GREMLIN Database
FMNP - Riboflavin transporter FmnP
UniProt: P50726 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 190 (176)
Sequences: 901 (732)
Seq/√Len: 55.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_A57_V8.5801.00
59_A83_F4.6491.00
46_I94_A3.6131.00
87_T92_P3.0751.00
88_L92_P2.8131.00
96_L112_L2.5861.00
58_E86_G2.5621.00
46_I54_G2.4831.00
19_L41_P2.4741.00
117_M163_G2.3031.00
92_P116_A2.2981.00
122_S156_L2.2971.00
85_A121_M2.2551.00
23_N34_K2.2431.00
27_P30_P2.2121.00
110_L167_T2.1951.00
114_T167_T2.1551.00
81_A129_I2.1141.00
150_A154_G2.1061.00
12_L45_A2.0381.00
8_V49_Y1.9651.00
101_N105_G1.8440.99
88_L120_L1.8280.99
33_L155_I1.8260.99
118_T156_L1.7120.99
88_L116_A1.6850.99
42_A58_E1.6710.99
55_I83_F1.6700.99
17_F64_L1.6410.99
23_N65_Q1.6210.98
42_A57_V1.6150.98
17_F68_I1.5510.98
13_S60_I1.5270.98
44_I177_L1.5150.98
106_L174_F1.5130.98
178_K182_E1.5120.98
137_L140_P1.5050.98
84_I124_L1.4980.97
100_L104_K1.4980.97
129_I133_Y1.4770.97
98_K101_N1.4770.97
100_L105_G1.4650.97
5_K177_L1.4530.97
9_V53_A1.4280.97
175_I178_K1.4270.97
130_L151_V1.4150.96
122_S152_V1.3780.96
152_V156_L1.3700.96
107_A111_L1.3440.95
81_A124_L1.3390.95
3_V7_V1.3190.95
55_I87_T1.3150.95
92_P113_G1.3070.94
11_M169_V1.2980.94
52_L55_I1.2590.93
47_L106_L1.2560.93
34_K65_Q1.2520.93
115_A119_I1.2240.92
16_A19_L1.2190.92
106_L175_I1.1930.91
119_I123_I1.1810.91
91_L95_F1.1780.91
132_A135_W1.1520.90
104_K108_V1.1490.89
26_F161_I1.1320.89
65_Q79_Q1.1230.88
109_S113_G1.0970.87
102_S175_I1.0910.87
124_L129_I1.0800.86
41_P54_G1.0700.86
13_S20_M1.0410.84
33_L154_G1.0380.84
49_Y164_I1.0340.84
114_T118_T1.0210.83
174_F178_K1.0100.82
122_S155_I1.0090.82
155_I159_N0.9930.81
66_Y69_Q0.9880.81
146_A149_T0.9830.81
44_I63_V0.9750.80
31_D119_I0.9730.80
114_T164_I0.9660.79
4_K8_V0.9640.79
11_M15_I0.9630.79
114_T163_G0.9600.79
121_M151_V0.9580.79
41_P82_N0.9570.79
122_S151_V0.9550.79
4_K10_S0.9530.79
134_T141_A0.9280.77
50_G120_L0.9260.77
47_L93_T0.9250.76
89_F94_A0.9190.76
66_Y76_P0.9110.75
107_A171_S0.9050.75
145_S149_T0.9000.74
6_L10_S0.8970.74
108_V177_L0.8960.74
54_G60_I0.8960.74
138_H141_A0.8880.73
82_N89_F0.8860.73
66_Y71_S0.8750.72
9_V57_V0.8750.72
24_F37_F0.8710.72
97_F106_L0.8680.72
6_L172_L0.8590.71
118_T160_M0.8470.70
130_L159_N0.8450.70
71_S79_Q0.8390.69
38_S65_Q0.8350.69
111_L127_V0.8350.69
96_L109_S0.8310.68
89_F167_T0.8270.68
30_P154_G0.8180.67
147_L150_A0.8110.67
103_A106_L0.8110.67
17_F20_M0.8100.66
21_L65_Q0.8100.66
42_A62_N0.8080.66
9_V60_I0.8070.66
35_I165_V0.8040.66
20_M82_N0.7990.65
33_L130_L0.7980.65
38_S42_A0.7960.65
46_I58_E0.7850.64
48_I182_E0.7810.64
65_Q76_P0.7710.63
47_L103_A0.7700.62
36_D162_K0.7700.62
113_G117_M0.7670.62
21_L70_G0.7630.62
42_A86_G0.7620.62
20_M61_K0.7620.62
62_N82_N0.7590.61
32_Y89_F0.7530.61
106_L170_F0.7510.61
39_D166_I0.7460.60
65_Q69_Q0.7450.60
122_S148_K0.7440.60
118_T154_G0.7430.60
33_L150_A0.7400.59
43_I89_F0.7300.58
150_A159_N0.7230.58
30_P157_P0.7160.57
39_D42_A0.7150.57
61_K82_N0.7150.57
56_A59_A0.7110.56
25_P53_A0.7060.56
136_F146_A0.7060.56
146_A150_A0.7060.56
83_F87_T0.7030.55
55_I91_L0.7020.55
124_L128_L0.7000.55
39_D162_K0.6970.55
173_I176_K0.6950.55
42_A90_I0.6950.55
141_A144_D0.6930.54
39_D86_G0.6920.54
40_V169_V0.6910.54
95_F98_K0.6850.54
23_N38_S0.6840.53
59_A148_K0.6830.53
43_I170_F0.6820.53
96_L181_I0.6780.53
46_I90_I0.6750.52
33_L159_N0.6640.51
47_L108_V0.6630.51
32_Y150_A0.6630.51
62_N86_G0.6600.51
93_T106_L0.6600.51
60_I87_T0.6570.51
33_L81_A0.6560.50
81_A130_L0.6540.50
39_D109_S0.6530.50
135_W153_A0.6530.50
134_T147_L0.6530.50
132_A139_S0.6460.49
12_L49_Y0.6450.49
3_V69_Q0.6450.49
67_I138_H0.6430.49
100_L108_V0.6400.49
20_M38_S0.6370.48
42_A45_A0.6330.48
139_S144_D0.6330.48
88_L91_L0.6270.47
160_M171_S0.6250.47
174_F181_I0.6240.47
84_I129_I0.6240.47
9_V56_A0.6230.47
154_G159_N0.6210.47
5_K49_Y0.6190.46
3_V8_V0.6180.46
27_P161_I0.6180.46
22_L111_L0.6150.46
5_K9_V0.6140.46
76_P121_M0.6130.46
134_T137_L0.6130.46
20_M79_Q0.6120.46
55_I59_A0.6110.46
80_V84_I0.6100.46
164_I167_T0.6080.45
29_L33_L0.6070.45
8_V12_L0.6060.45
83_F86_G0.6050.45
121_M132_A0.6040.45
74_G137_L0.6020.45
139_S147_L0.6010.45
111_L115_A0.6010.45
103_A171_S0.6010.45
97_F174_F0.6000.44
176_K179_P0.5960.44
171_S175_I0.5960.44
13_S62_N0.5960.44
92_P112_L0.5950.44
112_L116_A0.5950.44
58_E130_L0.5930.44
150_A155_I0.5900.43
134_T139_S0.5880.43
58_E82_N0.5860.43
48_I183_Q0.5810.42
27_P169_V0.5810.42
47_L172_L0.5810.42
112_L165_V0.5790.42
129_I155_I0.5770.42
52_L59_A0.5750.42
137_L144_D0.5750.42
81_A85_A0.5730.42
14_S148_K0.5670.41
14_S63_V0.5650.41
85_A170_F0.5640.41
154_G161_I0.5640.41
81_A137_L0.5630.41
110_L159_N0.5610.40
151_V159_N0.5550.40
14_S24_F0.5550.40
44_I48_I0.5540.40
93_T97_F0.5510.39
130_L155_I0.5490.39
93_T170_F0.5430.38
123_I159_N0.5420.38
77_V124_L0.5420.38
61_K150_A0.5380.38
52_L56_A0.5380.38
88_L121_M0.5370.38
11_M160_M0.5330.37
37_F69_Q0.5310.37
30_P62_N0.5290.37
150_A160_M0.5280.37
101_N182_E0.5230.36
103_A173_I0.5200.36
97_F170_F0.5170.36
46_I55_I0.5150.36
104_K173_I0.5130.35
13_S19_L0.5100.35
18_V124_L0.5100.35
41_P64_L0.5090.35
62_N83_F0.5060.35
118_T163_G0.5050.35
130_L134_T0.5050.35
54_G58_E0.5040.35
4_K179_P0.5030.35
49_Y116_A0.5030.35
18_V21_L0.5020.34
84_I107_A0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3p5nA 2 0.8842 100 0.546 Contact Map
3rlbA 1 0.9211 100 0.567 Contact Map
4rfsS 1 0.9105 99.9 0.602 Contact Map
4tkrA 2 0.9053 99.9 0.611 Contact Map
4hzuS 1 0.8368 99.8 0.676 Contact Map
4huqS 1 0.8579 99.8 0.691 Contact Map
4z7fA 2 0.8737 99.8 0.696 Contact Map
4dveA 3 0.9 99.7 0.712 Contact Map
4m5bA 1 0.8789 96.2 0.892 Contact Map
2jwaA 2 0.2211 6.5 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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