GERKC - BACSU - GREMLIN Contacts

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GERKC - Spore germination protein KC

UniProt:	P49941	Sequences: MVRKCLLAVLMLLSVIVLPGCWDKRELTDLAIISAIGIDRTNDSNYVLHLQIINPGNVAGGLQGGGAGDRPPVSVYSIEGNNITEALRKASMKVSRRLYFAHTNLVVINEKLAKEEGLDFVLDNLDRDTEFRTTATFVVAHKTKAENIVKILTPIDKIPSNKVNKTLDFTEAQYGRVVKINIQDVLKTLAANTMAPVIPGYMMIGDDKKGVSMENTQATDPKAILQADGLAVFDKAGYLKYWLEDDESVGAVWLMNKIQHTFINADWGKTKDAVSLQVTHQDTKLVPKMRNGRPYIHVKVSVEGIIDAVKYPFQLSDPKVLAAIEKALNKELEKEISHTVKKIKKNKIDFIGFGDTIYRKYPEQWEKMKDTWDKEYLPELPIDVKAETYIRRTGLRNNPIKHQFKDD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	407 (361)
Sequences:	2208 (1899)
Seq/√Len:	100.0

BACSU - GERKC YFKR YNDF GERBC GERAC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
297_H	383_D	5.056	1.00
110_E	114_K	4.336	1.00
299_K	385_K	4.301	1.00
247_E	342_K	4.085	1.00
267_W	311_Y	3.881	1.00
333_E	337_S	3.569	1.00
47_V	146_E	3.536	1.00
40_R	116_E	3.518	1.00
107_V	140_A	3.097	1.00
110_E	142_K	2.990	1.00
144_K	147_N	2.983	1.00
200_G	242_W	2.814	1.00
329_N	388_T	2.800	1.00
301_S	387_E	2.793	1.00
117_G	237_G	2.784	1.00
276_L	328_L	2.770	1.00
296_I	353_F	2.646	1.00
333_E	386_A	2.511	1.00
146_E	150_K	2.433	1.00
296_I	380_L	2.428	1.00
300_V	336_I	2.378	1.00
50_L	90_A	2.359	1.00
231_A	239_L	2.346	1.00
239_L	242_W	2.330	1.00
344_K	376_Y	2.318	1.00
303_E	391_R	2.293	1.00
139_V	231_A	2.279	1.00
48_L	86_A	2.278	1.00
250_G	339_T	2.251	1.00
295_Y	381_P	2.240	1.00
347_K	378_P	2.235	1.00
45_N	79_E	2.187	1.00
49_H	145_A	2.177	1.00
295_Y	383_D	2.144	1.00
185_V	196_P	2.138	1.00
343_I	376_Y	2.080	1.00
230_L	248_S	2.056	1.00
340_V	382_I	2.019	1.00
123_D	127_R	2.011	1.00
343_I	351_I	2.009	1.00
113_A	139_V	1.974	1.00
371_T	374_K	1.931	1.00
108_I	121_V	1.900	1.00
137_F	185_V	1.890	1.00
47_V	79_E	1.885	1.00
343_I	350_F	1.877	1.00
288_K	297_H	1.854	1.00
35_A	160_S	1.833	1.00
354_G	372_W	1.831	1.00
39_D	145_A	1.825	1.00
322_A	325_E	1.814	1.00
298_V	353_F	1.809	1.00
297_H	385_K	1.797	1.00
38_I	112_L	1.792	1.00
138_V	201_Y	1.791	1.00
78_I	89_K	1.784	1.00
109_N	145_A	1.775	1.00
230_L	251_A	1.743	1.00
33_I	98_L	1.743	1.00
185_V	198_I	1.737	1.00
197_V	251_A	1.720	1.00
87_L	100_F	1.700	1.00
364_Q	368_M	1.679	1.00
41_T	79_E	1.679	1.00
88_R	277_Q	1.665	1.00
192_N	369_K	1.644	1.00
39_D	109_N	1.626	1.00
276_L	304_G	1.623	1.00
45_N	81_N	1.612	1.00
36_I	103_T	1.599	1.00
200_G	239_L	1.587	1.00
37_G	145_A	1.565	1.00
250_G	332_L	1.564	1.00
139_V	233_F	1.561	1.00
142_K	202_M	1.555	1.00
293_R	381_P	1.541	1.00
287_P	294_P	1.531	1.00
302_V	388_T	1.525	1.00
113_A	233_F	1.501	1.00
296_I	357_I	1.494	1.00
244_E	247_E	1.480	1.00
35_A	149_V	1.455	1.00
138_V	167_L	1.453	1.00
303_E	389_Y	1.448	1.00
299_K	387_E	1.443	1.00
47_V	77_S	1.437	1.00
336_I	384_V	1.431	1.00
324_I	390_I	1.431	1.00
285_L	296_I	1.427	1.00
195_A	348_I	1.423	1.00
331_E	334_K	1.420	1.00
109_N	112_L	1.411	1.00
289_M	294_P	1.398	1.00
36_I	125_L	1.391	1.00
147_N	150_K	1.383	0.99
241_Y	348_I	1.381	0.99
323_A	327_A	1.377	0.99
325_E	329_N	1.371	0.99
342_K	346_N	1.366	0.99
193_T	354_G	1.359	0.99
329_N	333_E	1.359	0.99
256_N	283_T	1.350	0.99
77_S	146_E	1.345	0.99
108_I	113_A	1.341	0.99
232_V	350_F	1.340	0.99
163_V	201_Y	1.339	0.99
331_E	335_E	1.324	0.99
133_T	183_Q	1.322	0.99
340_V	384_V	1.319	0.99
341_K	344_K	1.310	0.99
108_I	118_L	1.308	0.99
140_A	143_T	1.304	0.99
47_V	144_K	1.300	0.99
81_N	85_E	1.291	0.99
339_T	343_I	1.285	0.99
41_T	47_V	1.284	0.99
373_D	376_Y	1.275	0.99
326_K	329_N	1.267	0.99
80_G	86_A	1.261	0.99
11_M	15_V	1.249	0.99
104_N	164_N	1.248	0.99
195_A	373_D	1.227	0.99
30_L	99_Y	1.215	0.99
254_L	351_I	1.212	0.99
204_I	226_Q	1.211	0.99
344_K	372_W	1.211	0.99
151_I	203_M	1.207	0.99
283_T	300_V	1.196	0.98
317_D	320_V	1.187	0.98
284_K	299_K	1.185	0.98
287_P	360_K	1.180	0.98
84_T	277_Q	1.177	0.98
314_Q	317_D	1.172	0.98
84_T	88_R	1.168	0.98
18_L	21_C	1.165	0.98
250_G	343_I	1.163	0.98
80_G	85_E	1.163	0.98
202_M	228_D	1.161	0.98
46_Y	112_L	1.158	0.98
33_I	100_F	1.156	0.98
111_K	145_A	1.145	0.98
193_T	352_G	1.139	0.98
31_A	52_I	1.139	0.98
51_Q	159_P	1.127	0.98
49_H	75_V	1.125	0.98
357_I	364_Q	1.125	0.98
328_L	388_T	1.124	0.98
80_G	89_K	1.119	0.98
251_A	350_F	1.101	0.97
302_V	332_L	1.101	0.97
84_T	307_D	1.099	0.97
49_H	77_S	1.095	0.97
290_R	295_Y	1.091	0.97
107_V	138_V	1.082	0.97
175_G	258_I	1.081	0.97
254_L	298_V	1.079	0.97
304_G	328_L	1.076	0.97
34_S	53_I	1.072	0.97
140_A	148_I	1.070	0.97
14_S	17_V	1.066	0.97
372_W	376_Y	1.062	0.97
241_Y	346_N	1.060	0.97
38_I	83_I	1.060	0.97
84_T	124_N	1.058	0.97
103_T	131_F	1.058	0.97
126_D	186_L	1.057	0.97
321_L	325_E	1.054	0.97
327_A	330_K	1.053	0.97
357_I	361_Y	1.048	0.97
113_A	231_A	1.043	0.96
244_E	248_S	1.040	0.96
330_K	333_E	1.040	0.96
78_I	90_A	1.039	0.96
37_G	144_K	1.033	0.96
202_M	226_Q	1.030	0.96
73_V	159_P	1.023	0.96
286_V	297_H	1.023	0.96
366_E	369_K	1.018	0.96
127_R	394_G	1.013	0.96
274_V	324_I	1.013	0.96
254_L	336_I	1.011	0.96
93_K	224_I	1.010	0.96
106_V	135_A	1.009	0.96
355_D	358_Y	1.008	0.96
247_E	338_H	1.006	0.96
287_P	361_Y	1.006	0.96
375_E	378_P	1.002	0.95
73_V	158_I	0.998	0.95
113_A	117_G	0.996	0.95
251_A	255_M	0.991	0.95
102_H	132_R	0.989	0.95
195_A	376_Y	0.989	0.95
357_I	365_W	0.987	0.95
234_D	240_K	0.987	0.95
337_S	384_V	0.976	0.95
305_I	392_R	0.974	0.95
262_F	277_Q	0.971	0.95
353_F	382_I	0.970	0.95
97_R	130_E	0.959	0.94
138_V	199_P	0.954	0.94
330_K	334_K	0.932	0.93
185_V	189_L	0.929	0.93
287_P	296_I	0.927	0.93
337_S	341_K	0.925	0.93
28_T	133_T	0.925	0.93
344_K	378_P	0.922	0.93
55_P	156_D	0.921	0.93
243_L	247_E	0.909	0.93
118_L	185_V	0.908	0.92
7_L	18_L	0.908	0.92
41_T	44_S	0.907	0.92
289_M	361_Y	0.907	0.92
148_I	203_M	0.906	0.92
286_V	299_K	0.906	0.92
128_D	307_D	0.899	0.92
37_G	49_H	0.897	0.92
240_K	348_I	0.891	0.92
234_D	348_I	0.888	0.92
106_V	125_L	0.887	0.92
375_E	379_E	0.886	0.92
119_D	237_G	0.885	0.91
109_N	140_A	0.880	0.91
263_I	335_E	0.879	0.91
355_D	359_R	0.878	0.91
110_E	242_W	0.877	0.91
341_K	345_K	0.876	0.91
114_K	233_F	0.876	0.91
25_R	30_L	0.871	0.91
309_V	313_F	0.864	0.90
111_K	114_K	0.863	0.90
285_L	298_V	0.861	0.90
106_V	137_F	0.857	0.90
194_M	352_G	0.856	0.90
241_Y	376_Y	0.855	0.90
117_G	233_F	0.852	0.90
356_T	359_R	0.850	0.90
232_V	243_L	0.840	0.89
113_A	239_L	0.836	0.89
15_V	19_P	0.833	0.89
185_V	233_F	0.828	0.89
320_V	323_A	0.823	0.88
36_I	50_L	0.821	0.88
287_P	356_T	0.819	0.88
78_I	86_A	0.816	0.88
7_L	11_M	0.816	0.88
93_K	226_Q	0.811	0.87
82_N	273_A	0.807	0.87
362_P	365_W	0.806	0.87
300_V	386_A	0.805	0.87
198_I	233_F	0.804	0.87
38_I	48_L	0.802	0.87
254_L	283_T	0.802	0.87
31_A	155_I	0.801	0.87
294_P	380_L	0.801	0.87
51_Q	73_V	0.792	0.86
333_E	384_V	0.790	0.86
332_L	336_I	0.787	0.86
326_K	330_K	0.785	0.86
148_I	201_Y	0.784	0.86
191_A	355_D	0.781	0.85
139_V	239_L	0.776	0.85
361_Y	364_Q	0.776	0.85
36_I	106_V	0.772	0.85
250_G	253_W	0.771	0.85
334_K	338_H	0.771	0.85
82_N	308_A	0.762	0.84
81_N	273_A	0.762	0.84
250_G	336_I	0.761	0.84
233_F	239_L	0.759	0.84
322_A	326_K	0.757	0.84
252_V	257_K	0.755	0.83
26_E	102_H	0.754	0.83
140_A	145_A	0.750	0.83
145_A	149_V	0.749	0.83
109_N	139_V	0.746	0.83
166_T	227_A	0.744	0.83
143_T	147_N	0.744	0.83
35_A	105_L	0.743	0.82
291_N	301_S	0.740	0.82
50_L	100_F	0.738	0.82
253_W	302_V	0.738	0.82
58_V	72_P	0.734	0.82
197_V	350_F	0.733	0.82
306_I	315_L	0.729	0.81
32_I	99_Y	0.727	0.81
340_V	351_I	0.726	0.81
84_T	128_D	0.725	0.81
372_W	378_P	0.725	0.81
356_T	360_K	0.723	0.81
253_W	258_I	0.722	0.81
289_M	364_Q	0.722	0.81
274_V	309_V	0.720	0.80
234_D	373_D	0.720	0.80
10_L	13_L	0.720	0.80
78_I	93_K	0.718	0.80
76_Y	94_V	0.718	0.80
233_F	237_G	0.717	0.80
181_N	184_D	0.717	0.80
84_T	308_A	0.712	0.80
76_Y	90_A	0.709	0.79
26_E	96_R	0.708	0.79
105_L	138_V	0.707	0.79
35_A	51_Q	0.706	0.79
304_G	388_T	0.705	0.79
37_G	109_N	0.704	0.79
332_L	388_T	0.703	0.79
364_Q	367_K	0.700	0.79
303_E	392_R	0.698	0.78
136_T	164_N	0.694	0.78
82_N	275_S	0.693	0.78
24_K	32_I	0.692	0.78
137_F	198_I	0.692	0.78
85_E	264_N	0.692	0.78
287_P	353_F	0.692	0.78
276_L	390_I	0.690	0.78
108_I	139_V	0.690	0.78
35_A	161_N	0.689	0.78
285_L	380_L	0.686	0.77
7_L	15_V	0.686	0.77
29_D	165_K	0.683	0.77
277_Q	307_D	0.683	0.77
37_G	146_E	0.682	0.77
200_G	231_A	0.681	0.77
91_S	129_T	0.681	0.77
112_L	121_V	0.680	0.77
36_I	48_L	0.679	0.76
142_K	242_W	0.675	0.76
253_W	332_L	0.675	0.76
40_R	111_K	0.672	0.76
19_P	22_W	0.672	0.76
368_M	375_E	0.671	0.76
288_K	295_Y	0.669	0.75
195_A	350_F	0.669	0.75
125_L	182_I	0.668	0.75
362_P	366_E	0.668	0.75
183_Q	187_K	0.667	0.75
188_T	194_M	0.666	0.75
340_V	344_K	0.666	0.75
15_V	18_L	0.663	0.75
143_T	229_G	0.661	0.75
278_V	304_G	0.661	0.75
31_A	94_V	0.661	0.75
161_N	165_K	0.660	0.74
38_I	106_V	0.660	0.74
118_L	233_F	0.660	0.74
51_Q	132_R	0.655	0.74
52_I	155_I	0.652	0.74
109_N	239_L	0.651	0.73
175_G	249_V	0.651	0.73
265_A	327_A	0.650	0.73
249_V	335_E	0.649	0.73
100_F	106_V	0.647	0.73
103_T	135_A	0.644	0.73
138_V	163_V	0.643	0.73
250_G	335_E	0.640	0.72
52_I	94_V	0.639	0.72
118_L	265_A	0.637	0.72
370_D	374_K	0.636	0.72
54_N	57_N	0.633	0.71
23_D	29_D	0.632	0.71
79_E	83_I	0.629	0.71
89_K	92_M	0.627	0.71
118_L	237_G	0.627	0.71
50_L	87_L	0.627	0.71
109_N	144_K	0.624	0.70
15_V	338_H	0.623	0.70
196_P	352_G	0.623	0.70
232_V	348_I	0.622	0.70
271_K	284_K	0.622	0.70
49_H	140_A	0.621	0.70
251_A	339_T	0.621	0.70
162_K	166_T	0.620	0.70
7_L	14_S	0.620	0.70
34_S	183_Q	0.620	0.70
180_I	188_T	0.618	0.70
33_I	90_A	0.617	0.69
249_V	253_W	0.615	0.69
339_T	342_K	0.615	0.69
243_L	251_A	0.614	0.69
302_V	327_A	0.613	0.69
197_V	230_L	0.612	0.69
37_G	150_K	0.612	0.69
336_I	339_T	0.611	0.69
114_K	239_L	0.605	0.68
140_A	229_G	0.605	0.68
301_S	389_Y	0.604	0.68
108_I	122_L	0.602	0.68
38_I	46_Y	0.602	0.68
107_V	145_A	0.601	0.67
49_H	146_E	0.601	0.67
153_T	156_D	0.600	0.67
371_T	375_E	0.598	0.67
277_Q	305_I	0.596	0.67
46_Y	121_V	0.595	0.67
53_I	162_K	0.595	0.67
266_D	273_A	0.592	0.66
28_T	162_K	0.592	0.66
22_W	365_W	0.591	0.66
347_K	374_K	0.591	0.66
182_I	185_V	0.591	0.66
252_V	256_N	0.590	0.66
19_P	23_D	0.590	0.66
114_K	319_K	0.590	0.66
110_E	200_G	0.587	0.66
56_G	107_V	0.587	0.66
55_P	67_A	0.587	0.66
195_A	346_N	0.585	0.65
16_I	114_K	0.584	0.65
253_W	335_E	0.583	0.65
114_K	242_W	0.583	0.65
344_K	380_L	0.583	0.65
52_I	76_Y	0.582	0.65
294_P	368_M	0.582	0.65
15_V	266_D	0.582	0.65
96_R	359_R	0.582	0.65
72_P	159_P	0.580	0.65
246_D	335_E	0.579	0.65
88_R	128_D	0.579	0.65
228_D	245_D	0.579	0.65
314_Q	318_P	0.578	0.64
32_I	73_V	0.576	0.64
6_L	18_L	0.575	0.64
92_M	245_D	0.575	0.64
318_P	322_A	0.575	0.64
84_T	129_T	0.574	0.64
285_L	356_T	0.574	0.64
249_V	351_I	0.572	0.64
51_Q	75_V	0.572	0.64
196_P	354_G	0.572	0.64
193_T	196_P	0.572	0.64
113_A	118_L	0.569	0.63
10_L	17_V	0.568	0.63
243_L	339_T	0.568	0.63
13_L	291_N	0.568	0.63
122_L	246_D	0.567	0.63
264_N	275_S	0.567	0.63
99_Y	104_N	0.567	0.63
276_L	346_N	0.565	0.63
293_R	379_E	0.562	0.62
22_W	241_Y	0.562	0.62
256_N	274_V	0.562	0.62
110_E	239_L	0.562	0.62
8_A	12_L	0.562	0.62
95_S	153_T	0.561	0.62
128_D	277_Q	0.561	0.62
41_T	45_N	0.561	0.62
278_V	281_Q	0.560	0.62
184_D	188_T	0.560	0.62
194_M	355_D	0.559	0.62
81_N	264_N	0.559	0.62
151_I	225_L	0.559	0.62
53_I	157_K	0.558	0.62
294_P	357_I	0.558	0.62
55_P	96_R	0.557	0.62
313_F	320_V	0.556	0.61
243_L	342_K	0.556	0.61
51_Q	158_I	0.555	0.61
17_V	326_K	0.555	0.61
46_Y	298_V	0.554	0.61
153_T	162_K	0.554	0.61
40_R	44_S	0.554	0.61
139_V	198_I	0.553	0.61
9_V	17_V	0.552	0.61
340_V	376_Y	0.552	0.61
304_G	325_E	0.551	0.61
15_V	48_L	0.551	0.61
339_T	350_F	0.550	0.61
94_V	98_L	0.550	0.61
7_L	389_Y	0.550	0.61
89_K	174_Y	0.549	0.60
51_Q	149_V	0.548	0.60
244_E	299_K	0.547	0.60
9_V	292_G	0.547	0.60
186_L	396_R	0.546	0.60
27_L	167_L	0.546	0.60
253_W	263_I	0.545	0.60
199_P	227_A	0.545	0.60
96_R	156_D	0.544	0.60
254_L	340_V	0.544	0.60
328_L	390_I	0.543	0.60
258_I	281_Q	0.540	0.59
88_R	91_S	0.539	0.59
24_K	156_D	0.538	0.59
92_M	176_R	0.535	0.59
27_L	72_P	0.535	0.59
37_G	107_V	0.534	0.58
30_L	101_A	0.534	0.58
105_L	160_S	0.532	0.58
49_H	111_K	0.532	0.58
271_K	292_G	0.532	0.58
188_T	265_A	0.532	0.58
40_R	46_Y	0.531	0.58
161_N	164_N	0.531	0.58
252_V	395_L	0.530	0.58
32_I	143_T	0.530	0.58
117_G	239_L	0.528	0.58
156_D	165_K	0.527	0.57
285_L	348_I	0.527	0.57
91_S	98_L	0.527	0.57
32_I	182_I	0.526	0.57
102_H	145_A	0.526	0.57
59_A	72_P	0.525	0.57
51_Q	102_H	0.525	0.57
184_D	246_D	0.523	0.57
101_A	196_P	0.521	0.57
274_V	304_G	0.518	0.56
282_D	386_A	0.518	0.56
297_H	331_E	0.518	0.56
11_M	14_S	0.518	0.56
105_L	163_V	0.516	0.56
75_V	159_P	0.516	0.56
34_S	227_A	0.515	0.56
25_R	82_N	0.515	0.56
51_Q	160_S	0.514	0.56
351_I	382_I	0.514	0.56
37_G	51_Q	0.513	0.55
189_L	237_G	0.513	0.55
28_T	54_N	0.513	0.55
282_D	347_K	0.512	0.55
357_I	362_P	0.512	0.55
119_D	159_P	0.511	0.55
122_L	137_F	0.510	0.55
195_A	352_G	0.510	0.55
38_I	108_I	0.510	0.55
35_A	145_A	0.509	0.55
333_E	385_K	0.509	0.55
21_C	127_R	0.509	0.55
6_L	17_V	0.507	0.55
8_A	327_A	0.507	0.55
22_W	362_P	0.505	0.54
101_A	252_V	0.504	0.54
9_V	16_I	0.504	0.54
142_K	200_G	0.503	0.54
33_I	50_L	0.503	0.54
180_I	199_P	0.503	0.54
305_I	391_R	0.503	0.54
17_V	338_H	0.502	0.54
6_L	319_K	0.502	0.54
47_V	390_I	0.501	0.54
294_P	364_Q	0.501	0.54
22_W	132_R	0.501	0.54
271_K	345_K	0.500	0.54

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3n54B	5	0.7543	100	0.229	Contact Map
4n4rB	1	0.3661	37.6	0.962	Contact Map
3utkA	1	0.2138	30.7	0.964	Contact Map
3zbiC	1	0.0688	27.6	0.965	Contact Map
3wfdC	1	0.3145	25.8	0.965	Contact Map
2pptA	2	0.3636	17.3	0.968	Contact Map
4fybB	1	0.3292	12.1	0.97	Contact Map
3qaxA	1	0.5577	11.6	0.97	Contact Map
4pj0V	1	0.2703	10.9	0.971	Contact Map
4n6kA	1	0.688	7.7	0.972	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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