GREMLIN Database
YMAB - Uncharacterized protein YmaB
UniProt: P50619 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 206 (192)
Sequences: 131 (103)
Seq/√Len: 7.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
191_Y203_D3.3520.91
69_K160_Q3.2340.89
75_F177_G3.0760.87
60_K149_G3.0590.86
67_V90_N2.9760.85
141_I179_W2.8350.82
60_K142_N2.6890.78
77_Y93_S2.6640.77
10_V171_E2.5740.75
83_G89_H2.3860.69
26_G143_D2.3750.68
24_F144_D2.3390.67
28_Y35_A2.1490.60
93_S151_V2.0860.58
13_R142_N2.0320.56
136_V160_Q2.0160.55
48_M53_A2.0010.55
80_L113_L1.9900.54
83_G141_I1.9800.54
173_E185_L1.9780.54
94_L186_K1.8530.49
143_D149_G1.8250.48
78_E176_A1.8110.47
77_Y149_G1.7940.46
10_V53_A1.7850.46
113_L167_V1.7550.45
54_E63_I1.7480.45
194_L202_V1.7420.44
151_V154_G1.7370.44
61_Q151_V1.6480.41
96_F155_I1.6080.39
6_E101_N1.5870.38
5_D100_M1.5690.38
62_P125_L1.5680.38
91_K146_N1.5530.37
61_Q95_G1.5330.36
62_P200_F1.5170.36
61_Q93_S1.5090.36
67_V156_L1.5080.35
105_G110_A1.5070.35
64_P75_F1.5010.35
161_L185_L1.4770.34
13_R83_G1.4440.33
60_K143_D1.4420.33
62_P156_L1.4390.33
64_P85_E1.4390.33
64_P194_L1.4360.33
60_K144_D1.4250.33
12_P16_V1.4130.32
104_E116_N1.4050.32
117_T177_G1.4010.32
48_M56_D1.3940.31
72_D181_K1.3920.31
82_G200_F1.3840.31
85_E154_G1.3830.31
155_I185_L1.3810.31
113_L157_S1.3750.31
46_R179_W1.3490.30
20_E24_F1.3460.30
87_R154_G1.3390.30
7_M101_N1.3250.29
76_L179_W1.3210.29
60_K201_V1.3100.29
70_R73_E1.3080.29
80_L89_H1.2880.28
58_R103_I1.2860.28
83_G149_G1.2630.27
16_V167_V1.2410.26
13_R179_W1.2300.26
196_T199_Q1.2300.26
65_Y95_G1.2290.26
93_S185_L1.2250.26
24_F142_N1.2080.25
50_R148_V1.2040.25
82_G173_E1.1970.25
13_R60_K1.1820.25
24_F60_K1.1810.25
10_V26_G1.1750.25
50_R54_E1.1710.24
114_K127_I1.1680.24
91_K131_D1.1600.24
55_E175_I1.1470.24
155_I182_V1.1410.24
26_G142_N1.0840.22
66_V184_E1.0820.22
181_K184_E1.0680.22
169_V177_G1.0640.21
58_R73_E1.0550.21
85_E151_V1.0450.21
109_F112_V1.0320.21
53_A194_L1.0270.20
60_K96_F1.0270.20
14_D33_R1.0230.20
100_M116_N1.0220.20
130_E180_M1.0220.20
87_R151_V1.0050.20
84_G143_D1.0050.20
50_R87_R0.9950.20
174_Q177_G0.9830.19
44_A162_K0.9630.19
28_Y137_T0.9610.19
13_R17_F0.9540.19
40_Q146_N0.9460.18
83_G113_L0.9390.18
85_E93_S0.9340.18
67_V111_E0.9300.18
117_T141_I0.9280.18
87_R93_S0.9270.18
40_Q136_V0.9270.18
7_M14_D0.9220.18
28_Y145_E0.9180.18
7_M86_S0.9180.18
7_M23_T0.9160.18
103_I187_Q0.9080.18
32_S58_R0.8990.17
72_D130_E0.8860.17
8_I106_A0.8800.17
125_L193_R0.8790.17
49_R52_D0.8760.17
57_P144_D0.8750.17
64_P177_G0.8710.17
64_P87_R0.8650.17
65_Y154_G0.8560.16
54_E148_V0.8550.16
73_E111_E0.8530.16
5_D8_I0.8500.16
91_K184_E0.8350.16
5_D20_E0.8340.16
12_P57_P0.8290.16
27_V53_A0.8280.16
94_L202_V0.8250.16
32_S155_I0.8220.16
67_V141_I0.8070.15
81_A122_E0.8070.15
185_L194_L0.8060.15
71_E106_A0.8010.15
72_D182_V0.7990.15
27_V125_L0.7880.15
13_R80_L0.7820.15
101_N142_N0.7820.15
72_D105_G0.7810.15
141_I148_V0.7650.15
20_E55_E0.7630.14
69_K158_A0.7610.14
125_L161_L0.7560.14
185_L202_V0.7550.14
178_K182_V0.7530.14
27_V150_K0.7490.14
45_Y149_G0.7480.14
26_G84_G0.7430.14
62_P161_L0.7420.14
50_R139_G0.7390.14
93_S143_D0.7390.14
117_T174_Q0.7380.14
86_S191_Y0.7380.14
94_L130_E0.7330.14
35_A112_V0.7290.14
28_Y34_V0.7230.14
52_D127_I0.7210.14
89_H139_G0.7210.14
121_L139_G0.7150.14
41_I69_K0.7130.14
93_S149_G0.7130.14
68_I121_L0.7120.14
16_V38_M0.6950.13
6_E142_N0.6940.13
97_G123_E0.6910.13
97_G124_E0.6910.13
97_G152_H0.6910.13
97_G195_E0.6910.13
97_G197_W0.6910.13
98_G119_R0.6910.13
97_G120_E0.6910.13
97_G119_R0.6910.13
120_E124_E0.6910.13
120_E123_E0.6910.13
99_H152_H0.6910.13
119_R197_W0.6910.13
120_E152_H0.6910.13
119_R195_E0.6910.13
99_H197_W0.6910.13
120_E195_E0.6910.13
98_G120_E0.6910.13
119_R152_H0.6910.13
120_E197_W0.6910.13
119_R123_E0.6910.13
152_H195_E0.6910.13
98_G197_W0.6910.13
99_H119_R0.6910.13
99_H120_E0.6910.13
99_H123_E0.6910.13
99_H124_E0.6910.13
99_H195_E0.6910.13
124_E197_W0.6910.13
124_E195_E0.6910.13
124_E152_H0.6910.13
98_G123_E0.6910.13
123_E152_H0.6910.13
98_G124_E0.6910.13
123_E195_E0.6910.13
123_E197_W0.6910.13
98_G152_H0.6910.13
119_R124_E0.6910.13
98_G195_E0.6910.13
152_H197_W0.6910.13
88_L120_E0.6910.13
88_L195_E0.6910.13
88_L97_G0.6910.13
88_L98_G0.6910.13
88_L99_H0.6910.13
88_L119_R0.6910.13
88_L123_E0.6910.13
88_L124_E0.6910.13
88_L152_H0.6910.13
88_L197_W0.6910.13
28_Y111_E0.6880.13
7_M184_E0.6880.13
160_Q199_Q0.6880.13
136_V187_Q0.6850.13
114_K163_P0.6830.13
84_G171_E0.6830.13
49_R116_N0.6820.13
140_L157_S0.6820.13
110_A150_K0.6810.13
5_D52_D0.6770.13
80_L159_L0.6760.13
50_R63_I0.6750.13
94_L182_V0.6720.13
53_A109_F0.6680.13
121_L159_L0.6660.13
83_G175_I0.6640.13
12_P24_F0.6610.13
87_R148_V0.6590.13
77_Y151_V0.6560.13
174_Q194_L0.6410.12
162_K166_Q0.6360.12
105_G167_V0.6280.12
49_R80_L0.6270.12
60_K93_S0.6260.12
69_K108_S0.6260.12
54_E87_R0.6240.12
68_I166_Q0.6210.12
61_Q77_Y0.6160.12
131_D166_Q0.6150.12
13_R51_G0.6130.12
92_L125_L0.6130.12
52_D200_F0.6120.12
125_L186_K0.6080.12
76_L157_S0.6070.12
22_L34_V0.6010.12
25_Q28_Y0.5990.12
8_I100_M0.5960.12
25_Q48_M0.5920.11
35_A58_R0.5830.11
86_S122_E0.5760.11
42_E64_P0.5750.11
67_V185_L0.5740.11
13_R149_G0.5720.11
73_E138_L0.5700.11
16_V146_N0.5690.11
13_R24_F0.5680.11
95_G151_V0.5670.11
78_E142_N0.5580.11
20_E49_R0.5570.11
92_L193_R0.5560.11
10_V125_L0.5520.11
56_D63_I0.5460.11
80_L175_I0.5430.11
27_V140_L0.5420.11
59_F72_D0.5410.11
43_A74_V0.5380.11
80_L157_S0.5350.11
58_R180_M0.5300.10
73_E183_S0.5300.10
114_K118_D0.5270.10
141_I172_K0.5230.10
158_A201_V0.5210.10
127_I131_D0.5180.10
34_V62_P0.5150.10
146_N192_N0.5130.10
81_A91_K0.5130.10
62_P77_Y0.5110.10
45_Y169_V0.5110.10
38_M146_N0.5100.10
13_R48_M0.5090.10
68_I94_L0.5080.10
7_M49_R0.5010.10
101_N116_N0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3e57A 2 0.8689 100 0.608 Contact Map
1hztA 1 0.6553 98.9 0.845 Contact Map
1q27A 1 0.7961 98.8 0.853 Contact Map
2b0vA 2 0.6262 98.7 0.855 Contact Map
1sjyA 2 0.665 98.7 0.857 Contact Map
3f6aA 2 0.6165 98.7 0.859 Contact Map
2pnyA 1 0.8738 98.6 0.862 Contact Map
3dupA 2 0.9563 98.5 0.864 Contact Map
4kyxA 2 0.6165 98.5 0.865 Contact Map
4nfwA 6 0.6311 98.5 0.865 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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