GREMLIN Database
RIR2 - Ribonucleoside-diphosphate reductase subunit beta
UniProt: P50621 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 329 (299)
Sequences: 2188 (790)
Seq/√Len: 45.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
133_K241_E5.7951.00
244_E257_K4.8381.00
49_K52_Q4.2311.00
265_N278_E4.0151.00
240_L261_R3.9151.00
35_I104_S3.8871.00
132_Q136_Q3.5471.00
155_K227_F3.5201.00
56_M117_T3.4961.00
53_D57_K3.3681.00
48_G51_E2.9941.00
233_N276_Y2.9631.00
229_I276_Y2.9401.00
162_Y232_L2.8791.00
236_Y277_F2.8361.00
229_I268_L2.5411.00
158_V228_A2.4931.00
229_I274_D2.4211.00
240_L257_K2.4081.00
157_M208_L2.3951.00
164_E198_E2.3371.00
229_I273_F2.3041.00
66_D105_Y2.2491.00
236_Y264_A2.2181.00
230_D234_Q2.1751.00
226_E230_D2.1121.00
44_W52_Q2.0460.99
97_E164_E2.0380.99
129_K133_K2.0120.99
43_T46_Y1.9910.99
233_N277_F1.9710.99
158_V271_L1.9490.99
37_L107_N1.9350.99
69_Q142_Y1.9020.99
261_R279_E1.8690.99
209_A216_Q1.8660.99
228_A273_F1.8570.99
41_L45_K1.8480.99
26_V31_L1.8360.99
10_W88_A1.8360.99
56_M113_A1.8350.99
198_E201_H1.8220.99
222_A225_R1.8200.99
97_E198_E1.8130.99
229_I233_N1.8010.99
222_A226_E1.7850.98
91_N94_A1.7580.98
237_E241_E1.7480.98
104_S190_I1.7180.98
178_F184_L1.6660.98
32_P104_S1.6660.98
144_A155_K1.6450.97
25_N96_M1.6450.97
134_K239_E1.6410.97
50_N249_Q1.6300.97
89_V204_Y1.6090.97
17_F211_E1.5890.97
23_N33_E1.5710.97
193_L196_R1.5440.96
91_N99_A1.5430.96
151_I227_F1.5210.96
227_F230_D1.5150.96
244_E254_H1.4970.95
15_D83_G1.4940.95
44_W56_M1.4920.95
172_F307_Y1.4820.95
136_Q140_G1.4760.95
269_M275_P1.4660.95
101_H201_H1.4400.94
154_F209_A1.4200.94
209_A273_F1.4130.94
25_N93_M1.4050.94
168_F194_I1.3930.93
257_K261_R1.3690.93
92_F96_M1.3680.93
255_D258_K1.3650.93
168_F198_E1.3640.93
149_D152_S1.3420.92
133_K234_Q1.3340.92
92_F95_M1.3240.91
140_G234_Q1.3110.91
26_V32_P1.3090.91
51_E183_K1.3080.91
189_E305_N1.2960.91
166_F232_L1.2840.90
297_H302_M1.2540.89
32_P35_I1.2520.89
225_R274_D1.2410.88
168_F172_F1.2390.88
298_D301_S1.2380.88
233_N237_E1.2210.88
70_G99_A1.2180.88
52_Q56_M1.2120.87
108_I187_S1.2120.87
244_E248_D1.2110.87
45_K114_P1.2010.87
47_L184_L1.1890.86
287_L290_L1.1880.86
117_T120_E1.1810.86
21_F87_K1.1720.85
241_E244_E1.1690.85
23_N103_K1.1600.85
303_K309_K1.1580.85
218_E274_D1.1410.84
62_L69_Q1.1390.84
134_K242_Y1.1390.84
136_Q274_D1.1380.84
173_Y243_T1.1350.84
213_Y220_K1.1310.83
97_E168_F1.1260.83
173_Y287_L1.1250.83
55_Y187_S1.1240.83
50_N248_D1.1210.83
7_A12_K1.1190.83
16_D20_M1.1130.82
23_N31_L1.1110.82
41_L111_T1.1000.82
54_T246_L1.0820.80
210_Q213_Y1.0700.80
301_S304_G1.0680.80
61_G242_Y1.0640.79
87_K91_N1.0500.78
51_E250_V1.0440.78
48_G257_K1.0350.77
171_G194_I1.0350.77
240_L244_E1.0270.77
32_P107_N1.0230.77
17_F20_M1.0220.77
172_F198_E1.0180.76
151_I223_E1.0150.76
144_A151_I1.0150.76
237_E240_L1.0110.76
201_H307_Y1.0100.76
35_I193_L1.0060.75
258_K279_E1.0030.75
294_T306_G0.9980.75
19_Q23_N0.9970.75
180_G286_V0.9930.74
172_F201_H0.9910.74
212_I215_K0.9890.74
225_R229_I0.9850.74
213_Y225_R0.9730.73
42_L45_K0.9730.73
211_E215_K0.9710.73
176_L195_L0.9680.73
202_G267_A0.9670.72
230_D237_E0.9610.72
35_I196_R0.9530.71
17_F207_L0.9520.71
39_G43_T0.9490.71
206_G270_N0.9480.71
101_H197_D0.9440.71
136_Q230_D0.9430.71
248_D255_D0.9360.70
152_S155_K0.9350.70
179_Y188_G0.9280.69
236_Y261_R0.9250.69
81_V153_L0.9210.69
225_R273_F0.9140.68
29_F92_F0.9130.68
138_I163_L0.9110.68
49_K255_D0.9090.68
22_Y103_K0.9060.67
202_G266_K0.9050.67
66_D187_S0.9040.67
263_N267_A0.9020.67
261_R277_F0.8930.66
88_A91_N0.8900.66
134_K238_N0.8890.66
74_M79_E0.8870.66
26_V100_V0.8850.66
262_Y266_K0.8790.65
45_K50_N0.8750.65
66_D201_H0.8710.64
236_Y240_L0.8690.64
101_H307_Y0.8670.64
18_T211_E0.8650.64
54_T250_V0.8640.64
160_S205_V0.8630.64
32_P100_V0.8620.64
285_I288_N0.8610.63
36_A39_G0.8580.63
151_I221_K0.8580.63
204_Y208_L0.8550.63
227_F231_L0.8530.63
170_S260_I0.8500.62
18_T207_L0.8490.62
88_A99_A0.8490.62
308_K313_E0.8480.62
248_D254_H0.8460.62
123_E127_Q0.8460.62
166_F170_S0.8400.62
136_Q276_Y0.8380.61
262_Y284_P0.8370.61
15_D211_E0.8370.61
66_D307_Y0.8350.61
95_M100_V0.8270.60
248_D253_S0.8270.60
295_K306_G0.8230.60
106_S110_M0.8220.60
164_E172_F0.8160.59
43_T178_F0.8100.59
164_E168_F0.8090.59
101_H172_F0.8060.58
165_S267_A0.8040.58
80_H156_A0.8040.58
153_L157_M0.8040.58
283_N286_V0.8020.58
204_Y207_L0.8010.58
76_I79_E0.7990.58
286_V290_L0.7960.57
229_I275_P0.7940.57
21_F203_V0.7920.57
7_A11_S0.7880.57
151_I224_L0.7870.56
19_Q103_K0.7830.56
45_K230_D0.7830.56
162_Y259_F0.7820.56
189_E193_L0.7800.56
97_E201_H0.7780.56
127_Q274_D0.7770.56
46_Y183_K0.7750.55
23_N27_K0.7720.55
37_L190_I0.7720.55
162_Y235_L0.7720.55
175_P191_I0.7690.55
202_G262_Y0.7690.55
265_N275_P0.7670.55
265_N279_E0.7660.54
164_E201_H0.7650.54
133_K137_M0.7610.54
107_N110_M0.7600.54
25_N204_Y0.7600.54
37_L186_Q0.7600.54
180_G189_E0.7560.53
173_Y255_D0.7550.53
268_L276_Y0.7540.53
298_D304_G0.7540.53
45_K120_E0.7540.53
197_D201_H0.7530.53
17_F32_P0.7510.53
93_M168_F0.7480.53
66_D197_D0.7470.53
198_E307_Y0.7460.53
18_T86_R0.7440.52
182_G305_N0.7410.52
192_N295_K0.7410.52
286_V289_G0.7390.52
134_K298_D0.7370.52
25_N28_Q0.7360.52
46_Y120_E0.7330.51
38_N41_L0.7290.51
122_F131_L0.7290.51
243_T260_I0.7280.51
101_H198_E0.7240.50
42_L241_E0.7230.50
100_V310_A0.7210.50
91_N227_F0.7200.50
19_Q22_Y0.7180.50
9_N12_K0.7130.49
144_A150_E0.7120.49
70_G94_A0.7120.49
14_E84_H0.7090.49
39_G42_L0.7080.49
261_R265_N0.7060.49
295_K302_M0.7040.48
214_N273_F0.7010.48
86_R208_L0.6920.47
105_Y201_H0.6920.47
207_L211_E0.6900.47
259_F299_F0.6890.47
168_F201_H0.6880.47
136_Q277_F0.6880.47
31_L100_V0.6880.47
155_K231_L0.6850.47
142_Y169_Y0.6850.47
130_Y245_D0.6840.46
299_F304_G0.6820.46
209_A271_L0.6810.46
297_H304_G0.6810.46
106_S309_K0.6790.46
308_K311_T0.6770.46
25_N89_V0.6760.46
49_K233_N0.6760.46
62_L171_G0.6760.46
74_M78_A0.6750.46
275_P278_E0.6720.45
81_V157_M0.6710.45
34_E303_K0.6710.45
42_L255_D0.6690.45
66_D262_Y0.6670.45
133_K238_N0.6670.45
274_D278_E0.6650.45
129_K274_D0.6640.44
25_N200_I0.6630.44
205_V260_I0.6620.44
179_Y192_N0.6580.44
52_Q117_T0.6580.44
66_D106_S0.6560.44
120_E244_E0.6550.44
194_I198_E0.6530.43
60_A199_A0.6530.43
213_Y216_Q0.6510.43
162_Y228_A0.6500.43
152_S240_L0.6500.43
211_E218_E0.6500.43
66_D168_F0.6480.43
179_Y184_L0.6440.43
53_D58_V0.6430.42
257_K260_I0.6430.42
69_Q163_L0.6430.42
46_Y49_K0.6390.42
55_Y62_L0.6350.42
54_T174_Y0.6340.42
60_A121_V0.6310.41
49_K218_E0.6300.41
141_L227_F0.6290.41
65_L69_Q0.6280.41
215_K218_E0.6260.41
254_H257_K0.6250.41
46_Y274_D0.6210.40
127_Q136_Q0.6190.40
173_Y260_I0.6190.40
75_P78_A0.6180.40
137_M141_L0.6160.40
293_K308_K0.6150.40
243_T257_K0.6150.40
30_W40_D0.6130.40
105_Y172_F0.6120.40
216_Q220_K0.6110.39
165_S186_Q0.6100.39
244_E261_R0.6080.39
57_K246_L0.6070.39
108_I169_Y0.6050.39
289_G294_T0.6040.39
289_G292_T0.6030.39
95_M99_A0.6030.39
214_N230_D0.6000.38
295_K305_N0.5990.38
128_N245_D0.5970.38
137_M234_Q0.5970.38
237_E244_E0.5960.38
25_N92_F0.5950.38
49_K244_E0.5940.38
87_K304_G0.5940.38
160_S202_G0.5930.38
66_D205_V0.5930.38
250_V258_K0.5890.37
120_E127_Q0.5870.37
49_K228_A0.5850.37
232_L264_A0.5830.37
259_F267_A0.5830.37
29_F65_L0.5820.37
130_Y246_L0.5800.37
199_A203_V0.5790.36
57_K260_I0.5780.36
49_K274_D0.5770.36
128_N162_Y0.5760.36
160_S170_S0.5750.36
14_E100_V0.5750.36
269_M278_E0.5740.36
59_L187_S0.5740.36
21_F204_Y0.5740.36
236_Y260_I0.5730.36
225_R230_D0.5720.36
66_D172_F0.5720.36
105_Y202_G0.5700.36
174_Y178_F0.5690.36
166_F264_A0.5650.35
26_V92_F0.5650.35
226_E278_E0.5640.35
109_F166_F0.5630.35
20_M234_Q0.5630.35
105_Y198_E0.5620.35
63_T247_Y0.5600.35
30_W101_H0.5580.35
122_F125_V0.5560.34
214_N255_D0.5560.34
63_T109_F0.5550.34
251_G283_N0.5550.34
265_N268_L0.5550.34
64_L193_L0.5550.34
218_E221_K0.5530.34
206_G271_L0.5510.34
129_K253_S0.5500.34
123_E254_H0.5480.34
36_A186_Q0.5460.34
16_D45_K0.5450.33
52_Q254_H0.5440.33
62_L298_D0.5440.33
171_G175_P0.5440.33
273_F276_Y0.5430.33
163_L175_P0.5430.33
16_D78_A0.5410.33
66_D101_H0.5380.33
221_K224_L0.5380.33
233_N280_E0.5360.33
143_K255_D0.5360.33
168_F307_Y0.5350.33
310_A314_P0.5330.32
180_G183_K0.5330.32
251_G254_H0.5320.32
184_L190_I0.5320.32
69_Q73_G0.5290.32
155_K224_L0.5280.32
100_V246_L0.5280.32
116_E120_E0.5280.32
46_Y178_F0.5280.32
6_D14_E0.5280.32
86_R204_Y0.5270.32
6_D126_K0.5270.32
29_F100_V0.5270.32
24_Q56_M0.5250.32
97_E172_F0.5250.32
165_S202_G0.5240.32
239_E242_Y0.5230.32
252_L256_V0.5220.31
12_K85_Q0.5220.31
270_N301_S0.5210.31
101_H168_F0.5210.31
133_K136_Q0.5190.31
92_F100_V0.5190.31
59_L63_T0.5190.31
155_K223_E0.5170.31
151_I217_T0.5160.31
164_E194_I0.5160.31
288_N291_N0.5140.31
22_Y32_P0.5140.31
15_D18_T0.5120.31
172_F197_D0.5120.31
134_K168_F0.5120.31
97_E105_Y0.5120.31
183_K233_N0.5100.30
129_K237_E0.5100.30
240_L253_S0.5100.30
55_Y184_L0.5090.30
173_Y256_V0.5080.30
226_E229_I0.5070.30
197_D284_P0.5070.30
159_A231_L0.5050.30
68_E134_K0.5050.30
289_G308_K0.5040.30
212_I216_Q0.5020.30
68_E108_I0.5020.30
53_D249_Q0.5010.30
299_F307_Y0.5010.30
47_L52_Q0.5000.30
35_I186_Q0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4dr0A 2 0.8815 100 0.09 Contact Map
4n83A 4 0.8602 100 0.113 Contact Map
4bmoA 2 0.8754 100 0.114 Contact Map
3n37A 2 0.8571 100 0.115 Contact Map
3dhzA 2 0.8632 100 0.123 Contact Map
1jk0A 1 0.8389 100 0.131 Contact Map
1h0oA 2 0.8328 100 0.138 Contact Map
1mxrA 2 0.8723 100 0.139 Contact Map
1jk0B 1 0.7508 100 0.141 Contact Map
2p1iA 2 0.769 100 0.15 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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