GREMLIN Database
YKHA - Uncharacterized acyl-CoA thioester hydrolase YkhA
UniProt: P49851 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 172 (147)
Sequences: 2552 (1492)
Seq/√Len: 123.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_I114_L3.4921.00
87_T127_P3.1511.00
47_S80_S2.9121.00
54_R126_V2.6911.00
146_V150_N2.4711.00
136_E139_I2.4141.00
149_A153_K2.3391.00
24_D35_K2.2601.00
25_T72_Q2.2561.00
37_M64_V2.2261.00
44_A116_F2.2251.00
83_T93_F2.1881.00
68_K107_E2.1841.00
35_K38_S2.1831.00
31_L36_L2.1511.00
41_D58_T2.0201.00
98_K107_E1.9821.00
70_I109_A1.9741.00
147_Q150_N1.9591.00
12_S51_H1.9271.00
32_F38_S1.9091.00
120_D124_K1.8131.00
20_V31_L1.7851.00
74_D107_E1.7611.00
108_L111_T1.7091.00
133_P138_E1.6601.00
26_N33_G1.6341.00
139_I143_N1.6201.00
52_C90_M1.5791.00
99_E106_R1.5371.00
74_D100_H1.5351.00
93_F141_L1.4951.00
77_C106_R1.4631.00
47_S82_V1.4451.00
83_T91_E1.4451.00
43_I78_L1.4321.00
38_S42_D1.4071.00
91_E148_R1.3911.00
84_W146_V1.3741.00
83_T141_L1.3731.00
150_N154_N1.3721.00
78_L94_V1.3621.00
79_E97_I1.3611.00
70_I76_V1.3561.00
18_S42_D1.3221.00
26_N32_F1.2901.00
151_E154_N1.2831.00
60_S115_T1.2631.00
90_M128_V1.2591.00
15_V79_E1.2551.00
37_M61_M1.2420.99
86_G89_S1.2360.99
100_H103_T1.2100.99
50_R99_E1.1940.99
30_T71_G1.1840.99
154_N157_R1.1820.99
135_T138_E1.1780.99
97_I106_R1.1710.99
133_P142_H1.1670.99
13_K81_Y1.1410.99
84_W142_H1.1240.99
85_V133_P1.1240.99
51_H131_V1.1220.99
13_K79_E1.1200.99
70_I96_V1.0660.98
24_D39_Y1.0650.98
61_M114_L1.0610.98
119_L125_P1.0610.98
94_V114_L1.0580.98
93_F113_F1.0340.98
47_S92_V1.0300.98
39_Y78_L1.0280.98
52_C56_T1.0190.98
51_H130_R0.9940.97
62_D152_R0.9810.97
143_N147_Q0.9690.97
150_N153_K0.9640.97
45_S49_A0.9570.97
43_I80_S0.9500.97
33_G66_F0.9480.97
77_C97_I0.9430.97
143_N146_V0.9420.97
36_L110_A0.9410.96
15_V77_C0.9200.96
102_M121_S0.9200.96
84_W145_A0.9180.96
48_A56_T0.9170.96
89_S117_V0.9110.96
83_T113_F0.9100.96
16_K42_D0.9070.96
37_M114_L0.9030.96
135_T139_I0.9020.96
136_E140_M0.8960.95
134_E138_E0.8880.95
137_E140_M0.8870.95
41_D57_V0.8830.95
100_H105_E0.8810.95
36_L70_I0.8750.95
46_I75_S0.8750.95
91_E145_A0.8680.94
142_H145_A0.8600.94
95_K108_L0.8580.94
49_A101_L0.8570.94
59_A89_S0.8510.94
18_S39_Y0.8460.94
51_H90_M0.8330.93
59_A117_V0.8250.93
79_E95_K0.8170.93
97_I108_L0.8120.92
140_M144_T0.8120.92
71_G74_D0.8040.92
59_A65_D0.8010.92
147_Q151_E0.8000.92
21_F42_D0.7900.91
75_S101_L0.7850.91
44_A94_V0.7850.91
16_K43_I0.7770.91
48_A92_V0.7760.90
31_L35_K0.7740.90
91_E152_R0.7680.90
118_A128_V0.7660.90
31_L70_I0.7630.90
150_N157_R0.7510.89
14_V43_I0.7500.89
74_D98_K0.7470.89
145_A148_R0.7430.88
58_T129_P0.7410.88
52_C55_E0.7380.88
153_K157_R0.7360.88
14_V47_S0.7340.88
133_P139_I0.7340.88
99_E104_G0.7320.88
76_V90_M0.7280.87
62_D113_F0.7200.87
40_I96_V0.7140.86
32_F42_D0.7080.86
22_P72_Q0.7070.86
21_F38_S0.7050.86
44_A114_L0.7000.85
30_T110_A0.6920.85
153_K156_K0.6920.85
36_L60_S0.6900.85
88_S125_P0.6860.84
132_V139_I0.6830.84
23_L56_T0.6810.84
77_C99_E0.6760.83
51_H128_V0.6660.82
53_R104_G0.6610.82
81_Y141_L0.6530.81
121_S126_V0.6520.81
39_Y76_V0.6490.81
67_L108_L0.6470.81
57_V89_S0.6440.80
29_N73_K0.6440.80
81_Y93_F0.6430.80
92_V116_F0.6430.80
50_R77_C0.6410.80
105_E127_P0.6410.80
82_V90_M0.6400.80
151_E155_R0.6360.79
39_Y42_D0.6360.79
40_I112_S0.6360.79
39_Y64_V0.6350.79
25_T73_K0.6340.79
144_T148_R0.6310.79
57_V61_M0.6300.79
60_S65_D0.6230.78
84_W149_A0.6160.77
51_H82_V0.6150.77
80_S94_V0.6150.77
82_V131_V0.6090.76
23_L38_S0.6030.76
35_K39_Y0.5970.75
50_R89_S0.5930.75
122_N125_P0.5900.74
120_D125_P0.5900.74
116_F133_P0.5800.73
41_D86_G0.5790.73
17_T20_V0.5780.73
14_V46_I0.5780.73
40_I78_L0.5750.72
83_T95_K0.5710.72
12_S92_V0.5700.72
144_T147_Q0.5690.71
87_T143_N0.5680.71
95_K111_T0.5680.71
113_F141_L0.5650.71
120_D126_V0.5650.71
81_Y95_K0.5640.71
30_T35_K0.5630.71
22_P66_F0.5620.71
48_A90_M0.5600.70
137_E141_L0.5590.70
136_E143_N0.5570.70
65_D155_R0.5540.69
27_N72_Q0.5520.69
44_A92_V0.5520.69
143_N153_K0.5510.69
21_F32_F0.5510.69
81_Y138_E0.5490.69
27_N32_F0.5410.68
93_F108_L0.5380.67
42_D149_A0.5380.67
91_E149_A0.5360.67
57_V119_L0.5340.67
95_K113_F0.5340.67
68_K98_K0.5330.67
41_D89_S0.5300.66
93_F111_T0.5220.65
102_M137_E0.5220.65
38_S55_E0.5200.65
45_S58_T0.5190.65
61_M110_A0.5160.64
46_I50_R0.5140.64
62_D148_R0.5140.64
119_L124_K0.5130.64
140_M147_Q0.5070.63
21_F45_S0.5050.62
149_A156_K0.5040.62
136_E146_V0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mobA 3 0.9302 100 0.366 Contact Map
4ncpA 5 0.9419 100 0.367 Contact Map
4zv3A 3 0.8605 100 0.421 Contact Map
1y7uA 5 0.9535 100 0.441 Contact Map
2qq2A 5 0.907 100 0.448 Contact Map
2q2bA 5 0.8198 100 0.449 Contact Map
1vpmA 5 0.9128 99.9 0.479 Contact Map
4ienA 5 0.8953 99.9 0.525 Contact Map
2v1oA 5 0.8198 99.9 0.533 Contact Map
2gvhA 3 0.7267 99.8 0.592 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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