HMP - BACSU - GREMLIN Contacts

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HMP - Flavohemoprotein

UniProt:	P49852	Sequences: MLDNKTIEIIKSTVPVLQQHGETITGRFYDRMFQDHPELLNIFNQTNQKKKTQRTALANAVIAAAANIDQLGNIIPVVKQIGHKHRSIGIKPEHYPIVGKYLLIAIKDVLGDAATPDIMQAWEKAYGVIADAFIGIEKDMYEQAEEQAGGWKEYKPFVIAKKERESKEITSFYLKPEDSKPLPEFQAGQYISIKVRIPDSEYTHIRQYSLSDMPGKDYYRISVKKDGVVSSYLHDGLQEGDSIEISAPAGDFVLDHASQKDLVLISAGVGITPMISMLKTSVSKQPERQILFIHAAKNSEYHALRHEVEEAAKHSAVKTAFVYREPTEEDRAGDLHFHEGQIDQQFLKELIANTDADYYICGSPSFITAMHKLVSELGSAPESIHYELFGPQLSLAQSV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	399 (359)
Sequences:	2739 (1848)
Seq/√Len:	97.5

ECOLI - HMP CYSJ
BACSU - HMP CYSJ CYPE CYPD

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
159_I	237_L	5.729	1.00
279_K	307_E	4.212	1.00
302_H	323_Y	3.489	1.00
160_A	175_K	3.466	1.00
191_I	245_I	3.228	1.00
18_Q	66_A	3.178	1.00
194_K	244_E	3.158	1.00
162_K	170_T	3.131	1.00
70_Q	73_N	3.107	1.00
32_M	97_I	3.095	1.00
238_Q	241_D	3.089	1.00
212_D	279_K	2.994	1.00
158_V	175_K	2.913	1.00
263_V	356_A	2.874	1.00
156_P	244_E	2.816	1.00
161_K	239_E	2.797	1.00
156_P	242_S	2.783	1.00
211_S	222_S	2.746	1.00
174_L	221_I	2.651	1.00
266_S	274_M	2.599	1.00
86_R	249_A	2.491	1.00
225_K	235_D	2.408	1.00
161_K	173_Y	2.382	1.00
27_R	31_R	2.326	1.00
103_L	123_E	2.282	1.00
114_A	119_M	2.244	1.00
308_V	319_T	2.212	1.00
131_D	135_G	2.137	1.00
299_S	326_P	2.095	1.00
79_K	136_I	2.048	1.00
223_V	233_L	2.032	1.00
158_V	177_E	2.021	1.00
171_S	220_R	2.020	1.00
175_K	217_D	2.009	1.00
159_I	174_L	1.988	1.00
280_T	284_K	1.925	1.00
173_Y	220_R	1.908	1.00
312_A	317_V	1.897	1.00
295_A	324_R	1.896	1.00
192_S	205_I	1.878	1.00
281_S	286_P	1.877	1.00
87_S	207_Q	1.875	1.00
156_P	177_E	1.875	1.00
31_R	104_I	1.869	1.00
293_I	342_I	1.844	1.00
26_G	30_D	1.836	1.00
169_I	269_V	1.810	1.00
20_H	23_T	1.774	1.00
105_A	109_V	1.763	1.00
340_G	343_D	1.758	1.00
262_L	281_S	1.752	1.00
138_K	152_K	1.740	1.00
254_L	277_M	1.729	1.00
305_R	309_E	1.725	1.00
31_R	108_D	1.719	1.00
35_D	101_Y	1.710	1.00
120_Q	124_K	1.703	1.00
310_E	314_H	1.664	1.00
158_V	242_S	1.663	1.00
271_I	292_F	1.651	1.00
297_K	324_R	1.645	1.00
107_K	116_P	1.611	1.00
113_A	116_P	1.599	1.00
157_F	245_I	1.583	1.00
175_K	218_Y	1.579	1.00
237_L	241_D	1.573	1.00
247_A	250_G	1.565	1.00
260_K	357_D	1.558	1.00
16_V	19_Q	1.556	1.00
16_V	113_A	1.552	1.00
27_R	30_D	1.538	1.00
115_T	118_I	1.521	1.00
71_L	78_V	1.514	1.00
163_E	173_Y	1.511	1.00
291_L	320_A	1.506	1.00
22_E	55_T	1.501	1.00
27_R	108_D	1.501	1.00
263_V	358_Y	1.493	1.00
91_K	94_H	1.474	1.00
375_S	381_P	1.473	1.00
17_L	21_G	1.464	1.00
157_F	176_P	1.441	1.00
192_S	207_Q	1.436	1.00
232_Y	237_L	1.436	1.00
264_L	274_M	1.430	1.00
261_D	289_Q	1.425	1.00
46_T	50_K	1.423	1.00
192_S	246_S	1.406	1.00
360_I	384_I	1.402	0.99
99_G	103_L	1.402	0.99
295_A	342_I	1.397	0.99
30_D	34_Q	1.387	0.99
119_M	123_E	1.383	0.99
195_V	229_V	1.379	0.99
266_S	294_H	1.378	0.99
265_I	358_Y	1.377	0.99
165_E	171_S	1.372	0.99
177_E	242_S	1.352	0.99
57_L	60_A	1.336	0.99
187_A	280_T	1.332	0.99
343_D	376_E	1.331	0.99
296_A	301_Y	1.330	0.99
168_E	297_K	1.322	0.99
173_Y	218_Y	1.321	0.99
91_K	96_P	1.315	0.99
138_K	142_E	1.305	0.99
35_D	100_K	1.302	0.99
289_Q	318_K	1.292	0.99
82_G	136_I	1.289	0.99
120_Q	123_E	1.289	0.99
360_I	371_H	1.288	0.99
62_I	66_A	1.281	0.99
167_K	300_E	1.279	0.99
299_S	305_R	1.275	0.99
266_S	292_F	1.273	0.99
380_A	383_S	1.269	0.99
53_Q	57_L	1.265	0.99
145_E	152_K	1.254	0.99
17_L	62_I	1.242	0.99
169_I	303_A	1.225	0.99
197_I	200_S	1.225	0.99
275_I	304_L	1.216	0.99
159_I	162_K	1.207	0.98
271_I	304_L	1.193	0.98
22_E	26_G	1.192	0.98
302_H	305_R	1.188	0.98
19_Q	23_T	1.181	0.98
194_K	203_T	1.177	0.98
344_Q	348_K	1.176	0.98
326_P	336_H	1.164	0.98
275_I	307_E	1.162	0.98
298_N	325_E	1.161	0.98
26_G	54_R	1.159	0.98
225_K	231_S	1.155	0.98
64_A	129_I	1.148	0.98
278_L	308_V	1.147	0.98
61_V	69_D	1.146	0.98
371_H	375_S	1.145	0.98
107_K	119_M	1.144	0.98
23_T	26_G	1.143	0.98
132_A	136_I	1.142	0.98
31_R	35_D	1.138	0.98
124_K	128_V	1.137	0.98
295_A	322_V	1.133	0.98
116_P	120_Q	1.121	0.97
61_V	106_I	1.114	0.97
103_L	110_L	1.111	0.97
136_I	139_D	1.104	0.97
87_S	192_S	1.103	0.97
306_H	310_E	1.101	0.97
185_F	276_S	1.094	0.97
344_Q	377_L	1.091	0.97
309_E	321_F	1.089	0.97
324_R	369_A	1.082	0.97
35_D	104_I	1.079	0.97
122_W	125_A	1.073	0.97
118_I	125_A	1.069	0.97
282_V	317_V	1.066	0.97
32_M	101_Y	1.063	0.97
20_H	24_I	1.051	0.96
155_K	180_K	1.049	0.96
193_I	221_I	1.042	0.96
344_Q	347_L	1.034	0.96
40_L	45_Q	1.032	0.96
187_A	276_S	1.030	0.96
123_E	127_G	1.029	0.96
98_V	102_L	1.028	0.96
111_G	115_T	1.025	0.96
172_F	233_L	1.025	0.96
100_K	104_I	1.023	0.96
231_S	235_D	1.021	0.96
77_V	80_Q	1.021	0.96
260_K	355_D	1.017	0.96
355_D	383_S	1.015	0.95
78_V	82_G	1.011	0.95
197_I	204_H	1.010	0.95
162_K	237_L	1.008	0.95
126_Y	130_A	1.008	0.95
222_S	304_L	1.004	0.95
312_A	319_T	0.989	0.95
298_N	327_T	0.989	0.95
346_F	350_L	0.981	0.95
137_E	141_Y	0.981	0.95
79_K	83_H	0.974	0.94
32_M	38_E	0.974	0.94
211_S	220_R	0.959	0.94
204_H	229_V	0.958	0.94
191_I	210_L	0.956	0.94
64_A	68_I	0.954	0.94
101_Y	104_I	0.954	0.94
16_V	20_H	0.953	0.94
162_K	238_Q	0.952	0.94
122_W	126_Y	0.950	0.94
99_G	106_I	0.945	0.93
103_L	119_M	0.943	0.93
31_R	101_Y	0.937	0.93
300_E	327_T	0.937	0.93
96_P	100_K	0.936	0.93
344_Q	376_E	0.933	0.93
71_L	75_I	0.931	0.93
223_V	230_S	0.928	0.93
226_D	231_S	0.917	0.92
164_R	170_T	0.916	0.92
193_I	243_I	0.909	0.92
357_D	383_S	0.908	0.92
24_I	27_R	0.905	0.92
226_D	235_D	0.903	0.92
52_T	55_T	0.897	0.92
60_A	64_A	0.893	0.91
160_A	218_Y	0.893	0.91
24_I	105_A	0.893	0.91
139_D	142_E	0.892	0.91
262_L	288_R	0.891	0.91
358_Y	379_S	0.888	0.91
336_H	339_E	0.887	0.91
264_L	288_R	0.886	0.91
39_L	42_I	0.883	0.91
267_A	369_A	0.883	0.91
67_N	70_Q	0.882	0.91
212_D	216_K	0.882	0.91
265_I	370_M	0.878	0.91
33_F	37_P	0.876	0.91
76_P	79_K	0.876	0.91
166_S	169_I	0.874	0.90
114_A	118_I	0.871	0.90
321_F	337_F	0.870	0.90
93_E	96_P	0.868	0.90
310_E	313_K	0.865	0.90
271_I	308_V	0.864	0.90
340_G	344_Q	0.864	0.90
106_I	110_L	0.861	0.90
136_I	140_M	0.860	0.90
63_A	77_V	0.860	0.90
171_S	222_S	0.850	0.89
267_A	366_F	0.848	0.89
307_E	310_E	0.846	0.89
356_A	361_C	0.844	0.89
21_G	25_T	0.841	0.89
341_Q	369_A	0.840	0.89
260_K	383_S	0.831	0.88
65_A	68_I	0.830	0.88
346_F	349_E	0.830	0.88
307_E	311_A	0.828	0.88
16_V	110_L	0.827	0.88
167_K	301_Y	0.827	0.88
265_I	293_I	0.825	0.88
163_E	239_E	0.825	0.88
154_Y	194_K	0.823	0.88
274_M	292_F	0.823	0.88
343_D	346_F	0.822	0.88
214_P	276_S	0.821	0.87
36_H	39_L	0.818	0.87
36_H	100_K	0.818	0.87
324_R	341_Q	0.816	0.87
364_P	367_I	0.815	0.87
168_E	301_Y	0.815	0.87
118_I	122_W	0.814	0.87
165_E	211_S	0.810	0.87
85_H	102_L	0.808	0.87
169_I	222_S	0.806	0.86
373_L	376_E	0.806	0.86
304_L	307_E	0.805	0.86
98_V	103_L	0.802	0.86
267_A	363_S	0.800	0.86
107_K	112_D	0.799	0.86
103_L	106_I	0.798	0.86
326_P	337_F	0.797	0.86
64_A	86_R	0.797	0.86
237_L	243_I	0.796	0.86
17_L	68_I	0.794	0.86
337_F	340_G	0.793	0.86
126_Y	129_I	0.793	0.86
30_D	54_R	0.792	0.86
371_H	384_I	0.791	0.85
39_L	207_Q	0.789	0.85
186_Q	253_V	0.784	0.85
225_K	234_H	0.782	0.85
96_P	99_G	0.776	0.84
263_V	291_L	0.776	0.84
372_K	376_E	0.774	0.84
289_Q	354_T	0.772	0.84
255_D	357_D	0.769	0.84
86_R	89_G	0.768	0.84
164_R	167_K	0.762	0.83
344_Q	381_P	0.762	0.83
158_V	240_G	0.760	0.83
114_A	117_D	0.757	0.83
130_A	137_E	0.756	0.83
357_D	385_H	0.755	0.83
204_H	207_Q	0.755	0.83
363_S	367_I	0.754	0.83
46_T	49_K	0.754	0.83
348_K	352_A	0.753	0.83
82_G	133_F	0.752	0.82
122_W	130_A	0.750	0.82
335_L	338_H	0.749	0.82
211_S	221_I	0.749	0.82
96_P	110_L	0.749	0.82
299_S	336_H	0.747	0.82
311_A	317_V	0.743	0.82
121_A	125_A	0.739	0.81
151_W	155_K	0.736	0.81
75_I	83_H	0.735	0.81
261_D	288_R	0.735	0.81
302_H	321_F	0.734	0.81
149_G	155_K	0.733	0.81
193_I	324_R	0.732	0.81
265_I	366_F	0.728	0.80
149_G	154_Y	0.728	0.80
133_F	137_E	0.727	0.80
174_L	245_I	0.726	0.80
99_G	111_G	0.726	0.80
60_A	77_V	0.726	0.80
127_G	131_D	0.724	0.80
51_K	54_R	0.724	0.80
27_R	35_D	0.723	0.80
68_I	74_I	0.721	0.80
375_S	384_I	0.720	0.80
117_D	122_W	0.720	0.80
116_P	119_M	0.719	0.80
188_G	209_S	0.719	0.80
262_L	290_I	0.718	0.79
345_Q	349_E	0.717	0.79
114_A	125_A	0.713	0.79
327_T	336_H	0.713	0.79
115_T	125_A	0.713	0.79
53_Q	60_A	0.711	0.79
170_T	234_H	0.710	0.79
18_Q	62_I	0.710	0.79
46_T	54_R	0.710	0.79
53_Q	56_A	0.708	0.79
29_Y	53_Q	0.702	0.78
289_Q	355_D	0.697	0.77
155_K	219_Y	0.695	0.77
275_I	308_V	0.694	0.77
185_F	219_Y	0.694	0.77
84_K	87_S	0.693	0.77
351_I	356_A	0.693	0.77
25_T	58_A	0.691	0.77
320_A	338_H	0.691	0.77
134_I	137_E	0.690	0.77
20_H	118_I	0.690	0.77
200_S	228_V	0.690	0.77
128_V	132_A	0.688	0.77
302_H	319_T	0.688	0.77
264_L	278_L	0.687	0.76
96_P	131_D	0.686	0.76
198_P	236_G	0.685	0.76
281_S	290_I	0.682	0.76
71_L	74_I	0.680	0.76
194_K	205_I	0.677	0.75
172_F	234_H	0.675	0.75
365_S	368_T	0.673	0.75
282_V	308_V	0.673	0.75
204_H	228_V	0.672	0.75
118_I	121_A	0.672	0.75
254_L	262_L	0.671	0.75
51_K	57_L	0.671	0.75
155_K	178_D	0.669	0.74
117_D	121_A	0.666	0.74
122_W	129_I	0.664	0.74
128_V	133_F	0.662	0.74
278_L	311_A	0.661	0.74
106_I	109_V	0.661	0.74
149_G	153_E	0.661	0.74
154_Y	246_S	0.659	0.73
185_F	210_L	0.659	0.73
74_I	77_V	0.658	0.73
32_M	36_H	0.657	0.73
95_Y	103_L	0.657	0.73
126_Y	134_I	0.655	0.73
275_I	292_F	0.655	0.73
50_K	54_R	0.653	0.73
329_E	340_G	0.650	0.72
99_G	110_L	0.649	0.72
49_K	52_T	0.647	0.72
79_K	82_G	0.647	0.72
267_A	324_R	0.645	0.72
43_F	85_H	0.645	0.72
293_I	322_V	0.644	0.72
23_T	27_R	0.643	0.72
23_T	31_R	0.643	0.72
170_T	222_S	0.642	0.71
325_E	329_E	0.638	0.71
129_I	132_A	0.636	0.71
326_P	339_E	0.636	0.71
260_K	380_A	0.636	0.71
80_Q	83_H	0.633	0.70
20_H	26_G	0.631	0.70
52_T	60_A	0.631	0.70
194_K	246_S	0.629	0.70
82_G	86_R	0.627	0.70
232_Y	236_G	0.626	0.70
190_Y	207_Q	0.625	0.69
358_Y	374_V	0.623	0.69
92_P	96_P	0.622	0.69
135_G	139_D	0.622	0.69
255_D	288_R	0.621	0.69
348_K	351_I	0.615	0.68
174_L	243_I	0.614	0.68
271_I	275_I	0.613	0.68
57_L	69_D	0.613	0.68
264_L	277_M	0.612	0.68
54_R	57_L	0.611	0.68
99_G	102_L	0.611	0.68
213_M	279_K	0.610	0.68
17_L	22_E	0.610	0.68
374_V	379_S	0.609	0.67
52_T	360_I	0.609	0.67
295_A	366_F	0.608	0.67
112_D	115_T	0.607	0.67
55_T	62_I	0.605	0.67
97_I	101_Y	0.605	0.67
103_L	111_G	0.604	0.67
130_A	134_I	0.604	0.67
121_A	126_Y	0.604	0.67
160_A	239_E	0.603	0.67
53_Q	85_H	0.602	0.67
55_T	59_N	0.601	0.66
192_S	204_H	0.601	0.66
106_I	111_G	0.600	0.66
252_F	361_C	0.598	0.66
212_D	218_Y	0.598	0.66
336_H	341_Q	0.597	0.66
278_L	317_V	0.597	0.66
18_Q	46_T	0.596	0.66
182_L	185_F	0.595	0.66
186_Q	256_H	0.594	0.66
132_A	135_G	0.593	0.65
80_Q	251_D	0.592	0.65
36_H	101_Y	0.591	0.65
56_A	65_A	0.590	0.65
66_A	69_D	0.589	0.65
90_I	95_Y	0.589	0.65
366_F	370_M	0.587	0.65
176_P	219_Y	0.587	0.65
296_A	323_Y	0.586	0.64
92_P	110_L	0.585	0.64
77_V	83_H	0.584	0.64
79_K	139_D	0.580	0.64
68_I	125_A	0.580	0.64
42_I	46_T	0.579	0.64
57_L	65_A	0.579	0.64
51_K	56_A	0.578	0.63
219_Y	304_L	0.576	0.63
127_G	135_G	0.576	0.63
31_R	40_L	0.576	0.63
150_G	153_E	0.574	0.63
292_F	308_V	0.574	0.63
138_K	145_E	0.570	0.62
274_M	294_H	0.569	0.62
302_H	308_V	0.567	0.62
95_Y	98_V	0.567	0.62
157_F	182_L	0.567	0.62
174_L	219_Y	0.564	0.62
323_Y	326_P	0.564	0.62
186_Q	255_D	0.564	0.62
340_G	369_A	0.563	0.61
89_G	246_S	0.560	0.61
342_I	377_L	0.560	0.61
58_A	61_V	0.560	0.61
92_P	103_L	0.559	0.61
165_E	222_S	0.559	0.61
90_I	93_E	0.558	0.61
74_I	83_H	0.553	0.60
297_K	325_E	0.552	0.60
95_Y	106_I	0.551	0.60
342_I	345_Q	0.550	0.60
185_F	212_D	0.549	0.59
63_A	66_A	0.549	0.59
28_F	39_L	0.548	0.59
42_I	90_I	0.547	0.59
95_Y	102_L	0.546	0.59
127_G	133_F	0.545	0.59
75_I	78_V	0.545	0.59
27_R	32_M	0.543	0.59
195_V	204_H	0.541	0.58
57_L	64_A	0.541	0.58
275_I	279_K	0.541	0.58
260_K	356_A	0.539	0.58
298_N	306_H	0.539	0.58
157_F	304_L	0.538	0.58
216_K	279_K	0.537	0.58
182_L	247_A	0.537	0.58
282_V	311_A	0.537	0.58
126_Y	137_E	0.537	0.58
257_A	260_K	0.536	0.58
189_Q	250_G	0.534	0.57
64_A	78_V	0.534	0.57
219_Y	247_A	0.534	0.57
115_T	119_M	0.533	0.57
98_V	110_L	0.533	0.57
254_L	303_A	0.533	0.57
99_G	123_E	0.532	0.57
368_T	372_K	0.532	0.57
209_S	295_A	0.532	0.57
163_E	306_H	0.530	0.57
224_K	267_A	0.530	0.57
125_A	129_I	0.529	0.57
209_S	273_P	0.529	0.57
265_I	374_V	0.528	0.57
102_L	110_L	0.526	0.56
65_A	85_H	0.526	0.56
57_L	62_I	0.525	0.56
360_I	364_P	0.525	0.56
62_I	65_A	0.524	0.56
286_P	290_I	0.523	0.56
64_A	128_V	0.521	0.56
148_A	153_E	0.519	0.55
360_I	370_M	0.518	0.55
274_M	295_A	0.518	0.55
42_I	94_H	0.518	0.55
299_S	328_E	0.517	0.55
23_T	36_H	0.517	0.55
104_I	108_D	0.517	0.55
190_Y	250_G	0.516	0.55
57_L	61_V	0.516	0.55
372_K	375_S	0.515	0.55
94_H	97_I	0.514	0.55
369_A	373_L	0.512	0.54
105_A	121_A	0.512	0.54
327_T	339_E	0.512	0.54
335_L	339_E	0.511	0.54
361_C	387_E	0.510	0.54
327_T	335_L	0.510	0.54
186_Q	360_I	0.510	0.54
319_T	337_F	0.509	0.54
80_Q	140_M	0.509	0.54
114_A	121_A	0.508	0.54
75_I	79_K	0.508	0.54
99_G	126_Y	0.506	0.53
63_A	68_I	0.505	0.53
60_A	81_I	0.503	0.53
345_Q	348_K	0.502	0.53
306_H	382_E	0.502	0.53
149_G	180_K	0.501	0.53
65_A	84_K	0.500	0.53
224_K	234_H	0.500	0.53

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1gvhA	3	0.985	100	0.269	Contact Map
1cqxA	2	0.9875	100	0.27	Contact Map
4g1vA	3	0.9499	100	0.305	Contact Map
1tllA	2	0.9524	100	0.485	Contact Map
3qe2A	1	0.9499	100	0.506	Contact Map
2bpoA	1	0.9549	100	0.512	Contact Map
1ddgA	1	0.6165	100	0.531	Contact Map
1f20A	1	0.6541	100	0.543	Contact Map
4dqlA	2	0.5865	100	0.558	Contact Map
3jqqA	2	0.5965	100	0.565	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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