GREMLIN Database
HMP - Flavohemoprotein
UniProt: P49852 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 399 (359)
Sequences: 2739 (1848)
Seq/√Len: 97.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
159_I237_L5.7291.00
279_K307_E4.2121.00
302_H323_Y3.4891.00
160_A175_K3.4661.00
191_I245_I3.2281.00
18_Q66_A3.1781.00
194_K244_E3.1581.00
162_K170_T3.1311.00
70_Q73_N3.1071.00
32_M97_I3.0951.00
238_Q241_D3.0891.00
212_D279_K2.9941.00
158_V175_K2.9131.00
263_V356_A2.8741.00
156_P244_E2.8161.00
161_K239_E2.7971.00
156_P242_S2.7831.00
211_S222_S2.7461.00
174_L221_I2.6511.00
266_S274_M2.5991.00
86_R249_A2.4911.00
225_K235_D2.4081.00
161_K173_Y2.3821.00
27_R31_R2.3261.00
103_L123_E2.2821.00
114_A119_M2.2441.00
308_V319_T2.2121.00
131_D135_G2.1371.00
299_S326_P2.0951.00
79_K136_I2.0481.00
223_V233_L2.0321.00
158_V177_E2.0211.00
171_S220_R2.0201.00
175_K217_D2.0091.00
159_I174_L1.9881.00
280_T284_K1.9251.00
173_Y220_R1.9081.00
312_A317_V1.8971.00
295_A324_R1.8961.00
192_S205_I1.8781.00
281_S286_P1.8771.00
87_S207_Q1.8751.00
156_P177_E1.8751.00
31_R104_I1.8691.00
293_I342_I1.8441.00
26_G30_D1.8361.00
169_I269_V1.8101.00
20_H23_T1.7741.00
105_A109_V1.7631.00
340_G343_D1.7581.00
262_L281_S1.7521.00
138_K152_K1.7401.00
254_L277_M1.7291.00
305_R309_E1.7251.00
31_R108_D1.7191.00
35_D101_Y1.7101.00
120_Q124_K1.7031.00
310_E314_H1.6641.00
158_V242_S1.6631.00
271_I292_F1.6511.00
297_K324_R1.6451.00
107_K116_P1.6111.00
113_A116_P1.5991.00
157_F245_I1.5831.00
175_K218_Y1.5791.00
237_L241_D1.5731.00
247_A250_G1.5651.00
260_K357_D1.5581.00
16_V19_Q1.5561.00
16_V113_A1.5521.00
27_R30_D1.5381.00
115_T118_I1.5211.00
71_L78_V1.5141.00
163_E173_Y1.5111.00
291_L320_A1.5061.00
22_E55_T1.5011.00
27_R108_D1.5011.00
263_V358_Y1.4931.00
91_K94_H1.4741.00
375_S381_P1.4731.00
17_L21_G1.4641.00
157_F176_P1.4411.00
192_S207_Q1.4361.00
232_Y237_L1.4361.00
264_L274_M1.4301.00
261_D289_Q1.4251.00
46_T50_K1.4231.00
192_S246_S1.4061.00
360_I384_I1.4020.99
99_G103_L1.4020.99
295_A342_I1.3970.99
30_D34_Q1.3870.99
119_M123_E1.3830.99
195_V229_V1.3790.99
266_S294_H1.3780.99
265_I358_Y1.3770.99
165_E171_S1.3720.99
177_E242_S1.3520.99
57_L60_A1.3360.99
187_A280_T1.3320.99
343_D376_E1.3310.99
296_A301_Y1.3300.99
168_E297_K1.3220.99
173_Y218_Y1.3210.99
91_K96_P1.3150.99
138_K142_E1.3050.99
35_D100_K1.3020.99
289_Q318_K1.2920.99
82_G136_I1.2890.99
120_Q123_E1.2890.99
360_I371_H1.2880.99
62_I66_A1.2810.99
167_K300_E1.2790.99
299_S305_R1.2750.99
266_S292_F1.2730.99
380_A383_S1.2690.99
53_Q57_L1.2650.99
145_E152_K1.2540.99
17_L62_I1.2420.99
169_I303_A1.2250.99
197_I200_S1.2250.99
275_I304_L1.2160.99
159_I162_K1.2070.98
271_I304_L1.1930.98
22_E26_G1.1920.98
302_H305_R1.1880.98
19_Q23_T1.1810.98
194_K203_T1.1770.98
344_Q348_K1.1760.98
326_P336_H1.1640.98
275_I307_E1.1620.98
298_N325_E1.1610.98
26_G54_R1.1590.98
225_K231_S1.1550.98
64_A129_I1.1480.98
278_L308_V1.1470.98
61_V69_D1.1460.98
371_H375_S1.1450.98
107_K119_M1.1440.98
23_T26_G1.1430.98
132_A136_I1.1420.98
31_R35_D1.1380.98
124_K128_V1.1370.98
295_A322_V1.1330.98
116_P120_Q1.1210.97
61_V106_I1.1140.97
103_L110_L1.1110.97
136_I139_D1.1040.97
87_S192_S1.1030.97
306_H310_E1.1010.97
185_F276_S1.0940.97
344_Q377_L1.0910.97
309_E321_F1.0890.97
324_R369_A1.0820.97
35_D104_I1.0790.97
122_W125_A1.0730.97
118_I125_A1.0690.97
282_V317_V1.0660.97
32_M101_Y1.0630.97
20_H24_I1.0510.96
155_K180_K1.0490.96
193_I221_I1.0420.96
344_Q347_L1.0340.96
40_L45_Q1.0320.96
187_A276_S1.0300.96
123_E127_G1.0290.96
98_V102_L1.0280.96
111_G115_T1.0250.96
172_F233_L1.0250.96
100_K104_I1.0230.96
231_S235_D1.0210.96
77_V80_Q1.0210.96
260_K355_D1.0170.96
355_D383_S1.0150.95
78_V82_G1.0110.95
197_I204_H1.0100.95
162_K237_L1.0080.95
126_Y130_A1.0080.95
222_S304_L1.0040.95
312_A319_T0.9890.95
298_N327_T0.9890.95
346_F350_L0.9810.95
137_E141_Y0.9810.95
79_K83_H0.9740.94
32_M38_E0.9740.94
211_S220_R0.9590.94
204_H229_V0.9580.94
191_I210_L0.9560.94
64_A68_I0.9540.94
101_Y104_I0.9540.94
16_V20_H0.9530.94
162_K238_Q0.9520.94
122_W126_Y0.9500.94
99_G106_I0.9450.93
103_L119_M0.9430.93
31_R101_Y0.9370.93
300_E327_T0.9370.93
96_P100_K0.9360.93
344_Q376_E0.9330.93
71_L75_I0.9310.93
223_V230_S0.9280.93
226_D231_S0.9170.92
164_R170_T0.9160.92
193_I243_I0.9090.92
357_D383_S0.9080.92
24_I27_R0.9050.92
226_D235_D0.9030.92
52_T55_T0.8970.92
60_A64_A0.8930.91
160_A218_Y0.8930.91
24_I105_A0.8930.91
139_D142_E0.8920.91
262_L288_R0.8910.91
358_Y379_S0.8880.91
336_H339_E0.8870.91
264_L288_R0.8860.91
39_L42_I0.8830.91
267_A369_A0.8830.91
67_N70_Q0.8820.91
212_D216_K0.8820.91
265_I370_M0.8780.91
33_F37_P0.8760.91
76_P79_K0.8760.91
166_S169_I0.8740.90
114_A118_I0.8710.90
321_F337_F0.8700.90
93_E96_P0.8680.90
310_E313_K0.8650.90
271_I308_V0.8640.90
340_G344_Q0.8640.90
106_I110_L0.8610.90
136_I140_M0.8600.90
63_A77_V0.8600.90
171_S222_S0.8500.89
267_A366_F0.8480.89
307_E310_E0.8460.89
356_A361_C0.8440.89
21_G25_T0.8410.89
341_Q369_A0.8400.89
260_K383_S0.8310.88
65_A68_I0.8300.88
346_F349_E0.8300.88
307_E311_A0.8280.88
16_V110_L0.8270.88
167_K301_Y0.8270.88
265_I293_I0.8250.88
163_E239_E0.8250.88
154_Y194_K0.8230.88
274_M292_F0.8230.88
343_D346_F0.8220.88
214_P276_S0.8210.87
36_H39_L0.8180.87
36_H100_K0.8180.87
324_R341_Q0.8160.87
364_P367_I0.8150.87
168_E301_Y0.8150.87
118_I122_W0.8140.87
165_E211_S0.8100.87
85_H102_L0.8080.87
169_I222_S0.8060.86
373_L376_E0.8060.86
304_L307_E0.8050.86
98_V103_L0.8020.86
267_A363_S0.8000.86
107_K112_D0.7990.86
103_L106_I0.7980.86
326_P337_F0.7970.86
64_A86_R0.7970.86
237_L243_I0.7960.86
17_L68_I0.7940.86
337_F340_G0.7930.86
126_Y129_I0.7930.86
30_D54_R0.7920.86
371_H384_I0.7910.85
39_L207_Q0.7890.85
186_Q253_V0.7840.85
225_K234_H0.7820.85
96_P99_G0.7760.84
263_V291_L0.7760.84
372_K376_E0.7740.84
289_Q354_T0.7720.84
255_D357_D0.7690.84
86_R89_G0.7680.84
164_R167_K0.7620.83
344_Q381_P0.7620.83
158_V240_G0.7600.83
114_A117_D0.7570.83
130_A137_E0.7560.83
357_D385_H0.7550.83
204_H207_Q0.7550.83
363_S367_I0.7540.83
46_T49_K0.7540.83
348_K352_A0.7530.83
82_G133_F0.7520.82
122_W130_A0.7500.82
335_L338_H0.7490.82
211_S221_I0.7490.82
96_P110_L0.7490.82
299_S336_H0.7470.82
311_A317_V0.7430.82
121_A125_A0.7390.81
151_W155_K0.7360.81
75_I83_H0.7350.81
261_D288_R0.7350.81
302_H321_F0.7340.81
149_G155_K0.7330.81
193_I324_R0.7320.81
265_I366_F0.7280.80
149_G154_Y0.7280.80
133_F137_E0.7270.80
174_L245_I0.7260.80
99_G111_G0.7260.80
60_A77_V0.7260.80
127_G131_D0.7240.80
51_K54_R0.7240.80
27_R35_D0.7230.80
68_I74_I0.7210.80
375_S384_I0.7200.80
117_D122_W0.7200.80
116_P119_M0.7190.80
188_G209_S0.7190.80
262_L290_I0.7180.79
345_Q349_E0.7170.79
114_A125_A0.7130.79
327_T336_H0.7130.79
115_T125_A0.7130.79
53_Q60_A0.7110.79
170_T234_H0.7100.79
18_Q62_I0.7100.79
46_T54_R0.7100.79
53_Q56_A0.7080.79
29_Y53_Q0.7020.78
289_Q355_D0.6970.77
155_K219_Y0.6950.77
275_I308_V0.6940.77
185_F219_Y0.6940.77
84_K87_S0.6930.77
351_I356_A0.6930.77
25_T58_A0.6910.77
320_A338_H0.6910.77
134_I137_E0.6900.77
20_H118_I0.6900.77
200_S228_V0.6900.77
128_V132_A0.6880.77
302_H319_T0.6880.77
264_L278_L0.6870.76
96_P131_D0.6860.76
198_P236_G0.6850.76
281_S290_I0.6820.76
71_L74_I0.6800.76
194_K205_I0.6770.75
172_F234_H0.6750.75
365_S368_T0.6730.75
282_V308_V0.6730.75
204_H228_V0.6720.75
118_I121_A0.6720.75
254_L262_L0.6710.75
51_K57_L0.6710.75
155_K178_D0.6690.74
117_D121_A0.6660.74
122_W129_I0.6640.74
128_V133_F0.6620.74
278_L311_A0.6610.74
106_I109_V0.6610.74
149_G153_E0.6610.74
154_Y246_S0.6590.73
185_F210_L0.6590.73
74_I77_V0.6580.73
32_M36_H0.6570.73
95_Y103_L0.6570.73
126_Y134_I0.6550.73
275_I292_F0.6550.73
50_K54_R0.6530.73
329_E340_G0.6500.72
99_G110_L0.6490.72
49_K52_T0.6470.72
79_K82_G0.6470.72
267_A324_R0.6450.72
43_F85_H0.6450.72
293_I322_V0.6440.72
23_T27_R0.6430.72
23_T31_R0.6430.72
170_T222_S0.6420.71
325_E329_E0.6380.71
129_I132_A0.6360.71
326_P339_E0.6360.71
260_K380_A0.6360.71
80_Q83_H0.6330.70
20_H26_G0.6310.70
52_T60_A0.6310.70
194_K246_S0.6290.70
82_G86_R0.6270.70
232_Y236_G0.6260.70
190_Y207_Q0.6250.69
358_Y374_V0.6230.69
92_P96_P0.6220.69
135_G139_D0.6220.69
255_D288_R0.6210.69
348_K351_I0.6150.68
174_L243_I0.6140.68
271_I275_I0.6130.68
57_L69_D0.6130.68
264_L277_M0.6120.68
54_R57_L0.6110.68
99_G102_L0.6110.68
213_M279_K0.6100.68
17_L22_E0.6100.68
374_V379_S0.6090.67
52_T360_I0.6090.67
295_A366_F0.6080.67
112_D115_T0.6070.67
55_T62_I0.6050.67
97_I101_Y0.6050.67
103_L111_G0.6040.67
130_A134_I0.6040.67
121_A126_Y0.6040.67
160_A239_E0.6030.67
53_Q85_H0.6020.67
55_T59_N0.6010.66
192_S204_H0.6010.66
106_I111_G0.6000.66
252_F361_C0.5980.66
212_D218_Y0.5980.66
336_H341_Q0.5970.66
278_L317_V0.5970.66
18_Q46_T0.5960.66
182_L185_F0.5950.66
186_Q256_H0.5940.66
132_A135_G0.5930.65
80_Q251_D0.5920.65
36_H101_Y0.5910.65
56_A65_A0.5900.65
66_A69_D0.5890.65
90_I95_Y0.5890.65
366_F370_M0.5870.65
176_P219_Y0.5870.65
296_A323_Y0.5860.64
92_P110_L0.5850.64
77_V83_H0.5840.64
79_K139_D0.5800.64
68_I125_A0.5800.64
42_I46_T0.5790.64
57_L65_A0.5790.64
51_K56_A0.5780.63
219_Y304_L0.5760.63
127_G135_G0.5760.63
31_R40_L0.5760.63
150_G153_E0.5740.63
292_F308_V0.5740.63
138_K145_E0.5700.62
274_M294_H0.5690.62
302_H308_V0.5670.62
95_Y98_V0.5670.62
157_F182_L0.5670.62
174_L219_Y0.5640.62
323_Y326_P0.5640.62
186_Q255_D0.5640.62
340_G369_A0.5630.61
89_G246_S0.5600.61
342_I377_L0.5600.61
58_A61_V0.5600.61
92_P103_L0.5590.61
165_E222_S0.5590.61
90_I93_E0.5580.61
74_I83_H0.5530.60
297_K325_E0.5520.60
95_Y106_I0.5510.60
342_I345_Q0.5500.60
185_F212_D0.5490.59
63_A66_A0.5490.59
28_F39_L0.5480.59
42_I90_I0.5470.59
95_Y102_L0.5460.59
127_G133_F0.5450.59
75_I78_V0.5450.59
27_R32_M0.5430.59
195_V204_H0.5410.58
57_L64_A0.5410.58
275_I279_K0.5410.58
260_K356_A0.5390.58
298_N306_H0.5390.58
157_F304_L0.5380.58
216_K279_K0.5370.58
182_L247_A0.5370.58
282_V311_A0.5370.58
126_Y137_E0.5370.58
257_A260_K0.5360.58
189_Q250_G0.5340.57
64_A78_V0.5340.57
219_Y247_A0.5340.57
115_T119_M0.5330.57
98_V110_L0.5330.57
254_L303_A0.5330.57
99_G123_E0.5320.57
368_T372_K0.5320.57
209_S295_A0.5320.57
163_E306_H0.5300.57
224_K267_A0.5300.57
125_A129_I0.5290.57
209_S273_P0.5290.57
265_I374_V0.5280.57
102_L110_L0.5260.56
65_A85_H0.5260.56
57_L62_I0.5250.56
360_I364_P0.5250.56
62_I65_A0.5240.56
286_P290_I0.5230.56
64_A128_V0.5210.56
148_A153_E0.5190.55
360_I370_M0.5180.55
274_M295_A0.5180.55
42_I94_H0.5180.55
299_S328_E0.5170.55
23_T36_H0.5170.55
104_I108_D0.5170.55
190_Y250_G0.5160.55
57_L61_V0.5160.55
372_K375_S0.5150.55
94_H97_I0.5140.55
369_A373_L0.5120.54
105_A121_A0.5120.54
327_T339_E0.5120.54
335_L339_E0.5110.54
361_C387_E0.5100.54
327_T335_L0.5100.54
186_Q360_I0.5100.54
319_T337_F0.5090.54
80_Q140_M0.5090.54
114_A121_A0.5080.54
75_I79_K0.5080.54
99_G126_Y0.5060.53
63_A68_I0.5050.53
60_A81_I0.5030.53
345_Q348_K0.5020.53
306_H382_E0.5020.53
149_G180_K0.5010.53
65_A84_K0.5000.53
224_K234_H0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1gvhA 3 0.985 100 0.269 Contact Map
1cqxA 2 0.9875 100 0.27 Contact Map
4g1vA 3 0.9499 100 0.305 Contact Map
1tllA 2 0.9524 100 0.485 Contact Map
3qe2A 1 0.9499 100 0.506 Contact Map
2bpoA 1 0.9549 100 0.512 Contact Map
1ddgA 1 0.6165 100 0.531 Contact Map
1f20A 1 0.6541 100 0.543 Contact Map
4dqlA 2 0.5865 100 0.558 Contact Map
3jqqA 2 0.5965 100 0.565 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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