GREMLIN Database
MUTL - DNA mismatch repair protein MutL
UniProt: P49850 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 627 (575)
Sequences: 3626 (2634)
Seq/√Len: 109.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_T60_N8.6001.00
36_I184_V5.1791.00
39_D62_E5.1151.00
114_S140_K4.8381.00
45_I174_V4.6081.00
108_H148_N4.5941.00
231_E288_T4.3461.00
28_V55_I3.3451.00
471_K576_S3.1981.00
116_G140_K3.1751.00
65_E68_D3.1471.00
42_V60_N3.0171.00
32_V174_V2.9911.00
115_T118_G2.9331.00
69_C113_T2.9141.00
5_I82_K2.8631.00
120_G138_S2.8611.00
122_K134_S2.8351.00
542_A546_E2.7911.00
69_C121_T2.7511.00
73_F109_L2.7501.00
574_K578_K2.7441.00
110_E122_K2.7351.00
294_V305_V2.6781.00
267_V283_T2.5811.00
46_D56_R2.5411.00
451_L458_L2.5171.00
224_H231_E2.5001.00
127_G151_F2.4551.00
27_V149_L2.4441.00
47_I170_I2.4351.00
440_Y453_Q2.4221.00
44_E187_R2.3891.00
49_E53_A2.3691.00
501_E553_L2.3371.00
3_K68_D2.3351.00
590_A594_D2.3341.00
108_H126_Q2.2881.00
64_M69_C2.2801.00
54_S145_V2.2541.00
253_V305_V2.2481.00
450_I588_I2.2351.00
126_Q131_I2.2221.00
226_S231_E2.2181.00
444_Q463_Q2.2091.00
233_K288_T2.2071.00
112_T136_S2.1081.00
461_I592_L2.1081.00
8_S11_L2.1021.00
518_F531_C2.0931.00
112_T122_K2.0541.00
70_K133_E2.0501.00
56_R143_E2.0491.00
451_L460_I2.0471.00
208_L235_Y2.0421.00
224_H233_K2.0191.00
520_E530_R2.0191.00
167_L190_H2.0091.00
604_C608_R2.0061.00
573_C606_H1.9831.00
54_S147_S1.9771.00
448_T579_A1.9441.00
589_K593_D1.9421.00
52_L163_V1.9411.00
309_K312_E1.9151.00
441_P450_I1.8991.00
508_H511_E1.8941.00
486_V531_C1.8871.00
113_T121_T1.8661.00
203_D206_H1.8631.00
48_E54_S1.8631.00
251_S263_L1.8481.00
43_I184_V1.8441.00
565_E569_I1.8311.00
185_S200_G1.8281.00
110_E147_S1.8241.00
510_Q513_E1.8111.00
251_S267_V1.8101.00
6_Q74_R1.7831.00
46_D58_L1.7771.00
72_A100_L1.7751.00
71_R74_R1.7691.00
28_V170_I1.7581.00
442_I458_L1.7551.00
494_T526_S1.7521.00
573_C604_C1.7361.00
513_E518_F1.7341.00
198_T207_V1.7031.00
172_D176_R1.6921.00
223_L285_I1.6911.00
29_K33_E1.6871.00
462_D465_A1.6851.00
42_V185_S1.6751.00
200_G207_V1.6681.00
473_E598_T1.6661.00
573_C608_R1.6651.00
112_T145_V1.6611.00
212_Y250_S1.6511.00
441_P588_I1.6431.00
71_R77_A1.6371.00
47_I167_L1.6351.00
253_V307_L1.6301.00
464_H573_C1.6221.00
27_V55_I1.6171.00
64_M72_A1.6131.00
270_G318_R1.6101.00
46_D189_R1.6001.00
577_I583_L1.5891.00
167_L195_L1.5761.00
464_H608_R1.5721.00
615_S618_E1.5651.00
470_I591_L1.5631.00
498_S501_E1.5561.00
221_L324_V1.5561.00
461_I466_A1.5501.00
73_F125_L1.5471.00
474_Y594_D1.5441.00
452_A461_I1.5321.00
194_N197_Q1.5211.00
112_T120_G1.5191.00
138_S143_E1.5181.00
469_R598_T1.5121.00
223_L236_I1.5111.00
125_L130_I1.5071.00
112_T138_S1.4991.00
505_I527_Y1.4971.00
36_I181_H1.4891.00
225_V320_G1.4781.00
165_T169_N1.4741.00
232_V316_L1.4711.00
464_H606_H1.4641.00
445_M451_L1.4631.00
110_E145_V1.4631.00
540_E543_E1.4471.00
550_Q554_D1.4461.00
506_E521_S1.4441.00
64_M68_D1.4421.00
64_M70_K1.4391.00
442_I451_L1.4381.00
584_R587_E1.4381.00
509_K513_E1.4261.00
249_M283_T1.4221.00
73_F111_I1.4221.00
501_E546_E1.4211.00
595_L601_P1.4211.00
111_I123_L1.4201.00
363_P366_S1.4121.00
595_L598_T1.4081.00
93_L255_G1.4031.00
445_M458_L1.3951.00
543_E547_E1.3881.00
230_F287_I1.3871.00
467_Q471_K1.3731.00
585_N589_K1.3681.00
233_K286_E1.3641.00
529_V545_I1.3511.00
66_N118_G1.3421.00
468_E606_H1.3401.00
594_D597_S1.3401.00
69_C111_I1.3381.00
267_V321_I1.3371.00
69_C123_L1.3281.00
36_I93_L1.3281.00
511_E514_S1.3261.00
464_H467_Q1.3261.00
124_V132_S1.3241.00
49_E163_V1.3230.99
242_T279_R1.3230.99
444_Q583_L1.3200.99
502_A527_Y1.3150.99
66_N121_T1.3150.99
260_N310_E1.3130.99
463_Q583_L1.3090.99
447_G582_H1.2990.99
468_E573_C1.2960.99
187_R197_Q1.2960.99
464_H604_C1.2840.99
44_E189_R1.2840.99
474_Y478_K1.2800.99
457_G613_H1.2780.99
265_K314_H1.2700.99
9_D13_N1.2690.99
32_V186_I1.2680.99
464_H468_E1.2670.99
479_V568_A1.2540.99
101_P105_S1.2470.99
226_S229_D1.2460.99
208_L284_F1.2410.99
476_R568_A1.2390.99
72_A111_I1.2390.99
81_I86_D1.2320.99
269_E318_R1.2280.99
171_T188_L1.2260.99
89_R292_I1.2240.99
469_R473_E1.2210.99
167_L188_L1.2170.99
494_T528_I1.2150.99
577_I591_L1.2150.99
436_V439_M1.2130.99
496_H526_S1.2110.99
103_I146_V1.2090.99
27_V146_V1.2090.99
503_L507_Q1.1980.99
225_V316_L1.1950.99
585_N588_I1.1900.99
465_A468_E1.1880.99
468_E604_C1.1860.99
106_V149_L1.1800.99
361_K364_E1.1760.99
57_V144_I1.1740.99
293_L308_S1.1730.99
52_L160_M1.1710.99
365_K368_A1.1710.99
361_K370_S1.1700.99
566_E570_M1.1660.99
3_K62_E1.1630.99
606_H609_P1.1510.99
446_H457_G1.1500.99
545_I549_I1.1480.99
290_D293_L1.1450.99
3_K65_E1.1450.99
454_N457_G1.1420.99
450_I463_Q1.1360.98
444_Q588_I1.1330.98
174_V186_I1.1290.98
471_K575_G1.1270.98
66_N135_R1.1160.98
123_L130_I1.1150.98
444_Q464_H1.1130.98
10_E14_K1.1070.98
109_L125_L1.0950.98
221_L236_I1.0890.98
117_E140_K1.0890.98
475_F568_A1.0870.98
14_K84_E1.0870.98
172_D175_N1.0790.98
442_I445_M1.0770.98
471_K474_Y1.0750.98
237_A282_I1.0740.98
569_I572_S1.0710.98
501_E550_Q1.0690.98
460_I612_I1.0680.98
521_S524_S1.0680.98
264_V283_T1.0640.98
35_A39_D1.0610.98
363_P367_T1.0580.98
497_Y505_I1.0530.97
570_M574_K1.0530.97
368_A372_S1.0520.97
502_A521_S1.0480.97
237_A241_I1.0460.97
237_A242_T1.0460.97
28_V32_V1.0450.97
185_S197_Q1.0430.97
581_R587_E1.0380.97
127_G152_N1.0380.97
167_L171_T1.0330.97
367_T372_S1.0320.97
81_I90_V1.0300.97
369_P372_S1.0270.97
205_R235_Y1.0240.97
232_V287_I1.0190.97
504_I508_H1.0170.97
363_P372_S1.0150.97
223_L234_G1.0150.97
205_R217_A1.0140.97
95_F302_K1.0130.97
603_T610_I1.0110.97
56_R145_V1.0100.97
298_V306_R1.0090.97
16_A19_E1.0090.97
438_I441_P1.0080.97
522_F526_S1.0030.97
439_M452_A1.0000.97
573_C578_K0.9990.97
259_K303_L0.9980.96
408_E411_D0.9960.96
364_E367_T0.9940.96
367_T370_S0.9920.96
148_N151_F0.9910.96
234_G285_I0.9900.96
11_L84_E0.9870.96
477_E599_S0.9860.96
32_V177_I0.9840.96
445_M619_M0.9830.96
446_H616_T0.9830.96
214_T218_K0.9820.96
472_Y565_E0.9800.96
468_E608_R0.9780.96
120_G137_S0.9770.96
121_T133_E0.9770.96
66_N133_E0.9760.96
230_F313_L0.9700.96
363_P369_P0.9620.96
366_S369_P0.9610.96
171_T175_N0.9600.96
32_V45_I0.9600.96
32_V43_I0.9600.96
252_V286_E0.9590.96
464_H473_E0.9580.96
44_E58_L0.9560.96
111_I144_I0.9550.96
9_D129_N0.9520.95
578_K606_H0.9490.95
64_M115_T0.9480.95
368_A371_Y0.9450.95
365_K371_Y0.9430.95
21_V155_A0.9420.95
318_R322_K0.9410.95
293_L309_K0.9400.95
365_K372_S0.9390.95
289_M294_V0.9390.95
573_C609_P0.9370.95
255_G288_T0.9350.95
124_V131_I0.9330.95
363_P371_Y0.9320.95
202_G207_V0.9280.95
322_K326_K0.9230.95
295_D302_K0.9230.95
27_V103_I0.9220.95
509_K527_Y0.9180.94
583_L588_I0.9180.94
465_A608_R0.9180.94
567_A570_M0.9160.94
250_S257_Y0.9150.94
110_E124_V0.9140.94
243_R248_Y0.9140.94
287_I316_L0.9130.94
529_V541_E0.9080.94
70_K74_R0.9080.94
319_D323_D0.9070.94
201_N206_H0.9060.94
189_R194_N0.9050.94
604_C609_P0.9040.94
508_H552_V0.9030.94
69_C72_A0.9020.94
571_M575_G0.9020.94
564_R568_A0.9010.94
512_L545_I0.8990.94
19_E24_P0.8980.94
75_R113_T0.8950.94
532_H541_E0.8920.94
28_V47_I0.8900.93
598_T601_P0.8900.93
95_F98_E0.8900.93
6_Q12_S0.8890.93
10_E287_I0.8880.93
364_E369_P0.8870.93
456_N613_H0.8870.93
276_P603_T0.8850.93
45_I57_V0.8850.93
271_Y281_P0.8840.93
27_V31_L0.8820.93
573_C577_I0.8810.93
174_V196_L0.8800.93
225_V323_D0.8780.93
471_K475_F0.8740.93
273_T603_T0.8730.93
452_A592_L0.8710.93
115_T140_K0.8710.93
447_G580_N0.8670.93
50_A167_L0.8660.93
367_T371_Y0.8650.92
494_T523_G0.8640.92
602_F611_I0.8640.92
271_Y325_F0.8640.92
25_A173_V0.8610.92
53_A148_N0.8600.92
488_E531_C0.8590.92
595_L602_F0.8580.92
323_D327_Q0.8570.92
257_Y303_L0.8570.92
60_N140_K0.8560.92
187_R194_N0.8540.92
219_K238_L0.8530.92
362_V365_K0.8530.92
22_E306_R0.8510.92
19_E299_H0.8500.92
251_S264_V0.8480.92
470_I598_T0.8460.92
276_P279_R0.8460.92
93_L180_A0.8460.92
472_Y476_R0.8460.92
462_D467_Q0.8450.92
454_N613_H0.8440.92
315_D319_D0.8430.91
65_E115_T0.8430.91
459_Y613_H0.8400.91
222_P233_K0.8390.91
446_H453_Q0.8380.91
289_M293_L0.8360.91
107_S410_S0.8330.91
463_Q468_E0.8330.91
503_L506_E0.8330.91
251_S283_T0.8310.91
483_E514_S0.8300.91
518_F530_R0.8280.91
475_F575_G0.8270.91
13_N101_P0.8240.91
162_T165_T0.8240.91
415_E419_T0.8230.90
96_R99_A0.8230.90
28_V31_L0.8210.90
520_E528_I0.8210.90
522_F528_I0.8210.90
604_C607_G0.8170.90
93_L181_H0.8150.90
164_H168_G0.8150.90
504_I553_L0.8130.90
416_Q419_T0.8120.90
465_A473_E0.8100.90
170_I188_L0.8100.90
130_I133_E0.8100.90
352_T423_E0.8060.90
14_K105_S0.8050.90
230_F316_L0.8040.89
467_Q578_K0.8030.89
246_R268_H0.8020.89
593_D596_R0.8010.89
436_V596_R0.7990.89
600_D603_T0.7980.89
243_R247_N0.7980.89
182_P235_Y0.7960.89
450_I464_H0.7960.89
314_H318_R0.7950.89
414_A417_P0.7940.89
361_K367_T0.7870.88
460_I614_H0.7840.88
265_K269_E0.7810.88
465_A573_C0.7800.88
177_I186_I0.7790.88
101_P104_A0.7770.88
465_A610_I0.7770.88
104_A123_L0.7770.88
28_V174_V0.7750.88
444_Q450_I0.7750.88
236_I321_I0.7740.88
23_R155_A0.7730.88
95_F99_A0.7690.87
362_V371_Y0.7680.87
561_K565_E0.7670.87
462_D573_C0.7660.87
220_M237_A0.7660.87
496_H525_N0.7650.87
364_E368_A0.7620.87
347_E350_F0.7610.87
450_I583_L0.7610.87
222_P235_Y0.7600.87
464_H578_K0.7590.87
578_K608_R0.7590.87
221_L238_L0.7590.87
464_H577_I0.7580.87
343_A351_I0.7570.86
601_P605_P0.7560.86
505_I549_I0.7550.86
579_A606_H0.7550.86
216_V282_I0.7550.86
546_E550_Q0.7540.86
113_T118_G0.7540.86
70_K130_I0.7500.86
15_I19_E0.7490.86
35_A145_V0.7490.86
159_Y307_L0.7480.86
176_R257_Y0.7470.86
27_V107_S0.7440.85
343_A347_E0.7420.85
16_A299_H0.7400.85
475_F572_S0.7390.85
575_G578_K0.7380.85
17_A24_P0.7310.84
441_P452_A0.7300.84
38_A57_V0.7300.84
59_D63_G0.7280.84
365_K369_P0.7280.84
256_R302_K0.7260.84
465_A604_C0.7260.84
561_K564_R0.7250.84
234_G237_A0.7240.84
519_L527_Y0.7230.84
502_A525_N0.7220.84
222_P234_G0.7210.84
577_I606_H0.7200.84
230_F289_M0.7200.84
500_N553_L0.7190.83
494_T522_F0.7190.83
588_I592_L0.7170.83
597_S614_H0.7170.83
20_V76_H0.7170.83
363_P368_A0.7160.83
502_A506_E0.7150.83
47_I188_L0.7150.83
320_G324_V0.7140.83
24_P50_A0.7110.83
246_R280_H0.7110.83
237_A271_Y0.7100.83
493_L542_A0.7090.83
448_T463_Q0.7040.82
598_T610_I0.7020.82
423_E427_E0.7010.82
439_M596_R0.6990.82
463_Q577_I0.6980.82
3_K67_E0.6970.82
29_K296_V0.6970.82
261_F265_K0.6960.81
578_K604_C0.6960.81
18_G300_P0.6950.81
219_K222_P0.6940.81
204_V286_E0.6930.81
476_R565_E0.6930.81
205_R222_P0.6920.81
441_P585_N0.6920.81
4_V113_T0.6910.81
297_N302_K0.6890.81
316_L320_G0.6880.81
417_P428_Q0.6870.81
510_Q514_S0.6860.81
169_N265_K0.6860.81
64_M67_E0.6840.80
450_I462_D0.6840.80
422_Q425_H0.6840.80
159_Y487_Q0.6830.80
362_V367_T0.6820.80
406_T410_S0.6820.80
462_D608_R0.6820.80
420_F426_E0.6800.80
7_L11_L0.6790.80
178_A211_I0.6790.80
475_F479_V0.6780.80
67_E70_K0.6770.80
28_V45_I0.6770.80
24_P299_H0.6750.79
213_G595_L0.6740.79
253_V258_I0.6740.79
182_P207_V0.6720.79
532_H537_P0.6720.79
592_L596_R0.6720.79
348_Q351_I0.6710.79
579_A608_R0.6710.79
124_V134_S0.6700.79
601_P611_I0.6700.79
365_K370_S0.6690.79
468_E473_E0.6690.79
262_P310_E0.6690.79
577_I608_R0.6660.79
605_P608_R0.6660.79
95_F295_D0.6660.79
567_A571_M0.6650.78
95_F300_P0.6650.78
441_P592_L0.6650.78
475_F571_M0.6640.78
517_V529_V0.6630.78
43_I62_E0.6620.78
598_T611_I0.6620.78
307_L314_H0.6620.78
476_R599_S0.6600.78
236_I283_T0.6590.78
573_C579_A0.6590.78
48_E53_A0.6570.78
18_G299_H0.6570.78
108_H151_F0.6570.78
55_I146_V0.6570.78
444_Q468_E0.6560.78
459_Y469_R0.6550.77
176_R303_L0.6530.77
345_K350_F0.6520.77
462_D473_E0.6520.77
33_E297_N0.6520.77
572_S575_G0.6500.77
266_A270_G0.6500.77
171_T196_L0.6480.77
64_M71_R0.6470.77
76_H105_S0.6470.77
444_Q462_D0.6460.76
463_Q467_Q0.6460.76
29_K297_N0.6460.76
406_T411_D0.6450.76
40_S195_L0.6450.76
441_P589_K0.6450.76
414_A420_F0.6440.76
577_I580_N0.6440.76
449_Y464_H0.6430.76
511_E515_V0.6420.76
12_S89_R0.6410.76
209_A217_A0.6400.76
601_P610_I0.6390.76
588_I603_T0.6380.76
98_E254_N0.6370.75
446_H469_R0.6370.75
454_N459_Y0.6360.75
349_Q352_T0.6360.75
466_A595_L0.6350.75
463_Q601_P0.6350.75
366_S371_Y0.6350.75
11_L90_V0.6340.75
212_Y248_Y0.6320.75
345_K348_Q0.6320.75
362_V369_P0.6310.75
157_L160_M0.6310.75
458_L614_H0.6300.75
497_Y527_Y0.6300.75
497_Y501_E0.6290.75
364_E371_Y0.6290.75
232_V285_I0.6290.75
114_S118_G0.6290.75
23_R166_E0.6280.74
366_S370_S0.6280.74
579_A604_C0.6270.74
517_V545_I0.6270.74
345_K349_Q0.6270.74
34_N37_D0.6260.74
119_A136_S0.6250.74
561_K570_M0.6230.74
81_I95_F0.6230.74
253_V306_R0.6220.74
15_I18_G0.6220.74
363_P370_S0.6210.74
547_E550_Q0.6210.74
503_L521_S0.6200.73
317_I324_V0.6190.73
364_E370_S0.6190.73
465_A606_H0.6190.73
448_T578_K0.6180.73
275_L325_F0.6170.73
449_Y466_A0.6160.73
444_Q467_Q0.6140.73
595_L611_I0.6140.73
118_G121_T0.6120.73
577_I604_C0.6100.72
70_K123_L0.6100.72
84_E90_V0.6100.72
505_I545_I0.6090.72
21_V218_K0.6090.72
207_V212_Y0.6090.72
464_H580_N0.6090.72
473_E476_R0.6090.72
109_L144_I0.6090.72
464_H469_R0.6090.72
75_R101_P0.6090.72
287_I317_I0.6080.72
87_L92_T0.6080.72
21_V106_V0.6070.72
68_D72_A0.6070.72
96_R295_D0.6060.72
58_L138_S0.6050.72
255_G286_E0.6040.72
19_E23_R0.6030.71
225_V232_V0.6030.71
47_I190_H0.6020.71
219_K240_E0.6010.71
5_I619_M0.6010.71
410_S414_A0.6000.71
17_A299_H0.6000.71
104_A109_L0.6000.71
32_V173_V0.5990.71
529_V617_Y0.5990.71
509_K519_L0.5980.71
186_I307_L0.5980.71
462_D606_H0.5970.71
249_M450_I0.5960.71
566_E569_I0.5960.71
499_T509_K0.5950.70
15_I105_S0.5940.70
179_L284_F0.5930.70
269_E272_H0.5930.70
249_M268_H0.5920.70
87_L166_E0.5910.70
227_S316_L0.5910.70
9_D12_S0.5900.70
106_V160_M0.5900.70
579_A603_T0.5880.70
467_Q576_S0.5880.70
523_G526_S0.5880.70
578_K612_I0.5850.69
41_T424_C0.5840.69
19_E33_E0.5840.69
443_G468_E0.5830.69
411_D432_A0.5830.69
540_E544_L0.5820.69
362_V370_S0.5820.69
297_N300_P0.5810.69
96_R300_P0.5800.68
208_L220_M0.5800.68
595_L605_P0.5790.68
361_K369_P0.5790.68
573_C605_P0.5790.68
80_K95_F0.5790.68
462_D468_E0.5790.68
21_V105_S0.5780.68
341_A344_I0.5780.68
569_I573_C0.5780.68
263_L317_I0.5770.68
237_A587_E0.5770.68
423_E426_E0.5770.68
114_S117_E0.5760.68
245_S550_Q0.5760.68
419_T423_E0.5750.68
96_R302_K0.5740.68
505_I591_L0.5720.67
17_A77_A0.5720.67
98_E300_P0.5720.67
41_T183_E0.5710.67
266_A314_H0.5710.67
229_D290_D0.5700.67
80_K94_G0.5700.67
465_A471_K0.5700.67
364_E372_S0.5690.67
243_R280_H0.5690.67
368_A388_E0.5690.67
574_K579_A0.5690.67
104_A125_L0.5690.67
88_F306_R0.5680.67
16_A76_H0.5660.67
596_R599_S0.5660.67
424_C427_E0.5650.66
449_Y462_D0.5650.66
596_R602_F0.5640.66
159_Y207_V0.5640.66
253_V289_M0.5620.66
588_I602_F0.5620.66
7_L47_I0.5620.66
565_E571_M0.5610.66
595_L610_I0.5610.66
512_L617_Y0.5590.66
16_A24_P0.5590.66
177_I257_Y0.5590.66
95_F297_N0.5580.66
268_H271_Y0.5570.65
223_L432_A0.5570.65
204_V235_Y0.5560.65
20_V98_E0.5560.65
60_N116_G0.5560.65
472_Y605_P0.5550.65
173_V177_I0.5540.65
362_V372_S0.5540.65
559_D562_K0.5530.65
166_E296_V0.5530.65
236_I270_G0.5520.65
519_L556_K0.5500.64
420_F427_E0.5500.64
310_E314_H0.5490.64
52_L157_L0.5490.64
99_A302_K0.5490.64
249_M264_V0.5490.64
6_Q323_D0.5480.64
441_P444_Q0.5480.64
450_I469_R0.5480.64
8_S276_P0.5470.64
521_S525_N0.5470.64
366_S415_E0.5470.64
566_E580_N0.5470.64
311_T315_D0.5470.64
578_K609_P0.5470.64
210_A289_M0.5460.64
588_I596_R0.5460.64
422_Q477_E0.5450.64
256_R297_N0.5450.64
366_S407_L0.5450.64
190_H195_L0.5440.64
469_R472_Y0.5440.64
242_T610_I0.5430.63
578_K581_R0.5430.63
299_H304_E0.5430.63
174_V188_L0.5420.63
209_A214_T0.5420.63
346_N350_F0.5410.63
45_I335_Q0.5410.63
265_K268_H0.5410.63
18_G24_P0.5400.63
220_M284_F0.5400.63
325_F538_K0.5400.63
38_A62_E0.5390.63
572_S576_S0.5390.63
50_A163_V0.5390.63
502_A524_S0.5370.63
229_D312_E0.5370.63
21_V593_D0.5370.63
295_D300_P0.5370.63
94_G97_G0.5370.63
19_E297_N0.5360.62
587_E614_H0.5340.62
65_E69_C0.5330.62
30_E99_A0.5330.62
208_L211_I0.5330.62
174_V198_T0.5330.62
519_L529_V0.5320.62
460_I473_E0.5320.62
417_P420_F0.5320.62
182_P204_V0.5310.62
81_I92_T0.5310.62
107_S146_V0.5300.62
180_A255_G0.5290.61
421_E427_E0.5280.61
438_I455_E0.5280.61
573_C580_N0.5260.61
211_I615_S0.5260.61
7_L64_M0.5260.61
200_G212_Y0.5260.61
460_I619_M0.5250.61
127_G130_I0.5240.61
33_E75_R0.5240.61
361_K365_K0.5240.61
569_I574_K0.5240.61
56_R171_T0.5240.61
16_A22_E0.5240.61
114_S137_S0.5230.61
352_T415_E0.5200.60
13_N29_K0.5200.60
388_E406_T0.5200.60
461_I530_R0.5190.60
69_C125_L0.5190.60
372_S408_E0.5190.60
107_S292_I0.5180.60
64_M276_P0.5180.60
212_Y459_Y0.5180.60
231_E416_Q0.5180.60
199_N206_H0.5170.60
563_L574_K0.5170.60
176_R259_K0.5170.60
243_R246_R0.5170.60
260_N298_V0.5160.60
421_E433_S0.5160.60
13_N177_I0.5160.60
413_S426_E0.5140.59
560_I567_A0.5130.59
586_D589_K0.5130.59
23_R301_S0.5130.59
407_L431_P0.5120.59
40_S453_Q0.5120.59
30_E302_K0.5110.59
18_G29_K0.5110.59
347_E387_E0.5110.59
444_Q473_E0.5100.59
35_A118_G0.5100.59
467_Q577_I0.5090.59
270_G321_I0.5090.59
68_D113_T0.5080.58
352_T361_K0.5080.58
439_M616_T0.5080.58
348_Q370_S0.5080.58
596_R601_P0.5080.58
410_S426_E0.5080.58
20_V51_G0.5070.58
76_H304_E0.5070.58
486_V532_H0.5060.58
463_Q580_N0.5060.58
23_R169_N0.5060.58
443_G448_T0.5050.58
19_E22_E0.5050.58
339_K343_A0.5050.58
347_E351_I0.5040.58
506_E509_K0.5040.58
414_A419_T0.5040.58
217_A235_Y0.5040.58
186_I211_I0.5040.58
449_Y465_A0.5030.58
20_V297_N0.5030.58
179_L250_S0.5030.58
418_E429_P0.5020.57
411_D430_Q0.5020.57
345_K413_S0.5020.57
46_D187_R0.5010.57
499_T525_N0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3h4lA 2 0.5215 100 0.533 Contact Map
1b63A 2 0.5183 100 0.545 Contact Map
1h7sA 1 0.4673 100 0.548 Contact Map
4p7aA 2 0.4705 100 0.56 Contact Map
3kdgA 2 0.3062 100 0.693 Contact Map
3ncvA 2 0.2998 100 0.697 Contact Map
3cwvA 1 0.4928 100 0.72 Contact Map
4e4wB 1 0.3238 100 0.726 Contact Map
4ipeA 2 0.8038 100 0.749 Contact Map
1kijA 2 0.5327 100 0.75 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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