GREMLIN Database
YKKB - Uncharacterized protein YkkB
UniProt: P49855 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 172 (152)
Sequences: 19411 (14963)
Seq/√Len: 1213.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
111_Q147_K2.8321.00
132_A145_A2.8101.00
15_R70_E2.7281.00
71_D74_T2.4411.00
15_R21_D2.4111.00
8_V72_K2.2971.00
34_D102_R2.2941.00
134_I142_I2.2871.00
94_M127_F2.1731.00
152_Y155_T2.1661.00
83_I121_G2.1271.00
134_I145_A2.0981.00
11_R112_E2.0971.00
9_T116_A2.0191.00
143_R146_E1.9321.00
142_I146_E1.9131.00
96_I114_A1.7991.00
32_D102_R1.7921.00
119_D123_N1.7871.00
17_M68_I1.7781.00
118_L150_M1.7661.00
68_I77_F1.7511.00
9_T112_E1.7081.00
23_A45_K1.7041.00
24_T77_F1.6631.00
118_L130_M1.6591.00
81_C113_A1.6261.00
101_A104_H1.6191.00
128_G158_K1.6191.00
22_Q49_R1.6081.00
114_A148_I1.5901.00
70_E75_G1.5631.00
142_I152_Y1.5621.00
44_D47_Q1.5421.00
13_R72_K1.5311.00
45_K49_R1.5191.00
51_W55_N1.4981.00
100_F110_A1.4971.00
116_A119_D1.4921.00
98_Y145_A1.4181.00
139_K142_I1.4041.00
146_E152_Y1.3941.00
7_L116_A1.3911.00
69_A100_F1.3551.00
69_A113_A1.3341.00
19_D53_N1.3151.00
111_Q144_V1.3121.00
136_P155_T1.3111.00
98_Y141_S1.3071.00
120_Y124_E1.2711.00
71_D78_L1.2681.00
129_K153_S1.2411.00
8_V13_R1.2351.00
22_Q52_V1.2331.00
57_R61_G1.2171.00
78_L104_H1.2131.00
13_R70_E1.2091.00
81_C117_C1.1911.00
24_T76_E1.1881.00
121_G130_M1.1691.00
110_A144_V1.1381.00
80_Q99_M1.1131.00
76_E103_R1.1121.00
9_T12_I1.1111.00
26_F45_K1.1101.00
71_D109_Y1.1081.00
22_Q45_K1.1071.00
93_V131_A1.1071.00
132_A150_M1.0981.00
7_L14_L1.0891.00
7_L120_Y1.0781.00
121_G125_R1.0771.00
35_V105_W1.0611.00
49_R53_N1.0571.00
95_E133_L1.0441.00
76_E104_H1.0291.00
29_L99_M1.0291.00
67_W117_C1.0281.00
111_Q115_R1.0261.00
105_W140_A1.0121.00
102_R105_W1.0001.00
141_S145_A0.9961.00
24_T27_G0.9951.00
145_A150_M0.9851.00
153_S157_R0.9771.00
144_V148_I0.9691.00
19_D49_R0.9661.00
29_L101_A0.9571.00
19_D56_Q0.9541.00
71_D107_N0.9531.00
67_W120_Y0.9511.00
43_K47_Q0.9511.00
17_M80_Q0.9491.00
71_D76_E0.9391.00
120_Y125_R0.9371.00
87_Q91_Q0.9191.00
58_N64_V0.9171.00
42_L48_T0.9151.00
106_G140_A0.8901.00
70_E77_F0.8901.00
118_L148_I0.8811.00
34_D37_T0.8801.00
115_R119_D0.8741.00
139_K143_R0.8741.00
13_R75_G0.8671.00
12_I113_A0.8671.00
12_I109_Y0.8661.00
46_R49_R0.8651.00
111_Q148_I0.8611.00
98_Y110_A0.8541.00
115_R148_I0.8511.00
93_V129_K0.8501.00
50_E54_W0.8451.00
26_F48_T0.8441.00
58_N63_G0.8431.00
121_G127_F0.8421.00
83_I117_C0.8421.00
27_G101_A0.8391.00
21_D70_E0.8381.00
139_K146_E0.8221.00
112_E116_A0.8221.00
100_F109_Y0.8171.00
38_Y135_D0.8171.00
34_D105_W0.8111.00
22_Q26_F0.8101.00
27_G103_R0.8071.00
71_D104_H0.8051.00
93_V159_W0.7951.00
24_T101_A0.7941.00
104_H107_N0.7921.00
69_A81_C0.7821.00
9_T14_L0.7801.00
23_A27_G0.7801.00
38_Y137_G0.7761.00
133_L156_I0.7631.00
76_E101_A0.7601.00
27_G76_E0.7471.00
19_D22_Q0.7401.00
32_D101_A0.7271.00
16_C59_E0.7261.00
36_M39_Y0.7241.00
106_G143_R0.7181.00
36_M41_G0.7161.00
114_A144_V0.7141.00
106_G111_Q0.7141.00
55_N66_L0.7111.00
50_E53_N0.7101.00
111_Q140_A0.7081.00
47_Q50_E0.7081.00
54_W58_N0.7061.00
156_I159_W0.7021.00
95_E131_A0.6981.00
53_N57_R0.6971.00
15_R68_I0.6931.00
10_D112_E0.6931.00
78_L109_Y0.6791.00
11_R108_G0.6761.00
134_I141_S0.6731.00
98_Y114_A0.6631.00
56_Q59_E0.6621.00
69_A109_Y0.6611.00
69_A110_A0.6521.00
27_G31_N0.6521.00
30_F99_M0.6521.00
26_F31_N0.6521.00
59_E65_S0.6511.00
66_L82_G0.6511.00
136_P142_I0.6481.00
43_K48_T0.6481.00
46_R50_E0.6471.00
92_T128_G0.6361.00
110_A114_A0.6341.00
143_R147_K0.6271.00
54_W57_R0.6201.00
48_T52_V0.6181.00
29_L77_F0.6141.00
100_F105_W0.6141.00
132_A141_S0.6131.00
118_L122_F0.6121.00
140_A143_R0.6121.00
18_E21_D0.6101.00
106_G144_V0.6091.00
81_C114_A0.6081.00
100_F104_H0.6071.00
15_R18_E0.6041.00
131_A156_I0.6041.00
84_V95_E0.6031.00
131_A159_W0.6031.00
98_Y144_V0.6021.00
30_F80_Q0.5991.00
69_A79_G0.5961.00
32_D105_W0.5961.00
151_H157_R0.5841.00
94_M121_G0.5841.00
39_Y99_M0.5821.00
154_K157_R0.5811.00
24_T70_E0.5801.00
16_C56_Q0.5711.00
52_V56_Q0.5701.00
109_Y112_E0.5671.00
129_K159_W0.5661.00
33_P37_T0.5651.00
142_I145_A0.5651.00
77_F80_Q0.5651.00
83_I94_M0.5641.00
35_V99_M0.5621.00
58_N62_Y0.5601.00
96_I130_M0.5471.00
12_I112_E0.5461.00
32_D103_R0.5431.00
94_M130_M0.5341.00
130_M150_M0.5271.00
35_V38_Y0.5271.00
98_Y132_A0.5261.00
133_L159_W0.5261.00
85_P94_M0.5251.00
144_V147_K0.5231.00
56_Q60_K0.5221.00
82_G97_G0.5211.00
92_T126_Q0.5191.00
114_A150_M0.5171.00
35_V39_Y0.5111.00
138_N141_S0.5091.00
17_M77_F0.5071.00
153_S156_I0.5031.00
10_D13_R0.5031.00
25_L52_V0.5011.00
122_F130_M0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fckA 2 0.9767 100 0.318 Contact Map
3pzjA 2 0.9709 100 0.344 Contact Map
3r9fA 1 0.9651 100 0.344 Contact Map
1yreA 2 0.9419 100 0.346 Contact Map
2vzyA 3 0.8895 100 0.351 Contact Map
1s7kA 2 0.8663 99.9 0.365 Contact Map
3fbuA 2 0.9302 99.9 0.373 Contact Map
3igrA 2 0.9767 99.9 0.382 Contact Map
1nslA 3 0.9651 99.9 0.383 Contact Map
2z10A 2 0.9477 99.9 0.385 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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