GREMLIN Database
GUDB - Cryptic catabolic NAD-specific glutamate dehydrogenase GudB
UniProt: P50735 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 427 (395)
Sequences: 5552 (2708)
Seq/√Len: 136.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
243_M248_A4.4401.00
229_V240_A3.7821.00
296_E318_N3.6431.00
228_V299_C3.5981.00
299_C321_A3.3751.00
211_I325_V3.3511.00
46_M74_D3.1931.00
273_D277_S3.1091.00
298_D320_R3.0911.00
338_K342_D2.8541.00
132_R136_R2.6821.00
115_Y362_Y2.6121.00
226_R249_K2.5731.00
340_L345_I2.5391.00
125_D128_D2.5341.00
252_G294_L2.4991.00
213_E216_K2.4981.00
220_I225_A2.4761.00
240_A253_I2.4521.00
341_S404_D2.4201.00
160_V307_I2.3911.00
213_E388_V2.3821.00
108_C358_V2.3801.00
143_R173_E2.2521.00
267_D270_Y2.2441.00
50_T94_V2.1921.00
241_K245_D2.1561.00
210_C353_A2.1341.00
227_V248_A2.1311.00
397_M401_R2.1281.00
207_V327_A2.1221.00
217_K399_N2.1081.00
227_V243_M2.1001.00
72_H101_S2.1001.00
57_M63_K2.0681.00
404_D407_L2.0401.00
313_E335_E2.0401.00
332_T340_L2.0351.00
163_N166_I1.9901.00
226_R247_G1.9821.00
209_I212_K1.9761.00
397_M415_R1.9741.00
391_F395_Y1.9671.00
396_E400_N1.9661.00
198_G376_E1.9531.00
311_I332_T1.9441.00
325_V353_A1.9151.00
54_P140_G1.8951.00
348_V353_A1.8861.00
253_I271_L1.8771.00
295_L302_L1.8681.00
378_E382_K1.8561.00
415_R419_E1.8491.00
213_E392_N1.8451.00
316_A339_I1.8101.00
83_I170_M1.7981.00
222_I248_A1.7821.00
124_C129_M1.7691.00
76_V112_D1.7591.00
217_K395_Y1.7581.00
312_T315_N1.7561.00
70_A101_S1.7531.00
192_V419_E1.7501.00
217_K391_F1.7381.00
79_T118_G1.7321.00
304_P328_A1.7211.00
272_L276_D1.7171.00
252_G297_L1.7061.00
228_V252_G1.6981.00
311_I319_I1.6601.00
256_A275_R1.6541.00
351_V410_Y1.6401.00
208_T246_A1.6371.00
403_I411_M1.6081.00
214_A323_I1.6081.00
221_D224_G1.6071.00
110_I352_L1.6061.00
212_K384_E1.5971.00
263_P287_D1.5951.00
339_I343_R1.5821.00
241_K272_L1.5721.00
142_V170_M1.5681.00
146_S178_D1.5441.00
143_R176_R1.5431.00
215_A301_I1.5411.00
212_K246_A1.5291.00
58_D130_S1.5041.00
48_L98_K1.4861.00
328_A331_P1.4741.00
403_I408_A1.4651.00
239_L303_V1.4641.00
90_T96_A1.4611.00
135_E139_R1.4371.00
139_R173_E1.4361.00
37_E61_S1.4301.00
214_A348_V1.4111.00
140_G143_R1.4111.00
173_E176_R1.4001.00
90_T95_K1.3911.00
207_V325_V1.3891.00
257_Y280_T1.3881.00
209_I384_E1.3821.00
227_V303_V1.3771.00
86_H307_I1.3761.00
325_V348_V1.3731.00
67_G141_Y1.3681.00
313_E339_I1.3631.00
217_K392_N1.3571.00
164_S200_E1.3571.00
26_H30_E1.3491.00
168_A190_P1.3431.00
56_R132_R1.3371.00
270_Y284_L1.3371.00
334_L337_T1.3361.00
124_C137_L1.3301.00
317_H339_I1.3101.00
385_K389_K1.3101.00
25_I29_L1.3041.00
251_V299_C1.2991.00
235_A327_A1.2941.00
74_D79_T1.2941.00
209_I380_E1.2881.00
67_G133_E1.2871.00
389_K393_N1.2851.00
286_N289_I1.2741.00
218_R346_L1.2621.00
279_G283_K1.2601.00
218_R322_K1.2561.00
239_L305_A1.2541.00
72_H105_S1.2541.00
220_I322_K1.2541.00
339_I342_D1.2421.00
143_R177_I1.2381.00
215_A222_I1.2381.00
48_L94_V1.2331.00
228_V297_L1.2311.00
352_L394_I1.2301.00
44_E66_T1.2191.00
68_Y123_V1.2131.00
274_R278_F1.2091.00
105_S417_M1.2071.00
302_L319_I1.1941.00
31_K400_N1.1931.00
211_I301_I1.1931.00
26_H43_K1.1921.00
259_G291_N1.1871.00
227_V301_I1.1871.00
226_R300_D1.1790.99
146_S177_I1.1770.99
53_I140_G1.1750.99
338_K341_S1.1740.99
292_Q296_E1.1730.99
131_F165_Q1.1690.99
368_N373_Y1.1660.99
111_I359_T1.1640.99
391_F405_M1.1610.99
403_I407_L1.1550.99
211_I303_V1.1540.99
311_I340_L1.1530.99
212_K216_K1.1510.99
392_N396_E1.1500.99
397_M412_V1.1430.99
208_T243_M1.1400.99
313_E317_H1.1260.99
25_I28_A1.1240.99
51_V145_I1.1160.99
129_M137_L1.1120.99
226_R263_P1.1090.99
228_V251_V1.1090.99
259_G289_I1.1070.99
290_T293_E1.1060.99
227_V250_V1.1050.99
243_M250_V1.1050.99
87_P125_D1.1040.99
70_A94_V1.1030.99
323_I346_L1.0910.99
251_V261_Y1.0890.99
49_L148_I1.0870.99
244_H269_D1.0840.99
106_L351_V1.0830.99
400_N415_R1.0780.99
293_E296_E1.0740.99
384_E388_V1.0720.99
381_E385_K1.0700.99
73_N421_S1.0670.99
205_K242_F1.0670.99
40_E43_K1.0630.99
237_S276_D1.0590.99
167_M170_M1.0550.99
85_F162_T1.0540.99
337_T406_R1.0490.99
274_R284_L1.0470.99
375_S385_K1.0460.99
229_V248_A1.0450.99
207_V211_I1.0450.99
226_R298_D1.0430.99
207_V303_V1.0420.99
401_R411_M1.0310.99
207_V305_A1.0300.99
214_A325_V1.0270.99
138_S142_V1.0260.99
85_F138_S1.0160.98
106_L417_M1.0160.98
244_H268_I1.0100.98
153_K179_E1.0080.98
212_K222_I1.0060.98
303_V325_V1.0050.98
238_Y241_K1.0030.98
237_S272_L0.9890.98
51_V67_G0.9860.98
162_T167_M0.9850.98
375_S378_E0.9830.98
66_T123_V0.9800.98
26_H29_L0.9790.98
124_C127_R0.9700.98
376_E380_E0.9690.98
337_T341_S0.9650.98
173_E177_I0.9650.98
274_R283_K0.9640.98
239_L243_M0.9640.98
414_V417_M0.9620.98
200_E238_Y0.9600.98
37_E40_E0.9530.98
111_I355_A0.9400.97
88_N96_A0.9380.97
190_P193_L0.9360.97
240_A250_V0.9360.97
359_T363_F0.9360.97
268_I272_L0.9340.97
249_K264_E0.9330.97
377_E381_E0.9320.97
249_K267_D0.9300.97
28_A32_L0.9270.97
30_E39_Y0.9260.97
207_V239_L0.9260.97
380_E384_E0.9250.97
243_M303_V0.9240.97
281_V288_T0.9210.97
75_S417_M0.9200.97
86_H160_V0.9190.97
23_T27_K0.9190.97
83_I141_Y0.9160.97
23_T26_H0.9150.97
397_M411_M0.9150.97
205_K380_E0.9130.97
270_Y273_D0.9060.97
240_A271_L0.9050.97
211_I323_I0.9040.97
54_P64_I0.9040.97
260_L281_V0.9030.97
255_D280_T0.9030.97
261_Y297_L0.8990.97
140_G173_E0.8930.96
147_Q179_E0.8930.96
232_F253_I0.8920.96
255_D275_R0.8900.96
147_Q151_P0.8880.96
27_K31_K0.8840.96
302_L310_Q0.8830.96
324_V332_T0.8770.96
48_L70_A0.8760.96
131_F135_E0.8740.96
262_D284_L0.8720.96
29_L32_L0.8670.96
57_M65_F0.8590.96
140_G144_A0.8590.96
321_A345_I0.8570.96
314_E317_H0.8550.96
178_D181_N0.8450.95
170_M173_E0.8440.95
311_I316_A0.8420.95
266_L271_L0.8370.95
291_N294_L0.8360.95
119_K203_T0.8340.95
23_T334_L0.8310.95
119_K329_N0.8300.95
145_I148_I0.8250.95
27_K30_E0.8240.95
244_H267_D0.8200.94
286_N290_T0.8170.94
361_S364_E0.8130.94
112_D386_M0.8120.94
95_K98_K0.8110.94
25_I39_Y0.8110.94
44_E47_R0.8100.94
358_V361_S0.8060.94
300_D322_K0.8060.94
28_A31_K0.8050.94
232_F271_L0.8040.94
171_M182_S0.8030.94
50_T66_T0.7970.93
324_V340_L0.7890.93
85_F122_I0.7890.93
244_H250_V0.7890.93
222_I227_V0.7890.93
40_E63_K0.7880.93
332_T336_G0.7870.93
281_V284_L0.7860.93
271_L284_L0.7860.93
271_L281_V0.7860.93
76_V116_G0.7850.93
135_E170_M0.7850.93
398_A403_I0.7830.93
399_N402_R0.7710.92
149_V170_M0.7700.92
101_S105_S0.7660.92
83_I156_P0.7660.92
332_T347_L0.7650.92
26_H39_Y0.7650.92
311_I350_D0.7640.92
42_L106_L0.7630.92
169_W172_D0.7610.92
296_E315_N0.7610.92
210_C394_I0.7600.92
120_G141_Y0.7590.92
238_Y242_F0.7570.92
242_F246_A0.7560.92
293_E315_N0.7560.92
269_D272_L0.7550.92
317_H343_R0.7550.92
136_R139_R0.7540.91
138_S141_Y0.7500.91
76_V109_G0.7440.91
204_A239_L0.7440.91
48_L97_V0.7430.91
298_D321_A0.7430.91
199_R360_V0.7420.91
140_G176_R0.7420.91
259_G296_E0.7400.91
229_V253_I0.7370.91
301_I323_I0.7350.90
51_V55_V0.7340.90
47_R71_Q0.7330.90
270_Y274_R0.7310.90
80_K358_V0.7310.90
313_E337_T0.7280.90
319_I324_V0.7280.90
280_T283_K0.7260.90
107_K329_N0.7260.90
395_Y399_N0.7240.90
319_I340_L0.7230.90
398_A401_R0.7200.89
23_T28_A0.7190.89
127_R256_A0.7180.89
53_I137_L0.7180.89
260_L271_L0.7170.89
381_E384_E0.7160.89
137_L140_G0.7160.89
346_L405_M0.7150.89
142_V145_I0.7100.89
312_T333_T0.7090.89
202_A234_N0.7080.89
217_K396_E0.7070.89
274_R285_F0.7030.88
63_K128_D0.7010.88
29_L39_Y0.6990.88
171_M175_S0.6990.88
303_V327_A0.6980.88
313_E336_G0.6960.88
340_L347_L0.6940.88
137_L142_V0.6920.88
412_V416_K0.6910.87
152_T369_N0.6900.87
158_P199_R0.6890.87
401_R415_R0.6870.87
142_V186_I0.6850.87
29_L34_Y0.6840.87
63_K129_M0.6830.87
232_F268_I0.6830.87
134_L278_F0.6830.87
324_V336_G0.6810.87
347_L350_D0.6790.87
158_P234_N0.6780.87
77_G150_G0.6780.87
161_F235_A0.6760.86
205_K384_E0.6740.86
127_R275_R0.6730.86
355_A359_T0.6700.86
139_R172_D0.6690.86
57_M77_G0.6670.86
274_R279_G0.6660.86
413_G417_M0.6660.86
414_V418_A0.6640.85
210_C325_V0.6630.85
71_Q153_K0.6620.85
360_V379_V0.6610.85
242_F380_E0.6590.85
321_A324_V0.6570.85
258_G282_T0.6570.85
165_Q169_W0.6550.85
311_I324_V0.6550.85
324_V345_I0.6550.85
203_T357_G0.6550.85
236_G255_D0.6520.84
347_L406_R0.6520.84
151_P182_S0.6510.84
261_Y287_D0.6510.84
56_R63_K0.6490.84
240_A268_I0.6490.84
50_T68_Y0.6480.84
252_G259_G0.6460.84
30_E33_G0.6440.84
24_V103_W0.6420.83
366_V372_F0.6410.83
393_N396_E0.6390.83
165_Q168_A0.6390.83
243_M301_I0.6390.83
241_K269_D0.6390.83
167_M193_L0.6380.83
218_R323_I0.6370.83
400_N403_I0.6370.83
103_W330_G0.6370.83
202_A360_V0.6360.83
202_A383_L0.6360.83
232_F328_A0.6350.83
49_L145_I0.6340.83
212_K388_V0.6330.83
226_R251_V0.6310.82
97_V101_S0.6300.82
111_I390_S0.6280.82
75_S105_S0.6270.82
337_T347_L0.6260.82
359_T387_M0.6260.82
262_D266_L0.6250.82
397_M408_A0.6220.81
398_A405_M0.6220.81
207_V353_A0.6220.81
367_Q374_W0.6210.81
228_V298_D0.6210.81
68_Y94_V0.6200.81
359_T386_M0.6200.81
289_I297_L0.6190.81
58_D136_R0.6180.81
139_R142_V0.6170.81
271_L275_R0.6150.81
196_S379_V0.6150.81
89_V121_G0.6140.81
235_A256_A0.6140.81
177_I186_I0.6130.80
199_R361_S0.6120.80
151_P183_P0.6120.80
214_A346_L0.6120.80
191_L197_H0.6120.80
27_K407_L0.6110.80
255_D258_G0.6100.80
170_M186_I0.6090.80
230_Q310_Q0.6090.80
109_G413_G0.6090.80
107_K119_K0.6080.80
32_L35_P0.6080.80
24_V28_A0.6070.80
28_A34_Y0.6070.80
80_K365_W0.6070.80
382_K385_K0.6070.80
327_A353_A0.6070.80
134_L138_S0.6040.80
215_A220_I0.6040.80
232_F281_V0.6040.80
75_S420_A0.6030.79
157_A358_V0.6030.79
215_A323_I0.6000.79
362_Y366_V0.6000.79
75_S421_S0.6000.79
27_K338_K0.6000.79
29_L33_G0.5990.79
196_S374_W0.5990.79
282_T288_T0.5980.79
311_I347_L0.5980.79
142_V149_V0.5980.79
28_A36_E0.5970.79
55_V65_F0.5970.79
28_A33_G0.5970.79
71_Q79_T0.5960.79
228_V259_G0.5960.79
292_Q314_E0.5940.78
254_S295_L0.5930.78
270_Y275_R0.5920.78
203_T354_S0.5920.78
130_S133_E0.5920.78
33_G36_E0.5910.78
203_T234_N0.5910.78
34_Y39_Y0.5830.77
259_G297_L0.5830.77
388_V392_N0.5820.77
273_D276_D0.5820.77
174_Y177_I0.5820.77
201_S238_Y0.5810.77
162_T202_A0.5810.77
275_R278_F0.5800.77
321_A340_L0.5790.77
312_T318_N0.5790.77
199_R234_N0.5780.77
258_G281_V0.5770.76
213_E217_K0.5770.76
232_F304_P0.5750.76
217_K346_L0.5730.76
76_V416_K0.5720.76
110_I393_N0.5720.76
36_E40_E0.5710.76
208_T242_F0.5710.76
131_F134_L0.5690.75
24_V27_K0.5690.75
262_D286_N0.5670.75
26_H31_K0.5660.75
114_P366_V0.5650.75
210_C352_L0.5650.75
348_V405_M0.5640.75
80_K108_C0.5640.75
348_V391_F0.5630.75
120_G138_S0.5630.75
112_D393_N0.5620.75
224_G247_G0.5620.75
308_E330_G0.5620.75
316_A340_L0.5610.74
97_V121_G0.5600.74
228_V294_L0.5590.74
360_V374_W0.5590.74
277_S283_K0.5590.74
35_P419_E0.5590.74
80_K115_Y0.5580.74
70_A118_G0.5570.74
275_R281_V0.5560.74
196_S360_V0.5560.74
386_M389_K0.5550.74
25_I30_E0.5550.74
210_C348_V0.5550.74
205_K241_K0.5550.74
85_F124_C0.5540.73
295_L310_Q0.5520.73
383_L387_M0.5500.73
395_Y405_M0.5490.73
34_Y37_E0.5470.73
112_D389_K0.5460.72
332_T337_T0.5440.72
58_D69_R0.5420.72
86_H256_A0.5410.72
229_V243_M0.5410.72
138_S170_M0.5410.72
30_E35_P0.5400.72
226_R261_Y0.5400.72
220_I300_D0.5390.71
272_L275_R0.5390.71
25_I43_K0.5390.71
99_A330_G0.5380.71
187_T361_S0.5380.71
254_S291_N0.5360.71
242_F245_D0.5360.71
395_Y398_A0.5350.71
38_V41_L0.5340.71
152_T371_G0.5340.71
259_G294_L0.5330.71
207_V235_A0.5330.71
251_V297_L0.5320.70
157_A234_N0.5310.70
288_T291_N0.5310.70
83_I120_G0.5300.70
214_A391_F0.5280.70
239_L327_A0.5270.70
194_G364_E0.5240.69
23_T30_E0.5240.69
158_P360_V0.5230.69
196_S367_Q0.5220.69
278_F283_K0.5210.69
278_F281_V0.5210.69
307_I310_Q0.5190.69
211_I327_A0.5190.69
311_I317_H0.5190.69
115_Y365_W0.5190.69
214_A395_Y0.5150.68
397_M400_N0.5140.68
119_K157_A0.5140.68
263_P285_F0.5130.68
317_H342_D0.5130.68
25_I414_V0.5130.68
312_T332_T0.5130.68
234_N360_V0.5130.68
143_R146_S0.5130.68
138_S166_I0.5120.68
333_T337_T0.5110.67
111_I386_M0.5100.67
208_T211_I0.5100.67
305_A327_A0.5090.67
56_R62_V0.5090.67
119_K354_S0.5070.67
27_K35_P0.5060.67
198_G379_V0.5060.67
241_K268_I0.5060.67
396_E399_N0.5050.67
142_V173_E0.5050.67
102_I106_L0.5040.66
57_M61_S0.5010.66
274_R281_V0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xgiA 6 0.9625 100 0.086 Contact Map
2yfqA 5 0.9157 100 0.087 Contact Map
3r3jA 5 0.9906 100 0.09 Contact Map
4fccA 5 0.9906 100 0.093 Contact Map
2bmaA 5 0.9906 100 0.094 Contact Map
3k92A 5 0.9789 100 0.098 Contact Map
2tmgA 5 0.9508 100 0.099 Contact Map
1bgvA 5 0.993 100 0.1 Contact Map
3aoeE 3 0.9742 100 0.101 Contact Map
1v9lA 4 0.9602 100 0.101 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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