GREMLIN Database
MECA2 - Adapter protein MecA 2
UniProt: P50734 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 194 (186)
Sequences: 816 (627)
Seq/√Len: 46.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
116_I189_I4.1701.00
184_N187_E3.9371.00
181_M188_T3.9251.00
136_Y172_R3.7281.00
116_I133_V2.9031.00
54_F78_K2.8701.00
113_F189_I2.7391.00
179_L182_D2.6681.00
131_G185_A2.6601.00
181_M189_I2.6091.00
109_Q139_Q2.4591.00
148_G151_T2.4541.00
173_L177_G2.3221.00
10_K38_H2.1651.00
131_G144_L2.1341.00
23_R41_F2.0460.99
112_S115_D2.0170.99
63_E73_V1.9920.99
135_H180_I1.9880.99
108_Y163_G1.9880.99
140_Y180_I1.9680.99
45_M59_P1.9070.99
93_Y97_Q1.8650.99
113_F117_I1.7780.98
74_V120_S1.7770.98
114_E118_Q1.6710.98
95_E98_V1.6700.98
132_T179_L1.6680.98
119_L159_L1.6550.98
38_H62_V1.6540.98
54_F59_P1.6170.97
40_L43_D1.6120.97
149_S153_E1.5940.97
60_I77_T1.5530.96
108_Y159_L1.5520.96
19_D76_V1.5490.96
93_Y96_M1.4960.96
32_K44_M1.4860.95
89_Y94_I1.4620.95
49_N55_E1.4560.95
134_Y174_Q1.4400.94
10_K40_L1.4170.94
113_F178_K1.3960.94
114_E177_G1.3730.93
13_I76_V1.3590.93
20_L41_F1.3470.92
32_K40_L1.3410.92
10_K63_E1.3350.92
5_R64_V1.3270.92
7_N10_K1.3050.91
117_I121_E1.2950.91
106_I156_V1.2900.90
117_I120_S1.2730.90
5_R52_L1.2530.89
112_S167_T1.2250.88
92_D95_E1.2090.87
20_L25_L1.2060.87
19_D66_S1.1960.87
10_K65_Y1.1960.87
93_Y98_V1.1930.87
59_P79_N1.1930.87
6_L9_N1.1770.86
36_K61_A1.1600.85
122_S162_Y1.1600.85
107_I173_L1.1540.85
158_V162_Y1.1460.84
25_L63_E1.1390.84
111_H137_D1.1380.84
40_L44_M1.1350.84
41_F54_F1.1290.83
29_D64_V1.1180.83
23_R30_L1.1070.82
89_Y93_Y1.1040.82
94_I97_Q1.1030.82
3_L60_I1.1000.82
45_M60_I1.0940.81
20_L23_R1.0820.81
164_N174_Q1.0800.81
46_N57_N1.0780.80
137_D172_R1.0760.80
4_E19_D1.0680.80
67_L70_Q1.0570.79
14_F37_V1.0490.79
111_H139_Q1.0480.79
33_D38_H1.0430.78
89_Y97_Q1.0420.78
109_Q164_N1.0370.78
13_I71_G1.0350.78
172_R176_Y1.0350.78
25_L39_Q1.0310.77
63_E66_S1.0250.77
135_H178_K1.0230.77
138_G183_G1.0150.76
20_L66_S1.0150.76
131_G186_V1.0100.76
188_T191_T1.0080.76
115_D118_Q1.0010.75
91_D96_M1.0000.75
132_T174_Q1.0000.75
93_Y101_D1.0000.75
10_K61_A0.9860.74
32_K60_I0.9800.74
94_I98_V0.9740.73
184_N188_T0.9720.73
110_F119_L0.9710.73
136_Y177_G0.9590.72
34_S64_V0.9570.72
24_G47_E0.9510.71
54_F76_V0.9400.71
20_L74_V0.9390.70
89_Y92_D0.9340.70
19_D23_R0.9310.70
108_Y118_Q0.9290.70
25_L35_F0.9130.68
34_S38_H0.9080.68
57_N140_Y0.9060.68
16_T44_M0.9050.68
90_D93_Y0.9050.68
90_D96_M0.9010.67
118_Q135_H0.8810.66
144_L159_L0.8810.66
95_E138_G0.8760.65
144_L190_Q0.8760.65
179_L183_G0.8720.65
2_R6_L0.8620.64
89_Y96_M0.8590.64
13_I17_L0.8500.63
92_D98_V0.8480.63
150_H180_I0.8430.62
54_F66_S0.8420.62
3_L61_A0.8400.62
32_K62_V0.8360.61
34_S63_E0.8290.61
19_D44_M0.8260.60
51_E159_L0.8210.60
92_D99_K0.8150.59
3_L52_L0.8140.59
59_P64_V0.8080.59
186_V191_T0.8040.58
98_V178_K0.8030.58
119_L186_V0.7920.57
146_D183_G0.7870.57
107_I115_D0.7860.57
111_H164_N0.7790.56
37_V71_G0.7670.55
111_H147_L0.7660.55
108_Y160_A0.7660.55
101_D111_H0.7650.55
90_D111_H0.7640.55
108_Y123_L0.7630.54
3_L66_S0.7610.54
23_R59_P0.7570.54
38_H79_N0.7520.53
75_I185_A0.7520.53
3_L65_Y0.7420.52
14_F65_Y0.7410.52
11_I56_A0.7400.52
59_P62_V0.7340.52
29_D35_F0.7310.51
10_K73_V0.7300.51
5_R53_G0.7300.51
25_L65_Y0.7260.51
106_I112_S0.7230.51
37_V66_S0.7200.50
62_V67_L0.7180.50
24_G28_E0.7160.50
5_R24_G0.7150.50
29_D77_T0.7130.50
59_P78_K0.7090.49
174_Q179_L0.7090.49
25_L32_K0.7030.49
119_L123_L0.7030.49
30_L35_F0.7030.49
36_K59_P0.7020.48
114_E157_A0.6950.48
38_H63_E0.6940.48
91_D97_Q0.6860.47
25_L34_S0.6850.47
45_M74_V0.6820.46
132_T140_Y0.6820.46
47_E52_L0.6820.46
23_R54_F0.6780.46
4_E23_R0.6770.46
13_I30_L0.6740.46
113_F181_M0.6700.45
37_V63_E0.6700.45
25_L57_N0.6660.45
3_L23_R0.6650.45
99_K136_Y0.6620.45
147_L151_T0.6600.44
29_D59_P0.6600.44
97_Q141_F0.6580.44
7_N77_T0.6570.44
94_I102_E0.6550.44
14_F17_L0.6510.43
23_R43_D0.6510.43
27_K31_W0.6490.43
58_G76_V0.6490.43
38_H54_F0.6450.43
14_F66_S0.6440.43
51_E145_E0.6440.43
29_D68_Q0.6440.43
13_I59_P0.6410.43
89_Y98_V0.6400.42
71_G117_I0.6400.42
65_Y74_V0.6370.42
2_R72_M0.6350.42
37_V61_A0.6320.42
19_D58_G0.6290.41
64_V79_N0.6270.41
47_E73_V0.6260.41
92_D97_Q0.6260.41
110_F163_G0.6250.41
71_G114_E0.6240.41
13_I48_A0.6240.41
122_S158_V0.6210.41
16_T112_S0.6160.40
117_I189_I0.6160.40
115_D174_Q0.6140.40
54_F62_V0.6120.40
19_D60_I0.6100.40
28_E31_W0.6080.39
76_V171_Y0.6040.39
42_K54_F0.6000.39
17_L70_Q0.5990.39
10_K33_D0.5990.39
68_Q114_E0.5990.39
85_E102_E0.5980.38
110_F135_H0.5960.38
164_N178_K0.5960.38
10_K62_V0.5930.38
115_D149_S0.5930.38
47_E64_V0.5830.37
111_H174_Q0.5780.37
31_W44_M0.5740.36
40_L119_L0.5720.36
85_E124_Q0.5710.36
117_I188_T0.5690.36
54_F64_V0.5660.36
170_I174_Q0.5640.35
17_L21_T0.5640.35
91_D94_I0.5640.35
94_I182_D0.5610.35
48_A55_E0.5580.35
55_E155_V0.5580.35
146_D167_T0.5570.35
38_H64_V0.5550.35
42_K62_V0.5540.34
27_K176_Y0.5540.34
2_R48_A0.5530.34
16_T37_V0.5510.34
138_G163_G0.5490.34
37_V42_K0.5470.34
138_G147_L0.5460.34
2_R14_F0.5450.34
41_F78_K0.5430.33
60_I65_Y0.5410.33
141_F154_G0.5390.33
68_Q72_M0.5390.33
8_Y156_V0.5360.33
186_V190_Q0.5340.33
56_A162_Y0.5290.32
100_L179_L0.5270.32
142_L185_A0.5230.32
27_K58_G0.5220.32
122_S180_I0.5200.31
12_K79_N0.5200.31
61_A74_V0.5200.31
90_D99_K0.5200.31
105_D162_Y0.5200.31
22_D56_A0.5180.31
5_R16_T0.5170.31
44_M77_T0.5160.31
92_D96_M0.5110.31
45_M58_G0.5110.31
4_E41_F0.5100.31
41_F59_P0.5060.30
116_I143_S0.5010.30
12_K74_V0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j3t1 1 0.4691 100 0.084 Contact Map
3jtnA 1 0.4639 99.9 0.58 Contact Map
3pxia 1 0.4691 99.9 0.581 Contact Map
3jtpA 3 0.4639 99.9 0.584 Contact Map
2d1pB 1 0.2784 20.3 0.944 Contact Map
1jx7A 5 0.2784 12.5 0.949 Contact Map
2d1pC 2 0.2732 10.8 0.951 Contact Map
2lnaA 1 0.3402 10 0.951 Contact Map
2hy5B 1 0.2784 9.1 0.952 Contact Map
1ug7A 1 0.3093 9 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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