FHUB - BACSU - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

FHUB - Iron(3+)-hydroxamate import system permease protein FhuB

UniProt:	P49936	Sequences: MHFHFCSKHSIKSAEKSDILKQQLIIIISNRKEVRQLSQHKNIRTASEEIQWTSRTYGAVIVLIAGLCLLCLGAFLSISLGAADIHLRTVWEAIFHYQPTKTSHQIIHDLRLPRTAAAALVGALLAVSGAIMQGMTRNPLAEPSIMGVTSGSAFAVSIAFAFFPGLSAMGLVLWSFAGAGLGASTVMGIGMFSRGGLTPVKLALAGTAVTYFFTGISTAIAIRFDVAQDISFWYAGGVAGVKWSGVQLLLIAGAVGLTLAFFIARSVTVLSLGDDLAKGLGQYTSAVKLVGMLIVVILTGAAVSIAGTIAFIGLIIPHITRFLVGVDYRWIIPCSAVLGAVLLVFADIAARLVNAPFETPVGALTSLIGVPFFFYLARRERRGL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	384 (321)
Sequences:	13161 (9353)
Seq/√Len:	522.0

ECOLI - FEPG FEPD FECC BTUC FECD FHUB
BACSU - FHUB FHUG YVRB YFME YFHA FEUB YFMD YFIZ YCLN FEUC YCLO
HALSA - Q9HMG7 BTUCA Q9HMG0
SULSO - Q97ZU1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
268_T	327_D	4.822	1.00
123_A	336_A	3.674	1.00
73_G	345_F	3.657	1.00
159_A	174_W	3.598	1.00
131_I	260_A	3.555	1.00
74_A	115_T	3.393	1.00
283_Y	286_A	3.225	1.00
124_L	253_G	3.117	1.00
131_I	291_G	3.051	1.00
119_A	340_A	2.983	1.00
118_A	238_V	2.961	1.00
320_T	338_L	2.881	1.00
89_T	103_S	2.667	1.00
117_A	241_V	2.605	1.00
124_L	302_A	2.552	1.00
124_L	298_L	2.544	1.00
127_V	336_A	2.457	1.00
74_A	119_A	2.455	1.00
89_T	92_E	2.400	1.00
154_F	216_I	2.373	1.00
274_D	288_K	2.358	1.00
70_L	341_V	2.351	1.00
69_L	341_V	2.314	1.00
127_V	257_L	2.260	1.00
121_V	302_A	2.233	1.00
130_A	335_S	2.164	1.00
79_S	87_L	2.137	1.00
154_F	213_F	2.110	1.00
268_T	328_Y	2.027	1.00
121_V	306_A	2.020	1.00
100_T	103_S	2.017	1.00
119_A	344_V	2.016	1.00
77_S	115_T	2.006	1.00
70_L	119_A	1.987	1.00
114_R	347_D	1.979	1.00
86_H	89_T	1.951	1.00
120_L	250_L	1.909	1.00
252_A	301_A	1.901	1.00
266_S	287_V	1.901	1.00
324_V	334_C	1.883	1.00
73_G	341_V	1.881	1.00
132_M	295_V	1.871	1.00
134_G	328_Y	1.851	1.00
63_L	334_C	1.817	1.00
158_I	162_F	1.814	1.00
157_S	217_S	1.774	1.00
241_V	245_G	1.760	1.00
269_V	282_Q	1.728	1.00
97_Y	104_H	1.724	1.00
263_I	266_S	1.713	1.00
88_R	92_E	1.704	1.00
179_A	300_G	1.690	1.00
259_L	294_I	1.683	1.00
101_K	104_H	1.606	1.00
256_G	298_L	1.593	1.00
312_I	343_L	1.591	1.00
349_A	353_V	1.590	1.00
70_L	337_V	1.578	1.00
116_A	246_V	1.540	1.00
104_H	108_H	1.540	1.00
130_A	331_I	1.539	1.00
286_A	290_V	1.512	1.00
156_V	175_S	1.511	1.00
263_I	290_V	1.508	1.00
183_A	296_V	1.494	1.00
256_G	297_I	1.485	1.00
62_V	334_C	1.478	1.00
350_A	361_V	1.477	1.00
155_A	174_W	1.472	1.00
76_L	79_S	1.465	1.00
66_G	337_V	1.464	1.00
93_A	108_H	1.457	1.00
73_G	344_V	1.454	1.00
91_W	95_F	1.453	1.00
349_A	364_L	1.452	1.00
242_K	245_G	1.436	1.00
76_L	80_L	1.432	1.00
320_T	331_I	1.423	1.00
128_S	298_L	1.423	1.00
238_V	343_L	1.416	1.00
66_G	334_C	1.403	1.00
59_A	330_W	1.396	1.00
117_A	305_I	1.385	1.00
77_S	348_I	1.374	1.00
153_A	217_S	1.362	1.00
247_Q	251_I	1.342	1.00
316_I	342_L	1.313	1.00
320_T	334_C	1.310	1.00
212_F	370_V	1.299	1.00
149_T	299_T	1.298	1.00
263_I	287_V	1.292	1.00
256_G	294_I	1.291	1.00
182_G	213_F	1.290	1.00
70_L	340_A	1.282	1.00
247_Q	250_L	1.263	1.00
155_A	178_G	1.250	1.00
126_A	316_I	1.248	1.00
66_G	338_L	1.232	1.00
330_W	333_P	1.221	1.00
278_K	285_S	1.221	1.00
251_I	255_V	1.220	1.00
263_I	291_G	1.208	1.00
153_A	234_Y	1.201	1.00
259_L	263_I	1.193	1.00
120_L	246_V	1.187	1.00
328_Y	331_I	1.179	1.00
135_M	291_G	1.179	1.00
286_A	289_L	1.176	1.00
306_A	309_I	1.175	1.00
351_R	358_E	1.173	1.00
130_A	328_Y	1.167	1.00
316_I	338_L	1.167	1.00
66_G	341_V	1.167	1.00
157_S	230_I	1.159	1.00
154_F	158_I	1.158	1.00
285_S	288_K	1.156	1.00
63_L	330_W	1.154	1.00
176_F	297_I	1.150	1.00
84_D	87_L	1.147	1.00
105_Q	109_D	1.145	1.00
287_V	290_V	1.145	1.00
83_A	106_I	1.143	1.00
276_L	279_G	1.141	1.00
102_T	105_Q	1.122	1.00
93_A	104_H	1.120	1.00
96_H	99_P	1.115	1.00
116_A	243_W	1.106	1.00
184_S	188_G	1.103	1.00
151_G	178_G	1.098	1.00
249_L	305_I	1.098	1.00
273_G	277_A	1.095	1.00
120_L	249_L	1.094	1.00
93_A	99_P	1.092	1.00
117_A	246_V	1.089	1.00
161_A	220_I	1.083	1.00
186_V	209_V	1.081	1.00
99_P	104_H	1.081	1.00
260_A	294_I	1.076	1.00
97_Y	108_H	1.075	1.00
167_S	170_G	1.058	1.00
174_W	178_G	1.054	1.00
61_I	64_I	1.051	1.00
130_A	332_I	1.047	1.00
123_A	126_A	1.045	1.00
269_V	280_L	1.043	1.00
249_L	253_G	1.030	1.00
151_G	182_G	1.029	1.00
74_A	344_V	1.028	1.00
123_A	340_A	1.027	1.00
118_A	343_L	1.026	1.00
118_A	344_V	1.025	1.00
309_I	343_L	1.021	1.00
80_L	352_L	1.020	1.00
366_S	371_P	1.017	1.00
173_L	177_A	1.006	1.00
349_A	352_L	1.005	1.00
93_A	107_I	0.990	1.00
158_I	220_I	0.990	1.00
108_H	112_L	0.989	1.00
115_T	348_I	0.985	1.00
330_W	334_C	0.983	1.00
210_T	214_T	0.983	1.00
347_D	351_R	0.980	1.00
331_I	335_S	0.977	1.00
73_G	348_I	0.977	1.00
93_A	97_Y	0.975	1.00
59_A	63_L	0.973	1.00
181_L	185_T	0.973	1.00
78_I	115_T	0.970	1.00
258_T	262_F	0.970	1.00
90_V	107_I	0.968	1.00
126_A	339_G	0.964	1.00
149_T	308_T	0.960	1.00
285_S	289_L	0.958	1.00
341_V	345_F	0.956	1.00
68_C	72_L	0.954	1.00
67_L	71_C	0.949	1.00
328_Y	333_P	0.949	1.00
81_G	111_R	0.946	1.00
302_A	306_A	0.944	1.00
150_S	213_F	0.942	1.00
230_I	234_Y	0.941	1.00
60_V	63_L	0.940	1.00
248_L	251_I	0.935	1.00
316_I	320_T	0.934	1.00
243_W	246_V	0.931	1.00
79_S	90_V	0.930	1.00
60_V	64_I	0.930	1.00
354_N	357_F	0.929	1.00
75_F	79_S	0.926	1.00
156_V	171_L	0.924	1.00
256_G	301_A	0.923	1.00
154_F	217_S	0.919	1.00
251_I	254_A	0.917	1.00
350_A	364_L	0.916	1.00
282_Q	287_V	0.916	1.00
259_L	290_V	0.908	1.00
223_R	226_V	0.903	1.00
255_V	258_T	0.900	1.00
93_A	103_S	0.900	1.00
104_H	109_D	0.898	1.00
187_M	285_S	0.898	1.00
148_V	179_A	0.896	1.00
275_D	278_K	0.892	1.00
287_V	291_G	0.890	1.00
154_F	220_I	0.889	1.00
345_F	349_A	0.888	1.00
160_F	171_L	0.884	1.00
324_V	330_W	0.884	1.00
99_P	103_S	0.883	1.00
61_I	65_A	0.882	1.00
267_V	291_G	0.880	1.00
124_L	128_S	0.873	1.00
144_S	149_T	0.865	1.00
123_A	257_L	0.861	1.00
128_S	295_V	0.860	1.00
372_F	375_Y	0.859	1.00
92_E	96_H	0.859	1.00
85_I	107_I	0.857	1.00
75_F	87_L	0.856	1.00
120_L	253_G	0.856	1.00
268_T	329_R	0.854	1.00
92_E	95_F	0.853	1.00
150_S	153_A	0.853	1.00
62_V	66_G	0.847	1.00
62_V	65_A	0.844	1.00
350_A	360_P	0.828	1.00
321_R	331_I	0.827	1.00
152_S	179_A	0.825	1.00
327_D	330_W	0.823	1.00
159_A	171_L	0.820	1.00
323_L	338_L	0.818	1.00
371_P	375_Y	0.818	1.00
254_A	258_T	0.816	1.00
67_L	337_V	0.816	1.00
158_I	163_F	0.809	1.00
92_E	97_Y	0.809	1.00
176_F	180_G	0.808	1.00
320_T	324_V	0.804	1.00
333_P	336_A	0.804	1.00
277_A	284_T	0.803	1.00
353_V	356_P	0.801	1.00
289_L	293_L	0.801	1.00
77_S	351_R	0.797	1.00
85_I	103_S	0.795	1.00
263_I	294_I	0.794	1.00
71_C	75_F	0.791	1.00
112_L	243_W	0.786	1.00
252_A	256_G	0.785	1.00
115_T	344_V	0.784	1.00
259_L	262_F	0.783	1.00
228_Q	231_S	0.782	1.00
352_L	355_A	0.782	1.00
187_M	289_L	0.778	1.00
312_I	365_T	0.776	1.00
292_M	296_V	0.773	1.00
126_A	130_A	0.771	1.00
129_G	317_P	0.770	1.00
260_A	291_G	0.770	1.00
166_L	170_G	0.767	1.00
179_A	296_V	0.765	1.00
123_A	253_G	0.759	1.00
136_T	203_A	0.750	1.00
142_E	145_I	0.749	1.00
180_G	300_G	0.749	1.00
224_F	227_A	0.748	1.00
245_G	305_I	0.747	1.00
132_M	146_M	0.746	1.00
126_A	336_A	0.746	1.00
320_T	323_L	0.746	1.00
114_R	351_R	0.742	1.00
127_V	332_I	0.738	1.00
274_D	278_K	0.737	1.00
367_L	371_P	0.736	1.00
70_L	344_V	0.734	1.00
309_I	361_V	0.734	1.00
354_N	359_T	0.733	1.00
343_L	365_T	0.732	1.00
183_A	292_M	0.732	1.00
189_I	205_A	0.730	1.00
157_S	221_A	0.729	1.00
70_L	74_A	0.727	1.00
264_A	329_R	0.724	1.00
148_V	183_A	0.723	1.00
72_L	75_F	0.723	1.00
301_A	305_I	0.723	1.00
337_V	341_V	0.722	1.00
268_T	333_P	0.720	1.00
177_A	181_L	0.720	1.00
249_L	301_A	0.719	1.00
78_I	107_I	0.718	1.00
105_Q	110_L	0.718	1.00
101_K	105_Q	0.712	1.00
114_R	358_E	0.712	1.00
134_G	271_S	0.711	1.00
244_S	247_Q	0.709	1.00
250_L	254_A	0.709	1.00
253_G	302_A	0.708	1.00
346_A	364_L	0.701	1.00
96_H	104_H	0.701	1.00
116_A	120_L	0.700	1.00
158_I	216_I	0.699	1.00
121_V	238_V	0.697	1.00
186_V	190_G	0.691	1.00
343_L	361_V	0.689	1.00
90_V	93_A	0.688	1.00
71_C	74_A	0.687	1.00
79_S	84_D	0.687	1.00
342_L	346_A	0.684	1.00
58_G	62_V	0.683	1.00
322_F	376_L	0.680	1.00
319_I	338_L	0.678	1.00
80_L	84_D	0.678	1.00
329_R	333_P	0.677	1.00
301_A	304_S	0.676	1.00
170_G	173_L	0.675	1.00
78_I	112_L	0.673	1.00
153_A	308_T	0.671	1.00
83_A	86_H	0.670	1.00
127_V	260_A	0.670	1.00
193_S	196_G	0.670	1.00
190_G	205_A	0.670	1.00
200_V	203_A	0.669	1.00
160_F	229_D	0.668	1.00
284_T	288_K	0.666	1.00
182_G	186_V	0.664	1.00
132_M	141_A	0.662	1.00
319_I	322_F	0.662	1.00
319_I	342_L	0.660	1.00
278_K	284_T	0.659	1.00
180_G	296_V	0.659	1.00
62_V	323_L	0.658	1.00
83_A	87_L	0.658	1.00
74_A	78_I	0.652	1.00
100_T	104_H	0.651	1.00
142_E	313_G	0.650	1.00
131_I	294_I	0.647	1.00
85_I	93_A	0.647	1.00
151_G	213_F	0.647	1.00
155_A	159_A	0.646	1.00
340_A	344_V	0.646	1.00
221_A	231_S	0.646	1.00
224_F	228_Q	0.643	1.00
299_T	303_V	0.643	1.00
336_A	340_A	0.642	1.00
249_L	252_A	0.639	1.00
266_S	282_Q	0.637	1.00
171_L	174_W	0.635	1.00
118_A	361_V	0.633	1.00
117_A	249_L	0.633	1.00
105_Q	108_H	0.632	1.00
238_V	361_V	0.630	1.00
125_L	312_I	0.629	1.00
270_L	284_T	0.627	1.00
66_G	70_L	0.625	1.00
231_S	234_Y	0.625	1.00
257_L	336_A	0.624	1.00
375_Y	379_R	0.623	1.00
274_D	284_T	0.620	1.00
268_T	271_S	0.618	1.00
345_F	348_I	0.618	1.00
257_L	261_F	0.617	1.00
300_G	304_S	0.617	1.00
262_F	266_S	0.616	1.00
205_A	208_A	0.616	1.00
150_S	214_T	0.615	1.00
266_S	269_V	0.614	1.00
112_L	116_A	0.614	1.00
315_I	373_F	0.614	1.00
342_L	368_I	0.613	1.00
72_L	76_L	0.611	1.00
123_A	127_V	0.608	1.00
256_G	260_A	0.607	1.00
92_E	99_P	0.607	1.00
261_F	264_A	0.606	1.00
128_S	299_T	0.606	1.00
160_F	230_I	0.606	1.00
347_D	358_E	0.606	1.00
149_T	152_S	0.604	1.00
75_F	91_W	0.603	1.00
226_V	229_D	0.602	1.00
89_T	99_P	0.598	1.00
243_W	247_Q	0.596	0.99
169_M	173_L	0.595	0.99
82_A	356_P	0.593	0.99
142_E	365_T	0.593	0.99
80_L	348_I	0.592	0.99
87_L	91_W	0.589	0.99
87_L	90_V	0.589	0.99
178_G	182_G	0.586	0.99
150_S	210_T	0.586	0.99
136_T	139_P	0.585	0.99
314_L	376_L	0.585	0.99
65_A	69_L	0.583	0.99
218_T	233_W	0.580	0.99
86_H	103_S	0.580	0.99
221_A	234_Y	0.580	0.99
148_V	186_V	0.579	0.99
248_L	301_A	0.577	0.99
127_V	253_G	0.576	0.99
194_R	197_L	0.575	0.99
253_G	258_T	0.574	0.99
198_T	201_K	0.574	0.99
132_M	148_V	0.573	0.99
378_R	381_R	0.572	0.99
283_Y	290_V	0.570	0.99
350_A	358_E	0.570	0.99
70_L	115_T	0.569	0.99
312_I	342_L	0.568	0.99
218_T	222_I	0.568	0.99
225_D	229_D	0.566	0.99
152_S	175_S	0.566	0.99
90_V	94_I	0.564	0.99
62_V	324_V	0.563	0.99
344_V	348_I	0.563	0.99
159_A	163_F	0.562	0.99
214_T	218_T	0.561	0.99
88_R	91_W	0.557	0.99
252_A	297_I	0.557	0.99
193_S	285_S	0.555	0.99
73_G	76_L	0.555	0.99
219_A	363_A	0.550	0.99
227_A	230_I	0.549	0.99
221_A	227_A	0.547	0.99
79_S	91_W	0.546	0.99
215_G	315_I	0.546	0.99
77_S	344_V	0.545	0.99
325_G	329_R	0.544	0.99
315_I	372_F	0.544	0.99
116_A	250_L	0.544	0.99
185_T	188_G	0.543	0.99
315_I	319_I	0.541	0.99
222_I	363_A	0.541	0.99
296_V	300_G	0.541	0.99
74_A	116_A	0.541	0.99
319_I	323_L	0.540	0.99
76_L	348_I	0.539	0.99
255_V	259_L	0.539	0.99
295_V	300_G	0.538	0.99
182_G	209_V	0.536	0.99
205_A	209_V	0.535	0.99
314_L	317_P	0.535	0.99
261_F	332_I	0.535	0.99
290_V	294_I	0.534	0.99
352_L	356_P	0.530	0.99
130_A	320_T	0.530	0.99
148_V	237_G	0.530	0.99
262_F	265_R	0.530	0.99
237_G	358_E	0.529	0.99
238_V	306_A	0.528	0.99
63_L	67_L	0.526	0.99
244_S	248_L	0.525	0.99
63_L	333_P	0.522	0.99
309_I	365_T	0.521	0.99
350_A	353_V	0.520	0.99
156_V	174_W	0.520	0.99
212_F	216_I	0.519	0.99
221_A	230_I	0.519	0.99
141_A	148_V	0.519	0.99
248_L	252_A	0.518	0.99
267_V	328_Y	0.518	0.99
119_A	238_V	0.517	0.99
65_A	68_C	0.517	0.99
222_I	235_A	0.517	0.99
180_G	293_L	0.516	0.99
107_I	112_L	0.515	0.99
185_T	209_V	0.515	0.99
246_V	249_L	0.515	0.99
90_V	95_F	0.515	0.99
142_E	308_T	0.514	0.99
375_Y	378_R	0.514	0.99
227_A	232_F	0.513	0.98
310_A	315_I	0.511	0.98
348_I	352_L	0.509	0.98
64_I	68_C	0.509	0.98
181_L	184_S	0.509	0.98
94_I	107_I	0.509	0.98
214_T	234_Y	0.508	0.98
183_A	187_M	0.506	0.98
187_M	197_L	0.504	0.98
146_M	156_V	0.501	0.98
319_I	372_F	0.500	0.98

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4g1uA	2	0.7656	100	0.307	Contact Map
2nq2A	2	0.7969	100	0.314	Contact Map
2qi9A	2	0.8359	100	0.323	Contact Map
4c7rA	3	0.1328	27.4	0.969	Contact Map
4ezcA	3	0.7786	24.8	0.97	Contact Map
4zw9A	1	0.8021	22	0.97	Contact Map
2m8rA	1	0.2109	19.4	0.971	Contact Map
4v3iA	2	0.0964	16.9	0.972	Contact Map
3rlbA	1	0.4375	16.9	0.972	Contact Map
4m64A	1	0.0599	15.5	0.972	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0109 seconds.