GREMLIN Database
FHUG - Iron(3+)-hydroxamate import system permease protein FhuG
UniProt: P49937 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 336 (317)
Sequences: 13865 (9846)
Seq/√Len: 553.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
223_N282_R4.9051.00
71_A291_A3.7881.00
107_F129_S3.6521.00
79_I215_T3.6121.00
22_V300_L3.5641.00
23_F63_I3.3601.00
238_A241_K3.2381.00
72_G208_I3.2191.00
67_L295_S3.1091.00
79_I246_L3.0831.00
66_S193_I2.9241.00
275_A293_I2.8591.00
65_L196_A2.7321.00
38_K51_D2.6391.00
72_G253_L2.6071.00
72_G257_C2.5871.00
75_V291_A2.4351.00
23_F67_L2.4111.00
229_D243_R2.3721.00
38_K41_Q2.3601.00
18_L296_F2.3521.00
102_L169_L2.3351.00
19_I296_F2.3081.00
75_V212_L2.2811.00
69_V257_C2.2581.00
28_N36_P2.1951.00
102_L166_F2.1671.00
279_T289_V2.1411.00
78_A290_S2.1341.00
48_T51_D2.0911.00
69_V261_A2.0751.00
223_N283_H2.0731.00
26_S63_I2.0421.00
62_R302_D2.0321.00
67_L299_L2.0191.00
19_I67_L1.9781.00
207_W256_S1.9351.00
68_L205_L1.9241.00
22_V296_F1.8901.00
35_A38_K1.8651.00
82_S283_H1.8571.00
106_L110_F1.8571.00
221_Y242_E1.8461.00
105_V170_L1.7961.00
80_L250_A1.7911.00
196_A200_M1.7701.00
224_I237_T1.7461.00
218_K221_Y1.7051.00
46_Q52_E1.6971.00
12_M289_V1.6871.00
134_A255_A1.6591.00
214_F249_A1.6581.00
37_L41_Q1.6031.00
267_L298_F1.6001.00
19_I292_F1.5831.00
304_L308_V1.5711.00
305_A316_V1.5441.00
104_V130_A1.5441.00
64_I201_I1.5421.00
241_K245_I1.5391.00
49_A52_E1.5211.00
211_L253_L1.5071.00
25_I28_N1.5071.00
218_K245_I1.5021.00
15_T292_F1.4801.00
211_L252_T1.4781.00
40_L44_F1.4671.00
52_E56_F1.4631.00
103_A129_S1.4621.00
42_V56_F1.4431.00
76_A253_L1.4311.00
275_A286_L1.4241.00
78_A286_L1.4231.00
304_L319_V1.4231.00
202_W206_P1.4011.00
22_V299_L1.3981.00
25_I29_L1.3951.00
11_V289_V1.3851.00
138_A251_V1.3831.00
218_K242_E1.3791.00
101_S170_L1.3751.00
202_W205_L1.3711.00
197_N200_M1.3681.00
15_T289_V1.3651.00
65_L260_A1.3611.00
285_T288_P1.3501.00
165_G325_A1.3421.00
193_I298_F1.3411.00
211_L249_A1.3101.00
271_A297_L1.2871.00
74_S271_A1.2871.00
275_A289_V1.2821.00
137_A166_F1.2811.00
26_S303_T1.2791.00
97_N254_A1.2791.00
283_H286_L1.2541.00
306_R313_E1.2541.00
68_L201_I1.2351.00
218_K246_L1.2271.00
214_F218_K1.2211.00
103_A133_G1.2201.00
206_P210_I1.2101.00
83_V246_L1.2071.00
78_A283_H1.1991.00
15_T293_I1.1981.00
101_S189_I1.1801.00
99_G133_G1.1791.00
15_T296_F1.1721.00
12_M285_T1.1681.00
233_T240_E1.1651.00
19_I295_S1.1621.00
105_V185_A1.1601.00
32_I54_V1.1591.00
271_A293_I1.1551.00
242_E245_I1.1521.00
241_K244_R1.1441.00
139_F143_I1.1291.00
141_I162_V1.1271.00
228_G232_A1.1261.00
264_I298_F1.1241.00
240_E243_R1.1201.00
129_S133_G1.1091.00
102_L106_L1.1051.00
204_I260_A1.1051.00
42_V52_E1.1051.00
78_A287_I1.1021.00
68_L204_I1.1001.00
302_D306_R1.0961.00
131_L252_T1.0931.00
231_L234_G1.0921.00
136_L140_L1.0901.00
71_A74_S1.0871.00
33_K36_P1.0841.00
261_A264_I1.0811.00
47_G52_E1.0801.00
109_Y173_F1.0741.00
128_F132_A1.0741.00
53_L57_E1.0711.00
66_S298_F1.0611.00
137_A141_I1.0611.00
56_F60_L1.0591.00
65_L201_I1.0561.00
224_I235_L1.0481.00
304_L307_N1.0481.00
215_T249_A1.0431.00
321_S326_P1.0381.00
146_W240_E1.0321.00
23_F299_L1.0291.00
214_F245_I1.0281.00
296_F300_L1.0281.00
288_P291_A1.0211.00
211_L256_S1.0151.00
64_I198_W1.0141.00
66_S299_L1.0101.00
71_A295_S1.0041.00
46_Q56_F1.0031.00
204_I208_I0.9991.00
283_H288_P0.9981.00
63_I303_T0.9911.00
50_R53_L0.9881.00
42_V55_L0.9881.00
22_V303_T0.9821.00
179_P183_M0.9821.00
213_L217_Y0.9751.00
99_G137_A0.9741.00
279_T285_T0.9731.00
29_L307_N0.9711.00
271_A275_A0.9701.00
146_W149_G0.9691.00
106_L173_F0.9641.00
122_G125_M0.9641.00
27_L63_I0.9581.00
230_Q233_T0.9561.00
210_I213_L0.9541.00
17_L21_V0.9481.00
240_E244_R0.9441.00
42_V46_Q0.9431.00
163_N167_N0.9411.00
10_I13_A0.9401.00
28_N39_T0.9361.00
16_F20_V0.9351.00
285_T289_V0.9331.00
286_L290_S0.9271.00
203_A206_P0.9271.00
198_W201_I0.9221.00
97_N263_G0.9221.00
98_A166_F0.9181.00
305_A319_V0.9171.00
39_T55_L0.9091.00
30_G59_R0.9081.00
102_L170_L0.9031.00
305_A315_P0.9021.00
206_P209_V0.9021.00
242_E246_L0.9001.00
142_Y240_E0.8981.00
24_F28_N0.8921.00
300_L304_L0.8891.00
42_V47_G0.8841.00
237_T242_E0.8831.00
222_L246_L0.8801.00
327_Y330_Y0.8791.00
102_L173_F0.8781.00
24_F36_P0.8751.00
77_G272_P0.8731.00
257_C261_A0.8681.00
104_V126_L0.8681.00
68_L208_I0.8671.00
72_G76_A0.8661.00
172_I176_K0.8621.00
178_D181_D0.8621.00
42_V51_D0.8541.00
71_A212_L0.8461.00
219_A284_Q0.8451.00
223_N284_Q0.8411.00
52_E57_E0.8401.00
309_L312_S0.8401.00
11_V14_V0.8401.00
98_A101_S0.8401.00
215_T246_L0.8361.00
34_I55_L0.8331.00
278_L293_I0.8311.00
41_Q45_G0.8301.00
308_V311_P0.8301.00
92_G97_N0.8291.00
63_I299_L0.8251.00
20_V24_F0.8231.00
62_R306_R0.8211.00
282_R285_T0.8201.00
76_A250_A0.8191.00
108_I126_L0.8111.00
41_Q44_F0.8091.00
11_V15_T0.8081.00
218_K249_A0.8031.00
185_A189_I0.8021.00
326_P330_Y0.8001.00
10_I14_V0.8001.00
126_L129_S0.7981.00
209_V213_L0.7981.00
214_F217_Y0.7941.00
307_N310_A0.7911.00
134_A251_V0.7901.00
298_F320_I0.7881.00
16_F292_F0.7871.00
107_F126_L0.7861.00
34_I51_D0.7851.00
96_I134_A0.7841.00
207_W211_L0.7831.00
143_I146_W0.7821.00
232_A239_V0.7791.00
229_D239_V0.7761.00
135_I255_A0.7761.00
20_V23_F0.7761.00
229_D233_T0.7731.00
84_S156_I0.7711.00
80_L94_L0.7701.00
26_S306_R0.7701.00
275_A278_L0.7681.00
62_R313_E0.7651.00
39_T42_V0.7631.00
322_V326_P0.7611.00
106_L111_F0.7571.00
71_A208_I0.7541.00
32_I35_A0.7511.00
19_I23_F0.7511.00
75_V215_T0.7511.00
131_L135_I0.7501.00
239_V243_R0.7481.00
284_Q288_P0.7471.00
105_V174_Q0.7441.00
21_V24_F0.7441.00
74_S78_A0.7431.00
276_R286_L0.7421.00
74_S291_A0.7411.00
142_Y244_R0.7411.00
267_L320_I0.7411.00
90_E93_I0.7401.00
183_M186_A0.7401.00
244_R248_L0.7401.00
275_A279_T0.7401.00
100_G134_A0.7391.00
309_L314_I0.7291.00
247_L251_V0.7261.00
19_I299_L0.7251.00
73_I267_L0.7221.00
179_P182_F0.7221.00
208_I257_C0.7211.00
41_Q46_Q0.7201.00
60_L198_W0.7181.00
200_M260_A0.7171.00
274_V293_I0.7101.00
297_L301_A0.7091.00
28_N33_K0.7051.00
292_F296_F0.7031.00
217_Y221_Y0.6981.00
126_L130_A0.6981.00
180_H184_Q0.6961.00
64_I68_L0.6941.00
125_M128_F0.6911.00
32_I36_P0.6911.00
256_S260_A0.6911.00
65_L204_I0.6901.00
205_L209_V0.6871.00
256_S259_A0.6841.00
141_I145_A0.6821.00
302_D313_E0.6811.00
138_A247_L0.6791.00
11_V278_L0.6781.00
49_A53_L0.6771.00
132_A136_L0.6771.00
264_I316_V0.6771.00
82_S226_Q0.6751.00
204_I256_S0.6751.00
53_L58_F0.6711.00
75_V287_I0.6701.00
133_G137_A0.6681.00
45_G52_E0.6681.00
216_L219_A0.6671.00
101_S263_G0.6661.00
223_N288_P0.6661.00
36_P39_T0.6651.00
233_T239_V0.6621.00
207_W252_T0.6581.00
138_A142_Y0.6551.00
69_V193_I0.6541.00
96_I138_A0.6541.00
90_E268_G0.6531.00
272_P290_S0.6521.00
277_R331_L0.6491.00
106_L169_L0.6491.00
199_N202_W0.6471.00
186_A189_I0.6461.00
76_A254_A0.6461.00
301_A319_V0.6451.00
84_S87_E0.6421.00
146_W150_V0.6411.00
15_T19_I0.6411.00
211_L215_T0.6401.00
23_F27_L0.6391.00
29_L33_K0.6381.00
223_N226_Q0.6371.00
109_Y177_M0.6361.00
108_I184_Q0.6351.00
60_L64_I0.6351.00
148_K154_R0.6341.00
99_G166_F0.6311.00
221_Y237_T0.6311.00
295_S299_L0.6291.00
53_L56_F0.6261.00
79_I249_A0.6261.00
145_A158_V0.6251.00
41_Q47_G0.6241.00
135_I251_V0.6191.00
21_V25_I0.6171.00
34_I42_V0.6151.00
103_A107_F0.6151.00
27_L55_L0.6141.00
124_F128_F0.6111.00
250_A255_A0.6111.00
71_A75_V0.6101.00
55_L60_L0.6091.00
274_V277_R0.6091.00
291_A295_S0.6071.00
27_L60_L0.6051.00
225_M239_V0.6031.00
269_L331_L0.6031.00
66_S316_V0.6031.00
274_V297_L0.6021.00
171_L188_W0.6011.00
143_I147_K0.6011.00
254_A258_V0.6001.00
89_A96_I0.6001.00
174_Q186_A0.5981.00
297_L323_L0.5981.00
300_L303_T0.5981.00
80_L89_A0.5951.00
74_S294_G0.5951.00
255_A259_A0.5921.00
48_T52_E0.5921.00
174_Q189_I0.5911.00
222_L283_H0.5911.00
24_F40_L0.5901.00
204_I207_W0.5891.00
97_N100_G0.5881.00
269_L272_P0.5871.00
14_V18_L0.5841.00
28_N40_L0.5831.00
142_Y146_W0.5821.00
80_L96_I0.5821.00
158_V161_G0.5811.00
181_D184_Q0.5790.99
37_L40_L0.5790.99
198_W202_W0.5780.99
100_G130_A0.5780.99
270_I328_F0.5770.99
193_I316_V0.5730.99
38_K47_G0.5730.99
274_V327_Y0.5710.99
144_L158_V0.5710.99
275_A290_S0.5710.99
212_L216_L0.5710.99
305_A313_E0.5680.99
167_N189_I0.5670.99
83_V250_A0.5660.99
280_G288_P0.5660.99
221_Y224_I0.5660.99
108_I185_A0.5640.99
264_I320_I0.5620.99
23_F64_I0.5620.99
35_A51_D0.5610.99
31_V311_P0.5600.99
19_I63_I0.5590.99
210_I214_F0.5590.99
303_T307_N0.5580.99
267_L297_L0.5570.99
298_F316_V0.5560.99
299_L303_T0.5560.99
203_A256_S0.5540.99
171_L175_L0.5530.99
36_P40_L0.5520.99
132_A135_I0.5510.99
153_I156_I0.5500.99
201_I205_L0.5500.99
12_M16_F0.5490.99
140_L143_I0.5460.99
98_A163_N0.5460.99
305_A308_V0.5460.99
110_F113_G0.5450.99
11_V279_T0.5440.99
13_A17_L0.5440.99
251_V255_A0.5420.99
208_I213_L0.5420.99
270_I327_Y0.5410.99
167_N171_L0.5410.99
245_I249_A0.5410.99
136_L139_F0.5390.99
96_I192_S0.5350.99
175_L318_L0.5320.99
96_I141_I0.5310.99
65_L69_V0.5300.99
307_N311_P0.5290.99
193_I261_A0.5280.99
90_E263_G0.5260.99
238_A245_I0.5260.99
217_Y220_R0.5250.99
158_V162_V0.5240.99
78_A275_A0.5240.99
90_E320_I0.5230.99
75_V208_I0.5210.99
25_I303_T0.5200.99
98_A167_N0.5190.99
168_A270_I0.5190.99
182_F185_A0.5190.99
104_V129_S0.5180.99
208_I212_L0.5180.99
220_R223_N0.5150.99
29_L303_T0.5150.99
99_G162_V0.5140.99
177_M182_F0.5120.99
305_A314_I0.5120.99
38_K45_G0.5120.99
246_L250_A0.5120.99
183_M189_I0.5110.99
305_A311_P0.5110.99
43_F55_L0.5110.99
265_A270_I0.5070.99
78_A82_S0.5070.99
216_L287_I0.5060.99
84_S154_R0.5050.99
64_I205_L0.5040.99
177_M181_D0.5040.99
172_I318_L0.5040.99
212_L215_T0.5040.99
26_S299_L0.5030.99
107_F111_F0.5030.99
174_Q182_F0.5000.99
238_A244_R0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nq2A 2 0.9167 100 0.175 Contact Map
2qi9A 2 0.9464 100 0.181 Contact Map
4g1uA 2 0.8839 100 0.183 Contact Map
1zcdA 1 0.5179 11.3 0.969 Contact Map
4tkrA 2 0.5089 10.1 0.969 Contact Map
2b2hA 3 0.628 8.8 0.97 Contact Map
3o7qA 1 0.3393 6.8 0.972 Contact Map
3rlbA 1 0.497 6.7 0.972 Contact Map
4hzuS 1 0.4792 6.6 0.972 Contact Map
4huqS 1 0.4732 6.3 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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