GREMLIN Database
YPBG - Uncharacterized protein YpbG
UniProt: P50733 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 259 (247)
Sequences: 4194 (3252)
Seq/√Len: 206.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_F79_G5.3381.00
77_I179_V3.8571.00
48_T254_T3.4541.00
38_L175_L3.2121.00
35_T256_C3.1121.00
76_V99_L2.8841.00
47_L103_G2.8801.00
50_F252_I2.6941.00
71_H252_I2.6911.00
35_T254_T2.6711.00
132_I139_V2.3901.00
107_V150_I2.3311.00
230_L251_H2.3231.00
123_Y135_R2.2571.00
33_T254_T2.2451.00
135_R154_D2.2091.00
108_F133_T2.1891.00
223_I228_A2.1891.00
142_S147_T2.1231.00
50_F68_A2.1101.00
216_Y219_G2.0291.00
221_T228_A2.0161.00
50_F73_P2.0001.00
52_I68_A1.9781.00
53_S232_S1.9741.00
45_P256_C1.9661.00
198_I227_A1.9191.00
48_T252_I1.9101.00
106_I131_V1.8741.00
151_A176_N1.8651.00
62_Q98_R1.8331.00
34_H230_L1.8271.00
49_I75_L1.8081.00
67_K71_H1.7971.00
78_I82_L1.7941.00
51_F199_L1.7941.00
33_T71_H1.7461.00
140_P149_A1.7371.00
77_I199_L1.7261.00
149_A174_Q1.7121.00
222_G231_I1.7111.00
102_F105_P1.6811.00
162_H165_E1.6621.00
28_G247_E1.6021.00
65_L69_R1.6011.00
199_L253_V1.5751.00
138_S169_E1.5721.00
132_I137_E1.5671.00
110_W123_Y1.5651.00
62_Q66_E1.5611.00
101_H105_P1.5461.00
69_R102_F1.5411.00
149_A176_N1.5291.00
167_I195_I1.5151.00
44_K146_H1.5091.00
46_P254_T1.5081.00
180_C200_S1.5051.00
41_M255_L1.4981.00
223_I226_N1.4961.00
40_K196_D1.4921.00
150_I177_I1.4701.00
50_F71_H1.4551.00
38_L41_M1.4431.00
107_V139_V1.4161.00
77_I150_I1.4121.00
140_P147_T1.4051.00
37_P256_C1.3951.00
79_G179_V1.3811.00
142_S145_G1.3721.00
24_A28_G1.3631.00
53_S79_G1.3591.00
211_G215_P1.3581.00
51_F232_S1.3551.00
34_H251_H1.3481.00
138_S149_A1.3411.00
125_I128_A1.3291.00
171_D174_Q1.3271.00
79_G199_L1.3241.00
32_K233_N1.3191.00
33_T252_I1.3181.00
52_I55_I1.2671.00
21_K25_T1.2621.00
153_V180_C1.2611.00
140_P174_Q1.2381.00
49_I255_L1.2371.00
79_G232_S1.2241.00
178_L195_I1.2191.00
151_A195_I1.2121.00
186_H227_A1.2081.00
138_S151_A1.1901.00
143_Y146_H1.1821.00
186_H229_Y1.1811.00
46_P256_C1.1801.00
230_L253_V1.1631.00
211_G214_G1.1631.00
78_I131_V1.1581.00
48_T71_H1.1541.00
155_D182_N1.1461.00
149_A170_L1.1431.00
232_S251_H1.1401.00
163_Y178_L1.1401.00
62_Q95_N1.1181.00
219_G233_N1.1181.00
221_T230_L1.1171.00
75_L107_V1.1011.00
64_L235_Y1.0841.00
209_R213_F1.0831.00
151_A167_I1.0761.00
31_L250_T1.0711.00
52_I78_I1.0701.00
124_S128_A1.0631.00
30_H247_E1.0601.00
31_L71_H1.0571.00
141_F150_I1.0541.00
123_Y127_K1.0531.00
67_K70_S1.0491.00
157_R182_N1.0431.00
156_I182_N1.0421.00
120_H124_S1.0361.00
115_Y154_D1.0321.00
32_K249_E1.0271.00
147_T174_Q1.0241.00
101_H106_I1.0171.00
51_F77_I1.0151.00
136_N154_D1.0151.00
176_N195_I1.0081.00
72_A102_F0.9931.00
65_L95_N0.9891.00
124_S127_K0.9761.00
20_A24_A0.9741.00
138_S166_A0.9731.00
21_K244_L0.9711.00
205_G233_N0.9560.99
127_K133_T0.9540.99
222_G229_Y0.9520.99
209_R246_A0.9520.99
166_A169_E0.9500.99
76_V101_H0.9450.99
108_F131_V0.9450.99
148_I175_L0.9410.99
67_K250_T0.9380.99
49_I77_I0.9310.99
123_Y133_T0.9300.99
56_H204_H0.9270.99
75_L141_F0.9260.99
55_I235_Y0.9250.99
100_V105_P0.9040.99
79_G109_V0.8960.99
68_A99_L0.8940.99
12_T16_A0.8940.99
21_K26_A0.8940.99
36_F221_T0.8910.99
51_F253_V0.8840.99
34_H221_T0.8800.99
197_V253_V0.8770.99
126_F131_V0.8750.99
97_K129_H0.8740.99
93_E128_A0.8700.99
93_E125_I0.8690.99
37_P228_A0.8670.99
151_A166_A0.8660.99
186_H224_V0.8630.99
22_M26_A0.8610.99
233_N246_A0.8520.99
34_H253_V0.8490.99
138_S170_L0.8490.99
32_K251_H0.8490.99
108_F126_F0.8470.99
51_F230_L0.8470.99
66_E98_R0.8460.99
20_A26_A0.8440.99
180_C185_I0.8420.99
78_I106_I0.8400.99
211_G245_G0.8390.99
177_I197_V0.8380.99
170_L176_N0.8380.99
22_M25_T0.8350.99
21_K24_A0.8340.99
236_G243_R0.8320.99
118_R121_K0.8280.99
205_G247_E0.8260.99
26_A237_T0.8250.99
178_L189_I0.8250.99
95_N98_R0.8190.98
82_L126_F0.8140.98
122_L126_F0.8120.98
76_V106_I0.8090.98
69_R101_H0.8090.98
47_L143_Y0.7970.98
17_A21_K0.7940.98
29_N67_K0.7870.98
162_H166_A0.7840.98
103_G143_Y0.7800.98
31_L252_I0.7770.98
217_E222_G0.7750.98
167_I170_L0.7680.98
19_T23_Y0.7660.98
112_N202_H0.7620.97
112_N204_H0.7520.97
186_H198_I0.7520.97
189_I198_I0.7500.97
60_I64_L0.7500.97
182_N203_T0.7470.97
55_I64_L0.7450.97
164_E168_K0.7410.97
94_E97_K0.7400.97
50_F250_T0.7370.97
18_M22_M0.7350.97
56_H113_N0.7350.97
63_D67_K0.7340.97
57_K61_D0.7240.97
113_N204_H0.7230.97
84_E238_T0.7180.96
165_E168_K0.7150.96
58_R61_D0.7120.96
211_G246_A0.7090.96
36_F197_V0.7050.96
82_L108_F0.7050.96
134_L137_E0.7040.96
151_A170_L0.7030.96
233_N248_P0.7010.96
69_R100_V0.7010.96
42_K46_P0.7010.96
110_W114_D0.6970.96
210_F214_G0.6960.96
49_I253_V0.6940.96
224_V227_A0.6930.96
58_R95_N0.6850.95
151_A178_L0.6850.95
153_V185_I0.6840.95
93_E129_H0.6800.95
55_I78_I0.6740.95
22_M244_L0.6740.95
23_Y26_A0.6700.95
69_R98_R0.6690.95
198_I229_Y0.6690.95
69_R76_V0.6680.95
127_K135_R0.6670.95
110_W119_Q0.6670.95
190_N194_G0.6660.95
25_T248_P0.6660.95
149_A171_D0.6640.94
97_K130_G0.6610.94
32_K230_L0.6600.94
139_V143_Y0.6600.94
25_T28_G0.6580.94
179_V199_L0.6550.94
126_F133_T0.6550.94
78_I96_I0.6530.94
125_I129_H0.6520.94
136_N153_V0.6520.94
23_Y27_K0.6510.94
56_H112_N0.6510.94
38_L196_D0.6490.94
51_F251_H0.6490.94
195_I198_I0.6470.94
110_W122_L0.6460.94
190_N227_A0.6460.94
41_M175_L0.6430.93
120_H123_Y0.6420.93
142_S146_H0.6410.93
83_A242_L0.6400.93
114_D122_L0.6380.93
16_A20_A0.6370.93
127_K137_E0.6360.93
38_L197_V0.6360.93
237_T241_P0.6350.93
81_D204_H0.6340.93
163_Y195_I0.6340.93
200_S229_Y0.6290.93
209_R212_K0.6290.93
57_K60_I0.6280.93
64_L68_A0.6260.93
190_N224_V0.6250.93
175_L196_D0.6220.92
205_G246_A0.6220.92
210_F213_F0.6210.92
188_Q192_D0.6210.92
78_I108_F0.6180.92
110_W154_D0.6140.92
26_A29_N0.6140.92
233_N249_E0.6080.91
178_L198_I0.6030.91
209_R214_G0.6020.91
55_I60_I0.6010.91
56_H81_D0.5980.91
187_E192_D0.5970.91
210_F238_T0.5960.91
153_V166_A0.5950.91
49_I177_I0.5950.91
190_N225_K0.5920.90
46_P255_L0.5890.90
47_L141_F0.5870.90
9_G13_V0.5850.90
208_I240_V0.5820.90
66_E70_S0.5820.90
208_I211_G0.5770.89
115_Y119_Q0.5740.89
73_P252_I0.5740.89
205_G215_P0.5740.89
156_I185_I0.5740.89
9_G17_A0.5720.89
38_L228_A0.5690.89
136_N166_A0.5670.88
164_E193_D0.5670.88
29_N235_Y0.5640.88
69_R103_G0.5630.88
107_V132_I0.5630.88
139_V150_I0.5620.88
150_I179_V0.5600.88
185_I188_Q0.5590.88
50_F79_G0.5590.88
28_G244_L0.5590.88
233_N251_H0.5590.88
165_E169_E0.5570.88
91_R94_E0.5560.87
90_A94_E0.5560.87
38_L255_L0.5550.87
177_I199_L0.5540.87
36_F253_V0.5530.87
65_L71_H0.5520.87
66_E69_R0.5510.87
58_R62_Q0.5500.87
84_E182_N0.5490.87
25_T247_E0.5480.87
31_L67_K0.5480.87
164_E192_D0.5460.86
52_I79_G0.5450.86
175_L197_V0.5430.86
119_Q123_Y0.5410.86
47_L255_L0.5400.86
156_I161_D0.5400.86
218_L222_G0.5380.86
46_P146_H0.5380.86
182_N238_T0.5350.85
207_Q241_P0.5340.85
180_C198_I0.5320.85
237_T242_L0.5320.85
92_I96_I0.5310.85
20_A25_T0.5310.85
71_H250_T0.5300.85
115_Y158_M0.5300.85
29_N64_L0.5290.85
18_M244_L0.5280.85
156_I184_E0.5250.84
121_K124_S0.5250.84
205_G212_K0.5250.84
223_I227_A0.5220.84
235_Y251_H0.5220.84
237_T240_V0.5200.84
79_G230_L0.5190.84
176_N196_D0.5190.84
203_T237_T0.5180.84
215_P218_L0.5160.83
158_M182_N0.5150.83
212_K245_G0.5140.83
205_G219_G0.5140.83
113_N233_N0.5120.83
184_E203_T0.5120.83
75_L105_P0.5100.83
209_R238_T0.5090.82
88_P91_R0.5090.82
8_A12_T0.5070.82
44_K145_G0.5070.82
36_F228_A0.5050.82
163_Y185_I0.5050.82
153_V156_I0.5050.82
211_G216_Y0.5040.82
34_H37_P0.5010.81
189_I227_A0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fbkA 2 0.9266 100 0.614 Contact Map
3rl5A 1 0.8417 100 0.626 Contact Map
4fbwA 2 0.8147 99.9 0.648 Contact Map
2z1aA 1 0.8263 99.9 0.66 Contact Map
2wdcA 1 0.8456 99.9 0.662 Contact Map
4ykeA 2 0.7876 99.9 0.664 Contact Map
3t1iA 2 0.8378 99.9 0.665 Contact Map
1uf3A 6 0.7181 99.9 0.673 Contact Map
3ztvA 2 0.8301 99.9 0.676 Contact Map
1ii7A 2 0.8108 99.9 0.68 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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