GREMLIN Database
GERKB - Spore germination protein KB
UniProt: P49940 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 373 (346)
Sequences: 23013 (14765)
Seq/√Len: 793.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
307_A310_M3.9961.00
44_C225_G3.8721.00
308_Y311_G3.6861.00
307_A311_G3.2661.00
211_K215_K3.1551.00
207_L212_D2.9191.00
7_S208_N2.8351.00
304_S307_A2.7971.00
83_S297_L2.6461.00
12_F219_I2.5671.00
304_S308_Y2.5621.00
155_G159_I2.5401.00
127_I316_I2.5131.00
8_I219_I2.5091.00
206_N292_V2.4761.00
357_V361_K2.4161.00
156_L160_I2.4021.00
67_K300_E2.3471.00
253_S256_Q2.3001.00
128_Y132_K2.2851.00
295_S299_K2.2831.00
11_L207_L2.2411.00
215_K219_I2.2181.00
266_R270_F2.1871.00
8_I12_F2.1811.00
307_A314_I2.1521.00
135_E139_R2.1391.00
205_P299_K2.0781.00
7_S10_Q2.0651.00
253_S257_T2.0351.00
71_D76_T2.0351.00
305_Q308_Y2.0251.00
8_I212_D1.9951.00
70_M82_F1.9881.00
156_L159_I1.9861.00
306_L311_G1.9791.00
71_D79_S1.9711.00
146_G150_L1.9601.00
45_A49_F1.9341.00
10_Q142_E1.8451.00
209_D212_D1.8351.00
311_G314_I1.8291.00
355_V359_K1.8161.00
155_G160_I1.7901.00
15_I220_A1.7821.00
12_F223_I1.7761.00
310_M314_I1.7521.00
218_M222_A1.7261.00
305_Q309_P1.7151.00
161_V165_I1.7121.00
166_D170_L1.6891.00
165_I168_H1.6861.00
6_I10_Q1.6661.00
357_V360_K1.6521.00
256_Q268_D1.6501.00
261_E266_R1.6471.00
105_L118_V1.6411.00
166_D169_N1.6321.00
51_F217_G1.6141.00
151_L274_A1.6031.00
203_I288_Y1.6001.00
101_F122_L1.5911.00
165_I237_S1.5861.00
308_Y312_L1.5811.00
61_Y72_D1.5711.00
163_G166_D1.5601.00
308_Y314_I1.5571.00
98_L283_V1.5411.00
256_Q261_E1.5351.00
354_I358_W1.5111.00
51_F221_M1.5081.00
306_L310_M1.5011.00
98_L123_M1.5001.00
10_Q138_A1.4941.00
39_A184_S1.4881.00
75_G78_L1.4881.00
240_D243_L1.4701.00
212_D215_K1.4541.00
222_A226_L1.4511.00
130_V284_S1.4501.00
126_S283_V1.4241.00
243_L257_T1.4211.00
269_V273_L1.4081.00
52_Y218_M1.4081.00
333_L337_P1.4001.00
131_R309_P1.3991.00
177_G180_P1.3941.00
247_S253_S1.3781.00
311_G315_L1.3731.00
37_W233_A1.3601.00
168_H171_K1.3551.00
64_S205_P1.3541.00
210_R214_K1.3541.00
56_G59_Q1.3511.00
120_A322_A1.3461.00
167_P171_K1.3321.00
168_H172_P1.3281.00
120_A320_T1.3271.00
68_E72_D1.3221.00
8_I215_K1.3161.00
312_L316_I1.3151.00
16_I223_I1.3141.00
35_D174_L1.3111.00
43_G188_Q1.3041.00
6_I11_L1.2951.00
209_D215_K1.2861.00
161_V164_T1.2861.00
167_P170_L1.2841.00
120_A124_V1.2751.00
259_K267_L1.2741.00
163_G167_P1.2741.00
208_N212_D1.2451.00
41_L229_A1.2431.00
161_V167_P1.2261.00
162_S166_D1.2161.00
113_T116_I1.2131.00
309_P312_L1.2051.00
343_P346_L1.2051.00
74_L78_L1.2041.00
346_L350_L1.1991.00
101_F276_I1.1931.00
87_I294_T1.1831.00
11_L216_M1.1811.00
15_I200_F1.1811.00
309_P313_G1.1791.00
63_N68_E1.1731.00
127_I131_R1.1731.00
358_W361_K1.1711.00
348_F354_I1.1681.00
58_Y69_Y1.1681.00
19_E224_S1.1661.00
307_A318_S1.1631.00
140_A144_L1.1591.00
80_W84_F1.1571.00
165_I170_L1.1561.00
9_R13_V1.1541.00
155_G158_L1.1531.00
124_V316_I1.1501.00
305_Q310_M1.1471.00
307_A312_L1.1401.00
144_L281_F1.1301.00
345_Q348_F1.1251.00
323_T326_S1.1151.00
125_V280_F1.1151.00
233_A237_S1.1091.00
348_F351_F1.1081.00
5_R208_N1.1051.00
139_R143_L1.1041.00
332_G336_V1.1021.00
183_H187_T1.0951.00
82_F350_L1.0921.00
328_H331_E1.0871.00
350_L354_I1.0851.00
162_S170_L1.0821.00
35_D181_V1.0801.00
330_N334_N1.0791.00
226_L230_L1.0781.00
102_G118_V1.0731.00
161_V166_D1.0711.00
20_L23_S1.0621.00
16_I224_S1.0571.00
67_K296_T1.0561.00
249_F253_S1.0521.00
97_V282_K1.0511.00
308_Y316_I1.0481.00
322_A326_S1.0461.00
164_T167_P1.0461.00
165_I169_N1.0441.00
329_L333_L1.0441.00
353_F357_V1.0411.00
345_Q349_P1.0401.00
315_L318_S1.0381.00
169_N172_P1.0371.00
14_M203_I1.0361.00
54_Y66_P1.0351.00
129_A140_A1.0351.00
77_K81_L1.0331.00
154_I157_V1.0321.00
313_G317_L1.0301.00
198_V202_M1.0231.00
314_I318_S1.0171.00
164_T172_P1.0131.00
26_I100_D1.0131.00
204_F213_V1.0111.00
340_I348_F1.0111.00
304_S311_G1.0101.00
294_T303_P1.0081.00
162_S165_I1.0061.00
96_R192_V1.0031.00
351_F354_I1.0011.00
164_T170_L1.0011.00
167_P172_P0.9971.00
63_N72_D0.9971.00
121_L125_V0.9951.00
308_Y318_S0.9951.00
139_R142_E0.9921.00
321_I324_N0.9881.00
134_I288_Y0.9841.00
141_A284_S0.9831.00
354_I357_V0.9801.00
70_M78_L0.9791.00
117_I121_L0.9791.00
114_P117_I0.9701.00
132_K305_Q0.9631.00
126_S284_S0.9631.00
6_I138_A0.9611.00
101_F280_F0.9601.00
341_H345_Q0.9501.00
343_P347_L0.9491.00
5_R135_E0.9481.00
112_D115_I0.9481.00
166_D171_K0.9451.00
118_V121_L0.9381.00
341_H346_L0.9371.00
149_Y227_I0.9351.00
124_V128_Y0.9351.00
128_Y131_R0.9341.00
124_V320_T0.9301.00
24_L28_P0.9231.00
305_Q311_G0.9211.00
8_I216_M0.9141.00
13_V142_E0.9081.00
48_L52_Y0.9071.00
166_D172_P0.9061.00
157_V160_I0.9021.00
162_S168_H0.8981.00
243_L246_R0.8971.00
260_V267_L0.8761.00
10_Q139_R0.8761.00
113_T117_I0.8761.00
247_S250_P0.8751.00
35_D173_V0.8751.00
74_L353_F0.8681.00
71_D300_E0.8661.00
315_L319_I0.8641.00
178_I182_L0.8631.00
351_F355_V0.8621.00
349_P352_L0.8611.00
164_T168_H0.8611.00
105_L276_I0.8601.00
102_G119_N0.8591.00
112_D116_I0.8551.00
127_I312_L0.8551.00
44_C194_F0.8531.00
356_A361_K0.8531.00
37_W236_I0.8511.00
163_G170_L0.8501.00
306_L314_I0.8491.00
9_R139_R0.8441.00
126_S287_L0.8441.00
349_P353_F0.8411.00
23_S29_G0.8411.00
346_L354_I0.8361.00
49_F53_L0.8351.00
48_L218_M0.8301.00
132_K136_V0.8281.00
163_G168_H0.8231.00
304_S310_M0.8221.00
238_V254_T0.8211.00
47_G197_V0.8211.00
154_I159_I0.8201.00
354_I361_K0.8191.00
225_G229_A0.8171.00
240_D257_T0.8141.00
304_S309_P0.8111.00
306_L309_P0.8101.00
53_L352_L0.8061.00
292_V295_S0.8051.00
163_G171_K0.8021.00
182_L186_F0.8011.00
163_G172_P0.7981.00
12_F216_M0.7931.00
56_G60_C0.7891.00
181_V184_S0.7851.00
199_L289_A0.7851.00
205_P295_S0.7841.00
130_V288_Y0.7831.00
321_I326_S0.7811.00
250_P254_T0.7801.00
219_I223_I0.7801.00
17_I145_F0.7761.00
98_L102_G0.7761.00
119_N323_T0.7721.00
9_R142_E0.7681.00
148_M278_G0.7681.00
28_P232_V0.7661.00
15_I19_E0.7651.00
104_M275_L0.7641.00
347_L351_F0.7601.00
165_I172_P0.7571.00
312_L315_L0.7561.00
21_G29_G0.7561.00
308_Y315_L0.7551.00
331_E334_N0.7531.00
133_G136_V0.7511.00
131_R313_G0.7501.00
77_K80_W0.7501.00
209_D214_K0.7501.00
255_I260_V0.7491.00
101_F279_G0.7461.00
307_A316_I0.7461.00
57_I69_Y0.7461.00
60_C361_K0.7451.00
287_L291_V0.7421.00
162_S169_N0.7361.00
329_L332_G0.7361.00
21_G24_L0.7341.00
163_G169_N0.7301.00
321_I325_F0.7281.00
138_A142_E0.7271.00
334_N337_P0.7261.00
306_L319_I0.7251.00
84_F303_P0.7251.00
174_L178_I0.7231.00
266_R269_V0.7211.00
30_S33_G0.7211.00
308_Y319_I0.7201.00
230_L234_I0.7171.00
348_F352_L0.7131.00
223_I227_I0.7121.00
21_G26_I0.7121.00
195_G198_V0.7101.00
308_Y325_F0.7101.00
136_V139_R0.7051.00
57_I73_M0.7031.00
21_G25_L0.7001.00
20_L25_L0.6991.00
116_I120_A0.6981.00
111_H114_P0.6981.00
110_Y113_T0.6981.00
325_F328_H0.6981.00
126_S280_F0.6981.00
12_F15_I0.6971.00
122_L283_V0.6961.00
331_E335_V0.6951.00
21_G28_P0.6941.00
94_A319_I0.6941.00
207_L213_V0.6921.00
123_M319_I0.6831.00
162_S167_P0.6821.00
37_W41_L0.6821.00
18_F286_Y0.6821.00
310_M313_G0.6801.00
38_I41_L0.6791.00
161_V168_H0.6791.00
51_F197_V0.6781.00
234_I237_S0.6771.00
55_Q59_Q0.6761.00
173_V176_N0.6761.00
136_V140_A0.6761.00
304_S312_L0.6731.00
86_Y90_F0.6721.00
64_S295_S0.6711.00
161_V170_L0.6711.00
178_I181_V0.6701.00
172_P175_A0.6671.00
170_L237_S0.6671.00
341_H348_F0.6651.00
18_F285_L0.6641.00
38_I181_V0.6631.00
322_A325_F0.6631.00
56_G357_V0.6621.00
67_K83_S0.6611.00
74_L355_V0.6581.00
5_R9_R0.6581.00
255_I259_K0.6581.00
105_L122_L0.6571.00
320_T324_N0.6561.00
164_T171_K0.6561.00
154_I158_L0.6541.00
164_T169_N0.6541.00
345_Q350_L0.6541.00
24_L27_T0.6531.00
355_V358_W0.6531.00
341_H344_F0.6511.00
342_L345_Q0.6501.00
142_E146_G0.6491.00
346_L352_L0.6491.00
38_I42_L0.6461.00
290_T294_T0.6461.00
19_E220_A0.6451.00
21_G228_V0.6441.00
314_I319_I0.6431.00
340_I354_I0.6421.00
171_K174_L0.6411.00
40_V193_P0.6381.00
67_K71_D0.6361.00
145_F148_M0.6341.00
328_H332_G0.6331.00
319_I322_A0.6311.00
349_P356_A0.6291.00
90_F286_Y0.6281.00
74_L357_V0.6271.00
73_M352_L0.6251.00
16_I145_F0.6241.00
174_L181_V0.6231.00
340_I345_Q0.6221.00
255_I258_I0.6221.00
343_P350_L0.6191.00
350_L353_F0.6191.00
352_L358_W0.6191.00
32_A39_A0.6191.00
345_Q352_L0.6171.00
40_V232_V0.6171.00
160_I234_I0.6171.00
316_I320_T0.6161.00
5_R134_I0.6161.00
249_F252_L0.6151.00
201_V217_G0.6091.00
51_F55_Q0.6071.00
298_F303_P0.6051.00
17_I21_G0.6031.00
31_M183_H0.6031.00
58_Y201_V0.6031.00
20_L227_I0.6021.00
72_D360_K0.6011.00
352_L356_A0.6011.00
127_I287_L0.6011.00
101_F105_L0.5981.00
104_M252_L0.5961.00
340_I343_P0.5961.00
34_R37_W0.5931.00
78_L81_L0.5921.00
58_Y213_V0.5921.00
157_V161_V0.5911.00
97_V100_D0.5901.00
53_L350_L0.5901.00
25_L28_P0.5881.00
161_V169_N0.5881.00
202_M289_A0.5861.00
31_M184_S0.5861.00
75_G79_S0.5861.00
283_V286_Y0.5841.00
43_G194_F0.5801.00
93_I96_R0.5801.00
37_W229_A0.5791.00
34_R241_V0.5791.00
131_R307_A0.5791.00
137_L288_Y0.5781.00
105_L109_A0.5771.00
124_V127_I0.5771.00
48_L221_M0.5761.00
102_G105_L0.5751.00
161_V172_P0.5751.00
42_L185_V0.5751.00
87_I91_A0.5751.00
20_L27_T0.5751.00
316_I319_I0.5751.00
231_T251_L0.5741.00
18_F199_L0.5741.00
254_T258_I0.5731.00
307_A313_G0.5721.00
66_P198_V0.5661.00
347_L352_L0.5651.00
257_T261_E0.5651.00
131_R305_Q0.5631.00
20_L24_L0.5601.00
214_K217_G0.5601.00
184_S187_T0.5531.00
305_Q318_S0.5521.00
342_L349_P0.5511.00
122_L126_S0.5481.00
93_I97_V0.5481.00
106_L115_I0.5461.00
341_H347_L0.5441.00
195_G344_F0.5431.00
97_V279_G0.5421.00
298_F301_K0.5411.00
150_L155_G0.5411.00
41_L45_A0.5411.00
22_S27_T0.5401.00
40_V228_V0.5381.00
344_F348_F0.5381.00
207_L216_M0.5371.00
349_P354_I0.5351.00
22_S25_L0.5351.00
243_L253_S0.5351.00
219_I222_A0.5341.00
97_V283_V0.5331.00
61_Y73_M0.5331.00
39_A188_Q0.5321.00
352_L355_V0.5321.00
236_I240_D0.5311.00
237_S240_D0.5291.00
55_Q217_G0.5271.00
336_V340_I0.5271.00
23_S27_T0.5251.00
134_I203_I0.5241.00
23_S28_P0.5231.00
237_S241_V0.5211.00
66_P202_M0.5211.00
32_A35_D0.5211.00
270_F274_A0.5201.00
185_V189_T0.5191.00
181_V185_V0.5181.00
223_I226_L0.5171.00
100_D104_M0.5161.00
269_V272_M0.5161.00
332_G337_P0.5151.00
231_T235_N0.5131.00
290_T315_L0.5121.00
81_L85_L0.5121.00
39_A181_V0.5111.00
110_Y114_P0.5111.00
14_M17_I0.5101.00
278_G281_F0.5091.00
343_P348_F0.5081.00
306_L318_S0.5081.00
6_I134_I0.5081.00
297_L303_P0.5071.00
20_L148_M0.5061.00
347_L354_I0.5061.00
138_A284_S0.5051.00
79_S83_S0.5051.00
95_A98_L0.5041.00
181_V188_Q0.5031.00
261_E269_V0.5031.00
211_K214_K0.5011.00
127_I315_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.9464 100 0.317 Contact Map
3giaA 1 0.9464 100 0.366 Contact Map
4djkA 2 0.9517 100 0.4 Contact Map
3dh4A 3 0.9383 98.7 0.838 Contact Map
2xq2A 2 0.933 98.5 0.85 Contact Map
2jlnA 1 0.9437 98.4 0.854 Contact Map
4wgvA 2 0.9276 98.3 0.857 Contact Map
4us3A 1 0.9651 97.7 0.876 Contact Map
2a65A 2 0.9705 97.6 0.88 Contact Map
4xp4A 1 0.9625 96.9 0.893 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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