MECA2 - BACSU - GREMLIN Contacts

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MECA2 - Adapter protein MecA 2

UniProt:	P50734	Sequences: MRLERLNYNKIKIFLTLDDLTDRGLTKEDLWKDSFKVHQLFKDMMNEANTELGFEANGPIAVEVYSLQAQGMVVIVTKNQDADSEDDEYDDDYIEMQVKLDESADIIYQFHSFEDIIQLSESLQRIGITGGTVYHYDGQYFLSLEDLGSHTAEGVVAVLAEYGNPTTLTIYRLQEYGKLIMDGNAVETIQTHFS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	194 (186)
Sequences:	816 (627)
Seq/√Len:	46.0

BACSU - MECA2 MECA1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
116_I	189_I	4.170	1.00
184_N	187_E	3.937	1.00
181_M	188_T	3.925	1.00
136_Y	172_R	3.728	1.00
116_I	133_V	2.903	1.00
54_F	78_K	2.870	1.00
113_F	189_I	2.739	1.00
179_L	182_D	2.668	1.00
131_G	185_A	2.660	1.00
181_M	189_I	2.609	1.00
109_Q	139_Q	2.459	1.00
148_G	151_T	2.454	1.00
173_L	177_G	2.322	1.00
10_K	38_H	2.165	1.00
131_G	144_L	2.134	1.00
23_R	41_F	2.046	0.99
112_S	115_D	2.017	0.99
63_E	73_V	1.992	0.99
135_H	180_I	1.988	0.99
108_Y	163_G	1.988	0.99
140_Y	180_I	1.968	0.99
45_M	59_P	1.907	0.99
93_Y	97_Q	1.865	0.99
113_F	117_I	1.778	0.98
74_V	120_S	1.777	0.98
114_E	118_Q	1.671	0.98
95_E	98_V	1.670	0.98
132_T	179_L	1.668	0.98
119_L	159_L	1.655	0.98
38_H	62_V	1.654	0.98
54_F	59_P	1.617	0.97
40_L	43_D	1.612	0.97
149_S	153_E	1.594	0.97
60_I	77_T	1.553	0.96
108_Y	159_L	1.552	0.96
19_D	76_V	1.549	0.96
93_Y	96_M	1.496	0.96
32_K	44_M	1.486	0.95
89_Y	94_I	1.462	0.95
49_N	55_E	1.456	0.95
134_Y	174_Q	1.440	0.94
10_K	40_L	1.417	0.94
113_F	178_K	1.396	0.94
114_E	177_G	1.373	0.93
13_I	76_V	1.359	0.93
20_L	41_F	1.347	0.92
32_K	40_L	1.341	0.92
10_K	63_E	1.335	0.92
5_R	64_V	1.327	0.92
7_N	10_K	1.305	0.91
117_I	121_E	1.295	0.91
106_I	156_V	1.290	0.90
117_I	120_S	1.273	0.90
5_R	52_L	1.253	0.89
112_S	167_T	1.225	0.88
92_D	95_E	1.209	0.87
20_L	25_L	1.206	0.87
19_D	66_S	1.196	0.87
10_K	65_Y	1.196	0.87
93_Y	98_V	1.193	0.87
59_P	79_N	1.193	0.87
6_L	9_N	1.177	0.86
36_K	61_A	1.160	0.85
122_S	162_Y	1.160	0.85
107_I	173_L	1.154	0.85
158_V	162_Y	1.146	0.84
25_L	63_E	1.139	0.84
111_H	137_D	1.138	0.84
40_L	44_M	1.135	0.84
41_F	54_F	1.129	0.83
29_D	64_V	1.118	0.83
23_R	30_L	1.107	0.82
89_Y	93_Y	1.104	0.82
94_I	97_Q	1.103	0.82
3_L	60_I	1.100	0.82
45_M	60_I	1.094	0.81
20_L	23_R	1.082	0.81
164_N	174_Q	1.080	0.81
46_N	57_N	1.078	0.80
137_D	172_R	1.076	0.80
4_E	19_D	1.068	0.80
67_L	70_Q	1.057	0.79
14_F	37_V	1.049	0.79
111_H	139_Q	1.048	0.79
33_D	38_H	1.043	0.78
89_Y	97_Q	1.042	0.78
109_Q	164_N	1.037	0.78
13_I	71_G	1.035	0.78
172_R	176_Y	1.035	0.78
25_L	39_Q	1.031	0.77
63_E	66_S	1.025	0.77
135_H	178_K	1.023	0.77
138_G	183_G	1.015	0.76
20_L	66_S	1.015	0.76
131_G	186_V	1.010	0.76
188_T	191_T	1.008	0.76
115_D	118_Q	1.001	0.75
91_D	96_M	1.000	0.75
132_T	174_Q	1.000	0.75
93_Y	101_D	1.000	0.75
10_K	61_A	0.986	0.74
32_K	60_I	0.980	0.74
94_I	98_V	0.974	0.73
184_N	188_T	0.972	0.73
110_F	119_L	0.971	0.73
136_Y	177_G	0.959	0.72
34_S	64_V	0.957	0.72
24_G	47_E	0.951	0.71
54_F	76_V	0.940	0.71
20_L	74_V	0.939	0.70
89_Y	92_D	0.934	0.70
19_D	23_R	0.931	0.70
108_Y	118_Q	0.929	0.70
25_L	35_F	0.913	0.68
34_S	38_H	0.908	0.68
57_N	140_Y	0.906	0.68
16_T	44_M	0.905	0.68
90_D	93_Y	0.905	0.68
90_D	96_M	0.901	0.67
118_Q	135_H	0.881	0.66
144_L	159_L	0.881	0.66
95_E	138_G	0.876	0.65
144_L	190_Q	0.876	0.65
179_L	183_G	0.872	0.65
2_R	6_L	0.862	0.64
89_Y	96_M	0.859	0.64
13_I	17_L	0.850	0.63
92_D	98_V	0.848	0.63
150_H	180_I	0.843	0.62
54_F	66_S	0.842	0.62
3_L	61_A	0.840	0.62
32_K	62_V	0.836	0.61
34_S	63_E	0.829	0.61
19_D	44_M	0.826	0.60
51_E	159_L	0.821	0.60
92_D	99_K	0.815	0.59
3_L	52_L	0.814	0.59
59_P	64_V	0.808	0.59
186_V	191_T	0.804	0.58
98_V	178_K	0.803	0.58
119_L	186_V	0.792	0.57
146_D	183_G	0.787	0.57
107_I	115_D	0.786	0.57
111_H	164_N	0.779	0.56
37_V	71_G	0.767	0.55
111_H	147_L	0.766	0.55
108_Y	160_A	0.766	0.55
101_D	111_H	0.765	0.55
90_D	111_H	0.764	0.55
108_Y	123_L	0.763	0.54
3_L	66_S	0.761	0.54
23_R	59_P	0.757	0.54
38_H	79_N	0.752	0.53
75_I	185_A	0.752	0.53
3_L	65_Y	0.742	0.52
14_F	65_Y	0.741	0.52
11_I	56_A	0.740	0.52
59_P	62_V	0.734	0.52
29_D	35_F	0.731	0.51
10_K	73_V	0.730	0.51
5_R	53_G	0.730	0.51
25_L	65_Y	0.726	0.51
106_I	112_S	0.723	0.51
37_V	66_S	0.720	0.50
62_V	67_L	0.718	0.50
24_G	28_E	0.716	0.50
5_R	24_G	0.715	0.50
29_D	77_T	0.713	0.50
59_P	78_K	0.709	0.49
174_Q	179_L	0.709	0.49
25_L	32_K	0.703	0.49
119_L	123_L	0.703	0.49
30_L	35_F	0.703	0.49
36_K	59_P	0.702	0.48
114_E	157_A	0.695	0.48
38_H	63_E	0.694	0.48
91_D	97_Q	0.686	0.47
25_L	34_S	0.685	0.47
45_M	74_V	0.682	0.46
132_T	140_Y	0.682	0.46
47_E	52_L	0.682	0.46
23_R	54_F	0.678	0.46
4_E	23_R	0.677	0.46
13_I	30_L	0.674	0.46
113_F	181_M	0.670	0.45
37_V	63_E	0.670	0.45
25_L	57_N	0.666	0.45
3_L	23_R	0.665	0.45
99_K	136_Y	0.662	0.45
147_L	151_T	0.660	0.44
29_D	59_P	0.660	0.44
97_Q	141_F	0.658	0.44
7_N	77_T	0.657	0.44
94_I	102_E	0.655	0.44
14_F	17_L	0.651	0.43
23_R	43_D	0.651	0.43
27_K	31_W	0.649	0.43
58_G	76_V	0.649	0.43
38_H	54_F	0.645	0.43
14_F	66_S	0.644	0.43
51_E	145_E	0.644	0.43
29_D	68_Q	0.644	0.43
13_I	59_P	0.641	0.43
89_Y	98_V	0.640	0.42
71_G	117_I	0.640	0.42
65_Y	74_V	0.637	0.42
2_R	72_M	0.635	0.42
37_V	61_A	0.632	0.42
19_D	58_G	0.629	0.41
64_V	79_N	0.627	0.41
47_E	73_V	0.626	0.41
92_D	97_Q	0.626	0.41
110_F	163_G	0.625	0.41
71_G	114_E	0.624	0.41
13_I	48_A	0.624	0.41
122_S	158_V	0.621	0.41
16_T	112_S	0.616	0.40
117_I	189_I	0.616	0.40
115_D	174_Q	0.614	0.40
54_F	62_V	0.612	0.40
19_D	60_I	0.610	0.40
28_E	31_W	0.608	0.39
76_V	171_Y	0.604	0.39
42_K	54_F	0.600	0.39
17_L	70_Q	0.599	0.39
10_K	33_D	0.599	0.39
68_Q	114_E	0.599	0.39
85_E	102_E	0.598	0.38
110_F	135_H	0.596	0.38
164_N	178_K	0.596	0.38
10_K	62_V	0.593	0.38
115_D	149_S	0.593	0.38
47_E	64_V	0.583	0.37
111_H	174_Q	0.578	0.37
31_W	44_M	0.574	0.36
40_L	119_L	0.572	0.36
85_E	124_Q	0.571	0.36
117_I	188_T	0.569	0.36
54_F	64_V	0.566	0.36
170_I	174_Q	0.564	0.35
17_L	21_T	0.564	0.35
91_D	94_I	0.564	0.35
94_I	182_D	0.561	0.35
48_A	55_E	0.558	0.35
55_E	155_V	0.558	0.35
146_D	167_T	0.557	0.35
38_H	64_V	0.555	0.35
42_K	62_V	0.554	0.34
27_K	176_Y	0.554	0.34
2_R	48_A	0.553	0.34
16_T	37_V	0.551	0.34
138_G	163_G	0.549	0.34
37_V	42_K	0.547	0.34
138_G	147_L	0.546	0.34
2_R	14_F	0.545	0.34
41_F	78_K	0.543	0.33
60_I	65_Y	0.541	0.33
141_F	154_G	0.539	0.33
68_Q	72_M	0.539	0.33
8_Y	156_V	0.536	0.33
186_V	190_Q	0.534	0.33
56_A	162_Y	0.529	0.32
100_L	179_L	0.527	0.32
142_L	185_A	0.523	0.32
27_K	58_G	0.522	0.32
122_S	180_I	0.520	0.31
12_K	79_N	0.520	0.31
61_A	74_V	0.520	0.31
90_D	99_K	0.520	0.31
105_D	162_Y	0.520	0.31
22_D	56_A	0.518	0.31
5_R	16_T	0.517	0.31
44_M	77_T	0.516	0.31
92_D	96_M	0.511	0.31
45_M	58_G	0.511	0.31
4_E	41_F	0.510	0.31
41_F	59_P	0.506	0.30
116_I	143_S	0.501	0.30
12_K	74_V	0.500	0.30

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3j3t1	1	0.4691	100	0.084	Contact Map
3jtnA	1	0.4639	99.9	0.58	Contact Map
3pxia	1	0.4691	99.9	0.581	Contact Map
3jtpA	3	0.4639	99.9	0.584	Contact Map
2d1pB	1	0.2784	20.3	0.944	Contact Map
1jx7A	5	0.2784	12.5	0.949	Contact Map
2d1pC	2	0.2732	10.8	0.951	Contact Map
2lnaA	1	0.3402	10	0.951	Contact Map
2hy5B	1	0.2784	9.1	0.952	Contact Map
1ug7A	1	0.3093	9	0.952	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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