GREMLIN Database
FHUB - Iron(3+)-hydroxamate import system permease protein FhuB
UniProt: P49936 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 384 (321)
Sequences: 13161 (9353)
Seq/√Len: 522.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
268_T327_D4.8221.00
123_A336_A3.6741.00
73_G345_F3.6571.00
159_A174_W3.5981.00
131_I260_A3.5551.00
74_A115_T3.3931.00
283_Y286_A3.2251.00
124_L253_G3.1171.00
131_I291_G3.0511.00
119_A340_A2.9831.00
118_A238_V2.9611.00
320_T338_L2.8811.00
89_T103_S2.6671.00
117_A241_V2.6051.00
124_L302_A2.5521.00
124_L298_L2.5441.00
127_V336_A2.4571.00
74_A119_A2.4551.00
89_T92_E2.4001.00
154_F216_I2.3731.00
274_D288_K2.3581.00
70_L341_V2.3511.00
69_L341_V2.3141.00
127_V257_L2.2601.00
121_V302_A2.2331.00
130_A335_S2.1641.00
79_S87_L2.1371.00
154_F213_F2.1101.00
268_T328_Y2.0271.00
121_V306_A2.0201.00
100_T103_S2.0171.00
119_A344_V2.0161.00
77_S115_T2.0061.00
70_L119_A1.9871.00
114_R347_D1.9791.00
86_H89_T1.9511.00
120_L250_L1.9091.00
252_A301_A1.9011.00
266_S287_V1.9011.00
324_V334_C1.8831.00
73_G341_V1.8811.00
132_M295_V1.8711.00
134_G328_Y1.8511.00
63_L334_C1.8171.00
158_I162_F1.8141.00
157_S217_S1.7741.00
241_V245_G1.7601.00
269_V282_Q1.7281.00
97_Y104_H1.7241.00
263_I266_S1.7131.00
88_R92_E1.7041.00
179_A300_G1.6901.00
259_L294_I1.6831.00
101_K104_H1.6061.00
256_G298_L1.5931.00
312_I343_L1.5911.00
349_A353_V1.5901.00
70_L337_V1.5781.00
116_A246_V1.5401.00
104_H108_H1.5401.00
130_A331_I1.5391.00
286_A290_V1.5121.00
156_V175_S1.5111.00
263_I290_V1.5081.00
183_A296_V1.4941.00
256_G297_I1.4851.00
62_V334_C1.4781.00
350_A361_V1.4771.00
155_A174_W1.4721.00
76_L79_S1.4651.00
66_G337_V1.4641.00
93_A108_H1.4571.00
73_G344_V1.4541.00
91_W95_F1.4531.00
349_A364_L1.4521.00
242_K245_G1.4361.00
76_L80_L1.4321.00
320_T331_I1.4231.00
128_S298_L1.4231.00
238_V343_L1.4161.00
66_G334_C1.4031.00
59_A330_W1.3961.00
117_A305_I1.3851.00
77_S348_I1.3741.00
153_A217_S1.3621.00
247_Q251_I1.3421.00
316_I342_L1.3131.00
320_T334_C1.3101.00
212_F370_V1.2991.00
149_T299_T1.2981.00
263_I287_V1.2921.00
256_G294_I1.2911.00
182_G213_F1.2901.00
70_L340_A1.2821.00
247_Q250_L1.2631.00
155_A178_G1.2501.00
126_A316_I1.2481.00
66_G338_L1.2321.00
330_W333_P1.2211.00
278_K285_S1.2211.00
251_I255_V1.2201.00
263_I291_G1.2081.00
153_A234_Y1.2011.00
259_L263_I1.1931.00
120_L246_V1.1871.00
328_Y331_I1.1791.00
135_M291_G1.1791.00
286_A289_L1.1761.00
306_A309_I1.1751.00
351_R358_E1.1731.00
130_A328_Y1.1671.00
316_I338_L1.1671.00
66_G341_V1.1671.00
157_S230_I1.1591.00
154_F158_I1.1581.00
285_S288_K1.1561.00
63_L330_W1.1541.00
176_F297_I1.1501.00
84_D87_L1.1471.00
105_Q109_D1.1451.00
287_V290_V1.1451.00
83_A106_I1.1431.00
276_L279_G1.1411.00
102_T105_Q1.1221.00
93_A104_H1.1201.00
96_H99_P1.1151.00
116_A243_W1.1061.00
184_S188_G1.1031.00
151_G178_G1.0981.00
249_L305_I1.0981.00
273_G277_A1.0951.00
120_L249_L1.0941.00
93_A99_P1.0921.00
117_A246_V1.0891.00
161_A220_I1.0831.00
186_V209_V1.0811.00
99_P104_H1.0811.00
260_A294_I1.0761.00
97_Y108_H1.0751.00
167_S170_G1.0581.00
174_W178_G1.0541.00
61_I64_I1.0511.00
130_A332_I1.0471.00
123_A126_A1.0451.00
269_V280_L1.0431.00
249_L253_G1.0301.00
151_G182_G1.0291.00
74_A344_V1.0281.00
123_A340_A1.0271.00
118_A343_L1.0261.00
118_A344_V1.0251.00
309_I343_L1.0211.00
80_L352_L1.0201.00
366_S371_P1.0171.00
173_L177_A1.0061.00
349_A352_L1.0051.00
93_A107_I0.9901.00
158_I220_I0.9901.00
108_H112_L0.9891.00
115_T348_I0.9851.00
330_W334_C0.9831.00
210_T214_T0.9831.00
347_D351_R0.9801.00
331_I335_S0.9771.00
73_G348_I0.9771.00
93_A97_Y0.9751.00
59_A63_L0.9731.00
181_L185_T0.9731.00
78_I115_T0.9701.00
258_T262_F0.9701.00
90_V107_I0.9681.00
126_A339_G0.9641.00
149_T308_T0.9601.00
285_S289_L0.9581.00
341_V345_F0.9561.00
68_C72_L0.9541.00
67_L71_C0.9491.00
328_Y333_P0.9491.00
81_G111_R0.9461.00
302_A306_A0.9441.00
150_S213_F0.9421.00
230_I234_Y0.9411.00
60_V63_L0.9401.00
248_L251_I0.9351.00
316_I320_T0.9341.00
243_W246_V0.9311.00
79_S90_V0.9301.00
60_V64_I0.9301.00
354_N357_F0.9291.00
75_F79_S0.9261.00
156_V171_L0.9241.00
256_G301_A0.9231.00
154_F217_S0.9191.00
251_I254_A0.9171.00
350_A364_L0.9161.00
282_Q287_V0.9161.00
259_L290_V0.9081.00
223_R226_V0.9031.00
255_V258_T0.9001.00
93_A103_S0.9001.00
104_H109_D0.8981.00
187_M285_S0.8981.00
148_V179_A0.8961.00
275_D278_K0.8921.00
287_V291_G0.8901.00
154_F220_I0.8891.00
345_F349_A0.8881.00
160_F171_L0.8841.00
324_V330_W0.8841.00
99_P103_S0.8831.00
61_I65_A0.8821.00
267_V291_G0.8801.00
124_L128_S0.8731.00
144_S149_T0.8651.00
123_A257_L0.8611.00
128_S295_V0.8601.00
372_F375_Y0.8591.00
92_E96_H0.8591.00
85_I107_I0.8571.00
75_F87_L0.8561.00
120_L253_G0.8561.00
268_T329_R0.8541.00
92_E95_F0.8531.00
150_S153_A0.8531.00
62_V66_G0.8471.00
62_V65_A0.8441.00
350_A360_P0.8281.00
321_R331_I0.8271.00
152_S179_A0.8251.00
327_D330_W0.8231.00
159_A171_L0.8201.00
323_L338_L0.8181.00
371_P375_Y0.8181.00
254_A258_T0.8161.00
67_L337_V0.8161.00
158_I163_F0.8091.00
92_E97_Y0.8091.00
176_F180_G0.8081.00
320_T324_V0.8041.00
333_P336_A0.8041.00
277_A284_T0.8031.00
353_V356_P0.8011.00
289_L293_L0.8011.00
77_S351_R0.7971.00
85_I103_S0.7951.00
263_I294_I0.7941.00
71_C75_F0.7911.00
112_L243_W0.7861.00
252_A256_G0.7851.00
115_T344_V0.7841.00
259_L262_F0.7831.00
228_Q231_S0.7821.00
352_L355_A0.7821.00
187_M289_L0.7781.00
312_I365_T0.7761.00
292_M296_V0.7731.00
126_A130_A0.7711.00
129_G317_P0.7701.00
260_A291_G0.7701.00
166_L170_G0.7671.00
179_A296_V0.7651.00
123_A253_G0.7591.00
136_T203_A0.7501.00
142_E145_I0.7491.00
180_G300_G0.7491.00
224_F227_A0.7481.00
245_G305_I0.7471.00
132_M146_M0.7461.00
126_A336_A0.7461.00
320_T323_L0.7461.00
114_R351_R0.7421.00
127_V332_I0.7381.00
274_D278_K0.7371.00
367_L371_P0.7361.00
70_L344_V0.7341.00
309_I361_V0.7341.00
354_N359_T0.7331.00
343_L365_T0.7321.00
183_A292_M0.7321.00
189_I205_A0.7301.00
157_S221_A0.7291.00
70_L74_A0.7271.00
264_A329_R0.7241.00
148_V183_A0.7231.00
72_L75_F0.7231.00
301_A305_I0.7231.00
337_V341_V0.7221.00
268_T333_P0.7201.00
177_A181_L0.7201.00
249_L301_A0.7191.00
78_I107_I0.7181.00
105_Q110_L0.7181.00
101_K105_Q0.7121.00
114_R358_E0.7121.00
134_G271_S0.7111.00
244_S247_Q0.7091.00
250_L254_A0.7091.00
253_G302_A0.7081.00
346_A364_L0.7011.00
96_H104_H0.7011.00
116_A120_L0.7001.00
158_I216_I0.6991.00
121_V238_V0.6971.00
186_V190_G0.6911.00
343_L361_V0.6891.00
90_V93_A0.6881.00
71_C74_A0.6871.00
79_S84_D0.6871.00
342_L346_A0.6841.00
58_G62_V0.6831.00
322_F376_L0.6801.00
319_I338_L0.6781.00
80_L84_D0.6781.00
329_R333_P0.6771.00
301_A304_S0.6761.00
170_G173_L0.6751.00
78_I112_L0.6731.00
153_A308_T0.6711.00
83_A86_H0.6701.00
127_V260_A0.6701.00
193_S196_G0.6701.00
190_G205_A0.6701.00
200_V203_A0.6691.00
160_F229_D0.6681.00
284_T288_K0.6661.00
182_G186_V0.6641.00
132_M141_A0.6621.00
319_I322_F0.6621.00
319_I342_L0.6601.00
278_K284_T0.6591.00
180_G296_V0.6591.00
62_V323_L0.6581.00
83_A87_L0.6581.00
74_A78_I0.6521.00
100_T104_H0.6511.00
142_E313_G0.6501.00
131_I294_I0.6471.00
85_I93_A0.6471.00
151_G213_F0.6471.00
155_A159_A0.6461.00
340_A344_V0.6461.00
221_A231_S0.6461.00
224_F228_Q0.6431.00
299_T303_V0.6431.00
336_A340_A0.6421.00
249_L252_A0.6391.00
266_S282_Q0.6371.00
171_L174_W0.6351.00
118_A361_V0.6331.00
117_A249_L0.6331.00
105_Q108_H0.6321.00
238_V361_V0.6301.00
125_L312_I0.6291.00
270_L284_T0.6271.00
66_G70_L0.6251.00
231_S234_Y0.6251.00
257_L336_A0.6241.00
375_Y379_R0.6231.00
274_D284_T0.6201.00
268_T271_S0.6181.00
345_F348_I0.6181.00
257_L261_F0.6171.00
300_G304_S0.6171.00
262_F266_S0.6161.00
205_A208_A0.6161.00
150_S214_T0.6151.00
266_S269_V0.6141.00
112_L116_A0.6141.00
315_I373_F0.6141.00
342_L368_I0.6131.00
72_L76_L0.6111.00
123_A127_V0.6081.00
256_G260_A0.6071.00
92_E99_P0.6071.00
261_F264_A0.6061.00
128_S299_T0.6061.00
160_F230_I0.6061.00
347_D358_E0.6061.00
149_T152_S0.6041.00
75_F91_W0.6031.00
226_V229_D0.6021.00
89_T99_P0.5981.00
243_W247_Q0.5960.99
169_M173_L0.5950.99
82_A356_P0.5930.99
142_E365_T0.5930.99
80_L348_I0.5920.99
87_L91_W0.5890.99
87_L90_V0.5890.99
178_G182_G0.5860.99
150_S210_T0.5860.99
136_T139_P0.5850.99
314_L376_L0.5850.99
65_A69_L0.5830.99
218_T233_W0.5800.99
86_H103_S0.5800.99
221_A234_Y0.5800.99
148_V186_V0.5790.99
248_L301_A0.5770.99
127_V253_G0.5760.99
194_R197_L0.5750.99
253_G258_T0.5740.99
198_T201_K0.5740.99
132_M148_V0.5730.99
378_R381_R0.5720.99
283_Y290_V0.5700.99
350_A358_E0.5700.99
70_L115_T0.5690.99
312_I342_L0.5680.99
218_T222_I0.5680.99
225_D229_D0.5660.99
152_S175_S0.5660.99
90_V94_I0.5640.99
62_V324_V0.5630.99
344_V348_I0.5630.99
159_A163_F0.5620.99
214_T218_T0.5610.99
88_R91_W0.5570.99
252_A297_I0.5570.99
193_S285_S0.5550.99
73_G76_L0.5550.99
219_A363_A0.5500.99
227_A230_I0.5490.99
221_A227_A0.5470.99
79_S91_W0.5460.99
215_G315_I0.5460.99
77_S344_V0.5450.99
325_G329_R0.5440.99
315_I372_F0.5440.99
116_A250_L0.5440.99
185_T188_G0.5430.99
315_I319_I0.5410.99
222_I363_A0.5410.99
296_V300_G0.5410.99
74_A116_A0.5410.99
319_I323_L0.5400.99
76_L348_I0.5390.99
255_V259_L0.5390.99
295_V300_G0.5380.99
182_G209_V0.5360.99
205_A209_V0.5350.99
314_L317_P0.5350.99
261_F332_I0.5350.99
290_V294_I0.5340.99
352_L356_P0.5300.99
130_A320_T0.5300.99
148_V237_G0.5300.99
262_F265_R0.5300.99
237_G358_E0.5290.99
238_V306_A0.5280.99
63_L67_L0.5260.99
244_S248_L0.5250.99
63_L333_P0.5220.99
309_I365_T0.5210.99
350_A353_V0.5200.99
156_V174_W0.5200.99
212_F216_I0.5190.99
221_A230_I0.5190.99
141_A148_V0.5190.99
248_L252_A0.5180.99
267_V328_Y0.5180.99
119_A238_V0.5170.99
65_A68_C0.5170.99
222_I235_A0.5170.99
180_G293_L0.5160.99
107_I112_L0.5150.99
185_T209_V0.5150.99
246_V249_L0.5150.99
90_V95_F0.5150.99
142_E308_T0.5140.99
375_Y378_R0.5140.99
227_A232_F0.5130.98
310_A315_I0.5110.98
348_I352_L0.5090.98
64_I68_C0.5090.98
181_L184_S0.5090.98
94_I107_I0.5090.98
214_T234_Y0.5080.98
183_A187_M0.5060.98
187_M197_L0.5040.98
146_M156_V0.5010.98
319_I372_F0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g1uA 2 0.7656 100 0.307 Contact Map
2nq2A 2 0.7969 100 0.314 Contact Map
2qi9A 2 0.8359 100 0.323 Contact Map
4c7rA 3 0.1328 27.4 0.969 Contact Map
4ezcA 3 0.7786 24.8 0.97 Contact Map
4zw9A 1 0.8021 22 0.97 Contact Map
2m8rA 1 0.2109 19.4 0.971 Contact Map
4v3iA 2 0.0964 16.9 0.972 Contact Map
3rlbA 1 0.4375 16.9 0.972 Contact Map
4m64A 1 0.0599 15.5 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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