_V	47_I	0.525	0.46
50_I	205_R	0.524	0.45
111_A	174_L	0.521	0.45
64_F	87_V	0.519	0.45
5_I	162_K	0.517	0.45
52_Y	72_G	0.516	0.44
80_W	106_V	0.515	0.44
68_F	180_F	0.513	0.44
95_E	98_D	0.511	0.44
104_A	153_R	0.511	0.44
54_L	173_L	0.508	0.43
187_N	190_Y	0.508	0.43
10_A	21_L	0.505	0.43
156_A	162_K	0.505	0.43
28_E	92_H	0.504	0.43
107_S	119_L	0.503	0.43
176_G	180_F	0.502	0.43
67_S	172_S	0.502	0.43
199_L	208_K	0.500	0.43

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4cadC	1	0.8991	97	0.844	Contact Map
5a63C	1	0.8853	33.5	0.93	Contact Map
4px7A	1	0.8853	8.6	0.946	Contact Map
4n7wA	2	0.8991	8.3	0.947	Contact Map
2rddB	1	0.1468	7.4	0.948	Contact Map
2m20A	2	0.1835	6.1	0.95	Contact Map
3giaA	1	0.9083	6	0.95	Contact Map
2nq2A	2	0.8991	5.9	0.95	Contact Map
4eneA	2	0.8945	5.3	0.951	Contact Map
3l1lA	2	0.9128	5.3	0.951	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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