GREMLIN Database
GERKC - Spore germination protein KC
UniProt: P49941 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 407 (361)
Sequences: 2208 (1899)
Seq/√Len: 100.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
297_H383_D5.0561.00
110_E114_K4.3361.00
299_K385_K4.3011.00
247_E342_K4.0851.00
267_W311_Y3.8811.00
333_E337_S3.5691.00
47_V146_E3.5361.00
40_R116_E3.5181.00
107_V140_A3.0971.00
110_E142_K2.9901.00
144_K147_N2.9831.00
200_G242_W2.8141.00
329_N388_T2.8001.00
301_S387_E2.7931.00
117_G237_G2.7841.00
276_L328_L2.7701.00
296_I353_F2.6461.00
333_E386_A2.5111.00
146_E150_K2.4331.00
296_I380_L2.4281.00
300_V336_I2.3781.00
50_L90_A2.3591.00
231_A239_L2.3461.00
239_L242_W2.3301.00
344_K376_Y2.3181.00
303_E391_R2.2931.00
139_V231_A2.2791.00
48_L86_A2.2781.00
250_G339_T2.2511.00
295_Y381_P2.2401.00
347_K378_P2.2351.00
45_N79_E2.1871.00
49_H145_A2.1771.00
295_Y383_D2.1441.00
185_V196_P2.1381.00
343_I376_Y2.0801.00
230_L248_S2.0561.00
340_V382_I2.0191.00
123_D127_R2.0111.00
343_I351_I2.0091.00
113_A139_V1.9741.00
371_T374_K1.9311.00
108_I121_V1.9001.00
137_F185_V1.8901.00
47_V79_E1.8851.00
343_I350_F1.8771.00
288_K297_H1.8541.00
35_A160_S1.8331.00
354_G372_W1.8311.00
39_D145_A1.8251.00
322_A325_E1.8141.00
298_V353_F1.8091.00
297_H385_K1.7971.00
38_I112_L1.7921.00
138_V201_Y1.7911.00
78_I89_K1.7841.00
109_N145_A1.7751.00
230_L251_A1.7431.00
33_I98_L1.7431.00
185_V198_I1.7371.00
197_V251_A1.7201.00
87_L100_F1.7001.00
364_Q368_M1.6791.00
41_T79_E1.6791.00
88_R277_Q1.6651.00
192_N369_K1.6441.00
39_D109_N1.6261.00
276_L304_G1.6231.00
45_N81_N1.6121.00
36_I103_T1.5991.00
200_G239_L1.5871.00
37_G145_A1.5651.00
250_G332_L1.5641.00
139_V233_F1.5611.00
142_K202_M1.5551.00
293_R381_P1.5411.00
287_P294_P1.5311.00
302_V388_T1.5251.00
113_A233_F1.5011.00
296_I357_I1.4941.00
244_E247_E1.4801.00
35_A149_V1.4551.00
138_V167_L1.4531.00
303_E389_Y1.4481.00
299_K387_E1.4431.00
47_V77_S1.4371.00
336_I384_V1.4311.00
324_I390_I1.4311.00
285_L296_I1.4271.00
195_A348_I1.4231.00
331_E334_K1.4201.00
109_N112_L1.4111.00
289_M294_P1.3981.00
36_I125_L1.3911.00
147_N150_K1.3830.99
241_Y348_I1.3810.99
323_A327_A1.3770.99
325_E329_N1.3710.99
342_K346_N1.3660.99
193_T354_G1.3590.99
329_N333_E1.3590.99
256_N283_T1.3500.99
77_S146_E1.3450.99
108_I113_A1.3410.99
232_V350_F1.3400.99
163_V201_Y1.3390.99
331_E335_E1.3240.99
133_T183_Q1.3220.99
340_V384_V1.3190.99
341_K344_K1.3100.99
108_I118_L1.3080.99
140_A143_T1.3040.99
47_V144_K1.3000.99
81_N85_E1.2910.99
339_T343_I1.2850.99
41_T47_V1.2840.99
373_D376_Y1.2750.99
326_K329_N1.2670.99
80_G86_A1.2610.99
11_M15_V1.2490.99
104_N164_N1.2480.99
195_A373_D1.2270.99
30_L99_Y1.2150.99
254_L351_I1.2120.99
204_I226_Q1.2110.99
344_K372_W1.2110.99
151_I203_M1.2070.99
283_T300_V1.1960.98
317_D320_V1.1870.98
284_K299_K1.1850.98
287_P360_K1.1800.98
84_T277_Q1.1770.98
314_Q317_D1.1720.98
84_T88_R1.1680.98
18_L21_C1.1650.98
250_G343_I1.1630.98
80_G85_E1.1630.98
202_M228_D1.1610.98
46_Y112_L1.1580.98
33_I100_F1.1560.98
111_K145_A1.1450.98
193_T352_G1.1390.98
31_A52_I1.1390.98
51_Q159_P1.1270.98
49_H75_V1.1250.98
357_I364_Q1.1250.98
328_L388_T1.1240.98
80_G89_K1.1190.98
251_A350_F1.1010.97
302_V332_L1.1010.97
84_T307_D1.0990.97
49_H77_S1.0950.97
290_R295_Y1.0910.97
107_V138_V1.0820.97
175_G258_I1.0810.97
254_L298_V1.0790.97
304_G328_L1.0760.97
34_S53_I1.0720.97
140_A148_I1.0700.97
14_S17_V1.0660.97
372_W376_Y1.0620.97
241_Y346_N1.0600.97
38_I83_I1.0600.97
84_T124_N1.0580.97
103_T131_F1.0580.97
126_D186_L1.0570.97
321_L325_E1.0540.97
327_A330_K1.0530.97
357_I361_Y1.0480.97
113_A231_A1.0430.96
244_E248_S1.0400.96
330_K333_E1.0400.96
78_I90_A1.0390.96
37_G144_K1.0330.96
202_M226_Q1.0300.96
73_V159_P1.0230.96
286_V297_H1.0230.96
366_E369_K1.0180.96
127_R394_G1.0130.96
274_V324_I1.0130.96
254_L336_I1.0110.96
93_K224_I1.0100.96
106_V135_A1.0090.96
355_D358_Y1.0080.96
247_E338_H1.0060.96
287_P361_Y1.0060.96
375_E378_P1.0020.95
73_V158_I0.9980.95
113_A117_G0.9960.95
251_A255_M0.9910.95
102_H132_R0.9890.95
195_A376_Y0.9890.95
357_I365_W0.9870.95
234_D240_K0.9870.95
337_S384_V0.9760.95
305_I392_R0.9740.95
262_F277_Q0.9710.95
353_F382_I0.9700.95
97_R130_E0.9590.94
138_V199_P0.9540.94
330_K334_K0.9320.93
185_V189_L0.9290.93
287_P296_I0.9270.93
337_S341_K0.9250.93
28_T133_T0.9250.93
344_K378_P0.9220.93
55_P156_D0.9210.93
243_L247_E0.9090.93
118_L185_V0.9080.92
7_L18_L0.9080.92
41_T44_S0.9070.92
289_M361_Y0.9070.92
148_I203_M0.9060.92
286_V299_K0.9060.92
128_D307_D0.8990.92
37_G49_H0.8970.92
240_K348_I0.8910.92
234_D348_I0.8880.92
106_V125_L0.8870.92
375_E379_E0.8860.92
119_D237_G0.8850.91
109_N140_A0.8800.91
263_I335_E0.8790.91
355_D359_R0.8780.91
110_E242_W0.8770.91
341_K345_K0.8760.91
114_K233_F0.8760.91
25_R30_L0.8710.91
309_V313_F0.8640.90
111_K114_K0.8630.90
285_L298_V0.8610.90
106_V137_F0.8570.90
194_M352_G0.8560.90
241_Y376_Y0.8550.90
117_G233_F0.8520.90
356_T359_R0.8500.90
232_V243_L0.8400.89
113_A239_L0.8360.89
15_V19_P0.8330.89
185_V233_F0.8280.89
320_V323_A0.8230.88
36_I50_L0.8210.88
287_P356_T0.8190.88
78_I86_A0.8160.88
7_L11_M0.8160.88
93_K226_Q0.8110.87
82_N273_A0.8070.87
362_P365_W0.8060.87
300_V386_A0.8050.87
198_I233_F0.8040.87
38_I48_L0.8020.87
254_L283_T0.8020.87
31_A155_I0.8010.87
294_P380_L0.8010.87
51_Q73_V0.7920.86
333_E384_V0.7900.86
332_L336_I0.7870.86
326_K330_K0.7850.86
148_I201_Y0.7840.86
191_A355_D0.7810.85
139_V239_L0.7760.85
361_Y364_Q0.7760.85
36_I106_V0.7720.85
250_G253_W0.7710.85
334_K338_H0.7710.85
82_N308_A0.7620.84
81_N273_A0.7620.84
250_G336_I0.7610.84
233_F239_L0.7590.84
322_A326_K0.7570.84
252_V257_K0.7550.83
26_E102_H0.7540.83
140_A145_A0.7500.83
145_A149_V0.7490.83
109_N139_V0.7460.83
166_T227_A0.7440.83
143_T147_N0.7440.83
35_A105_L0.7430.82
291_N301_S0.7400.82
50_L100_F0.7380.82
253_W302_V0.7380.82
58_V72_P0.7340.82
197_V350_F0.7330.82
306_I315_L0.7290.81
32_I99_Y0.7270.81
340_V351_I0.7260.81
84_T128_D0.7250.81
372_W378_P0.7250.81
356_T360_K0.7230.81
253_W258_I0.7220.81
289_M364_Q0.7220.81
274_V309_V0.7200.80
234_D373_D0.7200.80
10_L13_L0.7200.80
78_I93_K0.7180.80
76_Y94_V0.7180.80
233_F237_G0.7170.80
181_N184_D0.7170.80
84_T308_A0.7120.80
76_Y90_A0.7090.79
26_E96_R0.7080.79
105_L138_V0.7070.79
35_A51_Q0.7060.79
304_G388_T0.7050.79
37_G109_N0.7040.79
332_L388_T0.7030.79
364_Q367_K0.7000.79
303_E392_R0.6980.78
136_T164_N0.6940.78
82_N275_S0.6930.78
24_K32_I0.6920.78
137_F198_I0.6920.78
85_E264_N0.6920.78
287_P353_F0.6920.78
276_L390_I0.6900.78
108_I139_V0.6900.78
35_A161_N0.6890.78
285_L380_L0.6860.77
7_L15_V0.6860.77
29_D165_K0.6830.77
277_Q307_D0.6830.77
37_G146_E0.6820.77
200_G231_A0.6810.77
91_S129_T0.6810.77
112_L121_V0.6800.77
36_I48_L0.6790.76
142_K242_W0.6750.76
253_W332_L0.6750.76
40_R111_K0.6720.76
19_P22_W0.6720.76
368_M375_E0.6710.76
288_K295_Y0.6690.75
195_A350_F0.6690.75
125_L182_I0.6680.75
362_P366_E0.6680.75
183_Q187_K0.6670.75
188_T194_M0.6660.75
340_V344_K0.6660.75
15_V18_L0.6630.75
143_T229_G0.6610.75
278_V304_G0.6610.75
31_A94_V0.6610.75
161_N165_K0.6600.74
38_I106_V0.6600.74
118_L233_F0.6600.74
51_Q132_R0.6550.74
52_I155_I0.6520.74
109_N239_L0.6510.73
175_G249_V0.6510.73
265_A327_A0.6500.73
249_V335_E0.6490.73
100_F106_V0.6470.73
103_T135_A0.6440.73
138_V163_V0.6430.73
250_G335_E0.6400.72
52_I94_V0.6390.72
118_L265_A0.6370.72
370_D374_K0.6360.72
54_N57_N0.6330.71
23_D29_D0.6320.71
79_E83_I0.6290.71
89_K92_M0.6270.71
118_L237_G0.6270.71
50_L87_L0.6270.71
109_N144_K0.6240.70
15_V338_H0.6230.70
196_P352_G0.6230.70
232_V348_I0.6220.70
271_K284_K0.6220.70
49_H140_A0.6210.70
251_A339_T0.6210.70
162_K166_T0.6200.70
7_L14_S0.6200.70
34_S183_Q0.6200.70
180_I188_T0.6180.70
33_I90_A0.6170.69
249_V253_W0.6150.69
339_T342_K0.6150.69
243_L251_A0.6140.69
302_V327_A0.6130.69
197_V230_L0.6120.69
37_G150_K0.6120.69
336_I339_T0.6110.69
114_K239_L0.6050.68
140_A229_G0.6050.68
301_S389_Y0.6040.68
108_I122_L0.6020.68
38_I46_Y0.6020.68
107_V145_A0.6010.67
49_H146_E0.6010.67
153_T156_D0.6000.67
371_T375_E0.5980.67
277_Q305_I0.5960.67
46_Y121_V0.5950.67
53_I162_K0.5950.67
266_D273_A0.5920.66
28_T162_K0.5920.66
22_W365_W0.5910.66
347_K374_K0.5910.66
182_I185_V0.5910.66
252_V256_N0.5900.66
19_P23_D0.5900.66
114_K319_K0.5900.66
110_E200_G0.5870.66
56_G107_V0.5870.66
55_P67_A0.5870.66
195_A346_N0.5850.65
16_I114_K0.5840.65
253_W335_E0.5830.65
114_K242_W0.5830.65
344_K380_L0.5830.65
52_I76_Y0.5820.65
294_P368_M0.5820.65
15_V266_D0.5820.65
96_R359_R0.5820.65
72_P159_P0.5800.65
246_D335_E0.5790.65
88_R128_D0.5790.65
228_D245_D0.5790.65
314_Q318_P0.5780.64
32_I73_V0.5760.64
6_L18_L0.5750.64
92_M245_D0.5750.64
318_P322_A0.5750.64
84_T129_T0.5740.64
285_L356_T0.5740.64
249_V351_I0.5720.64
51_Q75_V0.5720.64
196_P354_G0.5720.64
193_T196_P0.5720.64
113_A118_L0.5690.63
10_L17_V0.5680.63
243_L339_T0.5680.63
13_L291_N0.5680.63
122_L246_D0.5670.63
264_N275_S0.5670.63
99_Y104_N0.5670.63
276_L346_N0.5650.63
293_R379_E0.5620.62
22_W241_Y0.5620.62
256_N274_V0.5620.62
110_E239_L0.5620.62
8_A12_L0.5620.62
95_S153_T0.5610.62
128_D277_Q0.5610.62
41_T45_N0.5610.62
278_V281_Q0.5600.62
184_D188_T0.5600.62
194_M355_D0.5590.62
81_N264_N0.5590.62
151_I225_L0.5590.62
53_I157_K0.5580.62
294_P357_I0.5580.62
55_P96_R0.5570.62
313_F320_V0.5560.61
243_L342_K0.5560.61
51_Q158_I0.5550.61
17_V326_K0.5550.61
46_Y298_V0.5540.61
153_T162_K0.5540.61
40_R44_S0.5540.61
139_V198_I0.5530.61
9_V17_V0.5520.61
340_V376_Y0.5520.61
304_G325_E0.5510.61
15_V48_L0.5510.61
339_T350_F0.5500.61
94_V98_L0.5500.61
7_L389_Y0.5500.61
89_K174_Y0.5490.60
51_Q149_V0.5480.60
244_E299_K0.5470.60
9_V292_G0.5470.60
186_L396_R0.5460.60
27_L167_L0.5460.60
253_W263_I0.5450.60
199_P227_A0.5450.60
96_R156_D0.5440.60
254_L340_V0.5440.60
328_L390_I0.5430.60
258_I281_Q0.5400.59
88_R91_S0.5390.59
24_K156_D0.5380.59
92_M176_R0.5350.59
27_L72_P0.5350.59
37_G107_V0.5340.58
30_L101_A0.5340.58
105_L160_S0.5320.58
49_H111_K0.5320.58
271_K292_G0.5320.58
188_T265_A0.5320.58
40_R46_Y0.5310.58
161_N164_N0.5310.58
252_V395_L0.5300.58
32_I143_T0.5300.58
117_G239_L0.5280.58
156_D165_K0.5270.57
285_L348_I0.5270.57
91_S98_L0.5270.57
32_I182_I0.5260.57
102_H145_A0.5260.57
59_A72_P0.5250.57
51_Q102_H0.5250.57
184_D246_D0.5230.57
101_A196_P0.5210.57
274_V304_G0.5180.56
282_D386_A0.5180.56
297_H331_E0.5180.56
11_M14_S0.5180.56
105_L163_V0.5160.56
75_V159_P0.5160.56
34_S227_A0.5150.56
25_R82_N0.5150.56
51_Q160_S0.5140.56
351_I382_I0.5140.56
37_G51_Q0.5130.55
189_L237_G0.5130.55
28_T54_N0.5130.55
282_D347_K0.5120.55
357_I362_P0.5120.55
119_D159_P0.5110.55
122_L137_F0.5100.55
195_A352_G0.5100.55
38_I108_I0.5100.55
35_A145_A0.5090.55
333_E385_K0.5090.55
21_C127_R0.5090.55
6_L17_V0.5070.55
8_A327_A0.5070.55
22_W362_P0.5050.54
101_A252_V0.5040.54
9_V16_I0.5040.54
142_K200_G0.5030.54
33_I50_L0.5030.54
180_I199_P0.5030.54
305_I391_R0.5030.54
17_V338_H0.5020.54
6_L319_K0.5020.54
47_V390_I0.5010.54
294_P364_Q0.5010.54
22_W132_R0.5010.54
271_K345_K0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3n54B 5 0.7543 100 0.229 Contact Map
4n4rB 1 0.3661 37.6 0.962 Contact Map
3utkA 1 0.2138 30.7 0.964 Contact Map
3zbiC 1 0.0688 27.6 0.965 Contact Map
3wfdC 1 0.3145 25.8 0.965 Contact Map
2pptA 2 0.3636 17.3 0.968 Contact Map
4fybB 1 0.3292 12.1 0.97 Contact Map
3qaxA 1 0.5577 11.6 0.97 Contact Map
4pj0V 1 0.2703 10.9 0.971 Contact Map
4n6kA 1 0.688 7.7 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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