GREMLIN Database
RECS - Probable ATP-dependent DNA helicase RecS
UniProt: P50729 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 496 (406)
Sequences: 19455 (12564)
Seq/√Len: 623.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_Q76_L5.2381.00
28_I168_L3.7231.00
48_Y134_V3.6741.00
274_Q279_Q3.6411.00
52_G59_V3.5971.00
63_S72_Q3.4621.00
273_Q277_H3.4251.00
238_R262_G3.3941.00
257_D280_L3.3731.00
235_C241_A3.3401.00
111_L116_L3.2691.00
39_P42_G3.2041.00
254_S282_V3.0551.00
235_C244_L2.9801.00
20_G36_A2.9731.00
73_V77_K2.9041.00
257_D274_Q2.8451.00
341_Q345_I2.7641.00
270_L274_Q2.7601.00
245_A256_A2.6301.00
29_L54_M2.5791.00
317_I329_S2.5251.00
231_G300_Y2.5151.00
235_C284_C2.5051.00
306_L331_L2.4641.00
205_L317_I2.3571.00
156_G160_K2.3291.00
221_I252_T2.1661.00
242_K258_F2.1521.00
204_A328_V2.1361.00
229_G299_R2.1021.00
255_R281_D2.0441.00
28_I34_T2.0391.00
200_R203_I1.9891.00
178_T181_D1.9831.00
223_L226_N1.9681.00
245_A258_F1.9571.00
48_Y170_L1.9491.00
297_D325_K1.9241.00
59_V132_L1.9241.00
206_R328_V1.9231.00
14_F46_L1.9151.00
245_A249_K1.8801.00
289_F293_V1.8721.00
32_K190_H1.8641.00
119_P124_K1.8291.00
220_V302_I1.8241.00
75_Q78_A1.8211.00
245_A284_C1.7971.00
178_T182_V1.7701.00
248_I284_C1.7681.00
269_I273_Q1.7581.00
33_D169_A1.7551.00
138_A169_A1.7481.00
241_A260_H1.7401.00
92_N95_E1.7251.00
219_R222_Q1.7191.00
73_V84_A1.7161.00
263_L271_I1.6901.00
58_M131_S1.6751.00
244_L284_C1.6721.00
240_W305_H1.6661.00
52_G134_V1.6631.00
85_A106_Y1.6591.00
359_I362_L1.6451.00
412_M415_K1.6251.00
257_D271_I1.5891.00
74_Q78_A1.5861.00
76_L108_F1.5801.00
422_V425_L1.5761.00
133_F167_V1.5741.00
358_V362_L1.5671.00
48_Y72_Q1.5671.00
303_H317_I1.5651.00
285_C289_F1.5451.00
401_V405_K1.5411.00
36_A170_L1.5341.00
139_H291_M1.5101.00
60_L130_I1.5061.00
52_G132_L1.5061.00
55_L132_L1.4921.00
106_Y109_L1.4881.00
223_L227_L1.4881.00
390_M393_L1.4521.00
233_V282_V1.4231.00
264_E267_D1.4151.00
62_V116_L1.4141.00
62_V111_L1.4121.00
213_T216_K1.4081.00
271_I280_L1.4001.00
244_L304_F1.3981.00
220_V304_F1.3701.00
338_F342_E1.3571.00
205_L313_F1.3521.00
241_A258_F1.3431.00
76_L110_Y1.3411.00
217_I247_E1.3381.00
348_E352_A1.3371.00
225_E252_T1.3361.00
362_L365_T1.3341.00
374_R378_L1.3321.00
359_I363_E1.3261.00
358_V363_E1.3071.00
355_I359_I1.2961.00
413_E417_E1.2891.00
58_M107_K1.2831.00
50_L53_Y1.2731.00
338_F341_Q1.2731.00
342_E345_I1.2721.00
389_M393_L1.2701.00
349_S352_A1.2681.00
380_Y383_G1.2651.00
357_D361_V1.2501.00
303_H316_E1.2501.00
76_L84_A1.2501.00
376_V380_Y1.2491.00
374_R377_L1.2491.00
234_Y316_E1.2451.00
181_D185_L1.2401.00
301_V320_A1.2371.00
415_K418_K1.2351.00
361_V365_T1.2321.00
377_L380_Y1.2151.00
217_I304_F1.2101.00
223_L330_I1.2091.00
237_T240_W1.2061.00
208_E219_R1.2061.00
27_S192_V1.2041.00
153_S156_G1.1941.00
352_A356_A1.1921.00
227_L328_V1.1921.00
242_K260_H1.1891.00
340_L344_I1.1881.00
199_N203_I1.1791.00
300_Y328_V1.1781.00
270_L273_Q1.1771.00
26_E30_S1.1751.00
247_E252_T1.1741.00
267_D271_I1.1741.00
241_A284_C1.1721.00
259_Y289_F1.1711.00
263_L267_D1.1681.00
381_G385_T1.1541.00
421_R424_F1.1501.00
403_L407_E1.1491.00
111_L125_L1.1491.00
363_E367_E1.1451.00
231_G302_I1.1441.00
419_M423_S1.1431.00
83_R107_K1.1371.00
53_Y56_D1.1341.00
63_S69_M1.1341.00
241_A245_A1.1321.00
45_S72_Q1.1311.00
69_M86_A1.1291.00
246_G249_K1.1231.00
73_V86_A1.1231.00
404_M407_E1.1231.00
384_E387_A1.1221.00
27_S34_T1.1181.00
214_A218_D1.1131.00
221_I247_E1.1121.00
85_A109_L1.1111.00
85_A99_V1.1101.00
213_T240_W1.1051.00
267_D270_L1.1041.00
240_W243_E1.1001.00
249_K256_A1.0991.00
179_L191_A1.0981.00
19_K23_D1.0971.00
154_K157_Q1.0861.00
398_K402_E1.0821.00
401_V404_M1.0821.00
364_K367_E1.0811.00
412_M416_L1.0711.00
28_I51_P1.0691.00
420_H423_S1.0671.00
220_V233_V1.0641.00
157_Q160_K1.0621.00
417_E421_R1.0581.00
413_E416_L1.0581.00
217_I244_L1.0531.00
246_G250_S1.0531.00
225_E254_S1.0501.00
419_M422_V1.0501.00
418_K421_R1.0501.00
22_Q26_E1.0501.00
71_D294_D1.0491.00
231_G282_V1.0491.00
27_S30_S1.0491.00
134_V168_L1.0481.00
94_Q98_F1.0481.00
402_E406_K1.0481.00
371_R375_D1.0481.00
74_Q77_K1.0471.00
179_L183_M1.0471.00
303_H331_L1.0461.00
149_R153_S1.0431.00
415_K419_M1.0431.00
381_G384_E1.0421.00
155_L158_L1.0421.00
182_V185_L1.0411.00
387_A394_F1.0401.00
23_D27_S1.0381.00
59_V134_V1.0361.00
232_I285_C1.0321.00
25_I50_L1.0311.00
361_V364_K1.0311.00
46_L50_L1.0301.00
360_R365_T1.0231.00
215_E218_D1.0211.00
380_Y385_T1.0211.00
230_P297_D1.0191.00
31_G166_P1.0181.00
358_V361_V1.0131.00
213_T217_I1.0131.00
221_I225_E1.0091.00
70_E269_I1.0031.00
352_A355_I1.0011.00
382_V389_M1.0001.00
375_D379_Q0.9991.00
272_Q295_K0.9931.00
188_L191_A0.9901.00
405_K410_Y0.9881.00
385_T388_R0.9861.00
211_A215_E0.9811.00
343_Q347_M0.9811.00
300_Y330_I0.9801.00
222_Q225_E0.9761.00
364_K368_R0.9721.00
222_Q226_N0.9701.00
33_D189_Q0.9681.00
24_I47_C0.9681.00
404_M408_I0.9611.00
229_G326_P0.9611.00
228_Q231_G0.9591.00
68_L292_G0.9551.00
359_I365_T0.9551.00
376_V379_Q0.9451.00
180_Q184_N0.9441.00
414_L418_K0.9441.00
96_R99_V0.9421.00
369_D372_R0.9361.00
57_G129_P0.9341.00
179_L182_V0.9321.00
405_K408_I0.9321.00
274_Q280_L0.9271.00
380_Y384_E0.9261.00
223_L302_I0.9231.00
383_G387_A0.9221.00
360_R364_K0.9201.00
98_F101_E0.9191.00
351_T355_I0.9161.00
35_I174_A0.9151.00
365_T368_R0.9111.00
345_I348_E0.9111.00
359_I364_K0.9101.00
382_V386_Q0.9091.00
410_Y414_L0.9081.00
26_E54_M0.9071.00
363_E366_E0.9051.00
369_D375_D0.9021.00
271_I283_I0.9021.00
203_I321_G0.9011.00
405_K409_S0.8991.00
400_S404_M0.8981.00
407_E410_Y0.8931.00
399_T403_L0.8901.00
374_R381_G0.8891.00
361_V367_E0.8881.00
419_M425_L0.8861.00
181_D184_N0.8851.00
70_E74_Q0.8831.00
124_K127_S0.8821.00
140_C143_E0.8821.00
397_G401_V0.8781.00
391_I394_F0.8771.00
216_K223_L0.8741.00
23_D26_E0.8681.00
356_A360_R0.8671.00
139_H315_Q0.8661.00
418_K426_L0.8661.00
216_K305_H0.8611.00
224_V254_S0.8611.00
376_V381_G0.8611.00
230_P278_N0.8611.00
383_G386_Q0.8601.00
132_L166_P0.8581.00
310_A342_E0.8541.00
309_T312_A0.8541.00
421_R425_L0.8521.00
75_Q79_R0.8481.00
420_H424_F0.8451.00
404_M410_Y0.8421.00
232_I283_I0.8411.00
379_Q384_E0.8401.00
376_V385_T0.8371.00
380_Y390_M0.8371.00
401_V413_E0.8361.00
356_A359_I0.8351.00
12_F78_A0.8251.00
73_V110_Y0.8241.00
399_T402_E0.8181.00
405_K413_E0.8171.00
287_N316_E0.8091.00
384_E389_M0.8081.00
307_P313_F0.8051.00
131_S165_P0.8041.00
386_Q390_M0.8031.00
24_I36_A0.8021.00
373_L377_L0.8021.00
55_L131_S0.7951.00
390_M394_F0.7951.00
124_K128_V0.7911.00
268_R275_F0.7911.00
408_I412_M0.7911.00
88_N265_S0.7891.00
348_E351_T0.7891.00
160_K163_G0.7881.00
374_R380_Y0.7881.00
275_F283_I0.7851.00
47_C51_P0.7841.00
217_I221_I0.7821.00
219_R223_L0.7811.00
307_P316_E0.7801.00
341_Q344_I0.7771.00
71_D76_L0.7761.00
413_E419_M0.7731.00
31_G55_L0.7731.00
52_G76_L0.7691.00
362_L368_R0.7691.00
223_L300_Y0.7691.00
272_Q275_F0.7671.00
387_A392_H0.7651.00
411_R415_K0.7651.00
388_R392_H0.7641.00
370_E381_G0.7611.00
415_K423_S0.7601.00
384_E388_R0.7561.00
61_I76_L0.7561.00
402_E407_E0.7561.00
98_F102_H0.7541.00
358_V365_T0.7531.00
24_I28_I0.7521.00
357_D363_E0.7491.00
350_V354_E0.7461.00
48_Y51_P0.7461.00
182_V186_L0.7431.00
378_L382_V0.7421.00
415_K424_F0.7421.00
351_T354_E0.7401.00
360_R363_E0.7391.00
379_Q385_T0.7391.00
224_V227_L0.7381.00
418_K425_L0.7361.00
340_L343_Q0.7341.00
379_Q386_Q0.7341.00
243_E247_E0.7341.00
164_H167_V0.7301.00
369_D374_R0.7281.00
412_M419_M0.7281.00
410_Y413_E0.7271.00
33_D167_V0.7251.00
385_T390_M0.7241.00
412_M422_V0.7211.00
151_D154_K0.7201.00
422_V426_L0.7201.00
71_D75_Q0.7191.00
423_S426_L0.7191.00
370_E376_V0.7191.00
386_Q389_M0.7191.00
421_R426_L0.7161.00
117_Q121_V0.7151.00
357_D364_K0.7101.00
376_V384_E0.7091.00
133_F164_H0.7091.00
273_Q276_I0.7091.00
155_L159_R0.7081.00
50_L54_M0.7081.00
189_Q192_V0.7061.00
38_L42_G0.7061.00
388_R393_L0.7031.00
386_Q393_L0.6991.00
356_A361_V0.6981.00
203_I329_S0.6961.00
401_V410_Y0.6941.00
358_V366_E0.6931.00
325_K367_E0.6931.00
406_K410_Y0.6921.00
351_T362_L0.6911.00
380_Y386_Q0.6901.00
339_E343_Q0.6891.00
377_L394_F0.6881.00
373_L376_V0.6871.00
397_G400_S0.6871.00
117_Q151_D0.6861.00
48_Y168_L0.6841.00
418_K422_V0.6821.00
379_Q382_V0.6811.00
417_E420_H0.6801.00
362_L366_E0.6801.00
412_M420_H0.6791.00
362_L367_E0.6791.00
377_L381_G0.6771.00
400_S407_E0.6771.00
357_D367_E0.6771.00
358_V368_R0.6731.00
354_E360_R0.6731.00
403_L406_K0.6701.00
35_I169_A0.6691.00
382_V385_T0.6681.00
412_M418_K0.6671.00
402_E408_I0.6661.00
153_S159_R0.6661.00
402_E405_K0.6651.00
388_R394_F0.6641.00
230_P298_I0.6631.00
387_A393_L0.6621.00
369_D376_V0.6621.00
419_M426_L0.6611.00
202_N326_P0.6591.00
265_S268_R0.6571.00
148_F151_D0.6561.00
199_N202_N0.6541.00
371_R379_Q0.6511.00
353_E357_D0.6501.00
407_E411_R0.6491.00
370_E377_L0.6481.00
55_L166_P0.6471.00
411_R414_L0.6461.00
372_R376_V0.6451.00
374_R379_Q0.6431.00
259_Y288_A0.6421.00
231_G235_C0.6411.00
378_L381_G0.6401.00
401_V409_S0.6401.00
177_E180_Q0.6401.00
385_T391_I0.6391.00
389_M392_H0.6381.00
359_I367_E0.6381.00
409_S412_M0.6381.00
350_V353_E0.6371.00
406_K409_S0.6371.00
416_L420_H0.6371.00
327_S330_I0.6351.00
403_L408_I0.6341.00
40_T172_A0.6331.00
36_A168_L0.6321.00
69_M110_Y0.6311.00
149_R156_G0.6301.00
280_L283_I0.6291.00
402_E410_Y0.6281.00
387_A391_I0.6241.00
202_N205_L0.6221.00
363_E368_R0.6211.00
97_Q101_E0.6211.00
381_G389_M0.6201.00
417_E423_S0.6201.00
416_L426_L0.6191.00
397_G402_E0.6181.00
414_L417_E0.6171.00
388_R391_I0.6171.00
354_E358_V0.6151.00
180_Q183_M0.6141.00
370_E380_Y0.6141.00
278_N297_D0.6111.00
356_A362_L0.6111.00
210_A215_E0.6111.00
298_I320_A0.6101.00
172_A318_G0.6081.00
68_L71_D0.6071.00
411_R421_R0.6051.00
381_G394_F0.6021.00
60_L133_F0.6021.00
94_Q97_Q0.6021.00
357_D362_L0.6001.00
411_R417_E0.5991.00
409_S413_E0.5981.00
156_G159_R0.5981.00
357_D360_R0.5981.00
416_L419_M0.5961.00
157_Q161_K0.5951.00
358_V367_E0.5931.00
372_R375_D0.5931.00
397_G404_M0.5921.00
200_R207_V0.5921.00
135_I142_S0.5901.00
65_L291_M0.5891.00
56_D129_P0.5891.00
303_H307_P0.5831.00
115_A118_S0.5831.00
88_N91_L0.5821.00
361_V368_R0.5811.00
397_G419_M0.5801.00
259_Y263_L0.5801.00
224_V231_G0.5801.00
370_E375_D0.5791.00
380_Y387_A0.5791.00
369_D373_L0.5761.00
357_D365_T0.5761.00
381_G386_Q0.5751.00
260_H263_L0.5751.00
378_L384_E0.5751.00
266_G270_L0.5751.00
401_V407_E0.5741.00
411_R416_L0.5741.00
352_A362_L0.5731.00
370_E374_R0.5721.00
48_Y63_S0.5721.00
337_D340_L0.5711.00
62_V144_W0.5711.00
370_E379_Q0.5701.00
408_I416_L0.5691.00
17_F50_L0.5681.00
72_Q76_L0.5651.00
415_K422_V0.5641.00
347_M351_T0.5641.00
211_A214_A0.5631.00
385_T393_L0.5631.00
400_S412_M0.5611.00
25_I29_L0.5601.00
258_F263_L0.5601.00
101_E157_Q0.5601.00
386_Q391_I0.5601.00
399_T406_K0.5591.00
271_I275_F0.5591.00
412_M423_S0.5591.00
204_A326_P0.5581.00
71_D79_R0.5581.00
214_A217_I0.5571.00
402_E409_S0.5571.00
290_G312_A0.5561.00
420_H426_L0.5551.00
413_E423_S0.5551.00
176_K311_E0.5541.00
404_M413_E0.5531.00
385_T394_F0.5531.00
399_T405_K0.5531.00
384_E390_M0.5521.00
132_L168_L0.5521.00
404_M414_L0.5491.00
337_D341_Q0.5491.00
410_Y415_K0.5481.00
415_K421_R0.5481.00
369_D377_L0.5471.00
27_S32_K0.5471.00
258_F271_I0.5471.00
220_V223_L0.5430.99
201_P205_L0.5410.99
411_R422_V0.5390.99
401_V417_E0.5380.99
268_R272_Q0.5360.99
96_R100_L0.5350.99
401_V416_L0.5350.99
401_V406_K0.5340.99
99_V102_H0.5330.99
407_E417_E0.5330.99
286_T316_E0.5320.99
291_M315_Q0.5320.99
213_T218_D0.5300.99
171_T174_A0.5300.99
398_K401_V0.5290.99
410_Y417_E0.5280.99
387_A390_M0.5280.99
398_K404_M0.5270.99
410_Y416_L0.5260.99
374_R391_I0.5260.99
397_G413_E0.5250.99
416_L422_V0.5250.99
352_A357_D0.5250.99
257_D283_I0.5250.99
375_D381_G0.5240.99
198_V201_P0.5230.99
221_I254_S0.5230.99
29_L55_L0.5230.99
336_G339_E0.5220.99
35_I182_V0.5220.99
27_S190_H0.5220.99
154_K158_L0.5220.99
134_V170_L0.5200.99
62_V141_I0.5200.99
399_T404_M0.5200.99
343_Q346_Q0.5190.99
401_V414_L0.5190.99
407_E413_E0.5180.99
236_P305_H0.5180.99
230_P299_R0.5170.99
374_R385_T0.5160.99
176_K180_Q0.5160.99
287_N312_A0.5150.99
269_I272_Q0.5150.99
385_T389_M0.5140.99
117_Q157_Q0.5140.99
342_E346_Q0.5130.99
230_P275_F0.5130.99
217_I252_T0.5130.99
20_G38_L0.5130.99
233_V302_I0.5130.99
404_M409_S0.5110.99
406_K412_M0.5080.99
377_L390_M0.5080.99
384_E391_I0.5080.99
400_S403_L0.5070.99
403_L410_Y0.5050.99
415_K420_H0.5040.99
411_R425_L0.5040.99
395_M398_K0.5020.99
178_T185_L0.5010.99
382_V388_R0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pxaA 1 0.7198 100 0.335 Contact Map
2db3A 1 0.7117 100 0.34 Contact Map
4w7sA 2 0.756 100 0.351 Contact Map
2v1xA 1 0.9335 100 0.352 Contact Map
1oywA 1 0.8669 100 0.355 Contact Map
4q48A 1 0.7762 100 0.355 Contact Map
4ljyA 1 0.744 100 0.355 Contact Map
4nhoA 1 0.7016 100 0.357 Contact Map
3mwyW 2 0.8105 100 0.358 Contact Map
4d25A 1 0.7117 100 0.363 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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