GREMLIN Database
YKKC - Multidrug resistance protein YkkC
UniProt: P49856 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 112 (100)
Sequences: 4313 (3046)
Seq/√Len: 304.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
86_L96_G3.0821.00
12_F38_F2.7091.00
45_K48_H2.6831.00
72_I79_V2.4731.00
19_G31_G2.4541.00
5_L45_K2.4261.00
2_K49_S2.2961.00
15_V35_G2.1501.00
10_A62_L2.0831.00
68_V87_I2.0471.00
70_S74_L1.9131.00
47_T55_V1.8511.00
89_V93_G1.8151.00
50_L55_V1.7651.00
88_G92_I1.6131.00
33_A37_I1.5691.00
16_W35_G1.5621.00
15_V31_G1.5541.00
89_V92_I1.5371.00
23_A26_A1.5361.00
81_W85_L1.4911.00
41_Y45_K1.4561.00
36_I40_F1.4461.00
18_I22_H1.4391.00
47_T52_V1.4301.00
16_W36_I1.4081.00
24_D28_T1.3441.00
18_I70_S1.3261.00
86_L93_G1.3261.00
90_L93_G1.3231.00
86_L100_V1.3191.00
20_L32_T1.3001.00
84_L88_G1.2991.00
64_T68_V1.2951.00
14_V66_G1.2931.00
5_L42_L1.2811.00
12_F35_G1.2661.00
22_H75_F1.2601.00
46_A55_V1.1981.00
43_L55_V1.1831.00
95_I99_L1.1761.00
86_L90_L1.1761.00
80_G83_K1.1691.00
3_W58_V1.1551.00
87_I97_L1.1511.00
82_P100_V1.1151.00
15_V19_G1.0791.00
79_V84_L1.0581.00
82_P85_L1.0571.00
78_P83_K1.0511.00
37_I41_Y1.0371.00
79_V83_K1.0321.00
71_E77_E1.0251.00
53_G57_A1.0111.00
4_G8_L0.9971.00
7_V62_L0.9941.00
23_A28_T0.9911.00
90_L94_V0.9751.00
92_I96_G0.9741.00
57_A60_T0.9621.00
77_E83_K0.9291.00
54_T83_K0.9051.00
81_W84_L0.9021.00
69_L73_V0.9011.00
65_A87_I0.9001.00
86_L89_V0.8981.00
83_K97_L0.8961.00
21_K25_S0.8871.00
7_V10_A0.8771.00
52_V67_T0.8681.00
19_G22_H0.8461.00
2_K50_L0.8411.00
19_G32_T0.8361.00
8_L42_L0.8341.00
91_L95_I0.8321.00
30_S34_I0.8311.00
64_T91_L0.8221.00
65_A91_L0.8191.00
10_A39_S0.8151.00
14_V70_S0.8131.00
16_W32_T0.8051.00
61_G94_V0.8041.00
58_V62_L0.7881.00
82_P86_L0.7790.99
9_A42_L0.7750.99
78_P81_W0.7710.99
17_V67_T0.7610.99
27_L48_H0.7570.99
71_E75_F0.7480.99
51_P54_T0.7340.99
18_I75_F0.7310.99
70_S75_F0.7290.99
13_E39_S0.7230.99
24_D27_L0.7190.99
89_V96_G0.7130.99
6_V55_V0.6890.99
2_K5_L0.6890.99
31_G35_G0.6880.99
72_I84_L0.6820.99
54_T57_A0.6760.98
19_G35_G0.6730.98
30_S33_A0.6700.98
62_L66_G0.6670.98
96_G100_V0.6650.98
11_V66_G0.6610.98
85_L89_V0.6610.98
60_T71_E0.6590.98
36_I60_T0.6560.98
45_K49_S0.6510.98
61_G64_T0.6420.98
20_L59_F0.6320.98
52_V75_F0.6260.98
32_T35_G0.6200.97
34_I38_F0.6170.97
21_K24_D0.6120.97
26_A29_W0.6100.97
20_L39_S0.6080.97
73_V76_H0.6060.97
19_G23_A0.6040.97
18_I71_E0.6010.97
11_V15_V0.5950.97
71_E83_K0.5910.96
23_A27_L0.5880.96
5_L46_A0.5860.96
57_A97_L0.5770.96
68_V97_L0.5770.96
9_A43_L0.5700.96
60_T98_K0.5680.96
40_F47_T0.5660.96
72_I78_P0.5650.95
6_V50_L0.5620.95
40_F44_M0.5510.95
6_V46_A0.5400.94
10_A94_V0.5380.94
19_G33_A0.5340.94
34_I37_I0.5310.94
16_W64_T0.5290.94
57_A87_I0.5270.94
66_G70_S0.5260.93
77_E80_G0.5250.93
25_S28_T0.5230.93
36_I52_V0.5220.93
25_S44_M0.5180.93
12_F32_T0.5180.93
86_L92_I0.5150.93
46_A50_L0.5080.92
64_T100_V0.5040.92
31_G34_I0.5030.92
18_I52_V0.5000.92
38_F42_L0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3b5dA 2 0.8839 99.9 0.395 Contact Map
2i68A 2 0.6964 99.9 0.421 Contact Map
1pw4A 1 1 9.2 0.932 Contact Map
4dx5A 3 0.9732 9.2 0.932 Contact Map
1l1yA 1 0.0982 4.5 0.941 Contact Map
4k0jA 3 0.8571 4.2 0.942 Contact Map
3w9iA 3 0.9554 4.1 0.942 Contact Map
4o9uB 2 0.7411 4 0.942 Contact Map
4xnjA 1 0.9196 3.9 0.942 Contact Map
3effK 4 0.7857 3.7 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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